Cell-specific regulation of the JC virus late gene
Project/Area Number |
20890005
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | Hokkaido University |
Principal Investigator |
ORBA Yasuko Hokkaido University, 人獣共通感染症リサーチセンター, 博士研究員 (60507169)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | JCウイルス / T抗原 / カフェイン / 細胞特異性 / Tag |
Research Abstract |
(1) Large T antigen of JC virus activates various promoters including JC virus late promoter. The enhancement of promoter activity by large T antigen is prominent in JC virus permissive cells. The cell-specific transcriptional regulation by T antigen is one of potential mechanisms of cell specificity for JC virus infection. (2) We found that caffeine had a pronounced antiviral effect in cells infected with JC virus. Caffeine suppressed expression of viral early proteins and viral DNA replication.
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Report
(3 results)
Research Products
(8 results)