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Genetic mechanism of parallel evolution of mimicry supergene in swallowtail butterflies

Research Project

Project/Area Number 20H00474
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Fujiwara Haruhiko  東京大学, 大学院新領域創成科学研究科, 教授 (40183933)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2022: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2021: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2020: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Keywordsスーパージーン / 擬態 / アゲハチョウ / 平行進化 / 遺伝子機能 / 染色体逆位 / 相同組換え / アゲハ蝶
Outline of Research at the Start

体表の紋様や体色によって捕食者を攪乱する擬態は広範な動物にみられる。擬態などの複雑な適応形質には、染色体上の隣接遺伝子群「超遺伝子(スーパージーン)」が制御しているものがある。シロオビアゲハとナガサキアゲハという近縁な2種の蝶はベイツ型擬態をする。その原因領域はいずれもスーパージーン構造をもつが、その構造や主要遺伝子の比較から両者は独立に平行進化したと考えられた。本研究では、アゲハチョウ属のベイツ型擬態の平行進化とスーパージーンの遺伝的背景を明らかにする。

Outline of Final Research Achievements

Some complex adaptive traits, such as mimicry, are controlled by groups of contiguous genes on a chromosome called ``supergene''. Chromosomal inversions suppress recombination in many supergenes, such as the region responsible for Batesian mimicry in Papilio polytes, but are absent in a mimicry supergene in the closely related Papilio machaon. In this study, we clarified for the first time that multiple genes that constitute the mimicry supergenes of these two species are involved in mimicry pattern formation. In addition, we clarified the genetic background and evolutionary process of parallel evolution of Batesian mimicry by comparing the structures of mimicry supergenes of related species of swallowtails.

Academic Significance and Societal Importance of the Research Achievements

スーパージーンは90年以上前に提唱された遺伝学的概念だが、その実体についてはほとんど実証されていなかった。近年、ゲノム解析の劇的な進展により、数多くの複雑な適応形質がスーパージーンで制御されていることが明らかになったが、スーパージーン内の遺伝子の機能や逆位の役割が明瞭になったものはない。本研究は、スーパージーン内外の複数の遺伝子が適応形質を生み出していること、さらに逆位の外側の遺伝子も形質発現に関与していることを、スーパージーンでは初めて実証した。また、シロオビアゲハとナガサキアゲハの擬態スーパージーンがどのように進化したかをゲノム構造の比較から明瞭にした。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (25 results)

All 2023 2022 2021 2020

All Journal Article (13 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Book (3 results)

  • [Journal Article] Functional unit of supergene in female-limited Batesian mimicry of Papilio polytes2023

    • Author(s)
      Komata Shinya、Yoda Shinichi、KonDo Yusuke、Shinozaki Souta、Tamai Kouki、Fujiwara Haruhiko
    • Journal Title

      Genetics

      Volume: 223 Issue: 2

    • DOI

      10.1093/genetics/iyac177

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic architecture and functional unit of mimicry supergene in female limited Batesian mimic Papilio butterflies.2022

    • Author(s)
      Komata S, Kajitani R, Itoh T, Fujiwara H.
    • Journal Title

      Philosophical Transactions of the Royal Society B

      Volume: - Issue: 1856 Pages: 20210198-20210198

    • DOI

      10.1098/rstb.2021.0198

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] doublesex Controls Both Hindwing and Abdominal Mimicry Traits in the Female-Limited Batesian Mimicry of Papilio memnon2022

    • Author(s)
      Shinya Komata、Chung-Ping Lin、Haruhiko Fujiwara
    • Journal Title

      Frontiers in Insect Science

      Volume: 2

    • DOI

      10.3389/finsc.2022.929518

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dimorphic Female-Limited Batesian Mimicry in Two Papilio Butterflies2022

    • Author(s)
      Fujiwara Haruhiko、Komata Shinya
    • Journal Title

      Spectrum of Sex: The Molecular Bases that Induce Various Sexual Phenotypes

      Volume: book Pages: 37-52

    • DOI

      10.1007/978-981-19-5359-0_3

    • ISBN
      9789811953583, 9789811953590
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroporation can be used to explore the gene function in the silkworm, Bombyx mori. , 64 (7),2021

    • Author(s)
      ZHOU Wen-Lin, Haruhiko FUJIWARA, Nozomi UEMURA, YE Ai-Hong, WU Xue-Hui, CHEN Xue-Dong, ZHANG Ting-Ting, CAO Jin-RuSyu
    • Journal Title

      Acta Entomologica Sinica

      Volume: 64 Pages: 809-816

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic switch in UV response of mimicry-related pale-yellow colors in Batesian mimic butterfly, Papilio polytes2021

    • Author(s)
      Yoda, S. Sakakura, K., Kitamura, T., KonDo, Y., Sato, K., Ohnuki, R., Someya, T., Komata, S., Kojima, T., Yoshioka, S. and Fujiwara, H.
    • Journal Title

      Science Advances

      Volume: 7 Issue: 2

    • DOI

      10.1126/sciadv.abd6475

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A corset function of exoskeletal ECM promotes body elongation in Drosophila.2021

    • Author(s)
      Tajiri, R., Fujiwara, H., Kojima, T.
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-020-01630-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 紫外線を使って毒チョウに擬態するアゲハ2021

    • Author(s)
      藤原晴彦
    • Journal Title

      化学

      Volume: 76 Pages: 72-72

    • Related Report
      2020 Annual Research Report
  • [Journal Article] スーパージーンによる不思議な進化2021

    • Author(s)
      藤原晴彦
    • Journal Title

      ニューサポート高校理科

      Volume: 36 Pages: 8-9

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Molecular mechanisms underlying pupal protective color switch in Papilio polytes butterflies.2020

    • Author(s)
      Yoda, S., Otaguro, E. Nobuta, M. and Fujiwara, H.
    • Journal Title

      Front.Ecol.Evol.

      Volume: 8 Pages: 51-51

    • DOI

      10.3389/fevo.2020.00051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Notch and delta control the switch and formation of camouflage patterns in caterpillars2020

    • Author(s)
      Jin, H., Yoda, S. Liu, L., Kojima, T. and Fujiwara, H.
    • Journal Title

      iScience

      Volume: 23 Issue: 7 Pages: 101315-101315

    • DOI

      10.1016/j.isci.2020.101315

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential factors involved in the precise targeting and insertion of telomere-specific non-LTR retrotransposon, SART1Bm.2020

    • Author(s)
      Nichuguti, N. and Fujiwara, H.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 8963-8963

    • DOI

      10.1038/s41598-020-65925-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Batesian mimicry has evolved with deleterious effects of the pleiotropic gene doublesex2020

    • Author(s)
      Komata S, Kitamura T, Fujiwara H.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21333-21333

    • DOI

      10.1038/s41598-020-78055-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] アゲハチョウ属のメスに限られたベイツ型擬態を制御するスーパージーンの機能と進化2022

    • Author(s)
      古俣慎也、依田真一、梶谷嶺、篠崎颯太、藤原晴彦
    • Organizer
      第24回日本進化学会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Presentation] Functional unit and evolutionary process of mimicry supergene in Papilio butterflies.2022

    • Author(s)
      Fujiwara, Haruhiko & Komata Shinya
    • Organizer
      The 11th International Workshop on Molecular Biology and Genetics of the Lepidoptera
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional unit and evolutionary process of mimicry supergene in Papilio butterflies.2022

    • Author(s)
      Fujiwara, Haruhiko & Komata, Shinya
    • Organizer
      The 11th International Workshop on Molecular Biology and Genetics of the Lepidoptera
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アゲハチョウの前翅/後翅のアイデンティティを決定する段階的な発生運命機構2021

    • Author(s)
      依田真一、篠崎颯太、吉岡伸也、藤原晴彦
    • Organizer
      第23回日本進化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ECMの変形による形づくり:ショウジョウバエ外骨格を例として2021

    • Author(s)
      田尻怜子、藤原晴彦、小嶋徹也
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Co-expression of JH binding protein and Bilin binding protein contributes to the accumulation of green pigments in Papilio memnon.2021

    • Author(s)
      Liang Liu, Shinya Komata, Haruhiko Fujiwara
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] シロオビアゲハの擬態を制御するスーパージーン内部遺伝子の発現動態と機能解析2021

    • Author(s)
      篠﨑颯太、依田真一、古俣慎也、田中智大、藤原晴彦
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゼブラフィッシュrDNAに転移する2種類の標的特的レトロトランスポゾンの転移解析2020

    • Author(s)
      鍜治桃子、朴享道、比嘉真鈴、藤原晴彦
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Insect body shape sculpted by cuticle deromation2020

    • Author(s)
      Reiko Tajiri, Haruhiko Fujiwara, Tetsuya Kojima
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Book] マーダー生物学2021

    • Author(s)
      S. Mader、藤原 晴彦
    • Total Pages
      560
    • Publisher
      東京化学同人
    • ISBN
      9784807909698
    • Related Report
      2020 Annual Research Report
  • [Book] ヒトゲノム事典2021

    • Author(s)
      藤原晴彦(分担執筆)
    • Total Pages
      448
    • Publisher
      一色出版
    • ISBN
      9784910389127
    • Related Report
      2020 Annual Research Report
  • [Book] カイコの科学2020

    • Author(s)
      藤原晴彦(分担執筆)
    • Total Pages
      224
    • Publisher
      朝倉書店
    • ISBN
      9784254420432
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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