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Elucidation of the Impact on School-Age Children's Health through Epigenome and Metagenome Interaction Analysis

Research Project

Project/Area Number 20H03928
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionUniversity of Yamanashi

Principal Investigator

Miyake Kunio  山梨大学, 大学院総合研究部, 准教授 (60550712)

Co-Investigator(Kenkyū-buntansha) 篠原 亮次  山梨大学, 大学院総合研究部, 特任教授 (00633116)
山縣 然太朗  山梨大学, 大学院総合研究部, 教授 (10210337)
望月 和樹  山梨大学, 大学院総合研究部, 教授 (80423838)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
KeywordsDOHaD / 出生コホート / 腸内細菌叢 / 神経発達 / アレルギー性鼻炎 / 低栄養 / 腸内細菌 / 遺伝子 / 遺伝子多型 / SNPs / エピゲノム / DNAメチル化 / メタゲノム
Outline of Research at the Start

胎児期や乳幼児期の環境要因が成長後の健康、疾患リスクにつながるというDOHaD説が提唱されており、近年エピゲノム との関連が考えられている。しかし、ヒトの出生までに起こったDNAメチル化が学童期まで維持されるのか、そしてメチル化がアウトカムに影響するのか、また出生後の環境要因はどう影響するのか、という点は明らかになっていない。本研究の目的は、出生コホート研究から胎児期から幼児期の環境要因が学童期の健康リスクに及ぼす影響について、エピゲノムおよび腸内細菌メタゲノムの両面からアプローチし、これまでにない新たな視点からDOHaD分子メカニズムを明らかにすることである。

Outline of Final Research Achievements

This study aims to elucidate the impact of environmental factors during the fetal and early childhood periods on diseases and the health and development of children up to school age, considering genetic backgrounds, from the perspectives of epigenome and gut microbiota metagenome analyses, using a large-scale birth cohort. As a result, several significant findings were revealed: (1) characteristic gut microbiota in underweight eight-year-old children, (2) the association between the prevalence of allergic rhinitis symptoms and gut microbiota in eight-year-olds, (3) an increased risk of developmental delays in children due to the combination of alcohol metabolism gene polymorphisms and maternal alcohol consumption during pregnancy, and (4) an increased risk of developmental delays in children due to maternal malnutrition during pregnancy. Future research will focus on elucidating more detailed molecular mechanisms.

Academic Significance and Societal Importance of the Research Achievements

本研究は、胎児期や乳幼児期のさまざまな環境要因が成長後の疾患リスクに関連するというDOHaD概念を強化する成果が得られ、分子疫学的エビデンスの一端を解明できた点は学術的意義が大きい。
我が国において、相対的貧困、妊婦の栄養不足が社会問題となっている。妊娠中母親の低栄養環境や飲酒が子どもの発達に悪影響を及ぼすリスクが高まるという本研究成果は、妊娠を考えている女性に対する情報提供や注意喚起に生かされた点で社会的意義が大きい。今後さらなるDOHaD分子メカニズムの解明及びリスクとなる環境要因やバイオマーカーの発見により、将来の疾患リスクを予測し、早期介入による先制医療を実現が期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (58 results)

All 2024 2023 2022 2021 2020 Other

All Journal Article (48 results) (of which Int'l Joint Research: 14 results,  Peer Reviewed: 48 results,  Open Access: 42 results) Presentation (6 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Infantile Peanut Introduction and Peanut Allergy in Regions With a Low Prevalence of Peanut Allergy: The Japan Environment and Children’s Study (JECS)2024

    • Author(s)
      Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Yui Hideki、Otawa Sanae、Horiuchi Sayaka、Miyake Kunio、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro、the Japan Environment and Children’s Study Group
    • Journal Title

      Journal of Epidemiology

      Volume: 34 Issue: 7 Pages: 324-330

    • DOI

      10.2188/jea.JE20230210

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2024-07-05
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study2024

    • Author(s)
      Kojima Reiji、Miyake Kunio、Shinohara Ryoji、Kushima Megumi、Yui Hideki、Otawa Sanae、Horiuchi Sayaka、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro、the Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
    • Journal Title

      The Journal of Dermatology

      Volume: 51 Issue: 4 Pages: 484-490

    • DOI

      10.1111/1346-8138.17157

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children’s Study (JECS)2024

    • Author(s)
      Ishiyama S、Mochizuki K、Shinohara R、Miyake K、Kushima M、Kojima R、Horiuchi S、Otawa S、Yui H、Ooka T、Akiyama Y、Yokomichi H、Yamagata Z、The Japan Environment and Children’s Study Group
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 7248-7248

    • DOI

      10.1038/s41598-024-55623-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal protein intake in early pregnancy and child development at age 3 years2023

    • Author(s)
      Miyake Kunio、Mochizuki Kazuki、Kushima Megumi、Shinohara Ryoji、Horiuchi Sayaka、Otawa Sanae、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Yamagata Zentaro、Japan Environment and Children’s Study Group
    • Journal Title

      Pediatric Research

      Volume: 2023 Issue: 1 Pages: 392-399

    • DOI

      10.1038/s41390-022-02435-8

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of birth season on allergic rhinitis and cedar pollinosis considering allergen and vitamin D exposure: The Japan Environment and Children's study (JECS)2023

    • Author(s)
      Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Miyake Kunio、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro
    • Journal Title

      Allergology International

      Volume: 72 Issue: 3 Pages: 411-417

    • DOI

      10.1016/j.alit.2023.01.003

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple pregnancy as a potential risk factor for postpartum depression: The Japan Environment and Children's Study2023

    • Author(s)
      Shinohara Satoshi、Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Miyake Kunio、Yui Hideki、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Yokomichi Hiroshi、Yamagata Zentaro
    • Journal Title

      Journal of Affective Disorders

      Volume: 329 Pages: 218-224

    • DOI

      10.1016/j.jad.2023.02.088

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interpregnancy weight change as a potential risk factor for large-for-gestational-age infants: the Japan Environment and Children’s Study2023

    • Author(s)
      Shinohara Satoshi、Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Miyake Kunio、Yui Hideki、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Yokomichi Hiroshi、Yamagata Zentaro、the Japan Environment and Children’s Study Group
    • Journal Title

      The Journal of Maternal-Fetal & Neonatal Medicine

      Volume: 36 Issue: 1 Pages: 2209251-2209251

    • DOI

      10.1080/14767058.2023.2209251

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of influenza vaccination or influenza virus infection history with subsequent infection risk among children: The Japan Environment and Children's Study (JECS)2023

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Horiuchi Sayaka、Kushima Megumi、Shinohara Ryoji、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yamagata Zentaro
    • Journal Title

      Preventive Medicine

      Volume: 173 Pages: 107599-107599

    • DOI

      10.1016/j.ypmed.2023.107599

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A nationwide, prospective, cohort study on exogenous oxytocin and delays in early child development: the Japan environment and children’s study2023

    • Author(s)
      Shinohara S、Horiuchi S、Shinohara R、Otawa S、Kushima M、Miyake K、Yui H、Kojima R、Ooka T、Akiyama Y、Yokomichi H、Buchholz A、Yamagata Z
    • Journal Title

      European Journal of Pediatrics

      Volume: 182 Issue: 9 Pages: 4059-4068

    • DOI

      10.1007/s00431-023-05079-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study2023

    • Author(s)
      Miyake Kunio、Horiuchi Sayaka、Shinohara Ryoji、Kushima Megumi、Otawa Sanae、Yui Hideki、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Mochizuki Kazuki、Yamagata Zentaro、The Japan Environment Children's Study Group
    • Journal Title

      Frontiers in Nutrition

      Volume: 10 Pages: 1203669-1203669

    • DOI

      10.3389/fnut.2023.1203669

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Obesity as a potential risk factor for stillbirth: The Japan Environment and Children’s Study2023

    • Author(s)
      Shinohara Satoshi、Shinohara Ryoji、Kojima Reiji、Horiuchi Sayaka、Otawa Sanae、Kushima Megumi、Miyake Kunio、Yui Hideki、Ooka Tadao、Akiyama Yuka、Yokomichi Hiroshi、Yamagata Zentaro
    • Journal Title

      Preventive Medicine Reports

      Volume: 35 Pages: 102391-102391

    • DOI

      10.1016/j.pmedr.2023.102391

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal smoking status before and during pregnancy and bronchial asthma at 3?years of age: a prospective cohort study2023

    • Author(s)
      Miyake K、Kushima M、Shinohara R、Horiuchi S、Otawa S、Akiyama Y、Ooka T、Kojima R、Yokomichi H、Yamagata Z、The Japan Environment and Children’s Study Group
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 3234-3234

    • DOI

      10.1038/s41598-023-30304-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and immunohistochemical profiling of NK/T-cell lymphomas reveals prognostically relevant BCOR-MYC association2023

    • Author(s)
      Oishi Naoki、Satou Akira、Miyaoka Masashi、Kawashima Ichiro、Segawa Takahiro、Miyake Kunio、Mochizuki Kunio、Kirito Keita、Feldman Andrew L.、Nakamura Naoya、Kondo Tetsuo
    • Journal Title

      Blood Advances

      Volume: 7 Issue: 1 Pages: 178-189

    • DOI

      10.1182/bloodadvances.2022007541

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Appropriate procedures to increase the adherence of children to blood collection: A cross‐sectional study2022

    • Author(s)
      Yui Hideki、Otawa Sanae、Horiuchi Sayaka、Kushima Megumi、Shinohara Ryoji、Kojima Reiji、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yokomichi Hiroshi、Yamagata Zentaro、The Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
    • Journal Title

      Health Science Reports

      Volume: 6 Issue: 1 Pages: 1-10

    • DOI

      10.1002/hsr2.1036

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel compound heterozygous mutations in <i>UHRF1</i> are associated with atypical immunodeficiency, centromeric instability and facial anomalies syndrome with distinctive genome-wide DNA hypomethylation2022

    • Author(s)
      Unoki Motoko、Velasco Guillaume、Kori Satomi、Arita Kyohei、Daigaku Yasukazu、Yeung Wan Kin Au、Fujimoto Akihiro、Ohashi Hirofumi、Kubota Takeo、Miyake Kunio、Sasaki Hiroyuki
    • Journal Title

      Human Molecular Genetics

      Volume: 32 Issue: 9 Pages: 1439-1456

    • DOI

      10.1093/hmg/ddac291

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to House Dust Mite Allergen and Endotoxin in Early Life and Sensitization and Allergic Rhinitis: The JECS2022

    • Author(s)
      Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Miyake Kunio、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro、the Japan Environment and Children’s Study Group
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 22 Pages: 14796-14796

    • DOI

      10.3390/ijerph192214796

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy2022

    • Author(s)
      Shinozaki Youichi、Leung Alex、Namekata Kazuhiko、Saitoh Sei、Nguyen Huy Bang、Takeda Akiko、Danjo Yosuke、Morizawa Yosuke M.、Shigetomi Eiji、Sano Fumikazu、Yoshioka Nozomu、Takebayashi Hirohide、Ohno Nobuhiko、Segawa Takahiro、Miyake Kunio、Kashiwagi Kenji、Harada Takayuki、Ohnuma Shin-ichi、Koizumi Schuichi
    • Journal Title

      Science Advances

      Volume: 8 Issue: 44 Pages: 1081-1081

    • DOI

      10.1126/sciadv.abq1081

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of egg protein levels in dust with allergy status and related factors2022

    • Author(s)
      Kojima Reiji、Miyake Kunio、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15372

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children’s Study cohort2022

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 6 Pages: e0269610-e0269610

    • DOI

      10.1371/journal.pone.0269610

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prenatal Negative Life Events and Childhood Allergies: The Japan Environment and Children’s Study (JECS)2022

    • Author(s)
      Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro、the Japan Environment and Children’s Study Group
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 183 Issue: 10 Pages: 1062-1070

    • DOI

      10.1159/000524854

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Methylation of Tumor Suppressive miRNAs in Plasma from Patients With Pancreaticobiliary Diseases2022

    • Author(s)
      OHTSUBO KOUSHIRO、MIYAKE KUNIO、ARAI SACHIKO、FUKUDA KOJI、SUZUKI CHIAKI、KOTANI HIROSHI、TANIMOTO AZUSA、NISHIYAMA AKIHIRO、NANJO SHIGEKI、YAMASHITA KANAME、TAKEUCHI SHINJI、YANO SEIJI
    • Journal Title

      Cancer Diagnosis Prognosis

      Volume: 2 Issue: 3 Pages: 378-383

    • DOI

      10.21873/cdp.10120

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of the incidence of atopic dermatitis until 3 years old with climate conditions in the first 6 months of life: Japan Environment and Children’s Study (JECS)2022

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 5 Pages: e0268204-e0268204

    • DOI

      10.1371/journal.pone.0268204

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS)2022

    • Author(s)
      Sekine Tetsuo、Tsuchiya Kyoichiro、Uchinuma Hiroyuki、Horiuchi Sayaka、Kushima Megumi、Otawa Sanae、Yokomichi Hiroshi、Miyake Kunio、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Shinohara Ryoji、Yamagata Zentaro、The Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 13 Issue: 8 Pages: 1444-1447

    • DOI

      10.1111/jdi.13796

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)2022

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Kushima Megumi、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 3 Pages: 1761-1761

    • DOI

      10.3390/ijerph19031761

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia2022

    • Author(s)
      Tamai Minori、Kasai Shin、Akahane Koshi、Thu Thao Nguyen、Kagami Keiko、Komatsu Chiaki、Abe Masako、Watanabe Atsushi、Goi Kumiko、Miyake Kunio、Inaba Toshiya、Takita Junko、Goto Hiroaki、Minegishi Masayoshi、Iwamoto Shotaro、Sugita Kanji、Inukai Takeshi
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: 218 Pages: 106068-106068

    • DOI

      10.1016/j.jsbmb.2022.106068

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adiposity rebound may be a predictive index of body size for adolescents?Based on retrospective cohort data in a Japanese rural area2022

    • Author(s)
      Haga Chiyori、Yokomichi Hiroshi、Tsuji Kyoko、Yamagata Zentaro
    • Journal Title

      Obesity Research &amp; Clinical Practice

      Volume: 16 Issue: 4 Pages: 50-55

    • DOI

      10.1001/jamapediatrics.2021.5778

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort2022

    • Author(s)
      Oishi Naoki、Segawa Takahiro、Miyake Kunio、Mochizuki Kunio、Kondo Tetsuo
    • Journal Title

      Histopathology

      Volume: 80 Issue: 5 Pages: 820-826

    • DOI

      10.1111/his.14617

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mother’s iodine exposure and infants’ hypothyroidism: the Japan Environment and Children’s Study (JECS)2022

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Kushima Megumi、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro
    • Journal Title

      Endocrine Journal

      Volume: 69 Issue: 1 Pages: 9-21

    • DOI

      10.1507/endocrj.EJ21-0168

    • NAID

      130008145295

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of allele-specific methylation of the <i>ASNS</i> gene with asparaginase sensitivity and prognosis in T-ALL2022

    • Author(s)
      Akahane Koshi、Kimura Shunsuke、Miyake Kunio、Watanabe Atsushi、Kagami Keiko、Yoshimura Kentaro、Shinohara Tamao、Harama Daisuke、Kasai Shin、Goi Kumiko、Kawai Tomoko、Hata Kenichiro、Kiyokawa Nobutaka、Koh Katsuyoshi、他7名
    • Journal Title

      Blood Advances

      Volume: 6 Issue: 1 Pages: 212-224

    • DOI

      10.1182/bloodadvances.2021004271

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography?a large database analysis in Japan2021

    • Author(s)
      Sato Chiaki、Sato Hiroki、Kamei Takashi、Shimamura Yuto、Tanaka Shinwa、Shiwaku Hironari、Shiota Junya、Ogawa Ryo、Yokomichi Hiroshi、Inoue Haruhiro
    • Journal Title

      Esophagus

      Volume: 19 Issue: 8 Pages: 182-188

    • DOI

      10.1136/oemed-2021-108034

    • NAID

      40022800230

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health2021

    • Author(s)
      Miyake Kunio、Miyashita Chihiro、Ikeda-Araki Atsuko、Miura Ryu、Itoh Sachiko、Yamazaki Keiko、Kobayashi Sumitaka、Masuda Hideyuki、Ooka Tadao、Yamagata Zentaro、Kishi Reiko
    • Journal Title

      Clinical Epigenetics

      Volume: 13 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s13148-021-01063-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health2021

    • Author(s)
      Miura Ryu、Ikeda-Araki Atsuko、Ishihara Toru、Miyake Kunio、Miyashita Chihiro、Nakajima Tamie、Kobayashi Sumitaka、Ishizuka Mayumi、Kubota Takeo、Kishi Reiko
    • Journal Title

      Science of The Total Environment

      Volume: 783 Pages: 147035-147035

    • DOI

      10.1016/j.scitotenv.2021.147035

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between gestational hair dye use and allergies at 3 years old: the Japan environment and Children's study2021

    • Author(s)
      Kojima Reiji、Shinohara Ryoji、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro
    • Journal Title

      Environmental Research

      Volume: 201 Pages: 111530-111530

    • DOI

      10.1016/j.envres.2021.111530

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia2021

    • Author(s)
      Watanabe Atsushi、Miyake Kunio、Akahane Koshi、Goi Kumiko、Kagami Keiko、Yagita Hideo、Inukai Takeshi
    • Journal Title

      Genes

      Volume: 12 Issue: 6 Pages: 864-864

    • DOI

      10.3390/genes12060864

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of the incidence of atopic dermatitis until 3 years old with birth month and with sunshine duration and humidity in the first 6 months of life: Japan Environment and Children’s Study2021

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Tsuchida Akiko、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Shinohara Ryoji、Inadera Hidekuni、Yamagata Zentaro
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 7 Pages: 1-6

    • DOI

      10.1136/bmjopen-2020-047226

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Screening of frequent variants associated with congenital hypothyroidism: a comparison with next generation sequencing2021

    • Author(s)
      Watanabe Daisuke、Yagasaki Hideaki、Narusawa Hiromune、Saito Tomohiro、Mitsui Yumiko、Miyake Kunio、Ohta Masanori、Inukai Takeshi
    • Journal Title

      Endocrine Journal

      Volume: 68 Issue: 12 Pages: 1411-1419

    • DOI

      10.1507/endocrj.EJ21-0353

    • NAID

      130008136503

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study2021

    • Author(s)
      Uchinuma Hiroyuki、Tsuchiya Kyoichiro、Sekine Tetsuo、Horiuchi Sayaka、Kushima Megumi、Otawa Sanae、Yokomichi Hiroshi、Miyake Kunio、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Shinohara Ryoji、Hirata Shuji、Yamagata Zentaro; Japan Environment and Children’s Study Group
    • Journal Title

      International Journal of Obesity

      Volume: 45 Issue: 12 Pages: 2666-2674

    • DOI

      10.1038/s41366-021-00947-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Household Income and Allergy Development in Children: The Japan Environment and Children’s Study2021

    • Author(s)
      Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro、the Japan Environment and Children’s Study Group
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 183 Issue: 2 Pages: 201-209

    • DOI

      10.1159/000519153

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elective cesarean delivery at term and its effects on respiratory distress at birth in Japan: The Japan Environment and Children's Study2021

    • Author(s)
      Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Yamagata Zentaro、The Japan Environment and Children's Study Group
    • Journal Title

      Health Science Reports

      Volume: 4 Issue: 4

    • DOI

      10.1002/hsr2.421

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Maternal Exposure to Chemicals during Pregnancy and the Risk of Foetal Death: The Japan Environment and Children’s Study2021

    • Author(s)
      Ooka Tadao、Horiuchi Sayaka、Shinohara Ryoji、Kojima Reiji、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yokomichi Hiroshi、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 22 Pages: 11748-11748

    • DOI

      10.3390/ijerph182211748

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of Maternal Active and Secondhand Smoking during Pregnancy on Childhood Obesity at 3 Years of Age: A Nested Case?Control Study from the Japan Environment and Children’s Study (JECS)2021

    • Author(s)
      Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Hirai Hiroyuki、Hashimoto Koichi、Shimabukuro Michio、Yamagata Zentaro、Japan Environment and Children’s Study Group
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 23 Pages: 12506-12506

    • DOI

      10.3390/ijerph182312506

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan2021

    • Author(s)
      Horiuchi Sayaka、Sakamoto Haruka、Abe Sarah K.、Shinohara Ryoji、Kushima Megumi、Otawa Sanae、Yui Hideki、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Mizutani Takashi、Yamagata Zentaro
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 12 Pages: e0261121-e0261121

    • DOI

      10.1371/journal.pone.0261121

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort2021

    • Author(s)
      Yokomichi Hiroshi、Mochizuki Mie、Hirata Makoto、Nagai Akiko、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Shinohara Ryoji、Miyake Kunio、Yamagata Zentaro、BioBank Japan Project
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 12 Issue: 8 Pages: 1425-1429

    • DOI

      10.1111/jdi.13483

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between preterm birth and maternal allergy considering IgE level2021

    • Author(s)
      Kojima Reiji、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Horiuchi Sayaka、Shinohara Ryoji、Yamagata Zentaro、Japan Environment, Children's Study Group
    • Journal Title

      Pediatrics International

      Volume: 63 Issue: 9 Pages: 1026-1032

    • DOI

      10.1111/ped.14635

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of influenza vaccination in infants and toddlers with and without prior infection history: The Japan Environment and Children’s Study2021

    • Author(s)
      Yokomichi Hiroshi、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Mochizuki Mie、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro
    • Journal Title

      Vaccine

      Volume: 39 Issue: 13 Pages: 1800-1804

    • DOI

      10.1016/j.vaccine.2021.02.044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL2020

    • Author(s)
      Atsushi Watanabe, Kunio Miyake, Jessica Nordlund, Ann-Christine Syvanen, Louise van der Weyden, Hiroaki Honda, Norimasa Yamasaki, Akiko Nagamachi, Toshiya Inaba, Tomokatsu Ikawa, Kevin Y Urayama, Nobutaka Kiyokawa, Akira Ohara, Shunsuke Kimura, Yasuo Kubota, Junko Takita, Hiroaki Goto, Kimiyoshi Sakaguchi, et al.
    • Journal Title

      Blood

      Volume: 136 Issue: 20 Pages: 2319-2333

    • DOI

      10.1182/blood.2019004090

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma2020

    • Author(s)
      Hanihara M, Miyake K, Watanabe A, Yamada Y, Oishi N, Kawataki T, Inukai T, Kondo T, Kinouchi H.
    • Journal Title

      Clin Epigenetics

      Volume: 12(1) Issue: 1 Pages: 174-174

    • DOI

      10.1186/s13148-020-00968-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LPCAT2 Methylation, a Novel Biomarker for the Severity of Cedar Pollen Allergic Rhinitis in Japan2020

    • Author(s)
      Watanabe H, Miyake K, Matsuoka T, Kojima R, Sakurai D, Masuyama K, Yamagata Z.
    • Journal Title

      Am J Rhinol Allergy.

      Volume: - Issue: 5 Pages: 631-639

    • DOI

      10.1177/1945892420983646

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 妊娠中の母親の栄養摂取と子どもの発達との関連 ーエコチル調査甲信ユニットセンターの研究よりー2023

    • Author(s)
      小島令嗣, 篠原亮次, 久島萌, 小田和早苗, 秋山有佳, 大岡忠生, 堀内清華, 三宅邦夫, 横道洋司, 山縣然太朗
    • Organizer
      第60回日本小児アレルギー学会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハウスダスト中の鶏卵タンパク量に関係する要因:エコチル調査より2023

    • Author(s)
      小島令嗣, 篠原亮次, 久島萌, 小田和早苗, 秋山有佳, 大岡忠生, 堀内清華, 三宅邦夫, 横道洋司, 山縣然太朗
    • Organizer
      第82回日本公衆衛生学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] STAT3活性化変異を有する節外性NK/T細胞リンパ腫・鼻型はCD30を高発現する2021

    • Author(s)
      大石 直輝,佐藤 啓,川島 一郎,瀬川 高弘,三宅 邦夫, 望月 邦夫,桐戸 敬太,近藤 哲夫
    • Organizer
      第61回日本リンパ網内系学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒトiPS細胞を用いた発生初期からのタバコ煙曝露による神経細胞分化への影響2021

    • Author(s)
      三宅 邦夫
    • Organizer
      日本環境変異原ゲノム学会第50回記念大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 膠芽腫におけるMGMT遺伝子メチル化の新規解析法 -HPLC法-2020

    • Author(s)
      埴原 光人、川瀧 智之、荻原 雅和、三宅 邦夫、渡邊 敦、大石 直輝、山田有理子、犬飼 岳史、木内 博之
    • Organizer
      日本脳神経外科学会第79回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 白血病細胞のASNS遺伝子のメチル化解析におけるHPLC法の有用性2020

    • Author(s)
      渡邊 敦, 三宅 邦夫, 篠原 珠緒, 原間 大輔, 笠井 慎, 村上 寧, 赤羽弘資, 合井 久美子,山田 有理子, 砂村 栄一郎, 與谷 卓也, 犬飼 岳史
    • Organizer
      第123回日本小児科学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Book] 精神神経疾患とエピジェネティクス2023

    • Author(s)
      三宅邦夫
    • Total Pages
      7
    • Publisher
      金原出版
    • Related Report
      2023 Annual Research Report
  • [Remarks] エコチル山梨ホームページ

    • URL

      https://ecochil-koushin.jp/yamanashi/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 山梨大学大学院総合研究部医学域社会医学講座ホームページ

    • URL

      https://www.med.yamanashi.ac.jp/social/heal0sci/

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 胃がん細胞の増殖抑制剤、胃がんの腫瘍形成抑制剤、胃がんを治療するための医薬、及び薬効予測方法2021

    • Inventor(s)
      犬飼 岳史、渡邊 敦、赤羽 弘資、三宅 邦夫
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-116120
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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