MRI-based analyses of olfactory information processing mechanism underlying relationships between odor/pheromone substances and olfactory responses such as behaviors
Project/Area Number |
20K05842
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 38030:Applied biochemistry-related
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Research Institution | Kumamoto University |
Principal Investigator |
Yoshinaga Sosuke 熊本大学, 大学院生命科学研究部(薬), 講師 (00448515)
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Co-Investigator(Kenkyū-buntansha) |
寺沢 宏明 熊本大学, 大学院生命科学研究部(薬), 教授 (10300956)
武田 光広 熊本大学, 大学院生命科学研究部(薬), 助教 (90508558)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 匂い / フェロモン / 脳・神経 / MRI / 嗅覚 |
Outline of Research at the Start |
本研究は、機能的MRI法を用いて、個々の匂い・フェロモンによる脳神経回路の活性化パターンについて、活性化部位の位置情報に時間軸を導入することにより、誘起される行動・情動・生理変化と関連づける情報処理メカニズムを明らかにすることを目的する。これらの相関をデータベース化することにより、性行動に影響する物質の同定および開発、さらには、実験用マウスの作製の促進や野生ネズミの繁殖制御につながることが期待される。
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Outline of Final Research Achievements |
Olfaction is one of the most important perceptions for animals to receive information from their environments, such as in case of species preservation and danger avoidance. The information is transmitted through odor and pheromone substances, resulting in emotional, behavioral or physiological changes. Here, we aimed to develop MRI-based fundamental technologies to acquire spatiotemporal information of odor-evoked brain activations. We successfully developed a computer-based odor stimulation system to give precisely time-regulated odor stimulations for independent component analyses under appropriate anesthesia conditions, resulting in improvement of sensitivity and discrimination abilities of odor responses.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、それぞれのフェロモンや匂い物質により誘起される性行動や生理的変化と、活性化される嗅神経ネットワークとの関係性を明らかにするための基盤技術の開発に成功した。この技術を利用して実験データを集積することにより、性行動に影響する物質の同定および開発、さらには、実験用マウスの作製の促進や野生ネズミの繁殖制御につながることが期待される。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Whole-brain fMRI study of mice under medetomidine/ketamine anesthesia to identify brain regions activated by musk odors.2023
Author(s)
Yoshinaga, S., Tsubakihara, Y., Fukumoto, T., Maita, S., Takeda, M., and Terasawa, H.
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Journal Title
Proc. Intl. Soc. Mag. Reson. Med.
Volume: 31
Related Report
Peer Reviewed
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[Journal Article] Muscone-evoked activations in the whole brains of mice, studied by the BOLD method using periodic stimulation and independent component analysis.2020
Author(s)
Hayashi, F., Takeda, M., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
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Journal Title
Proc. Intl. Soc. Mag. Reson. Med.
Volume: 28
Pages: 3946-3946
Related Report
Peer Reviewed
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[Presentation] Functional MRI studies of mouse whole brain stimulated by mouse odor with independent component analysis2020
Author(s)
Tsubakihara, Y., Takeda, M., Hayashi, F., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
Organizer
第48回日本磁気共鳴医学会大会
Related Report
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[Presentation] Muscone-evoked activations in the whole brains of mice, studied by the BOLD method using periodic stimulation and independent component analysis2020
Author(s)
Hayashi, F., Takeda, M., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
Organizer
2020 ISMRM (International Society for Magnetic Resonance in Medicine) & SMRT (Society for MR Radiographers &Technologists) Virtual Conference & Exhibition
Related Report
Int'l Joint Research