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Establishment of next-generation water supply system to control risk of non-tuberculous Mycobacterium

Research Project

Project/Area Number 20H02282
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 22060:Environmental systems for civil engineering-related
Research InstitutionThe University of Tokyo

Principal Investigator

Kasuga Ikuro  東京大学, 先端科学技術研究センター, 准教授 (20431794)

Co-Investigator(Kenkyū-buntansha) 星野 仁彦  国立感染症研究所, ハンセン病研究センター 感染制御部, 室長 (20569694)
栗栖 太  東京大学, 大学院工学系研究科(工学部), 教授 (30312979)
島崎 大  国立保健医療科学院, その他部局等, 上席主任研究官 (60322046)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords非結核性抗酸菌 / 水供給システム / 微生物再増殖 / 水道水
Outline of Research at the Start

近年、非結核性抗酸菌(NTM)による呼吸器疾患の増加が問題になっている。その感染経路は十分に明らかにされていないが、NTMは塩素に耐性があり水道水中に生残しやすいことから、水道水に由来するリスクが懸念されている。本研究は、水供給システムにおけるNTMの生理・生態を解明し、NTMを制御する次世代の水供給システムの要点を明らかにする研究である。

Outline of Final Research Achievements

We evaluated the potential of water supply systems as a source of infection by non-tuberculous mycobacteria (NTM), whose incidence rate has been increasing in Japan and other countries in recent years. Surveillance of NTM in household plumbing and showerheads revealed that Mycobacterium avium, a typical pathogenic NTM, was not detected, but other opportunistic pathogenic NTM were prevalent. These NTM groups were extremely chlorine resistant, suggesting that they can survive and regrow in the water supply system.

Academic Significance and Societal Importance of the Research Achievements

従来、水道水質の微生物リスクとしては大腸菌に代表される腸管疾患が注目されてきた。しかし、近年、エアロゾルを介して感染が生じる非結核性抗酸菌(NTM)が水供給システムで生残し、再増殖していることが示唆されている。これまでにNTMの存在状況に関する知見はほとんどなかったが、本研究の成果により、宅内水道水やシャワーヘッドにおいて、日和見感染性のNTMが存在していること、こうしたNTMは塩素耐性が極めて高く、浄水処理における消毒で完全に除去されずに給水末端に到達し、再増殖していることが示唆された。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (17 results)

All 2023 2022 2021 2020

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Complete Genome and Partial Megaplasmid Sequences of Mycobacterium pseudoshottsii Strain NJB1907-Z4, Isolated from an Aquarium-Reared Japanese Sardine (Sardinops melanostictus) in Japan2022

    • Author(s)
      Komine Takeshi, Fukano Hanako, Yoshida Mitsunori, Inohana Mari, Hoshino Yoshihiko, Kurata Osamu, Wada Shinpei
    • Journal Title

      Microbiology Resource Announcements

      Volume: 11 Issue: 12

    • DOI

      10.1128/mra.00785-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Draft Genome Sequences of Eight Mycobacterium montefiorense Strains Isolated from Salamanders in Captivity2022

    • Author(s)
      Komine Takeshi, Ihara Hyogo, Fukano Hanako, Hoshino Yoshihiko, Kurata Osamu, Wada Shinpei
    • Journal Title

      Microbiology Resource Announcements

      Volume: 11 Issue: 11

    • DOI

      10.1128/mra.00702-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic efficacy of rifalazil (KRM-1648) in a M. ulcerans-induced Buruli ulcer mouse model2022

    • Author(s)
      Fukano H, Nakanaga K, Goto M, Yoshida M, Ishii N, Hoshino Y.
    • Journal Title

      PLoS One

      Volume: 17 Issue: 10 Pages: e0274742-e0274742

    • DOI

      10.1371/journal.pone.0274742

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Draft Genome Sequences of 25 Mycobacterium marinum Strains Isolated from Animals and Environmental Components in Aquaria and an Aquaculture Farm2022

    • Author(s)
      Komine Takeshi, Fukano Hanako, Inohana Mari, Hoshino Yoshihiko, Kurata Osamu, Wada Shinpei
    • Journal Title

      Microbiology Resource Announcements

      Volume: 11 Issue: 10

    • DOI

      10.1128/mra.00851-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete Chromosomal Genome Sequence of Mycobacterium sp. Strain IWGMT90018-18076.2022

    • Author(s)
      Fukano H, Yoshida M, Kazumi Y, Sakagami N, Ato M, Mitarai S, Hoshino Y
    • Journal Title

      Microbiol Resour Announc.

      Volume: 11 Issue: 6

    • DOI

      10.1128/mra.00078-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The fate and risk of nontuberculous mycobacteria in the water supply system: a review2022

    • Author(s)
      Gan Yalan、Rahmatika Iftita、Kurisu Futoshi、Furumai Hiroaki、Simazaki Dai、Fukano Hanako、Hoshino Yoshihiko、Kasuga Ikuro
    • Journal Title

      H2Open Journal

      Volume: 5 Issue: 2 Pages: 1-17

    • DOI

      10.2166/h2oj.2022.144

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics of the Microbial Community and Opportunistic Pathogens after Water Stagnation in the Premise Plumbing of a Building2022

    • Author(s)
      Iftita Rahmatika, Ikuro Kasuga, Futoshi Kurisu, and Hiroaki Furumai
    • Journal Title

      Microbes and Environments

      Volume: 37 Issue: 1 Pages: n/a

    • DOI

      10.1264/jsme2.ME21065

    • ISSN
      1342-6311, 1347-4405
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bursitis, Bacteremia, and Disseminated Infection of <i>Mycobacteroides</i> (<i>Mycobacterium</i>) <i>abscessus</i> subsp. <i>massiliense</i>2021

    • Author(s)
      Oka K, Morioka H, Asakura T, Sato Y, Tetsuka N, Iguchi M, Kanematsu T, Fukano H, Hoshino Y, Kiyoi H,Yagi T.
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 18 Pages: 3041-3045

    • DOI

      10.2169/internalmedicine.6189-20

    • NAID

      130008088266

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-09-15
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three cases of otitis media caused by Mycobacterium abscessus subsp. abscessus: Importance of medical treatment and efficacy of surgery2021

    • Author(s)
      Nishiyama Y, Nishiyama T, Kanzaki S, Oishi N, Fujioka M, Yamada H, Ebisuno C, Kaiho M, Uwamino Y, Fukano H, Hoshino Y, Hasegawa N, Ogawa K.
    • Journal Title

      J Infect Chemother

      Volume: 27 Issue: 8 Pages: 1251-1257

    • DOI

      10.1016/j.jiac.2021.04.012

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human pathogenic Mycobacterium kansasii (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan2021

    • Author(s)
      Fukano Hanako、Terazono Tsukasa、Hirabayashi Aki、Yoshida Mitsunori、Suzuki Masato、Wada Shinpei、Ishii Norihisa、Hoshino Yoshihiko
    • Journal Title

      Emerging Microbes & Infections

      Volume: 10 Issue: 1 Pages: 220-222

    • DOI

      10.1080/22221751.2021.1878935

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Occurrence and Diversity of Nontuberculous Mycobacteria in Biofilms Developed in Showerheads in Dormitories and Houses2023

    • Author(s)
      Yalan Gan, Eriko Shibasaki, Futoshi Kurisu, Dai Simazaki, Ikuro Kasuga
    • Organizer
      第57回日本水環境学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Quantitative microbial risk assessment of nontuberculous mycobacteria in water supply system in Japan2022

    • Author(s)
      Yalan Gan, Futoshi Kurisu, Hiroaki Furumaui, and Ikuro Kasuga
    • Organizer
      WET2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 給水管における微生物再増殖と水質管理2021

    • Author(s)
      春日郁朗, Iftita Rahmatika, 栗栖太,古米弘明
    • Organizer
      第27回日本水環境学会シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dynamic changes of microbial communities from source to tap in chlorinated drinking water supply system2021

    • Author(s)
      Iftita Rahmatika, Ikuro Kasuga, Futoshi Kurisu and Hiroaki Furumai
    • Organizer
      The 9th Microbial Ecology & Water Engineering
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Removal efficiency of nontuberculous mycobacteria in a full-scale drinking water treatment plant2021

    • Author(s)
      Gan Yalan, Iftita Rahmatika, Ikuro Kasuga, Futoshi Kurisu and Hiroaki Furumai
    • Organizer
      Water Environment Technology Conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diversity of nontuberculous mycobacteria in drinking water in premise plumbing2021

    • Author(s)
      Iftita Rahmatika, Ikuro Kasuga, Futoshi Kurisu and Hiroaki Furumai
    • Organizer
      Water Environment Technology Conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] One-year monitoring of microbial regrowth and occurrence of opportunistic pathogens after stagnation in premise plumbing2020

    • Author(s)
      Iftita Rahmatika, Ikuro Kasuga, Futoshi Kurisu and Hiroaki Furumai
    • Organizer
      Water Environment Technology Conference 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2024-01-30  

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