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Development of Next-Generation Drug Delivery System Using Quantized Polysaccharide-DNA Complex (qSDC)

Research Project

Project/Area Number 20H00668
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionThe University of Kitakyushu

Principal Investigator

Sakurai Kazuo  北九州市立大学, 環境技術研究所, 教授 (70343431)

Co-Investigator(Kenkyū-buntansha) 和泉 弘人  産業医科大学, 産業生態科学研究所, 准教授 (50289576)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2022: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2021: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2020: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Keywords多糖β1,3グルカン / Dectin-1標的 / 量子化多糖核酸複合体 / 核酸医薬 / 多糖β1,3グルカン
Outline of Research at the Start

我々は天然由来の糖類の一つであるβ1,3グルカンと遺伝をつかさどるDNAなどの核酸が今までにない複合体を作ることを見出した。この複合体を核酸医薬のミクロ錠剤カプセルとしての応用展開を行ってきた。最近、核酸を1分子のみ含む均一なカプセルの合成に成功した。本研究では、この新しい複合体の構造・物性を明らかにするとともに、次世代のミクロ錠剤カプセルへの基礎技術への展開を目指していく。

Outline of Final Research Achievements

In this study, a novel gene delivery technology using the natural polysaccharide schizophyllan (SPG) was developed, focusing on the efficient delivery of small interfering RNA (siRNA) to antigen-presenting cells (APCs). Dectin-1, widely expressed in immune cells such as macrophages, monocytes, and dendritic cells, was targeted using SPG to deliver siRNA specifically to these cells. The expression of Dectin-1 in human peripheral blood mononuclear cells (PBMCs) was analyzed, confirming the cellular uptake and gene silencing activity of SPG-siRNA complexes. This technology promises the development of new therapeutic approaches aimed at immune modulation.

Academic Significance and Societal Importance of the Research Achievements

本研究は、遺伝子治療における新たな核酸医薬のデリバリー技術を提供し、特に免疫細胞を標的とした遺伝子サイレンシングの可能性を示した。これにより、自己免疫疾患、アレルギー、癌などの治療法の開発が進むことが期待される。また、特定の免疫細胞に遺伝子を送達する技術は、移植医療における拒絶反応の制御にも応用可能であり、広範な医療分野での利用が見込まれる。

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (62 results)

All 2023 2022 2021 2020 Other

All Journal Article (39 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 39 results,  Open Access: 4 results) Presentation (20 results) (of which Int'l Joint Research: 7 results,  Invited: 13 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia2023

    • Author(s)
      Oka Natsumi、Doan Van Thi Hong、Matsubara Hirofumi、Imai Takahiko、Yoshioka Yukie、Katsuki Jun、Fujii Shota、Nakamura Shinsuke、Shimazawa Masamitsu、Hara Hideaki、Sakurai Kazuo
    • Journal Title

      Journal of Controlled Release

      Volume: 353 Pages: 216-228

    • DOI

      10.1016/j.jconrel.2022.11.030

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Therapeutic Efficacy of Immunostimulatory CpG-ODN by Silencing SOCS-1 with Polysaccharide/miR-155 Complexes2023

    • Author(s)
      Sumiya Kazuki、Izumi Hiroto、Sakurai Kazuo
    • Journal Title

      ACS Applied Bio Materials

      Volume: 6 Issue: 2 Pages: 774-783

    • DOI

      10.1021/acsabm.2c00963

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding assay of human Dectin-1 variants for DNA/ β-glucan complex for active-targeting delivery of antisense DNA: Part II2023

    • Author(s)
      Sumiya Kazuki、Izumi Hiroto、Adachi Yoshiyuki、Mochizuki Shinichi、Sakurai Kazuo
    • Journal Title

      Carbohydrate Research

      Volume: 523 Pages: 108731-108731

    • DOI

      10.1016/j.carres.2022.108731

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Bottlebrushes for Immunostimulatory CpG ODN Delivery: Relationship among Cation Density, Complex Formation Ability, and Cytotoxicity2023

    • Author(s)
      Takano Shin、Miyashima Yusuke、Fujii Shota、Sakurai Kazuo
    • Journal Title

      Biomacromolecules

      Volume: 24 Issue: 3 Pages: 1299-1309

    • DOI

      10.1021/acs.biomac.2c01348

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dramatically Increased Binding Constant of Water-Soluble Cyclodextrin Hyperbranched Polymers: Explored with Diffusion Ordered NMR Spectroscopy (DOSY)2022

    • Author(s)
      Doan Anh Thi Ngoc、Doan Van Thi Hong、Katsuki Jun、Fujii Shota、Kono Hiroyuki、Sakurai Kazuo
    • Journal Title

      ACS Omega

      Volume: 7 Issue: 13 Pages: 10890-10900

    • DOI

      10.1021/acsomega.1c06194

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delivery of therapeutic oligonucleotides targeting Dectin-1 using quantized complexes2022

    • Author(s)
      Sumiya Kazuki、Izumi Hiroto、Matsunaga Takuya、Tanaka Motoko、Sakurai Kazuo
    • Journal Title

      Polymer Journal

      Volume: 54 Issue: 4 Pages: 591-601

    • DOI

      10.1038/s41428-021-00595-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Zwitterionic Polymers on the Tumor Permeability of Molecular Bottlebrush-Based Nanoparticles2022

    • Author(s)
      Fujii Shota、Takano Shin、Nakazawa Kohji、Sakurai Kazuo
    • Journal Title

      Biomacromolecules

      Volume: in press Issue: 7 Pages: 2846-2855

    • DOI

      10.1021/acs.biomac.2c00216

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation2022

    • Author(s)
      Nishida Chinatsu、Tomonaga Taisuke、Izumi Hiroto、Wang Ke-Yong、Higashi Hidenori、Ishidao Toru、Takeshita Jun-ichi、Ono Ryohei、Sumiya Kazuki、Fujii Shota、Mochizuki Shinichi、Sakurai Kazuo、Yamasaki Kei、Yatera Kazuhiro、Morimoto Yasuo
    • Journal Title

      Particle and Fibre Toxicology

      Volume: 19 Issue: 1 Pages: 1-17

    • DOI

      10.1186/s12989-022-00448-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Polyethylene Glycol (PEG) Conformations on the <i>In Vivo</i> Fate and Drug Release Behavior of PEGylated Core-Cross-Linked Polymeric Nanoparticles2022

    • Author(s)
      Kanamaru Takuma、Sakurai Kazuo、Fujii Shota
    • Journal Title

      Biomacromolecules

      Volume: 23 Issue: 9 Pages: 3909-3918

    • DOI

      10.1021/acs.biomac.2c00730

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zwitterionic Amino Acid Polymer-Grafted Core-Crosslinked Particle toward Tumor Delivery2022

    • Author(s)
      Fujii Shota、Sakurai Kazuo
    • Journal Title

      Biomacromolecules

      Volume: 23 Issue: 9 Pages: 3968-3977

    • DOI

      10.1021/acs.biomac.2c00803

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation2022

    • Author(s)
      Nishida Chinatsu、Izumi Hiroto、Tomonaga Taisuke、Wang Ke-Yong、Higashi Hidenori、Takeshita Jun-Ichi、Ono Ryohei、Sumiya Kazuki、Fujii Shota、Hata Yuki、Sakurai Kazuo、Higashi Yasuyuki、Yamasaki Kei、Yatera Kazuhiro、Morimoto Yasuo
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 18 Pages: 10345-10345

    • DOI

      10.3390/ijms231810345

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crosslinked Structure of Polyacrylic Acid Affects Pulmonary Fibrogenicity in Rats2022

    • Author(s)
      Tomonaga Taisuke、Nishida Chinatsu、Izumi Hiroto、Kawai Naoki、Wang Ke-Yong、Higashi Hidenori、Takeshita Jun-Ichi、Ono Ryohei、Sumiya Kazuki、Fujii Shota、Hata Yuki、Sakurai Kazuo、Morimoto Toshiki、Higashi Yasuyuki、Yamasaki Kei、Yatera Kazuhiro、Morimoto Yasuo
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 22 Pages: 13870-13870

    • DOI

      10.3390/ijms232213870

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antisense DNA cocktail therapy using short ?-1,3-glucan/oligonucleotide complexes2022

    • Author(s)
      Hata Yuki、Sumiya Kazuki、Izumi Hiroto、Sakurai Kazuo
    • Journal Title

      Polymer Journal

      Volume: 55 Issue: 3 Pages: 283-288

    • DOI

      10.1038/s41428-022-00720-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced In-vitro Efficacy of Antisense Delivery by Use of Low-molecular Weight Polysaccharide/DNA Complex2021

    • Author(s)
      Sumiya Kazuki、Izumi Hiroto、Mochizuki Shinichi、Sakurai Kazuo
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 6 Pages: 1191-1193

    • DOI

      10.1246/cl.210058

    • NAID

      130008053413

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water2021

    • Author(s)
      Kanamaru Takuma、Araki Masataka、Takahashi Rintaro、Fujii Shota、Shikata Toshiyuki、Murakami Daiki、Tanaka Masaru、Sakurai Kazuo
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 125 Issue: 26 Pages: 7251-7261

    • DOI

      10.1021/acs.jpcb.1c01864

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Weak Interplay between Hydrophobic Part of Water-soluble Polymers and Serum Protein2021

    • Author(s)
      Takano Shin、Islam Waliul、Fujii Shota、Maeda Hiroshi、Sakurai Kazuo
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 7 Pages: 1392-1393

    • DOI

      10.1246/cl.210156

    • NAID

      130008065522

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding assay of human Dectin-1 variants to DNA/β-glucan complex for active-targeting delivery of antisense DNA2021

    • Author(s)
      Fujiwara Nobuaki、Izumi Hiroto、Kira Ryoma、Morimoto Yasuo、Mochizuki Shinichi、Sakurai Kazuo
    • Journal Title

      Carbohydrate Research

      Volume: 500 Pages: 108219-108219

    • DOI

      10.1016/j.carres.2020.108219

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques2021

    • Author(s)
      Akiba Isamu、Sakurai Kazuo
    • Journal Title

      Polymer Journal

      Volume: 53 Issue: 9 Pages: 951-973

    • DOI

      10.1038/s41428-021-00489-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymer Micelles Composed of Molecular‐Bottlebrush‐Based Surfactants: Precisely Controlling Aggregation Number Corresponding to Polyhedral Structures2021

    • Author(s)
      Fujii Shota、Eichhorn Jonas、Schacher Felix H.、Brendel Johannes C.、Sakurai Kazuo
    • Journal Title

      Macromolecular Rapid Communications

      Volume: 42 Issue: 16 Pages: 2100285-2100285

    • DOI

      10.1002/marc.202100285

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manipulating the Morphology of Amphiphilic Graft-Copolymer Assemblies by Adjusting the Flexibility of the Main Chain2021

    • Author(s)
      Nishimura Tomoki、Fujii Shota、Sakurai Kazuo、Sasaki Yoshihiro、Akiyoshi Kazunari
    • Journal Title

      Macromolecules

      Volume: 54 Issue: 14 Pages: 7003-7009

    • DOI

      10.1021/acs.macromol.1c01030

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Analysis of an Octameric Resorcinarene Self-Assembly in Toluene and its Morphological Transition by Temperature2021

    • Author(s)
      Fujii Shota、Sakurai Kazuo
    • Journal Title

      The Journal of Physical Chemistry Letters

      Volume: 12 Issue: 28 Pages: 6464-6468

    • DOI

      10.1021/acs.jpclett.1c01978

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-1.3 Glucan Complex Drastically Suppresses Kidney Clearance of siRNA2021

    • Author(s)
      Uno Atsushi、Arima Kenji、Ushida Maki、Katayama Yuka、Shimazaki Masako、Amano Kanako、Namikawa Reiko、Sakurai Kazuo
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 10 Pages: 1778-1780

    • DOI

      10.1246/cl.210334

    • NAID

      130008101944

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel β-glucan?oligonucleotide complex selectively delivers siRNA to APCs via Dectin-12021

    • Author(s)
      Uno Atsushi、Arima Kenji、Shimazaki Masako、Ushida Maki、Amano Kanako、Namikawa Reiko、Sakurai Kazuo
    • Journal Title

      Journal of Controlled Release

      Volume: 338 Pages: 792-803

    • DOI

      10.1016/j.jconrel.2021.09.011

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Internalization into cancer cells of zwitterionic amino acid polymers <i>via</i> amino acid transporter recognition2021

    • Author(s)
      Takano Shin、Sakurai Kazuo、Fujii Shota
    • Journal Title

      Polymer Chemistry

      Volume: 12 Issue: 42 Pages: 6083-6087

    • DOI

      10.1039/d1py01010g

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unraveling Decisive Structural Parameters for the Self-Assembly of Supramolecular Polymer Bottlebrushes Based on Benzene Trisureas2020

    • Author(s)
      Gruschwitz Franka V.、Fu Mao-Chun、Klein Tobias、Takahashi Rintaro、Higashihara Tomoya、Hoeppener Stephanie、Nischang Ivo、Sakurai Kazuo、Brendel Johannes C.
    • Journal Title

      Macromolecules

      Volume: 53 Issue: 17 Pages: 7552-7560

    • DOI

      10.1021/acs.macromol.0c01361

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine2020

    • Author(s)
      Sasaki Shogo、Izumi Hiroto、Morimoto Yasuo、Sakurai Kazuo、Mochizuki Shinichi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 18 Pages: 115668-115668

    • DOI

      10.1016/j.bmc.2020.115668

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scattering Form Factor of Block Copolymer Micelles with Corona Chains Discretely Distributed on the Core Surface2020

    • Author(s)
      Takahashi Rintaro、Fujii Shota、Akiba Isamu、Sakurai Kazuo
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 124 Issue: 28 Pages: 6140-6146

    • DOI

      10.1021/acs.jpcb.0c04120

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monodisperse Micelles with Aggregation Numbers Related to Platonic Solids2020

    • Author(s)
      Lee Ji Ha、Fujii Shota、Takahashi Rintaro、Sakurai Kazuo
    • Journal Title

      Macromolecular Rapid Communications

      Volume: 41 Issue: 18 Pages: 2000227-2000227

    • DOI

      10.1002/marc.202000227

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles, and in vivo pharmacokinetics depending on the structural characteristics2020

    • Author(s)
      Matsuno Jun、Kanamaru Takuma、Arai Koichi、Tanaka Rena、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo、Fujii Shota
    • Journal Title

      Journal of Controlled Release

      Volume: 324 Pages: 405-412

    • DOI

      10.1016/j.jconrel.2020.05.035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Polymorphism of Resorcinarene Assemblies2020

    • Author(s)
      Fujii Shota、Miyake Rika、Campo Liliana de、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo
    • Journal Title

      Langmuir

      Volume: in press Issue: 22 Pages: 6222-6227

    • DOI

      10.1021/acs.langmuir.0c00861

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bundling Process of Citrulline Polypeptides upon UCST-Type Phase Separation2020

    • Author(s)
      Fujii Shota、Kuroyanagi Sotaro、Shimada Naohiko、Matsuno Jun、Lee Ji Ha、Takahashi Rintaro、Maruyama Atsushi、Sakurai Kazuo
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 124 Issue: 20 Pages: 4036-4043

    • DOI

      10.1021/acs.jpcb.0c00934

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Furry nanoparticles: synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles and their robust stability in vivo2020

    • Author(s)
      Tanaka Rena、Arai Koichi、Matsuno Jun、Soejima Miyo、Lee Ji Ha、Takahashi Rintaro、Sakurai Kazuo、Fujii Shota
    • Journal Title

      Polymer Chemistry

      Volume: 11 Issue: 27 Pages: 4408-4416

    • DOI

      10.1039/d0py00610f

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Binding Constant of Cyclodextrin to Alpha-mangostin in Hyperbranched Polymers2020

    • Author(s)
      Van Doan Thi Hong、Anh Doan Thi Ngoc、Fujii Shota、Sakurai Kazuo
    • Journal Title

      Chemistry Letters

      Volume: 49 Issue: 10 Pages: 1144-1146

    • DOI

      10.1246/cl.200210

    • NAID

      130007923149

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymersome formation induced by encapsulation of water-insoluble molecules within ABC triblock terpolymers2020

    • Author(s)
      Takahashi Rintaro、Miwa Shotaro、Rossel Carsten、Fujii Shota、Lee Ji Ha、Schacher Felix H.、Sakurai Kazuo
    • Journal Title

      Polymer Chemistry

      Volume: 11 Issue: 20 Pages: 3446-3452

    • DOI

      10.1039/d0py00426j

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis and Dilute Solution Properties of <i>N</i>-(2-Hydroxypropyl) methacrylamide-Based Copolymers2020

    • Author(s)
      Doi Kiyomasa、Takahashi Rintaro、Fujii Shota、Sakurai Kazuo
    • Journal Title

      Journal of Fiber Science and Technology

      Volume: 76 Issue: 9 Pages: 305-309

    • DOI

      10.2115/fiberst.2020-0033

    • NAID

      130007922388

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flower Necklaces of Controllable Length Formed From N-(2-Hydroxypropyl) Methacrylamide-Based Amphiphilic Statistical Copolymers2020

    • Author(s)
      Takahashi Rintaro、Doi Kiyomasa、Fujii Shota、Sakurai Kazuo
    • Journal Title

      Langmuir

      Volume: 36 Issue: 39 Pages: 11556-11563

    • DOI

      10.1021/acs.langmuir.0c02032

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X-ray Scattering and Cryotransmission Electron Microscopic Studies2020

    • Author(s)
      Aburai Kenichi、Hatanaka Kentaro、Takano Shin、Fujii Shota、Sakurai Kazuo
    • Journal Title

      Langmuir

      Volume: 36 Issue: 42 Pages: 12545-12554

    • DOI

      10.1021/acs.langmuir.0c01079

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligo-DNA Stoichiometrically Binds β-1,3-Glucan with the Best Fit Length2020

    • Author(s)
      Sumiya Kazuki、Matsunaga Takuya、Tanaka Motoko、Mochizuki Shinichi、Sakurai Kazuo
    • Journal Title

      Biomacromolecules

      Volume: 21 Issue: 12 Pages: 4823-4834

    • DOI

      10.1021/acs.biomac.0c01038

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overcoming the Necessity of a Lateral Aggregation in the Formation of Supramolecular Polymer Bottlebrushes in Water2020

    • Author(s)
      Klein Tobias、Ulrich Hans F.、Gruschwitz Franka V.、Kuchenbrod Maren T.、Takahashi Rintaro、Hoeppener Stephanie、Nischang Ivo、Sakurai Kazuo、Brendel Johannes C.
    • Journal Title

      Macromolecular Rapid Communications

      Volume: 42 Issue: 8 Pages: 2000585-2000585

    • DOI

      10.1002/marc.202000585

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 多糖核酸複合体におけるホスホロチオエート核酸の実用的役割と生命起源への想像2023

    • Author(s)
      櫻井 和朗
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Discovery of a Novel β-(1,3)-Glucan/DNA Complex and its Application to Targeting Delivery of Therapeutic Oligonucleotides2022

    • Author(s)
      Kazuo Sakurai
    • Organizer
      Exeter University Seminar
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DDSナノ粒子の構造解析2022

    • Author(s)
      櫻井 和朗
    • Organizer
      軟X線共鳴散乱・反射率/Resonant Soft X-ray Scattering and Reflectivity
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 日本発の核酸医薬の実用化を目指して2022

    • Author(s)
      櫻井 和朗
    • Organizer
      岐阜大学公開講座 先端を行く連合創薬医療情報研究科 次世代創薬を支えるモダリティー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 溶液中のバイオナノ粒子からのX線小角散乱2022

    • Author(s)
      櫻井 和朗
    • Organizer
      東京都産業技術研究センターヘルスケア関連セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 数学上の未解決問題とせっけんの化学の関連:ミセルの集合問題2022

    • Author(s)
      櫻井 和朗
    • Organizer
      計測自動制御学会九州支部学術講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Solution properties of monodisperse cross-linked poly (acrylic acid) particles made by radical precipitation polymerization2022

    • Author(s)
      Kazuo Sakurai
    • Organizer
      ACS Fall 2022 NATIONAL MEETING & EXPOSITION
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microphase separation induced by the segregation of side chains in styrene-acrylic-acid alternating copolymers2022

    • Author(s)
      Kazuo Sakurai
    • Organizer
      ACS Fall 2022 NATIONAL MEETING & EXPOSITION
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic efficacy of microRNA and immunoadjuvant combination therapy for tumors2022

    • Author(s)
      Kazuo Sakurai
    • Organizer
      18th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An alternating copolymer exhibiting the microphase-structure transition fromultrathin plate to unimeric sphere2022

    • Author(s)
      Kazuo Sakurai
    • Organizer
      ACS Spring2022 NATIONAL MEETING & EXPOSITION
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel cyclodextrin-based nanoparticle delivering alpha mangostin to treat brainischemia2022

    • Author(s)
      Kazuo Sakurai
    • Organizer
      ACS Spring2022 NATIONAL MEETING & EXPOSITION
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA を2分子含む多糖核酸複合体からの X 線小角散乱散乱2021

    • Author(s)
      櫻井 和朗
    • Organizer
      第70回高分子年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Me散乱を用いたサブから数十ミクロン粒子を含む溶液の解析2021

    • Author(s)
      櫻井 和朗
    • Organizer
      第70回高分子年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 小角X線散乱法で計測したナノ粒子製剤2021

    • Author(s)
      櫻井 和朗
    • Organizer
      SPring-8ユーザー協同体(SPRUC)研究会「小角散乱とナノ粒子製剤のCMC」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 多糖核酸複合体を用いた核酸医薬のDDS2021

    • Author(s)
      櫻井 和朗
    • Organizer
      日本化学会第101春季年会(2021)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ナノメディシンのレギュラトリーサイエンスにおける散乱法と電子顕微鏡の補完的役割2020

    • Author(s)
      櫻井 和朗
    • Organizer
      ソフトマテリアル研究拠点キックオフ・セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多糖拡散複合体を用いた核酸医薬の免疫系細胞への選択的デリバリー2020

    • Author(s)
      櫻井 和朗
    • Organizer
      第36回日本DDS学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多糖核酸複合体を用いた核酸医薬の免疫系細胞への選択的デリバリー2020

    • Author(s)
      櫻井 和朗
    • Organizer
      令和2年度赤尾研究室セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Characterizing Self-Assembled Nanoparticles of Drug Delivery by use of Solution Scattering Techniques2020

    • Author(s)
      Kazuo Sakurai
    • Organizer
      高分子学会 関東支部企画 GPS-K2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] レギュラトリーサイエンスから見た溶液中のナノ粒子の特性評価2020

    • Author(s)
      櫻井 和朗
    • Organizer
      フロンティアソフトマター開発専用ビームライン産学連合体(FSBL)第10回研究発表会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Remarks] 櫻井研究室ホームページ

    • URL

      https://www.sakurai-lab-kitakyushu.com/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 櫻井・望月研究室

    • URL

      http://www.sakurai-lab.jp/index.php/member/

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 粒子および粒子の製造方法、ならびに薬剤、薬剤の製造方法、抗がん剤2020

    • Inventor(s)
      櫻井和朗、他
    • Industrial Property Rights Holder
      北九州市立大学、他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas

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Published: 2020-04-28   Modified: 2025-01-30  

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