IL-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury
| Project/Area Number |
20890265
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
MIYOSHI Kan Hyogo College of Medicine, 医学部, 助教 (30454755)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | IL-18 / microglia / neuropathic pain / spinal cord / astrocytes / glial interaction / IL-18R / TLR4 |
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| Research Abstract |
Nerve injury induced a striking increase in IL-18 expression in the dorsal horn, and IL-18 was upregulated in hyperactive microglia. The functional inhibition of IL-18 signaling pathways suppressed injury-induced tactile allodynia and the induction of astroglial markers. Conversely, intrathecal injection of IL-18 induced behavioral, morphological, and biochemical changes similar to those observed after nerve injury. Our results indicate that IL-18-mediated microglia/astrocyte interactions in the spinal cord have a substantial role in the generation of tactile allodynia. Thus, blocking IL-18 signaling in glial cells might provide a fruitful strategy for treating neuropathic pain.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Synthesis of a novel 6, 14-epoxymorphinan derivative and its pharmacology2008
Author(s)
Nemoto, T., Fujii, H., Narita, M., Miyoshi, K., Nakamura, A., Suzuki, T., Nagase, H
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Journal Title
Bioorg. Med. Chem. Lett 18
Pages: 6398-6401
Related Report
Peer Reviewed
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[Journal Article] Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice2008
Author(s)
Nakamura, A., Narita, M., Miyoshi, K., Shindo, K., Okutsu, D., Suzuki, M., Higashiyama, K., Suzuki, T
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Journal Title
Psychopharmacology 200
Pages: 307-316
Related Report
Peer Reviewed
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[Journal Article] Syntheses of 4, 6'-epoxymorphinan derivatives and their pharmacologies2008
Author(s)
Nemoto, T., Fujii, H., Narita, M., Miyoshi, K., Nakamura, A., Suzuki, T., Nagase, H
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Journal Title
Bioorg. Med. Chem 16
Pages: 4304-4312
Related Report
Peer Reviewed
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[Journal Article] Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine2008
Author(s)
Narita, M., Nakamura, A., Ozaki, M., Imai, S., Miyoshi, K., Suzuki, M., Suzuki, T
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Journal Title
Neuropsychopharmacology 33
Pages: 1097-1112
Related Report
Peer Reviewed
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[Presentation] TRPA1 mediates gastric distension-induced visceral pain in rats2008
Author(s)
Kondo, T., Obata, K., Miyoshi, K., Sakurai, J., Miwa, H., Noguchi, k.
Organizer
The 38th Annual Meeting of the Society for Neuroscience
Place of Presentation
Washington D.C., U.S.A
Related Report
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