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Development of a microfluidic device for the time-dependency of taste interaction detection using lipid polymer membranes

Research Project

Project/Area Number 20K04502
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 21030:Measurement engineering-related
Research InstitutionShinshu University (2021-2022)
Kyushu University (2020)

Principal Investigator

Tahara Yusuke  信州大学, 学術研究院繊維学系, 助教 (80585927)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords味覚センサ / 脂質高分子膜 / 味の経時変化 / 吸着 / マイクロ流路 / 味覚 / 膜電位
Outline of Research at the Start

本研究は,官能試験でしか評価できない味強度の時間変化を計測するために,味物質の受容部として脂質高分子膜を用いたマイクロ流路型新規味覚センサの開発を目指す.味の時間変化を検出するために,味物質との静電相互作用や疎水性相互作用を引き起こす複数の脂質高分子膜と,味溶液を送液することで膜との吸脱着時間プロファイルを膜電位変化から計測可能なマイクロ流体デバイスを開発する.さらに,脂質高分子膜のマルチチャネル化による味情報の多次元化と統計解析手法を組み合わせることで,高甘味度甘味料やうま味物質の味の立ち上がりや味の余韻といったヒトの官能と一致する新規味覚センサの開発を行う.

Outline of Final Research Achievements

This study aimed to develop a novel taste sensor that can detect changes in human taste over time using a lipid polymer membrane and taste substance adsorption/desorption time profiles. A microfluidic device was fabricated by chemically bonding a polycarbonate film with a polydimethylsiloxane (PDMS) channel and a lipid polymer membrane, and a measurement system was developed in which the fluid was pumped by a micropump. The performance of the system was evaluated and the membrane potential was successfully measured for a taste sample solution, reflecting the interaction with the lipid polymer membrane over time. Therefore, it was shown that this sensor could be used to extract new taste information as a change in taste over time and to show the taste perceived by humans.

Academic Significance and Societal Importance of the Research Achievements

本成果は,ヒトが感じる味の経時変化を客観的に数値化するためのセンサの実現を示すものであり,味を計測するためのセンサとしての学術的な価値は高い.また,食品や医薬品,農産物といった分野において,産業への応用が期待される.

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (8 results)

All 2023 2022 2021

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Development of a microfluidic-based taste sensor using lipid polymer membrane2023

    • Author(s)
      Tahara Yusuke、Sassa Fumihiro、Takigawa Ryo、Kurihara Yuma
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 62 Issue: SG Pages: SG1014-SG1014

    • DOI

      10.35848/1347-4065/acb4fa

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 味のデジタル情報化技術2021

    • Author(s)
      田原 祐助
    • Journal Title

      Clinical Neuroscience

      Volume: 39(2) Pages: 188-189

    • Related Report
      2020 Research-status Report
  • [Presentation] Development of microfluidic-based taste sensor for detection of time dependent taste2022

    • Author(s)
      Y. Kurihara, R. Takigawa, F. Sassa, Y. Tahara
    • Organizer
      35th International Microprocesses and Nanotechnology Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂質高分子膜を用いたマイクロ流路型味覚センサの開発2022

    • Author(s)
      田原 祐助,鈴木 悠人
    • Organizer
      第36回実装学会春季講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of microfluidic-based taste sensor with lipid polymer membrane2021

    • Author(s)
      Y. Kurihara, R. Takigawa, F. Sassa, Y. Tahara
    • Organizer
      34th International Microprocesses and Nanotechnology Conference (MNC 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] eスポーツとデバイス技術2021

    • Author(s)
      田原 祐助
    • Organizer
      LIFE2020-2021
    • Related Report
      2021 Research-status Report
  • [Presentation] マイクロ流路を用いた味覚センサの開発2021

    • Author(s)
      田原 祐助,多喜川 良
    • Organizer
      第35回エレクトロニクス実装学会春季講演
    • Related Report
      2020 Research-status Report
  • [Book] Electronic Tonges2021

    • Author(s)
      K. Toko, Y. Tahara, M. Habara, H. Ikezaki
    • Total Pages
      26
    • Publisher
      IOP publishing Ltd.
    • ISBN
      9780750336857
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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