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Elucidation of the mechanism underlying the anti-allergy activity of fish oi metabolites and the strucre-anti-allergy activity relationship of ethanolamides of long-chain fatty acids

Research Project

Project/Area Number 20K05891
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionEhime University

Principal Investigator

Nishi Kosuke  愛媛大学, 農学研究科, 准教授 (80578097)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsドコサヘキサエン酸 / アレルギー / 魚油 / マスト細胞 / DHA / 構造活性相関 / ドコサヘキサエノイルエタノールアミド / T細胞 / サイトカイン
Outline of Research at the Start

本研究では、DHEAによるT細胞の機能調節の機序の解明を試みる。これにより、DHEAの作用点を同定することができ、アレルギー根治に重要な未知の標的因子の発見に繋がる可能性がある。さらに、免疫寛容を誘導するDHEAの作用機序を明らかにすることにより、DHEAを利用したアレルギーの症状緩和や根治に導く手法の確立に展開できる。
次に、DHEAと異なる脂肪酸構造をもつ類縁体の活性を評価する。様々な脂肪酸構造とT細胞機能調節との相関関係を理解することは、アレルギーの症状緩和や根治に導く機能性食品や医薬品の開発に向けて重要な基盤的知見となる。

Outline of Final Research Achievements

We have found that docosahexaenoyl ethanolamide, a metabolite of docosahexaenoic acid that is the main component of fish oil, may prevent the onset of allergic diseases. In addition, we synthesized ethanolamides of various long-chain fatty acids and evaluated their effect on the degranulation of rat basophilic leukemia RBL-2H3 cells. We found that ethanolamides of n-3 polyunsaturated long-chain fatty acids inhibit the degranulation whereas ethanolamides of n-6 polyunsaturated long-chain fatty acids do not.

Academic Significance and Societal Importance of the Research Achievements

現在、日本人の約半数がなんらかのアレルギー疾患に罹患しているといわれており、アレルギーは現代の日本人にとって、最も身近な非感染性疾患の一つである。アレルギーの治療には主に抗ヒスタミン薬が使用されるが、眠気、口渇、頭痛などの有害な副作用を伴う場合が多い。
本研究の成果として、魚油の摂取がアレルギー発症の予防に関連する可能性を示すことができた。また、各種脂肪酸の摂取とアレルギー予防との関連性の一端を明らかにすることができた。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (51 results)

All 2023 2022 2021 2020 Other

All Journal Article (17 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 16 results,  Open Access: 10 results) Presentation (30 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] p-Synephrine suppresses inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and alleviates systemic inflammatory response syndrome in mice.2022

    • Author(s)
      M. Ishida, C. Takekuni, K. Nishi, T. Sugahara
    • Journal Title

      Food and Function

      Volume: In press Issue: 9 Pages: 1-11

    • DOI

      10.1039/d2fo00299j

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Water and Ethanol Extracts of Tamarind (Tamarindus indica) Suppress Lipid Accumulation in 3T3-L1 Cells2022

    • Author(s)
      Harjadi Kenn Rafael、Ishida Momoko、Nishi Kosuke、Sugahara Takuya、Putra Agus Budiawan Naro
    • Journal Title

      Canrea Journal: Food Technology, Nutritions, and Culinary Journal

      Volume: 5 Pages: 1-11

    • DOI

      10.20956/canrea.v5i1.630

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Umbelliferose Isolated from Cuminum cyminum L. Seeds Inhibits Antigen-Induced Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells2022

    • Author(s)
      Ishida Momoko、Ohara Rika、Miyagawa Fuka、Kikuzaki Hiroe、Nishi Kosuke、Onda Hiroyuki、Yoshino Nanami、Sugahara Takuya
    • Journal Title

      Molecules

      Volume: 27 Issue: 13 Pages: 4101-4101

    • DOI

      10.3390/molecules27134101

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-Allergic Effect of Aqueous Extract of Coriander (Coriandrum sativum L.) Leaf in RBL-2H3 Cells and Cedar Pollinosis Model Mice2022

    • Author(s)
      Kitamura Yurika、Nishi Kosuke、Ishida Momoko、Nishimoto Sogo、Sugahara Takuya
    • Journal Title

      Nutraceuticals

      Volume: 2 Issue: 3 Pages: 170-180

    • DOI

      10.3390/nutraceuticals2030013

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aqueous Extract from Cuminum cyminum L. Seed Alleviates Ovalbumin-Induced Allergic Rhinitis in Mouse via Balancing of Helper T Cells2022

    • Author(s)
      Ishida Momoko、Miyagawa Fuka、Nishi Kosuke、Sugahara Takuya
    • Journal Title

      Foods

      Volume: 11 Issue: 20 Pages: 3224-3224

    • DOI

      10.3390/foods11203224

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of components in coriander (Coriandrum sativum L.) inhibiting degranulation of RBL-2H3 cells2022

    • Author(s)
      Ohara Rika、Sugahara Takuya、Sugie Yuna、Onda Hiroyuki、Yoshino Nanami、Nishi Kosuke、Ishida Momoko、Kikuzaki Hiroe
    • Journal Title

      Fitoterapia

      Volume: 163 Pages: 105298-105298

    • DOI

      10.1016/j.fitote.2022.105298

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses of 6-(2-hydroxy-6-phenylhexyl)-5,6-dihydro-2H-pyran-2-one derivatives and their cytotoxicities2022

    • Author(s)
      Ochi Ryota、Taniyama Yasuhiko、Nishiwaki Hisashi、Nishi Kosuke、Sugahara Takuya、Yamauchi Satoshi
    • Journal Title

      Phytochemistry Letters

      Volume: 52 Pages: 118-121

    • DOI

      10.1016/j.phytol.2022.10.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantages of filtration method for sperm-DNA genotyping in sexual assault cases2022

    • Author(s)
      Nakagawa Toshifumi、Doi Masanori、Nishi Kosuke、Sugahara Takuya
    • Journal Title

      Legal Medicine

      Volume: 54 Pages: 101988-101988

    • DOI

      10.1016/j.legalmed.2021.101988

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Effectiveness of Enzyme-linked Immunosorbent Assay as a Simple Method of <i>β</i>-Lactoglobulin Quantification in Yogurt2021

    • Author(s)
      菅原卓也、石田萌子、福田直大、逢阪江理、八塚愛実、永田洋子、西甲介、桑原雄二
    • Journal Title

      Nippon Shokuhin Kagaku Kogaku Kaishi

      Volume: 68 Issue: 8 Pages: 356-359

    • DOI

      10.3136/nskkk.68.356

    • NAID

      130008083568

    • ISSN
      1341-027X, 1881-6681
    • Year and Date
      2021-08-15
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulation of IgM Production in HB4C5 Cell Line and Mouse Splenocytes by Egg Yolk Extract from the Egg of Indonesian Native Chicken2021

    • Author(s)
      Rizka Mulyani、Eni Harmayani、Nurliyani、Kosuke Nishi、Momoko Ishida、Takuya Sugahara
    • Journal Title

      Tropical Animal Science Journal

      Volume: 44 Issue: 4 Pages: 511-519

    • DOI

      10.5398/tasj.2021.44.4.511

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Screening of Immunostimulatory Activity from Indonesian Kampung (Gallus domesticus) Egg White Water Extract: in vitro study2021

    • Author(s)
      Rizka Mulyani、Eni Harmayani、Nurliyani、Kosuke Nishi、Momoko Ishida、Takuya Sugahara
    • Journal Title

      Journal of Functional Food and Nutraceutical

      Volume: 3 Pages: 1-10

    • DOI

      10.33555/jffn.v3i1.68

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aqueous Extract from Leaves of Citrus unshiu Attenuates Lipopolysaccharide-Induced Inflammatory Responses in a Mouse Model of Systemic Inflammation2021

    • Author(s)
      Nishi Kosuke、Ito Takako、Kadota Ayumu、Ishida Momoko、Nishiwaki Hisashi、Fukuda Naohiro、Kanamoto Naoaki、Nagata Yoko、Sugahara Takuya
    • Journal Title

      Plants

      Volume: 10 Issue: 8 Pages: 1708-1708

    • DOI

      10.3390/plants10081708

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypocholesterolemic Activity of Kedawung (Parkia roxburghii)2021

    • Author(s)
      Fitriyana Nurul Isnaini、Nishi Kosuke、Sugahara Takuya
    • Journal Title

      Indonesian Journal of Science and Technology

      Volume: 6 Issue: 2 Pages: 353-360

    • DOI

      10.17509/ijost.v6i2.34544

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-Allergy Potential of Averrhoa bilimbi Linn. Fruit Water Extract Shown by Its Suppressive Effect on the Degranulation of RBL-2H3 Cells2021

    • Author(s)
      Santoso William Halim、Ishida Momoko、Nishi Kosuke、Sugahara Takuya、Putra Agus Budiawan Naro
    • Journal Title

      Journal of Functional Food and Nutraceutical

      Volume: 2 Pages: 81-88

    • DOI

      10.33555/jffn.v2i2.62

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells2020

    • Author(s)
      Nishi Kosuke、Mori Mizuki、Nakayama Daisuke、Sato Junna、Kim In-Hae、Kim Minju、Kim Songmun、Sugahara Takuya
    • Journal Title

      Biomedical Dermatology

      Volume: 4 Issue: 1 Pages: 7-7

    • DOI

      10.1186/s41702-020-0061-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of stereospecific cytotoxicity of (8R,8'R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring.2020

    • Author(s)
      S. Yamauchi, A. Nishimoto, H. Nishiwaki, K. Nishi, T. Sugahara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 30 Issue: 13 Pages: 127191-127191

    • DOI

      10.1016/j.bmcl.2020.127191

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Docosahexaenoyl ethanolamideのIgE依存性アレルギー反応への影響2020

    • Author(s)
      西 甲介
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 74 Pages: 39-43

    • Related Report
      2020 Research-status Report
  • [Presentation] スダチチンとデメトキシスダチチンの抗炎症効果2023

    • Author(s)
      田口裕菜, 石田萌子, 西甲介, 敷島康普, 三浦宏之, 菅原卓也
    • Organizer
      2022年度生物機能研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] フラボノイド5,7-Dihydroxyflavoneは破骨細胞分化を抑制する2023

    • Author(s)
      中田晶大, 西脇寿, 西甲介, 菅原卓也, 今井祐記
    • Organizer
      日本農芸化学会中四国支部第64回講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 食べて機能性を発揮する天然物有機化合物2022

    • Author(s)
      西甲介
    • Organizer
      日本農芸化学会中四国支部第44回市民フォーラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] クミン (Cuminum syminum L.) の脱顆粒抑制活性及び活性寄与成分の解明2022

    • Author(s)
      小原理加, 石田萌子, 宮川楓加, 菅原卓也, 西甲介, 恩田浩幸, 吉野七海, 米山茄那, 裏谷瑞穂, 平池葉月, 良知桃子, 菊崎泰枝
    • Organizer
      日本香辛料研究会第36回学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] パクチー水抽出物の抗アレルギー成分の探索研究2022

    • Author(s)
      池田剛, 中嶋圭介, 金光穂乃花, 石田萌子, 西甲介, 恩田浩幸, 吉野七海, 菅原卓也
    • Organizer
      日本香辛料研究会第36回学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 黒コショウの脂肪細胞に対する抗炎症効果2022

    • Author(s)
      延岡玲奈, 石田萌子, 西甲介, 恩田浩幸, 菅原卓也
    • Organizer
      日本香辛料研究会第36回学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Immunostimulation mechanisms of jellyfish collagen on mouse bone marrow-derived dendritic cells via Toll-like receptor 42022

    • Author(s)
      Agus Budiawan Naro Putra, Kosuke Nishi, Mikiharu Doi, Takuya Sugahara
    • Organizer
      The 9th International Symposium of Innovative Bioproduction Indonesia on Biotechnology and Bioengineering (ISIBio)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-allergy effect of passion fruit seed ethanol extract and identification of the active substances2022

    • Author(s)
      Takuya Sugahara, Ai Mizusaki, Yuki Murakami, Momoko Ishida, Kosuke Nishi
    • Organizer
      21st IUFoST World Congress 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-inflammatory effect of black pepper ethanol extract on adipocytes2022

    • Author(s)
      Rena Nobuoka, Kosuke Nishi, Momoko Ishida, Hiroyuki Onda, Takuya Sugahara
    • Organizer
      21st IUFoST World Congress 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-degranulation activity of black vinegar produced by traditional fermentation methods2022

    • Author(s)
      Mayu Yoshii, Momoko Ishida, Akira Fujii, Rintaro Hayase, Kosuke Nishi, Takuya Sugahara
    • Organizer
      21st IUFoST World Congress 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コリアンダー(Coriandrum sativum L.)葉水抽出物の脱顆粒抑制成分の探索研究2022

    • Author(s)
      池田剛, 中嶋圭介, 金光穂乃花, 石田萌子, 西甲介, 恩田浩幸, 吉野七海, 菅原卓也
    • Organizer
      日本生薬学会第68回年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 食品成分の抗アレルギー効果とそれを活用した商品開発2022

    • Author(s)
      菅原卓也, 安永翔, 原裕子, 白石敦, 坂根由梨, 鎌尾知行, 竹澤由起, 大橋裕一, 菊池泰三, 窪千明, 門田歩, 西甲介
    • Organizer
      日本生薬学会第68回年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] フラボノイド5,7-Dihydroxyflavoneは破骨細胞分化を抑制する2022

    • Author(s)
      中田晶大, 西脇寿, 西甲介, 菅原卓也, 今井祐記
    • Organizer
      日本ポリフェノール学会第15回学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Antiallergic activity of docosahexaenoic acid2022

    • Author(s)
      Kosuke Nishi
    • Organizer
      日本食品科学工学会第69回大会 国際交流シンポジウム「Innovation and International Collaboration of Food Science and Technology-International Cooperation Towards Sustainable Future-」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ポリメトキシフラボノイドの抗炎症効果に関する研究2022

    • Author(s)
      田口裕菜, 石田萌子, 西甲介, 敷島康普, 三浦宏之, 菅原卓也
    • Organizer
      第35回日本動物細胞工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 海産物水溶性抽出物の破骨細胞分化抑制効果に関する研究2022

    • Author(s)
      高石萌加, 西甲介, 石田萌子, 土居幹治, 松本淳一, 菅原卓也
    • Organizer
      第35回日本動物細胞工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] フラボノイドChrysinは破骨細胞分化を抑制する2022

    • Author(s)
      中田晶大, 西脇寿, 西甲介, 菅原卓也, 今井祐記
    • Organizer
      第40回日本骨代謝学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] コリアンダー葉水溶性抽出物の脱顆粒抑制効果に関する研究2022

    • Author(s)
      金光穂乃花, 池田剛, 石田萌子, 西甲介, 菊崎泰枝, 小原理加, 恩田浩幸, 菅原卓也
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 黒コショウエタノール抽出物の抗炎症作用に関する研究2022

    • Author(s)
      延岡玲奈, 石田萌子, 西甲介, 恩田浩幸, 菅原卓也
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] p-シネフリンの抗炎症効果とその作用機構に関する研究2022

    • Author(s)
      石田萌子, 竹國千尋, 西甲介, 菅原卓也
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 熟成期間の違いによる黒酢の抗アレルギー効果の比較に関する研究2022

    • Author(s)
      吉井万由, 石田萌子, 藤井暁, 早瀬倫太郎, 西甲介, 菅原卓也
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] キウイフルーツ水溶性抽出物の抗アレルギー作用に関する研究2022

    • Author(s)
      八木葵, 石田萌子, 西甲介, 門田歩, 菅原卓也
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Bengkoang水溶性抽出物の脱顆粒抑制効果に関する研究2021

    • Author(s)
      石田萌子、徳浦咲菜、西甲介、菅原卓也
    • Organizer
      第54回日本栄養・食糧学会中国・四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会
    • Related Report
      2021 Research-status Report
  • [Presentation] キウイフルーツ水溶性抽出物の抗アレルギー効果に関する研究2021

    • Author(s)
      八木葵、石田萌子、西甲介、菅原卓也
    • Organizer
      第54回日本栄養・食糧学会中国・四国支部大会・第7回日本栄養改善学会四国支部学術総会合同大会
    • Related Report
      2021 Research-status Report
  • [Presentation] クマリン類の抗アレルギー効果に関する研究2021

    • Author(s)
      小野智幹、石田萌子、西甲介、小原理加、菊﨑泰枝、吉野七海、菅原卓也
    • Organizer
      日本動物細胞工学会2021年度大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Piceatannol及びその類縁化合物の抗アレルギー効果に関する研究2021

    • Author(s)
      村上裕紀、石田萌子、西甲介、菅原卓也
    • Organizer
      日本動物細胞工学会2021年度大会
    • Related Report
      2021 Research-status Report
  • [Presentation] (-)-β-conidendrin及びその立体異性体の脱顆粒抑制効果に関する研究2021

    • Author(s)
      石田萌子、松原依莉彩、西甲介、山内聡、菅原卓也
    • Organizer
      日本動物細胞工学会2021年度大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Effect of docosahexaenoyl ethanolamide, a metabolite of docosahexaenoic acid, on allergic responses2020

    • Author(s)
      Yoshiki Kanayama、In-Hae Kim、Takuya Sugahara、Kosuke Nishi
    • Organizer
      The 33rd Annual and International Meeting of Japanese Association for Animal Cell Technology (JAACT2020 FUCHU)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Cirtrus unshiu leaf water-extract on inflammation-induced mouse macrophage cell line RAW264.7 cells2020

    • Author(s)
      Takako Ito、Kosuke Nishi、Momoko Ishida、Ayumu Kadota、Takuya Sugahara
    • Organizer
      The 33rd Annual and International Meeting of Japanese Association for Animal Cell Technology (JAACT2020 FUCHU)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] スダチチンの抗アレルギー効果に関する研究2020

    • Author(s)
      渡邉 愛子、石田 萌子、西 甲介、菅原 卓也
    • Organizer
      ノビレチン研究会第4回学術研究会
    • Related Report
      2020 Research-status Report
  • [Book] スパイス・ハーブの機能と応用2020

    • Author(s)
      森川 敏生ら
    • Total Pages
      353
    • Publisher
      シーエムシー出版
    • ISBN
      9784781315218
    • Related Report
      2020 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/read0152614

    • Related Report
      2020 Research-status Report
  • [Remarks] 食品機能学/動物細胞工学教育分野のホームページ

    • URL

      http://web-amb.agr.ehime-u.ac.jp/

    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] PPARγ2産生活性化剤、アディポネクチン産生活性化剤、及びMCP-1産生抑制剤2020

    • Inventor(s)
      菅原 卓也、西 甲介、石田 萌子、恩田 浩幸、吉野七海
    • Industrial Property Rights Holder
      菅原 卓也、西 甲介、石田 萌子、恩田 浩幸、吉野七海
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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