Study on the action mechanism of inhibition of natural origin on lipid droplet formation in macrophages.
Project/Area Number |
20810028
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Living organism molecular science
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Research Institution | Kitasato University |
Principal Investigator |
MATSUDA Daisuke Kitasato University, 薬学部, 助教 (20458764)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | ケミカルバイオロジー / 動脈硬化症 / 脂質代謝 / 天然由来阻害剤 |
Research Abstract |
The action mechanism of fungal beauveriolide on lipid droplet formation in macrophages was studied. Biochemical study revealed that beauveriolide inhibited acyl-CoA:cholesterol acyltransferase (ACAT) in mouse macrophages. Furthermore, the compound selectively inhibited ACAT1 isozyme in intact cells, while it inhibited both ACAT1 andACAT2 isozymes in microsomes. Cell biological study suggested that this discrepancy between intact cells and microsome might be due to the different membrane topology of the active sites between the two isozemes.
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Report
(3 results)
Research Products
(56 results)
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[Presentation] Pyripyropene A, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2, attenuate hypercholesterolemia and atherosclerosis in atherogenic mice2009
Author(s)
T. Ohshiro, D. Matsuda, K. Sakai, C. Degirolamo, H. Yagyu, L.L. Rudel, S. Omura, S. Ishibahi, H. Tomoda
Organizer
11th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds
Place of Presentation
San Sebastian, Spain
Related Report
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[Presentation] Pyripyropene A, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2, attenuates hypercholesterolemia and atherosclerosis in apolipoprotein E knockout mice2009
Author(s)
T. Ohshiro, K. Sakai, D. Matsuda, M. Ohtawa, T. Nagamitsu, H. Yagyu, L.L. Rudel, S. Omura, S. Ishibashi, H. Tomoda
Organizer
第41年日本動脈硬化学会総会・学術集会
Place of Presentation
下関
Related Report
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