エピゲノム・メタゲノム交互作用解析による学童期の健康に与える影響の解明

• Project/Area Number: 20H03928
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: University of Yamanashi
• Principal Investigator: 三宅 邦夫 山梨大学, 大学院総合研究部, 准教授 (60550712)
• Co-Investigator(Kenkyū-buntansha): 篠原 亮次 山梨大学, 大学院総合研究部, 特任教授 (00633116) ; 山縣 然太朗 山梨大学, 大学院総合研究部, 教授 (10210337) ; 望月 和樹 山梨大学, 大学院総合研究部, 教授 (80423838)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2023: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: DOHaD / 出生コホート / 腸内細菌 / 遺伝子 / アレルギー性鼻炎 / 神経発達 / 遺伝子多型 / SNPs / エピゲノム / 腸内細菌叢 / DNAメチル化 / メタゲノム

Outline of Research at the Start

胎児期や乳幼児期の環境要因が成長後の健康、疾患リスクにつながるというDOHaD説が提唱されており、近年エピゲノム との関連が考えられている。しかし、ヒトの出生までに起こったDNAメチル化が学童期まで維持されるのか、そしてメチル化がアウトカムに影響するのか、また出生後の環境要因はどう影響するのか、という点は明らかになっていない。本研究の目的は、出生コホート研究から胎児期から幼児期の環境要因が学童期の健康リスクに及ぼす影響について、エピゲノムおよび腸内細菌メタゲノムの両面からアプローチし、これまでにない新たな視点からDOHaD分子メカニズムを明らかにすることである。

Outline of Annual Research Achievements

近年、胎児期や乳幼児期の様々な環境要因(低栄養、ストレスや虐待などの成育環境、化学物質曝露など)が成長後の疾患発症リスク(肥満・糖尿病、アレルギー疾患、神経発達疾患など)につながるとするDOHaD（Developmental Origins of Health and Disease）概念が提唱されている。その分子メカニズムはまだ不明な点が多い。本研究は、本研究の目的は、大規模な出生コホートを用いて胎児期・乳幼児期の環境要因が学童期の疾患や子供の健康・発達に及ぼす影響について、遺伝的背景を考慮した腸内細菌メタゲノム解析の観点から明らかにすることを目的とする。
今年度は、エコチル研究に特化(化学物質や栄養代謝関連、ストレス、肥満、神経発達、アレルギー関連など)した96のSNPsについて、DNAの取得できた8歳児1,768名、母親1,946名についてデータを取得した。また母親の糞便からDNA抽出し、約500検体について次世代シークエンサーにより16SrRNAデータを取得した。さらに母子のアレルギー性鼻炎の詳細な調査を実施するため、質問票を作成し、約1800組の母子から回答を得た。疫学解析から、妊娠中の食物繊維摂取と子供の発達に与える影響について発表を行った。さらに母親のアルコール遺伝子多型を考慮した妊娠中の飲酒と３歳児の発達遅延の関係、アレルギー性鼻炎症状と特異的IgEの関係をそれぞれ明らかにし、現在論文投稿中である。今後はさらにこれまで取得したゲノム、メタゲノムデータを基に、分子疫学的解析を行う予定である。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Infantile Peanut Introduction and Peanut Allergy in Regions With a Low Prevalence of Peanut Allergy: The Japan Environment and Children’s Study (JECS) (2024)
  • Author(s): Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Yui Hideki、Otawa Sanae、Horiuchi Sayaka、Miyake Kunio、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro、the Japan Environment and Children’s Study Group
  • Journal Title: Journal of Epidemiology Volume: 34 Issue: 7 Pages: 324-330
  • DOI: 10.2188/jea.JE20230210
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2024-07-05
  • Peer Reviewed
• [Journal Article] Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study (2024)
  • Author(s): Kojima Reiji、Miyake Kunio、Shinohara Ryoji、Kushima Megumi、Yui Hideki、Otawa Sanae、Horiuchi Sayaka、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro、the Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
  • Journal Title: The Journal of Dermatology Volume: 51 Issue: 4 Pages: 484-490
  • DOI: 10.1111/1346-8138.17157
  • Peer Reviewed / Open Access
• [Journal Article] Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children’s Study (JECS) (2024)
  • Author(s): Ishiyama S、Mochizuki K、Shinohara R、Miyake K、Kushima M、Kojima R、Horiuchi S、Otawa S、Yui H、Ooka T、Akiyama Y、Yokomichi H、Yamagata Z、The Japan Environment and Children’s Study Group
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 7248-7248
  • DOI: 10.1038/s41598-024-55623-3
  • Peer Reviewed / Open Access
• [Journal Article] Maternal protein intake in early pregnancy and child development at age 3 years (2023)
  • Author(s): Miyake Kunio、Mochizuki Kazuki、Kushima Megumi、Shinohara Ryoji、Horiuchi Sayaka、Otawa Sanae、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Yamagata Zentaro、Japan Environment and Children’s Study Group
  • Journal Title: Pediatric Research Volume: 2023 Issue: 1 Pages: 392-399
  • DOI: 10.1038/s41390-022-02435-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of birth season on allergic rhinitis and cedar pollinosis considering allergen and vitamin D exposure: The Japan Environment and Children's study (JECS) (2023)
  • Author(s): Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Miyake Kunio、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro
  • Journal Title: Allergology International Volume: 72 Issue: 3 Pages: 411-417
  • DOI: 10.1016/j.alit.2023.01.003
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multiple pregnancy as a potential risk factor for postpartum depression: The Japan Environment and Children's Study (2023)
  • Author(s): Shinohara Satoshi、Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Miyake Kunio、Yui Hideki、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Yokomichi Hiroshi、Yamagata Zentaro
  • Journal Title: Journal of Affective Disorders Volume: 329 Pages: 218-224
  • DOI: 10.1016/j.jad.2023.02.088
  • Peer Reviewed / Open Access
• [Journal Article] Interpregnancy weight change as a potential risk factor for large-for-gestational-age infants: the Japan Environment and Children’s Study (2023)
  • Author(s): Shinohara Satoshi、Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Miyake Kunio、Yui Hideki、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Yokomichi Hiroshi、Yamagata Zentaro、the Japan Environment and Children’s Study Group
  • Journal Title: The Journal of Maternal-Fetal & Neonatal Medicine Volume: 36 Issue: 1 Pages: 2209251-2209251
  • DOI: 10.1080/14767058.2023.2209251
  • Peer Reviewed / Open Access
• [Journal Article] Association of influenza vaccination or influenza virus infection history with subsequent infection risk among children: The Japan Environment and Children's Study (JECS) (2023)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Horiuchi Sayaka、Kushima Megumi、Shinohara Ryoji、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yamagata Zentaro
  • Journal Title: Preventive Medicine Volume: 173 Pages: 107599-107599
  • DOI: 10.1016/j.ypmed.2023.107599
  • Peer Reviewed / Open Access
• [Journal Article] A nationwide, prospective, cohort study on exogenous oxytocin and delays in early child development: the Japan environment and children’s study (2023)
  • Author(s): Shinohara S、Horiuchi S、Shinohara R、Otawa S、Kushima M、Miyake K、Yui H、Kojima R、Ooka T、Akiyama Y、Yokomichi H、Buchholz A、Yamagata Z
  • Journal Title: European Journal of Pediatrics Volume: 182 Issue: 9 Pages: 4059-4068
  • DOI: 10.1007/s00431-023-05079-w
  • Peer Reviewed / Open Access
• [Journal Article] Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study (2023)
  • Author(s): Miyake Kunio、Horiuchi Sayaka、Shinohara Ryoji、Kushima Megumi、Otawa Sanae、Yui Hideki、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Mochizuki Kazuki、Yamagata Zentaro、The Japan Environment Children's Study Group
  • Journal Title: Frontiers in Nutrition Volume: 10 Pages: 1203669-1203669
  • DOI: 10.3389/fnut.2023.1203669
  • Peer Reviewed / Open Access
• [Journal Article] Obesity as a potential risk factor for stillbirth: The Japan Environment and Children’s Study (2023)
  • Author(s): Shinohara Satoshi、Shinohara Ryoji、Kojima Reiji、Horiuchi Sayaka、Otawa Sanae、Kushima Megumi、Miyake Kunio、Yui Hideki、Ooka Tadao、Akiyama Yuka、Yokomichi Hiroshi、Yamagata Zentaro
  • Journal Title: Preventive Medicine Reports Volume: 35 Pages: 102391-102391
  • DOI: 10.1016/j.pmedr.2023.102391
  • Peer Reviewed / Open Access
• [Journal Article] Maternal smoking status before and during pregnancy and bronchial asthma at 3?years of age: a prospective cohort study (2023)
  • Author(s): Miyake K、Kushima M、Shinohara R、Horiuchi S、Otawa S、Akiyama Y、Ooka T、Kojima R、Yokomichi H、Yamagata Z、The Japan Environment and Children’s Study Group
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 3234-3234
  • DOI: 10.1038/s41598-023-30304-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic and immunohistochemical profiling of NK/T-cell lymphomas reveals prognostically relevant BCOR-MYC association (2023)
  • Author(s): Oishi Naoki、Satou Akira、Miyaoka Masashi、Kawashima Ichiro、Segawa Takahiro、Miyake Kunio、Mochizuki Kunio、Kirito Keita、Feldman Andrew L.、Nakamura Naoya、Kondo Tetsuo
  • Journal Title: Blood Advances Volume: 7 Issue: 1 Pages: 178-189
  • DOI: 10.1182/bloodadvances.2022007541
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Appropriate procedures to increase the adherence of children to blood collection: A cross‐sectional study (2022)
  • Author(s): Yui Hideki、Otawa Sanae、Horiuchi Sayaka、Kushima Megumi、Shinohara Ryoji、Kojima Reiji、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yokomichi Hiroshi、Yamagata Zentaro、The Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
  • Journal Title: Health Science Reports Volume: 6 Issue: 1 Pages: 1-10
  • DOI: 10.1002/hsr2.1036
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel compound heterozygous mutations in <i>UHRF1</i> are associated with atypical immunodeficiency, centromeric instability and facial anomalies syndrome with distinctive genome-wide DNA hypomethylation (2022)
  • Author(s): Unoki Motoko、Velasco Guillaume、Kori Satomi、Arita Kyohei、Daigaku Yasukazu、Yeung Wan Kin Au、Fujimoto Akihiro、Ohashi Hirofumi、Kubota Takeo、Miyake Kunio、Sasaki Hiroyuki
  • Journal Title: Human Molecular Genetics Volume: 32 Issue: 9 Pages: 1439-1456
  • DOI: 10.1093/hmg/ddac291
  • Peer Reviewed
• [Journal Article] Exposure to House Dust Mite Allergen and Endotoxin in Early Life and Sensitization and Allergic Rhinitis: The JECS (2022)
  • Author(s): Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Miyake Kunio、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro、the Japan Environment and Children’s Study Group
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Issue: 22 Pages: 14796-14796
  • DOI: 10.3390/ijerph192214796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy (2022)
  • Author(s): Shinozaki Youichi、Leung Alex、Namekata Kazuhiko、Saitoh Sei、Nguyen Huy Bang、Takeda Akiko、Danjo Yosuke、Morizawa Yosuke M.、Shigetomi Eiji、Sano Fumikazu、Yoshioka Nozomu、Takebayashi Hirohide、Ohno Nobuhiko、Segawa Takahiro、Miyake Kunio、Kashiwagi Kenji、Harada Takayuki、Ohnuma Shin-ichi、Koizumi Schuichi
  • Journal Title: Science Advances Volume: 8 Issue: 44 Pages: 1081-1081
  • DOI: 10.1126/sciadv.abq1081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of egg protein levels in dust with allergy status and related factors (2022)
  • Author(s): Kojima Reiji、Miyake Kunio、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Yamagata Zentaro
  • Journal Title: Pediatrics International Volume: 64 Issue: 1
  • DOI: 10.1111/ped.15372
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children’s Study cohort (2022)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
  • Journal Title: PLOS ONE Volume: 17 Issue: 6 Pages: e0269610-e0269610
  • DOI: 10.1371/journal.pone.0269610
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prenatal Negative Life Events and Childhood Allergies: The Japan Environment and Children’s Study (JECS) (2022)
  • Author(s): Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro、the Japan Environment and Children’s Study Group
  • Journal Title: International Archives of Allergy and Immunology Volume: 183 Issue: 10 Pages: 1062-1070
  • DOI: 10.1159/000524854
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Methylation of Tumor Suppressive miRNAs in Plasma from Patients With Pancreaticobiliary Diseases (2022)
  • Author(s): OHTSUBO KOUSHIRO、MIYAKE KUNIO、ARAI SACHIKO、FUKUDA KOJI、SUZUKI CHIAKI、KOTANI HIROSHI、TANIMOTO AZUSA、NISHIYAMA AKIHIRO、NANJO SHIGEKI、YAMASHITA KANAME、TAKEUCHI SHINJI、YANO SEIJI
  • Journal Title: Cancer Diagnosis Prognosis Volume: 2 Issue: 3 Pages: 378-383
  • DOI: 10.21873/cdp.10120
  • Peer Reviewed / Open Access
• [Journal Article] Association of the incidence of atopic dermatitis until 3 years old with climate conditions in the first 6 months of life: Japan Environment and Children’s Study (JECS) (2022)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Kojima Reiji、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
  • Journal Title: PLOS ONE Volume: 17 Issue: 5 Pages: e0268204-e0268204
  • DOI: 10.1371/journal.pone.0268204
  • Peer Reviewed / Open Access
• [Journal Article] Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) (2022)
  • Author(s): Sekine Tetsuo、Tsuchiya Kyoichiro、Uchinuma Hiroyuki、Horiuchi Sayaka、Kushima Megumi、Otawa Sanae、Yokomichi Hiroshi、Miyake Kunio、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Shinohara Ryoji、Yamagata Zentaro、The Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group
  • Journal Title: Journal of Diabetes Investigation Volume: 13 Issue: 8 Pages: 1444-1447
  • DOI: 10.1111/jdi.13796
  • Peer Reviewed / Open Access
• [Journal Article] High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS) (2022)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Kushima Megumi、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Issue: 3 Pages: 1761-1761
  • DOI: 10.3390/ijerph19031761
  • Peer Reviewed / Open Access
• [Journal Article] Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia (2022)
  • Author(s): Tamai Minori、Kasai Shin、Akahane Koshi、Thu Thao Nguyen、Kagami Keiko、Komatsu Chiaki、Abe Masako、Watanabe Atsushi、Goi Kumiko、Miyake Kunio、Inaba Toshiya、Takita Junko、Goto Hiroaki、Minegishi Masayoshi、Iwamoto Shotaro、Sugita Kanji、Inukai Takeshi
  • Journal Title: The Journal of Steroid Biochemistry and Molecular Biology Volume: 218 Pages: 106068-106068
  • DOI: 10.1016/j.jsbmb.2022.106068
  • Peer Reviewed / Open Access
• [Journal Article] Adiposity rebound may be a predictive index of body size for adolescents?Based on retrospective cohort data in a Japanese rural area (2022)
  • Author(s): Haga Chiyori、Yokomichi Hiroshi、Tsuji Kyoko、Yamagata Zentaro
  • Journal Title: Obesity Research &amp; Clinical Practice Volume: 16 Issue: 4 Pages: 50-55
  • DOI: 10.1001/jamapediatrics.2021.5778
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Incidence, clinicopathological features and genetics of in‐situ follicular neoplasia: a comprehensive screening study in a Japanese cohort (2022)
  • Author(s): Oishi Naoki、Segawa Takahiro、Miyake Kunio、Mochizuki Kunio、Kondo Tetsuo
  • Journal Title: Histopathology Volume: 80 Issue: 5 Pages: 820-826
  • DOI: 10.1111/his.14617
  • Peer Reviewed
• [Journal Article] Mother’s iodine exposure and infants’ hypothyroidism: the Japan Environment and Children’s Study (JECS) (2022)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Kushima Megumi、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro
  • Journal Title: Endocrine Journal Volume: 69 Issue: 1 Pages: 9-21
  • DOI: 10.1507/endocrj.EJ21-0168
  • NAID: 130008145295
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Association of allele-specific methylation of the <i>ASNS</i> gene with asparaginase sensitivity and prognosis in T-ALL (2022)
  • Author(s): Akahane Koshi、Kimura Shunsuke、Miyake Kunio、Watanabe Atsushi、Kagami Keiko、Yoshimura Kentaro、Shinohara Tamao、Harama Daisuke、Kasai Shin、Goi Kumiko、Kawai Tomoko、Hata Kenichiro、Kiyokawa Nobutaka、Koh Katsuyoshi、他7名
  • Journal Title: Blood Advances Volume: 6 Issue: 1 Pages: 212-224
  • DOI: 10.1182/bloodadvances.2021004271
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography?a large database analysis in Japan (2021)
  • Author(s): Sato Chiaki、Sato Hiroki、Kamei Takashi、Shimamura Yuto、Tanaka Shinwa、Shiwaku Hironari、Shiota Junya、Ogawa Ryo、Yokomichi Hiroshi、Inoue Haruhiro
  • Journal Title: Esophagus Volume: 19 Issue: 8 Pages: 182-188
  • DOI: 10.1136/oemed-2021-108034
  • NAID: 40022800230
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health (2021)
  • Author(s): Miyake Kunio、Miyashita Chihiro、Ikeda-Araki Atsuko、Miura Ryu、Itoh Sachiko、Yamazaki Keiko、Kobayashi Sumitaka、Masuda Hideyuki、Ooka Tadao、Yamagata Zentaro、Kishi Reiko
  • Journal Title: Clinical Epigenetics Volume: 13 Issue: 1 Pages: 74-74
  • DOI: 10.1186/s13148-021-01063-z
  • Peer Reviewed / Open Access
• [Journal Article] Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health (2021)
  • Author(s): Miura Ryu、Ikeda-Araki Atsuko、Ishihara Toru、Miyake Kunio、Miyashita Chihiro、Nakajima Tamie、Kobayashi Sumitaka、Ishizuka Mayumi、Kubota Takeo、Kishi Reiko
  • Journal Title: Science of The Total Environment Volume: 783 Pages: 147035-147035
  • DOI: 10.1016/j.scitotenv.2021.147035
  • Peer Reviewed
• [Journal Article] Association between gestational hair dye use and allergies at 3 years old: the Japan environment and Children's study (2021)
  • Author(s): Kojima Reiji、Shinohara Ryoji、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro
  • Journal Title: Environmental Research Volume: 201 Pages: 111530-111530
  • DOI: 10.1016/j.envres.2021.111530
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (2021)
  • Author(s): Watanabe Atsushi、Miyake Kunio、Akahane Koshi、Goi Kumiko、Kagami Keiko、Yagita Hideo、Inukai Takeshi
  • Journal Title: Genes Volume: 12 Issue: 6 Pages: 864-864
  • DOI: 10.3390/genes12060864
  • Peer Reviewed / Open Access
• [Journal Article] Association of the incidence of atopic dermatitis until 3 years old with birth month and with sunshine duration and humidity in the first 6 months of life: Japan Environment and Children’s Study (2021)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Tsuchida Akiko、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Shinohara Ryoji、Inadera Hidekuni、Yamagata Zentaro
  • Journal Title: BMJ Open Volume: 11 Issue: 7 Pages: 1-6
  • DOI: 10.1136/bmjopen-2020-047226
  • Peer Reviewed / Open Access
• [Journal Article] Screening of frequent variants associated with congenital hypothyroidism: a comparison with next generation sequencing (2021)
  • Author(s): Watanabe Daisuke、Yagasaki Hideaki、Narusawa Hiromune、Saito Tomohiro、Mitsui Yumiko、Miyake Kunio、Ohta Masanori、Inukai Takeshi
  • Journal Title: Endocrine Journal Volume: 68 Issue: 12 Pages: 1411-1419
  • DOI: 10.1507/endocrj.EJ21-0353
  • NAID: 130008136503
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study (2021)
  • Author(s): Uchinuma Hiroyuki、Tsuchiya Kyoichiro、Sekine Tetsuo、Horiuchi Sayaka、Kushima Megumi、Otawa Sanae、Yokomichi Hiroshi、Miyake Kunio、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Shinohara Ryoji、Hirata Shuji、Yamagata Zentaro; Japan Environment and Children’s Study Group
  • Journal Title: International Journal of Obesity Volume: 45 Issue: 12 Pages: 2666-2674
  • DOI: 10.1038/s41366-021-00947-7
  • Peer Reviewed / Open Access
• [Journal Article] Association between Household Income and Allergy Development in Children: The Japan Environment and Children’s Study (2021)
  • Author(s): Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro、the Japan Environment and Children’s Study Group
  • Journal Title: International Archives of Allergy and Immunology Volume: 183 Issue: 2 Pages: 201-209
  • DOI: 10.1159/000519153
  • Peer Reviewed / Open Access
• [Journal Article] Elective cesarean delivery at term and its effects on respiratory distress at birth in Japan: The Japan Environment and Children's Study (2021)
  • Author(s): Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Yamagata Zentaro、The Japan Environment and Children's Study Group
  • Journal Title: Health Science Reports Volume: 4 Issue: 4
  • DOI: 10.1002/hsr2.421
  • Peer Reviewed / Open Access
• [Journal Article] Association between Maternal Exposure to Chemicals during Pregnancy and the Risk of Foetal Death: The Japan Environment and Children’s Study (2021)
  • Author(s): Ooka Tadao、Horiuchi Sayaka、Shinohara Ryoji、Kojima Reiji、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yokomichi Hiroshi、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 18 Issue: 22 Pages: 11748-11748
  • DOI: 10.3390/ijerph182211748
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Maternal Active and Secondhand Smoking during Pregnancy on Childhood Obesity at 3 Years of Age: A Nested Case?Control Study from the Japan Environment and Children’s Study (JECS) (2021)
  • Author(s): Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Hirai Hiroyuki、Hashimoto Koichi、Shimabukuro Michio、Yamagata Zentaro、Japan Environment and Children’s Study Group
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 18 Issue: 23 Pages: 12506-12506
  • DOI: 10.3390/ijerph182312506
  • Peer Reviewed / Open Access
• [Journal Article] Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan (2021)
  • Author(s): Horiuchi Sayaka、Sakamoto Haruka、Abe Sarah K.、Shinohara Ryoji、Kushima Megumi、Otawa Sanae、Yui Hideki、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Mizutani Takashi、Yamagata Zentaro
  • Journal Title: PLOS ONE Volume: 16 Issue: 12 Pages: e0261121-e0261121
  • DOI: 10.1371/journal.pone.0261121
  • Peer Reviewed / Open Access
• [Journal Article] All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort (2021)
  • Author(s): Yokomichi Hiroshi、Mochizuki Mie、Hirata Makoto、Nagai Akiko、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Shinohara Ryoji、Miyake Kunio、Yamagata Zentaro、BioBank Japan Project
  • Journal Title: Journal of Diabetes Investigation Volume: 12 Issue: 8 Pages: 1425-1429
  • DOI: 10.1111/jdi.13483
  • Peer Reviewed / Open Access
• [Journal Article] Association between preterm birth and maternal allergy considering IgE level (2021)
  • Author(s): Kojima Reiji、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Horiuchi Sayaka、Shinohara Ryoji、Yamagata Zentaro、Japan Environment, Children's Study Group
  • Journal Title: Pediatrics International Volume: 63 Issue: 9 Pages: 1026-1032
  • DOI: 10.1111/ped.14635
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of influenza vaccination in infants and toddlers with and without prior infection history: The Japan Environment and Children’s Study (2021)
  • Author(s): Yokomichi Hiroshi、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Mochizuki Mie、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro
  • Journal Title: Vaccine Volume: 39 Issue: 13 Pages: 1800-1804
  • DOI: 10.1016/j.vaccine.2021.02.044
  • Peer Reviewed / Open Access
• [Journal Article] Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL (2020)
  • Author(s): Atsushi Watanabe, Kunio Miyake, Jessica Nordlund, Ann-Christine Syvanen, Louise van der Weyden, Hiroaki Honda, Norimasa Yamasaki, Akiko Nagamachi, Toshiya Inaba, Tomokatsu Ikawa, Kevin Y Urayama, Nobutaka Kiyokawa, Akira Ohara, Shunsuke Kimura, Yasuo Kubota, Junko Takita, Hiroaki Goto, Kimiyoshi Sakaguchi, et al.
  • Journal Title: Blood Volume: 136 Issue: 20 Pages: 2319-2333
  • DOI: 10.1182/blood.2019004090
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma (2020)
  • Author(s): Hanihara M, Miyake K, Watanabe A, Yamada Y, Oishi N, Kawataki T, Inukai T, Kondo T, Kinouchi H.
  • Journal Title: Clin Epigenetics Volume: 12(1) Issue: 1 Pages: 174-174
  • DOI: 10.1186/s13148-020-00968-5
  • Peer Reviewed / Open Access
• [Journal Article] LPCAT2 Methylation, a Novel Biomarker for the Severity of Cedar Pollen Allergic Rhinitis in Japan (2020)
  • Author(s): Watanabe H, Miyake K, Matsuoka T, Kojima R, Sakurai D, Masuyama K, Yamagata Z.
  • Journal Title: Am J Rhinol Allergy. Volume: - Issue: 5 Pages: 631-639
  • DOI: 10.1177/1945892420983646
  • Peer Reviewed / Open Access
• [Presentation] 妊娠中の母親の栄養摂取と子どもの発達との関連 ーエコチル調査甲信ユニットセンターの研究よりー (2023)
  • Author(s): 小島令嗣, 篠原亮次, 久島萌, 小田和早苗, 秋山有佳, 大岡忠生, 堀内清華, 三宅邦夫, 横道洋司, 山縣然太朗
  • Organizer: 第60回日本小児アレルギー学会学術大会
• [Presentation] ハウスダスト中の鶏卵タンパク量に関係する要因：エコチル調査より (2023)
  • Author(s): 小島令嗣, 篠原亮次, 久島萌, 小田和早苗, 秋山有佳, 大岡忠生, 堀内清華, 三宅邦夫, 横道洋司, 山縣然太朗
  • Organizer: 第82回日本公衆衛生学会総会
• [Presentation] STAT3活性化変異を有する節外性NK/T細胞リンパ腫・鼻型はCD30を高発現する (2021)
  • Author(s): 大石 直輝，佐藤 啓，川島 一郎，瀬川 高弘，三宅 邦夫， 望月 邦夫，桐戸 敬太，近藤 哲夫
  • Organizer: 第61回日本リンパ網内系学会総会
• [Presentation] ヒトiPS細胞を用いた発生初期からのタバコ煙曝露による神経細胞分化への影響 (2021)
  • Author(s): 三宅 邦夫
  • Organizer: 日本環境変異原ゲノム学会第50回記念大会
• [Presentation] 膠芽腫におけるMGMT遺伝子メチル化の新規解析法 -HPLC法- (2020)
  • Author(s): 埴原 光人、川瀧 智之、荻原 雅和、三宅 邦夫、渡邊 敦、大石 直輝、山田有理子、犬飼 岳史、木内 博之
  • Organizer: 日本脳神経外科学会第79回学術集会
• [Presentation] 白血病細胞のASNS遺伝子のメチル化解析におけるHPLC法の有用性 (2020)
  • Author(s): 渡邊 敦, 三宅 邦夫, 篠原 珠緒, 原間 大輔, 笠井 慎, 村上 寧, 赤羽弘資, 合井 久美子,山田 有理子, 砂村 栄一郎, 與谷 卓也, 犬飼 岳史
  • Organizer: 第123回日本小児科学会学術集会
• [Book] 精神神経疾患とエピジェネティクス (2023)
  • Author(s): 三宅邦夫
  • Total Pages: 7
  • Publisher: 金原出版
• [Remarks] エコチル山梨ホームページ
  • URL: https://ecochil-koushin.jp/yamanashi/
• [Remarks] 山梨大学大学院総合研究部医学域社会医学講座ホームページ
  • URL: https://www.med.yamanashi.ac.jp/social/heal0sci/
• [Patent(Industrial Property Rights)] 胃がん細胞の増殖抑制剤、胃がんの腫瘍形成抑制剤、胃がんを治療するための医薬、及び薬効予測方法 (2021)
  • Inventor(s): 犬飼 岳史、渡邊 敦、赤羽 弘資、三宅 邦夫
  • Industrial Property Rights Holder: 国立大学法人山梨大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2021-116120
  • Filing Date: 2021