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Comparative study of plasma sources in the basis of ROS transportation in biological tissue model

Research Project

Project/Area Number 20K04430
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 21010:Power engineering-related
Research InstitutionNishinippon Institute of Technology

Principal Investigator

Kawasaki Toshiyuki  西日本工業大学, 工学部, 教授 (30352404)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsプラズマジェット / プラズマ医療 / プラズマ農業 / 活性酸素 / 酸化反応 / 気液化k面相互作用 / 大気圧プラズマジェット / 分布可視化 / 活性種輸送の高効率化 / 流れ制御 / 気液界面 / 活性種輸送 / 供給ガス / 大気圧非熱平衡プラズマ / 化学プローブ / 可視化
Outline of Research at the Start

現在,構造が異なる多種多様なプラズマ源が医療応用のために提案されている。しかしながら,どの構造が医療応用に最適なのかについての議論は極めて少ないのが現状である。そこで,我々独自の計測手法を用いて「生体内部の化学反応可視化」という視点で構造の最適化を行うことを目的とする。同時に,プラズマ照射が引き起こす化学反応のメカニズムを解明することも目的とする。結果として,プラズマ医療における安全かつ効果的なプラズマ源の構造が明らかになることが期待される。

Outline of Final Research Achievements

There is a wide variety of plasma-generators used in research on medical applications of plasma. However, little research has been done to optimize their structures. Therefore, the purpose of this study is to investigate the chemical and physical effects of plasma-generator structures on living tissues. In particular, we investigated the features of various generator structures using our original technique to visualize oxidation reaction. It was shown that the oxidation reactions induced in living organisms differ greatly depending on the generator structure. It was also clarified that the oxidation reactions were significantly different depending on the gas supplied to the generator. We believe that these results provide important information for the future development of plasma medicine.

Academic Significance and Societal Importance of the Research Achievements

プラズマ医療では生体内部に化学種をどう輸送するかが重要なポイントである。しかしながら,そのような観点でプラズマ源の比較研究はこれまで行われていなかった。そのような中,本研究では生体内部の化学種の分布を可視化しながらプラズマ源の比較を行った。どの発生器が良いのか悪いのか判断は現状では困難であるが,各プラズマ源の特長は把握することができた。今後はそれぞれのプラズマ源が有するどの特徴が有効なのかをさらに調べる必要がる。本研究成果によりそのスタートラインが整備された。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (38 results)

All 2023 2022 2021 2020 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (26 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Effect of supplied gas on ROS transport through liquid targets by plasma jet irradiation2023

    • Author(s)
      Heping Shi, Kecheng Shen, Toshiyuki Kawasaki
    • Journal Title

      International Journal of Plasma Environmental Science and Technology

      Volume: 17 Issue: 01 Pages: e01003-e01003

    • DOI

      10.34343/ijpest.2023.17.e01003

    • ISSN
      1881-8692, 2435-0125
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of initial surfactant concentration on plasma-induced liquid flows2021

    • Author(s)
      Kawasaki Toshiyuki、Kamasaki Masahiro、Takeuchi Nozomi、Mitsugi Fumiaki
    • Journal Title

      Journal of Applied Physics

      Volume: 130 Issue: 24

    • DOI

      10.1063/5.0071217

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of Retrogradation on KI?Starch Visualization of Reactive Oxygen Species Emitted by Plasma Jets2021

    • Author(s)
      Mitsugi Fumiaki、Wago Mizuki、Sakamoto Ryuji、Nishida Keisuke、Kawasaki Toshiyuki
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 49 Issue: 7 Pages: 2141-2147

    • DOI

      10.1109/tps.2021.3083400

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visualization of Plasma-Induced Liquid Flow Using KI?Starch and PIV2021

    • Author(s)
      Mitsugi Fumiaki、Kusumegi Shota、Nishida Keisuke、Kawasaki Toshiyuki
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 49 Issue: 1 Pages: 9-14

    • DOI

      10.1109/tps.2020.2986775

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Experimental identification of the reactive oxygen species transported into a liquid by plasma irradiation2020

    • Author(s)
      Kawasaki Toshiyuki、Koga Kazunori、Shiratani Masaharu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 59 Issue: 11 Pages: 110502-110502

    • DOI

      10.35848/1347-4065/abc3a1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 液中活性種の計測と化学反応シミュレーション2020

    • Author(s)
      川崎敏之,見市知昭,立花孝介,竹内希,金澤誠司
    • Journal Title

      静電気学会誌

      Volume: 44 Pages: 207-215

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] プラズマ照射によって誘起される液体流の制御に関する研究2023

    • Author(s)
      沈克成, 史合平, 西田誠, 川崎敏之
    • Organizer
      第24回静電気学会春期講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 供給ガスがプラズマ誘起流に与える影響2023

    • Author(s)
      沈克成, 史合平, 西田誠, 川崎敏之
    • Organizer
      電気学会研究会「誘電・絶縁材料/放電・プラズマ・パルスパワー/高電圧」
    • Related Report
      2022 Annual Research Report
  • [Presentation] Pressure Wave Measurement by Optical Wave Microphone During Plasma Formation2022

    • Author(s)
      Khing Zaw Phyo, Masahiro Kamasaki, Than Nu Nu San, Si Thu Han, Patamyar Oo, Toshiyuki Kawasaki, Fumiaki Mitsugi
    • Organizer
      2022年(令和4年度)応用物理学会九州支部学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] プラズマ由来の駆動力を利用した液体流の制御2022

    • Author(s)
      川崎敏之, 史合平, 沈克成
    • Organizer
      2022年(令和4年度)応用物理学会九州支部学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] プラズマ照射により生じる液体流の制御に関する研究2022

    • Author(s)
      川崎敏之
    • Organizer
      第38回九州・山口プラズマ研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] プラズマを照射した液体中の活性酸素分布と流れの可視化2022

    • Author(s)
      川崎敏之
    • Organizer
      (独)日本学術振興会 プラズマ材料科学 第153委員会 第158回研究会 『大気圧プラズマの“非接触”診断と実装』
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 周波数がプラズマ誘起流に与える影響2022

    • Author(s)
      史合平, 沈克成, 川崎敏之
    • Organizer
      2023年度(第76回)電気・情報関係学会九州支部連合大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液体へのArプラズマジェット照射による誘起流に関する研究2022

    • Author(s)
      史合平, 沈克成, 西田誠, 川崎敏之
    • Organizer
      第46回静電気学会全国大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Arプラズマジェットを照射した液体中のROS分布可視化2022

    • Author(s)
      沈克成, 史合平, 川崎敏之
    • Organizer
      第46回静電気学会全国大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Plasma-induced Liquid Flows in Surfactant Solution2022

    • Author(s)
      T. Kawasaki, H. Shi, K. Shen, M. Kamasaki, N. Takeuchi, F. Mitsugi
    • Organizer
      12th International Symposium on Non-Thermal/Thermal Plasma for Pollution Control & Sustainable Energy / International Symposium on Electrohydrodynamics 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] H. Shi, K. Shen, T. Kawasaki2022

    • Author(s)
      Liquid Flows Induced by an Argon Plasma Jet Irradiation
    • Organizer
      12th International Symposium on Non-Thermal/Thermal Plasma for Pollution Control & Sustainable Energy / International Symposium on Electrohydrodynamics 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two-dimensional Visualization of ROS Transported into a Tissue Model by an Argon Plasma Jet2022

    • Author(s)
      K. Shen, H. Shi, T. Kawasaki
    • Organizer
      12th International Symposium on Non-Thermal/Thermal Plasma for Pollution Control & Sustainable Energy / International Symposium on Electrohydrodynamics 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two-dimensional Visualization of ROS Transported into a Mimic Tissue Model by Plasma Jet2022

    • Author(s)
      Kecheng Shen, Heping Shi, Toshiyuki Kawasaki
    • Organizer
      International Young Electrostatic Scholar Symposium for Convergence Technology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Liquid Flows Induced by Argon Plasma Jet Irradiation2022

    • Author(s)
      Heping Shi, Kecheng Shen, Toshiyuki Kawasaki
    • Organizer
      International Young Electrostatic Scholar Symposium for Convergence Technology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プラズマが誘起する液体流と界面活性剤初期濃度の関係2022

    • Author(s)
      川崎敏之,釜崎雅大,竹内希,光木文秋
    • Organizer
      第39回プラズマプロセシング研究会/第34回プラズマ材料科学シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] プラズマジェット発生による衝撃波の光波マイクロホン計測2022

    • Author(s)
      釜崎雅大,Khing Zaw Phyo,川崎敏之,光木文秋
    • Organizer
      第39回プラズマプロセシング研究会/第34回プラズマ材料科学シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] プラズマ照射により界面活性剤水溶液中に生じる2 種類の液体流2022

    • Author(s)
      川崎敏之
    • Organizer
      2022 年静電気学会東北・関西・九州支部合同研究会/第449 回生存圏シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] プラズマジェット照射による液中ROS輸送に供給ガスが与える影響2022

    • Author(s)
      史合平,沈克成,川崎敏之
    • Organizer
      令和4年電気学会全国大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Two types of plasma-induced liquid flows and their mechanisms2021

    • Author(s)
      Toshiyuki Kawasaki, Masahiro Kamasaki, Nozomi Takeuchi, Fumiaki Mitsugi
    • Organizer
      EAPETEA-8 (The 8th East Asia Joint Symposium on Plasma and Electrostatics Technologies for Environmental Applications)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] PIV Analysis of Plasma-induced Liquid Flows in Surfactant Solutions2021

    • Author(s)
      Toshiyuki Kawasaki, Masahiro Kamasaki, Nozomi Takeuchi, Fumiaki Mitsugi
    • Organizer
      ICFD2021 (The 18th International Conference on Flow Dynamics)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマ照射が誘起する液体流に界面活性剤濃度が与える影響2021

    • Author(s)
      川崎敏之
    • Organizer
      第37回 九州・山口プラズマ研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Relationship between Plasma-Induced Liquid Flows and Surfactant Concentration2021

    • Author(s)
      Toshiyuki Kawasaki, Masahiro Kamasaki, Nozomi Takeuchi, Fumiaki Mitsugi
    • Organizer
      APSPT-12 (The 12th Asia-Pacific International Symposium on the Basics and Applications of Plasma Technology)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラズマ照射条件が液中誘起流に与える影響2021

    • Author(s)
      釜崎雅大,砂川風響,西田圭祐,竹内希,光木文秋,川崎敏之
    • Organizer
      令和3年電気学会全国大会
    • Related Report
      2020 Research-status Report
  • [Presentation] トレーサ粒子とKI-デンプン試薬を用いたプラズマ誘起流の可視化2021

    • Author(s)
      西田佳祐,和合瑞生,川崎敏之,光木文秋
    • Organizer
      第38回プラズマプロセシング研究会 / 第33回プラズマ材料科学シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] Experimental identification of key species for ROS transportation in the depth direction by plasma irradiation2020

    • Author(s)
      T. Kawasaki, K. Koga, and M. Shiratani
    • Organizer
      第30回日本MRS年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Experimental identification of reactive oxygen species transported in the liquid depth direction by plasma direct irradiation2020

    • Author(s)
      Toshiyuki Kawasaki
    • Organizer
      4th Asia Pacific Conference on Plasma Physics
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks]

    • URL

      https://www3.nishitech.ac.jp/education/teachers/tkawasak

    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      http://www.nishitech.ac.jp/cgi-bin/www/researchdb/researchdb-output.pl

    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      https://www3.nishitech.ac.jp/education/teachers/tkawasak

    • Related Report
      2020 Research-status Report
  • [Remarks]

    • URL

      http://www.nishitech.ac.jp/cgi-bin/www/researchdb/researchdb-output.pl

    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 洗浄装置及び洗浄方法2023

    • Inventor(s)
      川崎敏之
    • Industrial Property Rights Holder
      川崎敏之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-004755
    • Filing Date
      2023
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] プラズマ輸送装置およびプラズマ輸送方法2023

    • Inventor(s)
      川崎敏之
    • Industrial Property Rights Holder
      川崎敏之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-004756
    • Filing Date
      2023
    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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