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Study on integrated index and control of muscle relaxation

Research Project

Project/Area Number 20K04553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 21040:Control and system engineering-related
Research InstitutionUniversity of Hyogo

Principal Investigator

Furutani Eiko  兵庫県立大学, 工学研究科, 教授 (40219118)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords筋弛緩 / 非脱分極性筋弛緩薬 / 筋弛緩度指標 / 薬力学モデル / ロクロニウム / スガマデクス / 筋弛緩モニタ / 筋弛緩度制御
Outline of Research at the Start

本研究は,手術中の麻酔において,筋弛緩度を手術内容や進行状況に応じて適切なレベルに維持し,かつ覚醒時に安全に回復できる筋弛緩度制御を実現するシステムを開発することを目的として,筋弛緩薬の効果を適切に表せる数式モデルとあらゆるレベルの筋弛緩度を統合的に表せる筋弛緩度指標の構成,要求される筋弛緩度に適切に維持できる制御法,および覚醒後の安全性を確保するための筋弛緩回復薬の投与方法の研究を行う.

Outline of Final Research Achievements

This study is concerned with muscle relaxation control during surgical operation including laparoscopic surgery. First, we have constructed a mathematical model of the effect of non-depolarizing neuromuscular blockades considering its action mechanism. The constructed model can represent the effects of several non-depolarizing neuromuscular blockades, and describe both in vitro and in vivo experimental results. Then, based on the model, we have constructed a muscle relaxation index that may quantify all level of muscle relaxation. Moreover, we study infusion method of sugammadex, a neuromuscular reversal drug, to avoid recurarization after surgery by simulation. The result shows that a sufficient amount of sugammadex can be estimated from residual amount of the neuromuscular blockade.

Academic Significance and Societal Importance of the Research Achievements

本研究で構築した非脱分極性筋弛緩薬の作用機序に基づく筋反応を表すモデルにより,生体内外の実験結果を説明でき,また筋弛緩薬投与時の筋反応および筋弛緩状態を推定できることから,各患者にあわせてパラメータ設定できれば,個人差に応じた制御が可能となる.また,複数の筋弛緩度指標を統合した指標が構築できることが示唆される結果が得られたことから,手術内容や状況に合わせて容易に筋弛緩状態を調整可能となると考えられる.さらに,再筋弛緩を回避するための筋弛緩回復薬の投与方法の開発にも貢献できると考えられる.以上のように,本研究で得られた成果により,筋弛緩度の自動制御システムの開発に貢献できると考えられる.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2024 2022 2021 2020 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Simultaneous Modeling of In Vivo and In Vitro Effects of Nondepolarizing Neuromuscular Blocking Drugs2024

    • Author(s)
      HOSHINO Hikaru、FURUTANI Eiko
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 13 Issue: 0 Pages: 163-175

    • DOI

      10.14326/abe.13.163

    • ISSN
      2187-5219
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] On the relationship between inhibition and receptor occupancy by nondepolarizing neuromuscular blocking drugs2021

    • Author(s)
      Hoshino Hikaru、Furutani Eiko
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 18 Issue: 1 Pages: 15-15

    • DOI

      10.1186/s12976-021-00147-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 全身麻酔における筋弛緩度の統合的なモデル化 ー臨床データの個人差を考慮したパラメータ推定の一検討2024

    • Author(s)
      宮口大輝, 星野光, 古谷栄光, 菅原友道, 武田敏宏, 白神豪太郎
    • Organizer
      第68回システム制御情報学会研究発表講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 薬物動態コンパートメントモデルの実験的再現に関する一検討2022

    • Author(s)
      中村建海,星野光,古谷栄光
    • Organizer
      第66回システム制御情報学会研究発表講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 非脱分極性筋弛緩薬のシナプス前後のアセチルコリン受容体への作用を考慮した統合的薬力学モデルとそのパラメータ推定2021

    • Author(s)
      星野光,古谷栄光
    • Organizer
      第28回日本静脈麻酔学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Physiological modeling of concentration-effect relationship for nondepolarizing neuromuscular blocking drugs2020

    • Author(s)
      Hikaru Hoshino, Eiko Furutani, Tomonori Sugawara, Toshihiro Takeda, Yoshiharu Sawanobori, Gotaro Shirakami
    • Organizer
      42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Remarks] 統合的筋弛緩度指標と筋弛緩度制御の研究

    • URL

      https://www.eng.u-hyogo.ac.jp/faculty/furutani/kakenhi/kaken_20K04553.html

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2021 Research-status Report 2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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