| Project/Area Number |
20890231
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KITAHARA Syuji Tokyo Women's Medical University, 医学部, 助教 (40510235)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 血管新生 / 腫瘍血管 / 消化器腫瘍 / 腺腫 / 腺癌 / 悪性化 / APC^<Min / +>マウス / 微小環境 / 微小循環 / 過形成 / APC^<Win |
|---|
| Research Abstract |
We sought to characterize the micro-vascular changes in the intestine of Apc^<Min/+> mice that provide a unique model for the adenomatous polyposis and subsequent carcinoma, namely the adenoma-carcinoma sequence. Remarkable structural changes in the microvasculature were observed in villi of benign tumors (adenomas). The vascular density increased and their basement membranes become irregular. As tumors became malignant, the irregularity of tumor vessels with size variation became more prominent, including abnormal associations of pericytes and basement membranes. We conclude that the changes in local vascular networks may reflect the neoplastic transforming sequence of the intestinal epithelia, therefore being useful signs for prognosis of the tumors.
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