The effect of nutritional management during fetal life on vascular function and oxidative stress in rats with adult-onset diseases
| Project/Area Number |
20880030
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Kinki University |
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Principal Investigator |
SATOI Keiko Kinki University, 農学部, 助教 (70510874)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,133,000 (Direct Cost: ¥2,410,000、Indirect Cost: ¥723,000)
Fiscal Year 2009: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2008: ¥1,625,000 (Direct Cost: ¥1,250,000、Indirect Cost: ¥375,000)
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| Keywords | 栄養生化学 / 栄養 / 循環器 / 高血圧 / 循環器・高血圧 |
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| Research Abstract |
Some research show that the increase in the prevalence of adult-onset diseases and vascular disorders after the birth by exposure to undernutrition during fetal life. Moreover, previous research using stroke-prone spontaneously hypertensive rats (SHRSP), an animal model which develops hypertension and stroke, demonstrated the increased salt-sensitivity in rats whose dams were fed protein restricted diets during pregnancy. In this study, the effect of maternal exposure to low-protein diet on postnatal vascular function was examined. As a result, the study revealed that nutritional environment during fetal life possibly affects vascular function independently of increased blood pressure in SHRSP with metabolic disorders.
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Report
(3 results)
Research Products
(2 results)
