Immune reaction against tumor-antigen and allo-antigen after cord blood transplantation

• Project/Area Number: 20890096
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: NISHIDA Tetsuya Nagoya University, 医学部・附属病院, 医員 (80508929)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 臍帯血移植 / 腫瘍反応性T細胞 / 抗原提示細胞 / 成人T細胞性白血病 / サイトメガロウイルス / CTLA-4 / 抗原特異的T細胞 / 臍帶血移植

Research Abstract

Immune reaction against tumor-antigen and allo-antigen after cord blood transplantation was analyzed using adult T cell leukemia (ATL) cells. ATL cells activated with CD3/CD28 maintained characteristics of ATL and acquired the potential as an antigen presenting cells. ATL reactive T cells were not generated from post-transplant peripheral blood mononuclear cells isolated from ATL patients with clinical response. Immune reaction against cytomegalovirus after cord blood transplantation was also weaker than that after bone marrow transplantation and peripheral blood stem cell transplantation

Research Products

• [Journal Article] Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients. (2009)
  • Author(s): Nishida T, Murayama T, et al., (他9人、1番目)
  • Journal Title: International Journal of Hematology 89(1) Pages: 98-105
  • NAID: 10025159842
  • Peer Reviewed
• [Journal Article] Phase II study of tacrolimus and methotrexate for prophylaxis acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients. (2009)
  • Author(s): Nishida T
  • Journal Title: International Journal of Hematology 89 Pages: 98-105
  • NAID: 10025159842
  • Peer Reviewed
• [Presentation] Tetsuya Nishida Effect of Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) Haplotype on Allogeneic Hematopoietic Stem Cell Transplantation (2010)
  • Author(s): Miho Murase
  • Organizer: 2010 BMT Tandem Meeting
  • Place of Presentation: Orlando, Florida, US
  • Year and Date: 2010-02-27
• [Presentation] Effect of Cytotoxic T-Lymphocyte Antigen 4(CTLA-4)Haplotype on Allogeneic Hematopoietic Stem Cell Transplantation (2010)
  • Author(s): Miho Murase, Tetsuya Nishida
  • Organizer: 2010 BMT Tandem Meeting
  • Place of Presentation: Orlando, Florida, US
  • Year and Date: 2010-02-27
• [Presentation] 同種造血幹細胞移植におけるCytotoxic T-Lymphocyte Antigen 4(CTLA-4)遺伝子多型の影響 (2010)
  • Author(s): 村瀬未帆、西田徹也
  • Organizer: 第32回日本造血細胞移植学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2010-02-19
• [Presentation] HLA-A, B, DRB1遺伝子学的適合非血縁者間骨髄移植に対するFK506とCyclosporine Aを用いたGVHD予防法の臨床第III相試験 (2009)
  • Author(s): 西田徹也
  • Organizer: 第31回日本造血細胞移植学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-02-05
• [Presentation] HLA-A, B, DRBI遺伝子学的適合非血縁者間骨髄移植に対するFK506とCyclosporine Aを用いたGVHD予防法の臨床第III相試験 (2009)
  • Author(s): 西田徹也
  • Organizer: 第31回日本造血細胞移植学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-02-05
• [Presentation] 慢性リンパ性白血病に対する骨髄非破壊的同種造血幹細胞移植後の細胞傷害性T細胞と抗腫瘍効果との関連 (2008)
  • Author(s): 西田徹也
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10