Establishment of early therapeutic assessment method for cancer by combination of AMS and PET
Project/Area Number |
20890186
|
Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Yokohama City University |
Principal Investigator |
MINAMIMOTO Ryogo Yokohama City University, 附属病院, 助教 (40511655)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥2,925,000 (Direct Cost: ¥2,250,000、Indirect Cost: ¥675,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 癌 / 放射線 / 薬物反応 / がん / 薬物反応性 |
Research Abstract |
First we clarified the 14C concentration in blood and tumor as background. Second, as for FDG tracer, we showed that Accelerator mass spectrometry (AMS) analysis has an excellent correlation with biodistribution measurements using gamma counter regarded as PET measurement. Third, we evaluated the therapeutic effect by alternation of C14 concentration in blood compared to alternation of free DNA in the blood. At 24 hours post therapy, free DNA and C14 concentration in 5FU treatment group has difference compared to other groups.
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Report
(3 results)
Research Products
(7 results)