Development of innovative drug dosage regimens compatible with diverse treatment responsiveness in depression and schizophrenia

• Project/Area Number: 20K07134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Kumamoto University
• Principal Investigator: Saruwatari Junji 熊本大学, 大学院生命科学研究部(薬), 教授 (30543409)
• Co-Investigator(Kenkyū-buntansha): 古郡 規雄 獨協医科大学, 医学部, 准教授 (20333734) ; 城野 博史 熊本大学, 病院, 准教授 (40515483) ; 鬼木 健太郎 熊本大学, 大学院生命科学研究部(薬), 准教授 (00613407)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 精密医療 / 精神神経薬理学 / ファーマコメトリクス / 薬理ゲノム学 / 機械学習 / 精神疾患

Outline of Research at the Start

本研究は、新たな治療戦略の開発が求められている、うつ病と統合失調症を対象疾患として、全ての患者でQOL向上と健康寿命の延長を目指した、精密で合理的な臨床薬学研究である。具体的には、多面的な生物統計学・情報科学的手法を駆使して、当該患者の治療効果・副作用発現に関連する、あらゆる内的・外的要因（遺伝子型や生活習慣等、未知の因子含む）を評価し、モデリング&シミュレーションの手法で統合処理する。その結果を基に、上記患者に対して、最も効果的で、かつ、副作用リスクの低い最適な治療を提供するための、独自の個別化医療支援システムを構築・提起し、その臨床応用を目指す。

Outline of Final Research Achievements

In this study, we attempted to predict treatment responsiveness based on patient information and other factors using the frequently used antidepressant paroxetine as the target drug. The results of the analysis using blood paroxetine concentration and MADRS as indices of treatment responsiveness showed that pharmacokinetic parameters in the first week after the start of treatment could effectively predict the amount of change in MADRS up to the 8th week thereafter. On the other hand, a search for factors associated with antipsychotic-induced metabolic abnormalities related to increased mortality in patients with schizophrenia revealed a higher frequency of overweight in female patients taking three or more antipsychotic medications and a higher frequency of overweight in both men and women taking high doses of risperidone.

Academic Significance and Societal Importance of the Research Achievements

うつ病は人口の3%以上が、統合失調症は約1%が罹患する極めて頻度の高い精神疾患である。その治療の中心は薬物療法であるが、寛解・再発を繰り返し、約30%の患者で治療抵抗性を示す。加えて、抗精神病薬の長期投与では、肥満や糖尿病等の生活習慣病関連病態をきたし、服薬アドヒアランスの低下の他、生活の質（QOL）の低下や心血管イベントの増加（死亡率の増加）にも関係することが臨床で問題となっている。本研究の結果から、臨床薬学的検討により、うつ病や統合失調症の個別化投与設計が実現できる可能性を示すことが出来た。

Research Products

• [Journal Article] Additive Effects of Drinking Habits and a Susceptible Genetic Polymorphism on Cholesterol Efflux Capacity (2023)
  • Author(s): Matsumoto E, Oniki K, Ota-Kontani A, Seguchi Y, Sakamoto Y, Kaneko T, Imafuku T, Maeda H, Watanabe H, Maruyama T, Ogata Y, Yoshida M, Harada-Shiba M, Saruwatari J, Ogura M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 1 Pages: 23-38
  • DOI: 10.5551/jat.63277
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Serum Fatty Acid Composition Balance by Fuzzy C-Means Method in Individuals with or without Metabolic Dysfunction-Associated Fatty Liver Disease (2023)
  • Author(s): Nagase Yuka、Satoh Takao、Shigetome Keiichi、Tokumaru Naoto、Matsumoto Erika、Yamada Kazunori D.、Imafuku Tadashi、Watanabe Hiroshi、Maruyama Toru、Ogata Yasuhiro、Yoshida Minoru、Saruwatari Junji、Oniki Kentaro
  • Journal Title: Nutrients Volume: 15 Issue: 4 Pages: 809-809
  • DOI: 10.3390/nu15040809
  • Peer Reviewed / Open Access
• [Journal Article] Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 (2023)
  • Author(s): Higashi-Kuwata Nobuyo、Tsuji Kohei、Hayashi Hironori、Bulut Haydar、Kiso Maki、Imai Masaki、Ogata-Aoki Hiromi、Ishii Takahiro、Kobayakawa Takuya、Nakano Kenta、et al.
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 1076-1076
  • DOI: 10.1038/s41467-023-36729-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors associated with thrombocytopenia in patients treated with pegfilgrastim (2023)
  • Author(s): Nishimura Fumihiro、Ushijima Tomoko、Hamada Shinsuke、Miyamura Shigeyuki、Oniki Kentaro、Saruwatari Junji
  • Journal Title: Int. Journal of Clinical Pharmacology and Therapeutics Volume: - Issue: 06 Pages: 255-261
  • DOI: 10.5414/cp204367
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for Baerveldt glaucoma drainage implantation for uveitic glaucoma (2023)
  • Author(s): Manako Kiyofumi、Takahashi Eri、Saruwatari Junji、Matsumura Tomoyo、Kojima Sachi、Inoue Toshihiro
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 4473-4473
  • DOI: 10.1038/s41598-023-29244-1
  • Peer Reviewed / Open Access
• [Journal Article] New Insight Concerning Therapeutic Drug Monitoring—The Importance of the Concept of Psychonephrology— (2022)
  • Author(s): Hashimoto Mai、Maeda Hitoshi、Oniki Kentaro、Yasui-Furukori Norio、Watanabe Hiroshi、Saruwatari Junji、Kadowaki Daisuke
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 45 Issue: 7 Pages: 834-842
  • DOI: 10.1248/bpb.b22-00025
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2022-07-01
  • Peer Reviewed / Open Access
• [Journal Article] A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease (2022)
  • Author(s): Nagasaki Taisei、Maeda Hitoshi、Taguchi Kazuaki、Yanagisawa Hiroki、Nishida Kento、Kobayashi Kazuki、Wada Naoki、Noguchi Isamu、Murata Ryota、Sakai Hiromi、Kitagishi Hiroaki、Saruwatari Junji、Watanabe Hiroshi、Otagiri Masaki、Maruyama Toru
  • Journal Title: Redox Biology Volume: 54 Pages: 102371-102371
  • DOI: 10.1016/j.redox.2022.102371
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for intraocular pressure elevation in a six-month period after ab interno trabeculotomy using a Kahook Dual Blade (2022)
  • Author(s): Murakami-Kojima Setsu、Takahashi Eri、Eguchi-Matsumoto Momoka、Saruwatari Junji、Nakashima Kei-ichi、Inoue Toshihiro
  • Journal Title: BMC Ophthalmology Volume: 22 Issue: 1 Pages: 327-327
  • DOI: 10.1186/s12886-022-02545-1
  • Peer Reviewed / Open Access
• [Journal Article] Potent and biostable inhibitors of the main protease of SARS-CoV-2 (2022)
  • Author(s): Tsuji Kohei、Ishii Takahiro、Kobayakawa Takuya、Higashi-Kuwata Nobuyo、Azuma Chika、Nakayama Miyuki、Onishi Takato、Nakano Hiroki、Wada Naoya、Hori Miki、et al.
  • Journal Title: iScience Volume: 25 Issue: 11 Pages: 105365-105365
  • DOI: 10.1016/j.isci.2022.105365
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Outcomes and risk factors for ab interno trabeculotomy with a Kahook Dual Blade (2022)
  • Author(s): Murata Natsumi、Takahashi Eri、Saruwatari Junji、Kojima Sachi、Inoue Toshihiro
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 261 Issue: 2 Pages: 503-511
  • DOI: 10.1007/s00417-022-05799-z
  • Peer Reviewed / Open Access
• [Journal Article] East Asian variant aldehyde dehydrogenase type 2 genotype exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction in men: possible sex differences (2022)
  • Author(s): Ishida T, Arima Y, Mizuno Y, Harada E, Yamashita T, Sueta D, Sakamoto K, Suzuki S, Kaikita K, Yamada Y, Shimomura H, Oniki K, Saruwatari J, Hokimoto S, Yasue H, Tsujita K.
  • Journal Title: Heart and Vessels Volume: 37 Issue: 2 Pages: 184-193
  • DOI: 10.1007/s00380-021-01907-x
  • Peer Reviewed / Open Access
• [Journal Article] Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study (2022)
  • Author(s): Yan Y, Kondo N, Oniki K, Watanabe H, Imafuku T, Sakamoto Y, Shigaki T, Maruyama A, Nakazawa H, Kaneko T, Morita A, Yoshida A, Maeda H, Maruyama T, Jinnouchi H, Saruwatari J.
  • Journal Title: Journal of Diabetes Research Volume: 2022 Pages: 6934188-6934188
  • DOI: 10.1155/2022/6934188
  • Peer Reviewed / Open Access
• [Journal Article] Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH. (2022)
  • Author(s): Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M
  • Journal Title: J Control Release Volume: 341 Pages: 457-474
  • DOI: 10.1016/j.jconrel.2021.11.039
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis (2021)
  • Author(s): Nishimura F, Ushijima T, Nojima M, Hamada S, Hara K, Hamada Y, Kadowaki D, Miyamura S, Oniki K, Saruwatari J.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 44 Issue: 10 Pages: 1427-1432
  • DOI: 10.1248/bpb.b21-00215
  • NAID: 130008095787
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2021-10-01
  • Peer Reviewed
• [Journal Article] Clinical profiles of Asians with NAFLD: A systematic review and meta-analysis (2021)
  • Author(s): Kam L, Huang DQ, Teng MLP, Takahashi H, Tanaka K, Yasuda S, Fung J, Lee TY, Hyogo H, Ono M, Saruwatari J, Oniki K, Yeo YH, Barnett S, Henry L, Li J, Zou B, Cheung RC, Kumada T, Yuen MF, Eguchi Y, Toyoda H, Nguyen MH.
  • Journal Title: Digestive Diseases(Basel, Switzerland) Volume: - Issue: 6 Pages: 734-744
  • DOI: 10.1159/000521662
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of renal function using cystatin C-based estimated glomerular filtration rate in patients with urothelial carcinoma treated with gemcitabine and cisplatin chemotherapy (2021)
  • Author(s): Nishimura F, Ushijima T, Hamada S, Kadowaki D, Miyamura S, Oniki K, Saruwatari J.
  • Journal Title: Journal of Clinical Pharmacy and Therapeutics Volume: 46 Issue: 6 Pages: 1622-1628
  • DOI: 10.1111/jcpt.13501
  • Peer Reviewed
• [Journal Article] Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma (2021)
  • Author(s): Narahara S, Watanabe T, Nagaoka K, Fujimoto N, Furuta Y, Tanaka K, Tokunaga T, Kawasaki T, Yoshimaru Y, Setoyama H, Oniki K, Saruwatari J, Tateyama M, Naoe H, Tanaka M, Tanaka Y, Sasaki Y.
  • Journal Title: Hepatology Communications Volume: - Issue: 5 Pages: 1198-1212
  • DOI: 10.1002/hep4.1872
  • Peer Reviewed / Open Access
• [Journal Article] The effects of exosomes derived from trabecular meshwork cells on Schlemm’s canal endothelial cells (2021)
  • Author(s): Takahashi Eri、Saruwatari Junji、Fujimoto Tomokazu、Tanoue Yuki、Fukuda Takaichi、Inoue Toshihiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 21942-21942
  • DOI: 10.1038/s41598-021-01450-9
  • Peer Reviewed / Open Access
• [Journal Article] Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer (2021)
  • Author(s): Wakiya Taiichi、Ishido Keinosuke、Kimura Norihisa、Nagase Hayato、Yoshizawa Tadashi、Morohashi Satoko、Fujita Hiroaki、Kanda Taishu、Tatara Yota、Saruwatari Junji、Kijima Hiroshi、Hakamada Kenichi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 21197-21197
  • DOI: 10.1038/s41598-021-00727-3
  • Peer Reviewed / Open Access
• [Journal Article] Cysteinylated albumin as a potential biomarker for the progression of kidney disease in patients with type 2 diabetes (2021)
  • Author(s): Imafuku T, Watanabe H, Oniki K, Yoshida A, Kato H, Nakano T, Tokumaru K, Fujita I, Arimura N, Maeda H, Sakamoto Y, Kondo N, Morita A, Saruwatari J, Tanaka M, Matsushita K, Wada T, Fukagawa M, Otagiri M, Fitzgerald ML, Jinnouchi H, Maruyama T.
  • Journal Title: Diabetes Care Volume: 26 Issue: 6 Pages: e115-e117
  • DOI: 10.2337/dc20-3003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040. (2021)
  • Author(s): Ito T, Ishigami M, Zou B, Tanaka T, Takahashi H, Kurosaki M, Maeda M, Thin KN, Tanaka K, Takahashi Y, Itoh Y, Oniki K, Seko Y, Saruwatari J, Kawanaka M, Atsukawa M, Hyogo H, Ono M, Ogawa E, Barnett SD, Stave CD, Cheung RC, Fujishiro M, Eguchi Y, Toyoda H, Nguyen MH.
  • Journal Title: Hepatol Int. Volume: - Issue: 2 Pages: 366-379
  • DOI: 10.1007/s12072-021-10143-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Comparison of the Frequency of Prescription and Pharmacy Revisits between Baloxavir Marboxil and Neuraminidase Inhibitors in Influenza-Infected Pediatric Patients during the 2019–2020 Influenza Season (2020)
  • Author(s): Norikoshi Y, Ikeda T, Sasahara K, Hamada M, Torigoe E, Nagae M, Tashiro T, Horio F, Saruwatari J, Uchida Y, Anraku M.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 12 Pages: 1960-1965
  • DOI: 10.1248/bpb.b20-00543
  • NAID: 130007948709
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2020-12-01
  • Peer Reviewed / Open Access
• [Journal Article] The<I> DsbA-L</I> gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties. (2020)
  • Author(s): Kentaro Oniki, Hirofumi Nohara, Ryunosuke Nakashima, Yui Obata, Narumi Muto, Yuki Sakamoto, Keiko Ueno-Shuto, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto, and Junji Saruwatari.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 5973-5973
  • DOI: 10.1038/s41598-020-62872-5
  • Peer Reviewed / Open Access
• [Journal Article] Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function (2020)
  • Author(s): Fujikawa H, Sakamoto Y, Masuda N, Oniki K, Kamei S, Nohara H, Nakashima R, Maruta K, Kawakami T, Eto Y, Takahashi N, Takeo T, Nakagata N, Watanabe H, Otake K, Ogata Y, Tomioka NH, Hosoyamada M, Takada T, Ueno-Shuto K , Suico MA, Kai H, Saruwatari J, Shuto T.
  • Journal Title: Antioxidants Volume: 9 Issue: 5 Pages: 387-387
  • DOI: 10.3390/antiox9050387
  • Peer Reviewed / Open Access
• [Journal Article] The angiogenic effects of exosomes secreted from retinal pigment epithelial cells on endothelial cells. (2020)
  • Author(s): Fukushima A, Takahashi E, Saruwatari J, Tanihara H, Inoue T.
  • Journal Title: Biochemistry and biophysics reports Volume: 22 Pages: 100760-100760
  • DOI: 10.1016/j.bbrep.2020.100760
  • Peer Reviewed / Open Access
• [Journal Article] In vivo evaluation of drug dialyzability in a rat model of hemodialysis. (2020)
  • Author(s): Fukunaga M, Kadowaki D, Mori M, Hagiwara S, Narita Y, Saruwatari J, Tanaka R, Watanabe H, Yamasaki K, Taguchi K, Ito H, Maruyama T, Otagiri M, Hirata S.
  • Journal Title: PLoS One Volume: 15 Issue: 6 Pages: 20-26
  • DOI: 10.1371/journal.pone.0233925
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of methods for more accurate estimation of kidney function in people with high muscle mass. (2020)
  • Author(s): Ichigi M, Nakatani S, Murakami M, Harada Y, Utsumi S, Ogata M, Maehara Y, Ikeda H, Shimada H, Fukunaga M, Narita Y, Saruwatari J, Kondo Y, Ishitsuka Y, Irie T, Kadowaki D, Hirata S.
  • Journal Title: Clinical nephrology Volume: 94 Issue: 2 Pages: 86-96
  • DOI: 10.5414/cn110074
  • Peer Reviewed
• [Journal Article] The associations of the number of medications and the use of anticholinergics with recovery from tubal feeding: a longitudinal hospital-based study. (2020)
  • Author(s): Takata K, Oniki K, Tateyama Y, Yasuda H, Yokota M, Yamauchi S, Sugawara N, Yasui-Furukori N, Saruwatari J.
  • Journal Title: BMC Geriatr. Volume: 20 Issue: 1 Pages: 373-373
  • DOI: 10.1186/s12877-020-01778-3
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin E2-EP4 axis promotes lipolysis and fibrosis in adipose tissue leading to ectopic fat deposition and insulin resistance. (2020)
  • Author(s): Inazumi T, Yamada K, Shirata N, Sato H, Taketomi Y, Morita K, Hohjoh H, Tsuchiya S, Oniki K, Watanabe T, Sasaki Y, Oike Y, Ogata Y, Saruwatari J, Murakami M, Sugimoto Y.
  • Journal Title: Cell Rep. Volume: 33 Issue: 2 Pages: 108265-108265
  • DOI: 10.1016/j.celrep.2020.108265
  • Peer Reviewed / Open Access
• [Journal Article] ALT Levels for Asians With Metabolic Diseases: A Meta-analysis of 86 Studies With Individual Patient Data Validation. (2020)
  • Author(s): Huang DQ, Yeo YH, Tan E, Takahashi H, Yasuda S, Saruwatari J, Tanaka K, Oniki K, Kam LY, Muthiah MD, Hyogo H, Ono M, Barnett SD, Li J, Zou B, Fung J, Lee TY, Wong VW, Yuen MF, Dan YY, Lim SG, Cheung R, Toyoda H, Eguchi Y, Nguyen MH.
  • Journal Title: Hepatol Commun. Volume: 4 Issue: 11 Pages: 1624-1636
  • DOI: 10.1002/hep4.1593
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neonatal irritable sleep-wake rhythm as a predictor of autism spectrum disorders (2020)
  • Author(s): Miike T, Toyoura M, Tonooka S, Konishi Y, Oniki K, Saruwatari J, Tajima S, Kinoshita J, Nakai A, Kikuchi K.
  • Journal Title: Neurobiology of Sleep and Circadian Rhythms Volume: 9 Pages: 100053-100053
  • DOI: 10.1016/j.nbscr.2020.100053
  • Peer Reviewed / Open Access
• [Presentation] がんサバイバーに対する漢方処方の情報蓄積にむけた熊本大学病院での漢方薬の使用実態調査 (2023)
  • Author(s): 成瀨遥佳、三宅俊介、鬼木健太郎、猿渡淳二、城野博史
  • Organizer: 日本薬学会第１４３年会
• [Presentation] 抑肝散が抗認知症薬ドネペジル塩酸塩及び抗精神病薬リスペリドンの体内動態に及ぼす影響 (2023)
  • Author(s): 成瀬遥佳、金子哲也、倉本佳奈、釘本沙和、西村英里、豎道真菜、手束菜月、安東実咲、大井桃、大田雅子、村田司、浜田直優美、兼田桂一郎、古庄史郎、坂元正克、上田啓司、尾田一貴、鬼木健太郎、猿渡淳二、城野博史、古郡規雄
  • Organizer: 日本薬学会第１４３年会
• [Presentation] TDMと遺伝情報を活用した抗てんかん薬の個別化投与設計法の開発 (2022)
  • Author(s): 猿渡淳二
  • Organizer: 第38回日本TDM学会・学術大会
  • Invited
• [Presentation] 精神科において測定可能な薬物血中濃度と有効な利用方法 (2022)
  • Author(s): 猿渡淳二
  • Organizer: 第8回臨床精神薬理教育Webセミナー
  • Invited
• [Presentation] 血中脂肪酸バランスと脂肪肝に関する検討～PNPLA3遺伝子多型も考慮したクラスター分析～ (2022)
  • Author(s): 永瀬友花、鬼木健太郎、佐藤崇雄、吉田稔、猿渡淳二
  • Organizer: 医療薬学フォーラム２０２２第３０回クリニカルファーマシーシンポジウム
• [Presentation] 機械学習によるポリファーマシーの改善に向けた試み～高齢患者の嚥下機能に着目した検討～ (2022)
  • Author(s): 重留啓壱、鬼木健太郎、髙田恵司、建山幸、安田広樹、横田美有、山内紗衣、山田和範、猿渡淳二
  • Organizer: フォーラム2022 衛生薬学・環境トキコロジー
• [Presentation] 血中脂肪酸バランスのクラスターと脂肪肝罹患の関係 (2022)
  • Author(s): 永瀨友花、鬼木健太郎、佐藤崇雄、倉本佳奈、松本英里香、徳丸尚人、吉田稔、猿渡淳二
  • Organizer: フォーラム2022 衛生薬学・環境トキコロジー
• [Presentation] 漢方薬による薬物動態学的相互作用 (2022)
  • Author(s): 猿渡淳二
  • Organizer: 第３２回日本医療薬学会年会
  • Invited
• [Presentation] 遺伝情報と血中薬物濃度を活用した向精神薬の投与最適化への挑戦 (2022)
  • Author(s): 猿渡淳二
  • Organizer: 第３２回日本医療薬学会年会
  • Invited
• [Presentation] クラスター分析による血中脂肪酸バランスと脂肪肝罹患頻度の関連解析 (2022)
  • Author(s): 永瀬友花、鬼木健太郎、佐藤崇雄、吉田稔、猿渡淳二
  • Organizer: 第６２回日本臨床化学会年次学術集会
• [Presentation] SGLT2阻害薬の血糖降下・体重減少効果に対するSLC5A2 rs9934336多型の影響 (2022)
  • Author(s): 酒井伽音、鬼木健太郎、守田彩文、陣内秀昭、猿渡淳二
  • Organizer: 第６２回日本臨床化学会年次学術集会
• [Presentation] 機械学習による高齢患者の嚥下機能改善とポリファーマシー対策に向けた試み (2022)
  • Author(s): 重留啓壱、鬼木健太郎、髙田恵司、建山幸、安田広樹、横田美有、山内紗衣、古郡規雄、山田和範、猿渡淳二
  • Organizer: BPCNPNPPP4学会合同年会
• [Presentation] 機械学習による高齢者のポリファーマシー解消に向けた試み～嚥下機能に着目した減薬法の探索～ (2022)
  • Author(s): 重留啓壱、鬼木健太郎、髙田恵司、建山幸、安田広樹、横田美有、山内紗衣、古郡規雄、山田和範、猿渡淳二
  • Organizer: 第39回日本薬学会九州支部大会
• [Presentation] SLC5A2遺伝子多型がSGLT2阻害薬による血糖・体重減少作用に及ぼす影響に関する臨床的検討 (2022)
  • Author(s): 酒井伽音、守田彩文、鬼木健太郎、坂本優季、近藤亜美、松尾萌花、丸山阿加里、吉田陽、西村博之、塩山由紀、髙田雅文、井島廣子、宮本文夫、杉山正悟、稗島州雄、栗並昇、梶原敬三、陣内克紀、陣内冨男、陣内秀昭、猿渡淳二
  • Organizer: 日本薬学会第142年会
• [Presentation] ALDH2遺伝子多型と性差の組み合わせがbaPWVに与える影響に関する臨床研究 (2021)
  • Author(s): 近藤亜美、守田彩文、坂本優季、酒井伽音、丸山阿加里、近藤望、鬼木健太郎、吉田陽、西村博之、塩山由紀、髙田雅文、井島廣子、宮本文夫、杉山正悟、稗島州雄、栗並昇、梶原敬三、陣内克紀、陣内冨男、陣内秀昭、猿渡淳二
  • Organizer: 第64回日本糖尿病学会年次学術集会
• [Presentation] HDLのコレステロール引き抜き能に対する飲酒習慣の影響 (2021)
  • Author(s): 松本英里香、鬼木健太郎、小倉正恒、紺谷愛美、瀬口優里、坂本優季、今福匡志、渡邊博志、丸山徹、斯波真理子、緒方康博、吉田稔、猿渡淳二
  • Organizer: 医療薬学フォーラム2021 第29回クリニカルファーマシーシンポジウム
• [Presentation] 心筋梗塞患者におけるコレステロール引き抜き能の臨床的意義に関する検討 (2021)
  • Author(s): 松本英里香、鬼木健太郎、小倉正恒、紺谷愛美、瀬口優里、坂本優季、今福匡志、渡邊博志、丸山徹、斯波真理子、緒方康博、吉田稔、有馬勇一朗、辻田賢一、猿渡淳二
  • Organizer: 医療薬学フォーラム2021 第29回クリニカルファーマシーシンポジウム
• [Presentation] 向精神薬の薬物動態と個別化療法 (2021)
  • Author(s): 猿渡淳二
  • Organizer: 第31回日本医療薬学会年会
  • Invited
• [Presentation] HDLコレステロール引き抜き能と飲酒・喫煙習慣の関連についての検討 (2021)
  • Author(s): 松本英里香、鬼木健太郎、小倉正恒、吉田稔、猿渡淳二
  • Organizer: 第61回日本臨床化学会年次学術集会
• [Presentation] 糖尿病性腎臓病の予防最適化に向けたHbA1cの個体内変動の有用性評価 (2021)
  • Author(s): Yunyi Yan、近藤望、坂本優季、今福匡司、前田仁志、渡邊博志、丸山徹、吉田陽、陣内秀昭、猿渡淳二、鬼木健太郎
  • Organizer: 第38回日本薬学会九州支部大会
• [Presentation] HDL機能の臨床的意義の解明：コレステロール引き抜き能に対する飲酒喫煙習慣や心筋梗塞病態の影響に関する検討 (2021)
  • Author(s): 松本英里香、鬼木健太郎、小倉正恒、今福匡司、前田仁志、渡邊博志、丸山徹、吉田稔、斯波真理子、辻田賢一、猿渡淳二
  • Organizer: 第38回日本薬学会九州支部大会
• [Presentation] 抗てんかん薬clobazam及びその代謝物N-desmethylclobazamの母集団薬物動態同時解析並びに治療効果との関連性評価 (2021)
  • Author(s): 松瀬彰仁、金子哲也、鬼木健太郎、石津棟暎、猿渡淳二
  • Organizer: 第38回日本薬学会九州支部大会
• [Presentation] 糖尿病患者の動脈硬化と酸化ストレスに対するALDH2遺伝子多型の性別依存的な影響に関する臨床研究 (2021)
  • Author(s): 近藤亜美、守田彩文、鬼木健太郎、坂本優季、酒井伽音、吉田陽、今福匡司、前田仁志、渡邊博志、丸山徹、陣内秀昭、猿渡淳二
  • Organizer: 第38回日本薬学会九州支部大会
• [Presentation] 熊本地震後の女性左側海馬体積減少とe4因子保持者のMCIリスク上昇について (2021)
  • Author(s): 佐藤正、内田和彦、鬼木健太郎、田中素美、板井八重子、片山義勝、猿渡淳二、松田博史、納光弘
  • Organizer: 第40回日本認知症学会学術集会
• [Presentation] 精神科薬の薬物相互作用 (2021)
  • Author(s): 猿渡淳二、古郡規雄
  • Organizer: 第42回日本臨床薬理学会学術総会
  • Invited
• [Presentation] 抗精神病薬誘発性メタボリックシンドロームにおける用量依存性の検討 (2021)
  • Author(s): 中澤瞳、古郡規雄、菅原典夫、鬼木健太郎、猿渡淳二、山崎學、下田和孝、 寒河江豊昭、森隆夫、須貝拓朗、松田ひろし、鈴木雄太郎、尾関祐二、 土嶺章子、岡本呉賦、染矢俊幸
  • Organizer: 第30回日本臨床精神神経薬理学会学術集会
• [Presentation] 薬物動態とその個人差：遺伝要因と薬物相互作用を中心に (2021)
  • Author(s): 猿渡淳二
  • Organizer: 第30回日本臨床精神神経薬理学会学術集会（第20回臨床精神神経薬理学セミナー）
  • Invited
• [Presentation] Modeling＆simulation解析を用いたメタボリックメモリーの定量的評価 (2021)
  • Author(s): 志垣拓郎、鬼木健太郎、坂本優季、金子哲也、近藤望、丸山阿加里、吉田陽、西村博之、守田彩文、塩山由紀、高田雅文、井島廣子、陣内秀昭、猿渡淳二
  • Organizer: 日本薬学会 第141年会
• [Presentation] クロザピンの母集団薬物動態解析とTDMの有用性 (2020)
  • Author(s): 猿渡淳二、古郡規雄
  • Organizer: 第116回日本精神神経学会学術総会
  • Invited
• [Presentation] HbA1c値の個体内変動の定量化とその臨床的意義の検討 (2020)
  • Author(s): 近藤望、鬼木健太郎、陣内秀昭、猿渡淳二
  • Organizer: 第60回日本臨床化学会年次学術集会
• [Presentation] KCNQ1遺伝子多型（rs2237892）とDPP-4阻害薬の血糖降下作用に関する検討 (2020)
  • Author(s): 丸山阿加里、坂本優季、鬼木健太郎、近藤望、陣内秀昭、猿渡淳二
  • Organizer: 第60回日本臨床化学会年次学術集会
• [Remarks] 熊本大学大学院生命科学研究部 薬物治療学分野
  • URL: https://www.pharm.kumamoto-u.ac.jp/Labs/tiryougaku/