Establishment of early therapeutic assessment method for cancer by combination of AMS and PET

• Project/Area Number: 20890186
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Yokohama City University
• Principal Investigator: MINAMIMOTO Ryogo Yokohama City University, 附属病院, 助教 (40511655)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,925,000 (Direct Cost: ¥2,250,000、Indirect Cost: ¥675,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 癌 / 放射線 / 薬物反応 / がん / 薬物反応性

Research Abstract

First we clarified the 14C concentration in blood and tumor as background. Second, as for FDG tracer, we showed that Accelerator mass spectrometry (AMS) analysis has an excellent correlation with biodistribution measurements using gamma counter regarded as PET measurement. Third, we evaluated the therapeutic effect by alternation of C14 concentration in blood compared to alternation of free DNA in the blood. At 24 hours post therapy, free DNA and C14 concentration in 5FU treatment group has difference compared to other groups.

Research Products

• [Journal Article] Correlation analysis of measurement result between accelerator mass spectrometry and gamma counter. (2010)
  • Author(s): Ryogo Minamimoto・Yoshimi Hamabe・Chao Cheng・Marika Shimoda・Takashi Oka・Tomio Inoue
  • Journal Title: Ann Nucl Med. 2010 24巻 Pages: 45-52
  • NAID: 10026099936
  • Peer Reviewed
• [Journal Article] Correlation of PET and AMS analyses for early kinetics of 2-fluoro-2 deoxy-glucose (FDG) Nuclear Instruments and Methods in Physics Research (2010)
  • Author(s): Ryogo Minamimoto, Yoshimi Hamabe, Teiji Miyaoka, Chumpol Theeraladanon, Takashi Oka, Takao Matsui, Tomio Inoue
  • Journal Title: section B, Beam Interaction with Materials and Atoms 268巻 Pages: 1321-1323
  • Peer Reviewed
• [Journal Article] Correlation analysis of measurement result between accelerator mass spectrometry and gamma counter (2010)
  • Author(s): 南本亮吾
  • Journal Title: Annals of Nuclear Medicine 24 Pages: 45-52
  • NAID: 10026099936
  • Peer Reviewed
• [Journal Article] Correlation of PET and AMS analyses for early kinetics of 2-fluoro-2-deoxyglucose(FDG) (2010)
  • Author(s): 南本亮吾
  • Journal Title: Nuclear Instruments and Methods in Physics Research, section B, Beam Interaction with Materials and Atoms 268 Pages: 1321-1323
  • Peer Reviewed
• [Presentation] Advantage of Accelerator Mass Spectrometry (AMS) for drug research. (2009)
  • Author(s): Ryogo Minamimoto
  • Organizer: 2009 SNM annual meeting
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2009-06-15
• [Presentation] Advantage of Accelerator Mass Spectrometry(AMS)for drug research (2009)
  • Author(s): 南本亮吾
  • Organizer: 2009 SNM annual meeting
  • Place of Presentation: カナダ・トロント
  • Year and Date: 2009-06-15
• [Presentation] PETとAMSの相関性に関する検討 (2008)
  • Author(s): 南本亮吾
  • Organizer: 日本核医学会総会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2008-10-25