Molecular mechanism of phosphatidylserine exposure in apoptotic cells
Project/Area Number |
20890109
|
Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
Allocation Type | Single-year Grants |
Research Field |
General physiology
|
Research Institution | Kyoto University |
Principal Investigator |
SUZUKI Jun Kyoto University, 医学研究科, 特定研究員(科学研究) (30511894)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,094,000 (Direct Cost: ¥2,380,000、Indirect Cost: ¥714,000)
Fiscal Year 2009: ¥1,352,000 (Direct Cost: ¥1,040,000、Indirect Cost: ¥312,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | アポトーシス / ホスファチジルセリン / カルシウム / イオノフォア / ソーティング / Maleimide / Inside-out vesicle / ATP |
Research Abstract |
I investigated the mechanisms of phosphatidylserine (PS) exposure in apoptotic cells. Ca^<2+> was found to be the effecter for PS exposure. Using Ca2+ ionophore A23187, I designed the experimental system in which cells externalize PS without dying.
|
Report
(3 results)
Research Products
(4 results)