| Project/Area Number |
20890208
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OTSU Keishi Iwate Medical University, 歯学部, ポストドクター (60509066)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 発生・分化 / 歯学 / 細胞・組織 / シグナル伝達 / 象牙芽細胞 / 歯胚発生 / Rhoシグナリング / real time imaging / Rho シグナリング / slice culture |
|---|
| Research Abstract |
We have developed a new system that can observe the morphological change and molecular dynamics in a single cell during odontogenesis. We have established odontoblasts cell line from tooth germ mesenchymal cells with odontoblast marker. Using the cell line and mouse incisor organ culture, we demonstrated that ROCK, an effecter molecule of Rho small GTPase, plays an important role for the polarization and odontogenesis.
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