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Surface defects and morphology control of two-dimensional nanostructured titanium dioxide and its application to anti-infective medical materials

Research Project

Project/Area Number 20K05123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 26030:Composite materials and interfaces-related
Research InstitutionJapan Fine Ceramics Center

Principal Investigator

HASHIMOTO Masami  一般財団法人ファインセラミックスセンター, その他部局等, 上級研究員 (20450851)

Co-Investigator(Kenkyū-buntansha) 金高 弘恭  東北大学, 歯学研究科, 教授 (50292222)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsナノシート / 酸化チタン / 細胞増殖性 / 抗菌性 / 骨芽細胞活性 / 生体活性
Outline of Research at the Start

本研究では、特異な表面欠陥と形態を有する二次元のナノ構造酸化チタンを医療用インプラントに世界で初めて適用することによって、高い抗菌性と生体活性を同時に発現し、耐剥離寿命が1年以上の表面を構築することを目的とする。耐剥離寿命は、有限要素法による計算値と界面破壊靭性値による実験値から定量的な予測を行い、医用材料としての新たな取り組みを行う。本酸化チタンナノシートをコーティングした医療用インプラントは、感染防止医用材料としての応用を目指す。

Outline of Final Research Achievements

Biocompatibility and anti-infectivity are required for dental implants and catheters, and it is extremely difficult to improve these conflicting functions simultaneously. By forming titanium dioxide nanosheets, it is expected that not only the above conflicting functions can be controlled, but also the surfaces of components with various materials and shapes can be coated. We coated nanosheets on Ti implant surfaces at room temperature and explored their potential as a medical material. As a result, titanium dioxide nanosheets were successfully coated on medical components, and it was confirmed that they showed good cell proliferation properties. On the other hand, as for the antimicrobial property, first of all, hydroxyl radicals could not be confirmed from the results of electron spin resonance method, and antimicrobial property could not be confirmed in the antimicrobial property test using E. coli.

Academic Significance and Societal Importance of the Research Achievements

抗菌性と生体活性能を併せ持つ酸化チタンナノシートは、室温下で柔軟性のある基材にもコーティング可能なため、感染が問題になっているインプラントだけでなく、カテーテル等の経皮端子や手術室での噴霧による抗菌性環境の実現等が可能であると考えられる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (6 results)

All 2022 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Effect of heating conditions on the magnetic properties of micron-sized carboxyl modified-magnetite particles synthesized by a spray pyrolysis and heating process2022

    • Author(s)
      Hashimoto Masami、Takahashi Seiji、Kawahara Koichi、Ogawa Tomoyuki、Kawashita Masakazu
    • Journal Title

      Advanced Powder Technology

      Volume: 33 Issue: 2 Pages: 103412-103412

    • DOI

      10.1016/j.apt.2021.103412

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of hydrated phospholipid polymer interfaces between all‐polymer bearings for total hip arthroplasty2021

    • Author(s)
      Kyomoto Masayuki、Moro Toru、Yamane Shihori、Watanabe Kenichi、Hashimoto Masami、Tanaka Sakae、Ishihara Kazuhiko
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 110 Issue: 1 Pages: 89-102

    • DOI

      10.1002/jbm.b.34892

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生体用チタンの低酸素分圧下での熱処理による表面電位制御2021

    • Author(s)
      橋本雅美、小川貴史、北岡諭
    • Journal Title

      セラミックス

      Volume: 56 Pages: 522-525

    • Related Report
      2021 Research-status Report
  • [Presentation] ウイルスの高感度検出を目指した多孔質酸化鉄微粒子の開発2021

    • Author(s)
      橋本雅美、高橋誠治、川原浩一、横江大作、加藤丈晴、小川智之、川下将一
    • Organizer
      第34回秋季シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] ウイルス検出用の新規COOH基修飾-Fe3O4微粒子の開発2021

    • Author(s)
      橋本雅美、高橋誠治、川原浩一、横江大作、加藤丈晴、小川智之、川下将一
    • Organizer
      第43回日本バイオマテリアル学会
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 微粒子及びそれを含む組成物2020

    • Inventor(s)
      橋本雅美
    • Industrial Property Rights Holder
      橋本雅美
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-210688
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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