Molecular mechanism of phosphatidylserine exposure in apoptotic cells

• Project/Area Number: 20890109
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Kyoto University
• Principal Investigator: SUZUKI Jun Kyoto University, 医学研究科, 特定研究員(科学研究) (30511894)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,094,000 (Direct Cost: ¥2,380,000、Indirect Cost: ¥714,000); Fiscal Year 2009: ¥1,352,000 (Direct Cost: ¥1,040,000、Indirect Cost: ¥312,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: アポトーシス / ホスファチジルセリン / カルシウム / イオノフォア / ソーティング / Maleimide / Inside-out vesicle / ATP

Research Abstract

I investigated the mechanisms of phosphatidylserine (PS) exposure in apoptotic cells. Ca^<2+> was found to be the effecter for PS exposure. Using Ca2+ ionophore A23187, I designed the experimental system in which cells externalize PS without dying.

Research Products

• [Journal Article] Engulfment of Apoptotic Cells and its Physiological Roles (Review) (2010)
  • Author(s): Hanayama R, Miyanishi M, Yamaguchi H, Suzuki J, Nagata S.
  • Journal Title: Encyclopedia of Life Science (Review) Pages: 165-175
  • Peer Reviewed
• [Journal Article] Engulfment of Apoptotic Cells and its physiological Roles(Review). (2010)
  • Author(s): Hanayama R, Miyanishi M, Yamaguchi H, Suzuki J, Nagata S.
  • Journal Title: Encyclopedia of Life Sciences(Cell Death) Pages: 165-175
  • Peer Reviewed
• [Remarks]
  • URL: http://www2.mfour.med.kyoto-u.ac.jp/~nagata/
• [Remarks]
  • URL: http://www2.mfour.med.kyoto-u.ac.jp/~nagata/