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Toward Lab-in-a-drop: Contactless droplet manipulation by acoustic field

Research Project

Project/Area Number 20H02070
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 19010:Fluid engineering-related
Research InstitutionKogakuin University

Principal Investigator

Hasegawa Koji  工学院大学, 工学部, 准教授 (90647918)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywords非接触流体マニピュレーション / 音場浮遊法 / 液滴 / Lab-in-a-drop / 概念実証 / 混合 / 蒸発 / 非線形ダイナミクス / 混相流 / 乳化 / Lab in a drop / 反応
Outline of Research at the Start

近年、分析化学、生物、医学・創薬分野への音響場を用いた非接触流体マニピュレーションが積極導入され、社会実装を目指した研究が活発化している。本研究では、その実現のための道標となる統合的な現象把握と物理解明に取り組むとともに、浮遊液滴の安定浮遊・輸送・合体・混合・反応・蒸発に至る、非接触流体マニピュレーションを世界で初めて一気通貫で実現することを目指す。すなわち、既存の単一操作のみならず、連続的な複数プロセス操作を実装することで、世界に先駆けてLab in a drop(液滴内で混合や反応などの全操作を完結する)の実現に向けた音響場による非接触流体マニピュレーションの概念実証を目的とする。

Outline of Final Research Achievements

This study aimed to demonstrate the concept of contactless fluid manipulation using acoustic fields towards realizing Lab-in-a-drop. The objectives included: (i) verifying stable conditions for levitated droplets, (ii) integrating the levitation-to-evaporation process using the same droplets, (iii) demonstrating and integrating the levitation-to-evaporation process with different droplets, and (iv) conducting numerical analysis of contactless fluid manipulation in acoustic levitation. All these tasks were completed as initially planned. By employing comprehensive approaches including systematic experiments, numerical simulations, and theoretical modeling, our results successfully demonstrated the concept of contactless fluid manipulation using acoustic fields.

Academic Significance and Societal Importance of the Research Achievements

非接触流体マニピュレーションの実現には、音響場中の液滴の浮遊、輸送、合体、混合、蒸発などの動的現象を制御する技術開発と現象理解が課題となっていた。本研究では、音響場中に浮遊する同種・異種液滴の一連の非接触操作を可能にし、Lab in a dropの実現のための概念実証に成功した点に学術的意義がある。また、社会実装に必要な統合的物理解明と、得られた知見を基に技術開発・実装に取り組んだ点に社会的意義がある。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (40 results)

All 2024 2023 2022 2021 2020 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (25 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Airborne Ouzo: Evaporation-induced emulsification and phase separation dynamics of ternary droplets in acoustic levitation2024

    • Author(s)
      Mitsuno Misaki、Hasegawa Koji
    • Journal Title

      Physics of Fluids

      Volume: 36 Issue: 3

    • DOI

      10.1063/5.0192045

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contactless Manipulation of Levitated Droplets Driven by Acoustic Fields2023

    • Author(s)
      長谷川浩司
    • Journal Title

      JAPANESE JOURNAL OF MULTIPHASE FLOW

      Volume: 37 Issue: 1 Pages: 29-36

    • DOI

      10.3811/jjmf.2023.T004

    • ISSN
      0914-2843, 1881-5790
    • Year and Date
      2023-03-15
    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Coalescence and mixing dynamics of droplets in acoustic levitation by selective colour imaging and measurement2023

    • Author(s)
      Honda Kota、Fujiwara Kota、Hasegawa Koji、Kaneko Akiko、Abe Yutaka
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1

    • DOI

      10.1038/s41598-023-46008-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oscillation Dynamics of Multiple Water Droplets Levitated in an Acoustic Field2022

    • Author(s)
      Koji Hasegawa, Manami Murata
    • Journal Title

      Micromachines

      Volume: 13 Issue: 9 Pages: 1373-1373

    • DOI

      10.3390/mi13091373

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Reflector Geometry and Sample Radius on Levitation Stability in Acoustic Field2021

    • Author(s)
      Manami Murata, Koji Hasegawa
    • Journal Title

      International journal of microgravity science and application

      Volume: 38 Issue: 3 Pages: 380304

    • DOI

      10.15011/jasma.38.380304

    • NAID

      130008070026

    • ISSN
      2188-9783
    • Year and Date
      2021-07-31
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Followability in Transportation of Droplet by Using Counter-Faced Focused Ultrasound2021

    • Author(s)
      須田捷生, 金子暁子, 長谷川浩司, 阿部豊
    • Journal Title

      JAPANESE JOURNAL OF MULTIPHASE FLOW

      Volume: 35 Issue: 1 Pages: 68-76

    • DOI

      10.3811/jjmf.2021.011

    • NAID

      130008024967

    • ISSN
      0914-2843, 1881-5790
    • Year and Date
      2021-03-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility Study of Droplet Transportation via Ultrasonic Phased Array System2020

    • Author(s)
      Koji Hasegawa, Ayumu Watanabe, Akiko Kaneko, Yutaka Abe
    • Journal Title

      International journal of microgravity science and application

      Volume: 37 Issue: 2 Pages: 370203

    • DOI

      10.15011/jasma.37.2.370203

    • NAID

      130007838422

    • ISSN
      2188-9783
    • Year and Date
      2020-04-30
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transport Phenomena of a Droplet in Acoustic Levitation2020

    • Author(s)
      Koji Hasegawa, Yutaka Abe
    • Journal Title

      International journal of microgravity science and application

      Volume: 37 Issue: 2 Pages: 370201

    • DOI

      10.15011/jasma.37.2.370201

    • NAID

      130007838463

    • ISSN
      2188-9783
    • Year and Date
      2020-04-30
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acoustically induced breakup of levitated droplets2020

    • Author(s)
      Kohei Aoki, Koji Hasegawa
    • Journal Title

      AIP Advances

      Volume: 10 Issue: 5

    • DOI

      10.1063/1.5143395

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heat and mass transfer characteristics of binary droplets in acoustic levitation2020

    • Author(s)
      Yuya Sasaki, Koji Hasegawa, Akiko Kaneko, Yutaka Abe
    • Journal Title

      Physics of Fluids

      Volume: 32 Issue: 7

    • DOI

      10.1063/1.5144396

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion enhancement in a levitated droplet via oscillatory deformation2020

    • Author(s)
      Koyano Yuki、Kitahata Hiroyuki、Hasegawa Koji、Matsumoto Satoshi、Nishinari Katsuhiro、Watanabe Tadashi、Kaneko Akiko、Abe Yutaka
    • Journal Title

      Physical Review E

      Volume: 102 Issue: 3

    • DOI

      10.1103/physreve.102.033109

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breakup characteristics of levitated droplets in a resonant acoustic field2020

    • Author(s)
      Mizuki Naka, Koji Hasegawa
    • Journal Title

      Physics of Fluids

      Volume: 32 Issue: 12

    • DOI

      10.1063/5.0035994

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] 音響場で浮遊する液滴および泡沫の浮遊安定性2024

    • Author(s)
      大西一希,長谷川浩司
    • Organizer
      日本機械学会 関東学生会第63回学生員卒業研究発表講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Toward Lab-in-a-drop: Acoustic manipulation of droplets in air2023

    • Author(s)
      長谷川浩司
    • Organizer
      Multiphase Flow Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lab-in-a-drop approach: 音響場を駆使した浮遊液滴の非接触マニピュレーション2023

    • Author(s)
      長谷川浩司
    • Organizer
      第51回可視化情報シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 音響場で浮遊する多成分液滴の蒸発に伴う自然乳化・相分離2023

    • Author(s)
      光野海祥,長谷川浩司
    • Organizer
      第51回可視化情報シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] 音響場で浮遊する多成分液滴の蒸発に伴う自然乳化・相分離2023

    • Author(s)
      光野海祥,長谷川浩司
    • Organizer
      日本マイクログラビティ応用学会 第35回学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 音響場で浮遊するウーゾ液滴の自然乳化および相分離2023

    • Author(s)
      長谷川浩司,光野海祥
    • Organizer
      熱工学コンファレンス 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 音場浮遊させたOuzo液滴の蒸発・自然乳化現象の可視化計測2023

    • Author(s)
      光野海祥,長谷川 浩司
    • Organizer
      日本機械学会関東学生会第60回学生員卒業研究発表講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 音場浮遊させた懸濁液滴の乾燥挙動の解明2022

    • Author(s)
      相子珠希,金子暁子,長谷川浩司
    • Organizer
      日本混相流学会混相流シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] レーザー加熱下の音場浮遊液滴の形状変化と乾燥挙動2022

    • Author(s)
      相子珠希,金子暁子,シェンビャオ,長谷川浩司
    • Organizer
      日本機械学熱工学コンファレンス 2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 浮遊液滴非線形ダイナミクス研究報告2022

    • Author(s)
      阿部豊,松本聡,西成活裕,谷田桜子,渡辺正,北畑裕之,小谷野由紀,長谷川浩司,金子暁子,本田恒太,相子珠希
    • Organizer
      第36回宇宙環境利用シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 音響場で浮遊する微小液滴の蒸発・乾燥ダイナミクス2022

    • Author(s)
      村田愛美,長谷川浩司,相子珠希,金子暁子
    • Organizer
      日本機械学会関東支部第28期総会講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 懸濁液滴の乾燥過程における造粒挙動の解明2022

    • Author(s)
      相子珠希,本田恒太,藤原広太,金子暁子,村田愛美,長谷川浩司
    • Organizer
      日本機械学会関東支部第28期総会講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 界面の振動による超音波浮遊液滴の混合促進効果2021

    • Author(s)
      本田恒太,相子珠希,長谷川浩司,金子暁子,阿部豊
    • Organizer
      日本混相流学会混相流シンポジウム2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 音響場中の試料の浮遊安定性に及ぼすリフレクタ形状の影響2021

    • Author(s)
      村田愛美,長谷川浩司
    • Organizer
      第49回 可視化情報シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 収束超音波による浮遊液滴の合体・混合挙動2021

    • Author(s)
      本田恒太,相子珠希,長谷川浩司,金子暁子
    • Organizer
      日本マイクログラビティ応用学会 第33回学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 音場浮遊させた懸濁液滴の流動挙動2021

    • Author(s)
      相子珠希,本田恒太,藤原広太,長谷川浩司,金子暁子
    • Organizer
      日本マイクログラビティ応用学会 第33回学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 音響場で浮遊する複数試料の浮遊安定性2021

    • Author(s)
      村田愛美,長谷川浩司
    • Organizer
      日本マイクログラビティ応用学会 第33回学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Visualization of vibration behavior of multiple sample levitated in an acoustic field2021

    • Author(s)
      Manami Murata, Koji Hasegawa
    • Organizer
      The 20th International Symposium on Advanced Technology (ISAT-20)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波フェーズドアレイを用いた浮遊液滴の微粒化挙動の実験的検討2020

    • Author(s)
      中瑞希,長谷川浩司
    • Organizer
      日本混相流学会混相流シンポジウム2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音場浮遊液滴に生じる蒸発および析出プロセスの解明2020

    • Author(s)
      丸山侑太郎,長谷川浩司
    • Organizer
      日本混相流学会混相流シンポジウム2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 対向型集束超音波による浮遊液滴の搬送追従性2020

    • Author(s)
      須田捷生, 金子暁子, 長谷川浩司, 阿部豊
    • Organizer
      日本混相流学会混相流シンポジウム2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音場浮遊液滴の蒸発および析出プロセス2020

    • Author(s)
      丸山侑太郎,長谷川浩司
    • Organizer
      日本マイクログラビティ応用学会 第32回学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 対向型収束超音波を用いた浮遊液滴の微粒化メカニズム2020

    • Author(s)
      中瑞希,長谷川浩司
    • Organizer
      日本マイクログラビティ応用学会 第32回学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 浮遊液滴の安定性向上のための音場最適化2020

    • Author(s)
      村田愛美,長谷川浩司
    • Organizer
      第13回大学コンソーシアム八王子学生発表会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音響場を活用した浮遊液滴の微粒化挙動2020

    • Author(s)
      長谷川浩司,中瑞希
    • Organizer
      第29回 微粒化シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Book] Acoustic Levitation From Physics to Applications2020

    • Author(s)
      Duyang Zang, Asier Marzo, Marco A. B. Andrade, Xiao-Peng Chen, Zehui Zhang, Kangqi Liu, Koji Hasegawa, Yanju Wei, Da-Chuan Yin, Soichiro Tsujino, Takashi Tomizaki
    • Total Pages
      179
    • Publisher
      Springer Nature
    • ISBN
      9789813290655
    • Related Report
      2020 Annual Research Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/kojihasegawa

    • Related Report
      2023 Annual Research Report
  • [Remarks] 工学院大学 研究者情報データベース

    • URL

      https://er-web.sc.kogakuin.ac.jp/Profiles/10/0000962/profile.html?lang=ja&#chosho

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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