| Project/Area Number |
20880029
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
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|---|
| Research Institution | Azabu University |
|---|
Principal Investigator |
ASAI Fumitoshi Azabu University, 獣医学部, 教授 (00511677)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,276,000 (Direct Cost: ¥2,520,000、Indirect Cost: ¥756,000)
Fiscal Year 2009: ¥1,547,000 (Direct Cost: ¥1,190,000、Indirect Cost: ¥357,000)
Fiscal Year 2008: ¥1,729,000 (Direct Cost: ¥1,330,000、Indirect Cost: ¥399,000)
|
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| Keywords | 糖尿病 / 心血管リスク / バイオマーカー / インスリン抵抗性 |
|---|
| Research Abstract |
Present studies were performed to investigate pathophysiologic features related with diabetes and thrombosis, the main factor of cardiovascular risk, in the WBN/Kob-Lepr(fa) rat, a novel model of type 2 diabetes mellitus. It revealed that WBN/Kob-Lepr(fa) rats share a number of common features with human type 2 diabetic patients including obesity, insulin-resistance, damaged pancreatic β cells and abnormal thrombotic biomarkers. WBN/Kob-Lepr(fa) rats may be useful for diabetic researches.
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