Construction of diagnostic probability system indicate cervical lymph node metastasis using MRI

• Project/Area Number: 20890275
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Fukuoka Dental College
• Principal Investigator: FUKUNARI Fumiko Fukuoka Dental College, 歯学部, 医員 (30510234)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,224,000 (Direct Cost: ¥2,480,000、Indirect Cost: ¥744,000); Fiscal Year 2009: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 頸部リンパ節 / 口腔癌 / リンパ節転移 / MRI / 歯学 / 癌

Research Abstract

1. MR images obtained before surgery were correlated with the histopathological architecture of the cervical lymph nodes from oral squamous cell carcinoma obtained by neck dissection. On T2-weighted images, Very hyperintese and isointense areas were specific findings for lymph nodes containing metastases. On diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) images, it was difficult to differentiate metastatic from benign lymph nodes. 2. The positive predictive value (PPV) of each MRI findings, such as the signal intensity of the lymph node parenchyma on T2-weighted images, the pattern of signal intensity curve in dynamic MRI, were calculated. Using the PPV defined as diagnostic probability, the diagnostic results of cervical lymph node metastasis from oral squamous cell carcinoma using MRI may be quantitated.

Research Products

• [Journal Article] Cervical lymph nodes with or without metastases from oral squamous carcima: A correlation of MRI findings and histopathologic architecture
  • Author(s): Fumiko Fukunari, Kazuhiko Okamura, Ryousuke Zeze, Toyohiro Kagawa, Kenichiro Hashimoto, Kenji Yuasa.
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology (in press)
  • Peer Reviewed
• [Journal Article] Cervical lymph nodes with or without metastases from oral squamous carcima : A correlation of MRI findings and histopathologic architecture
  • Author(s): Fumiko Fukunari, et al.
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology (in press)
  • Peer Reviewed
• [Presentation] MR imaging characteristics of cervical metastatic lymph nodes (2008)
  • Author(s): Fumiko Fukunari, Kazuhiko Okamura, R Zeze, Ryousuke Zeze, Toyohiro Kagawa, Kenji Yuasa
  • Organizer: 第7回アジア口腔顎顔面放射線学会議
  • Place of Presentation: 奈良
  • Year and Date: 2008-11-22