Molecular basis of the unique follicular lymphomas

• Project/Area Number: 20K07375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Okayama University
• Principal Investigator: Yoshino Tadashi 岡山大学, 医歯薬学総合研究科, 特命教授 (70183704)
• Co-Investigator(Kenkyū-buntansha): 磯田 哲也 (田端哲也) 岡山大学, 医学部, 客員研究員 (40824602) ; 井川 卓朗 岡山大学, 医歯薬学域, 助教 (50803186) ; 田中 健大 岡山大学, 医歯薬学域, 講師 (70549857)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 濾胞性リンパ腫 / 十二指腸型 / 路傍性リンパ腫 / double hit / GCB型 / リンパ腫 / 分子基盤

Outline of Research at the Start

リンパ腫の罹患数は年間3万人を超えており、10万人あたり24.8人程度と推定されます。その頻度は米国のそれと同等で、罹患数は悪性腫瘍中第8位になりました。とりわけ濾胞性リンパ腫（FL）の患者数は増加著明で、40年間に25倍程度になり全リンパ腫の約2割を占めます。FLにはいくつか未解決の問題があります。われわれが樹立した十二指腸型のうち病勢進展例の分子基盤やdouble hitといわれる症例のなかでの緩徐進展例にどのような特徴があるかを明らかにします。

Outline of Final Research Achievements

We have established a novel subtype of the follicular lymphoma: The duodenal-type follicular lymphoma. Previously, extranodal follicular lymphoma is exceptional one , however, the duodenal-type duodenal lymmphoma is not rare but also whose moleclar characters are the initial stage of follicular lymphoma. This is unexpected characters and this entity is widely acccepted in the WHO classification, is included in the internatinonal consensus classification published in the Blood.

Academic Significance and Societal Importance of the Research Achievements

研究成果は、「十二指腸型」濾胞性リンパ腫という疾患単位の確立に結実し、それは最新のリンパ腫分類の中でも独立したものとして認められた。このことは、世界最高水準にあるわが国の消化管内視鏡医にも広く知られており、消化器のWHO分類にも収載され、患者さんの早期発見と適切な治療法（経過観察法を含む）の選択がなされるようになったので、国民福祉の向上にも寄与している。

Research Products

• [Journal Article] Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma (2022)
  • Author(s): Togitani K, Asagiri T, Iguchi M, Igawa T, Yoshino T, Kojima K.
  • Journal Title: Internal Medicine Volume: 61 Issue: 20 Pages: 3107-3110
  • DOI: 10.2169/internalmedicine.8968-21
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-10-15
  • Peer Reviewed / Open Access
• [Journal Article] The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee (2022)
  • Author(s): Campo Elias、Jaffe Elaine S.、Yoshino Tadashi、Zinzani Pier-Luigi、Dreyling Martin、Scott David W.、Winter Jane N.、Zelenetz Andrew D.
  • Journal Title: Blood Volume: 140 Issue: 11 Pages: 1229-1253
  • DOI: 10.1182/blood.2022015851
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Follicular lymphoma and marginal zone lymphoma: how many diseases? (2022)
  • Author(s): Laurent Camille、Cook James R.、Yoshino Tadashi、Quintanilla-Martinez Leticia、Jaffe Elaine S.
  • Journal Title: Virchows Archiv Volume: 482 Issue: 1 Pages: 149-162
  • DOI: 10.1007/s00428-022-03432-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinicopathologic analysis of gastric mucosa-associated lymphoid tissue lymphoma with or without c-Met expression. Clinicopathologic analysis of gastric mucosa-associated lymphoid tissue lymphoma with or without c-Met expression. (2020)
  • Author(s): Omote R, Gion Y, Omote S, Tari A, Tanaka T, Nishikori A, Yoshino T, Sato Y.
  • Journal Title: Med Mol Morphol. Volume: Jan 2 Issue: 3 Pages: 1-7
  • DOI: 10.1007/s00795-019-00241-6
  • Peer Reviewed
• [Journal Article] Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma (2020)
  • Author(s): Yoshino T, Tanaka T, Sato Y
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 60 Issue: 4 Pages: 124-129
  • DOI: 10.3960/jslrt.19041
  • NAID: 130007955990
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer (2020)
  • Author(s): Ikeda T, Gion Y, Sakamoto M, Tachibana T, Nishikori A, Nishimura MF, Yoshino T, Sato Y
  • Journal Title: Mod Pathol. Volume: June 9 Issue: 12 Pages: 1-12
  • DOI: 10.1038/s41379-020-0599-8
  • NAID: 120006948962
  • Peer Reviewed / Open Access
• [Journal Article] Consolidation with 90 Yttrium-ibritumomab tiuxetan after bendamustine and rituximab for relapsed follicular lymphoma (2020)
  • Author(s): Katsuhiro Miura , Hideki Tsujimura , Yasufumi Masaki , Tadashi Yoshino et al
  • Journal Title: Hematol Oncol Volume: Sep 25 Issue: 1 Pages: 1-10
  • DOI: 10.1002/hon.2809
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Technique for single-step lymphocyte isolation from an endoscopic biopsy specimen for the diagnosis of gastrointestinal lymphoma. (2020)
  • Author(s): Iwamuro M, Takahashi T, Watanabe N, Omote S, Matsueda K, Tanaka T, Ennishi D, Otsuka F, Yoshino T, Okada H.
  • Journal Title: MethodsX. Volume: Oct 10 Pages: 1-8
  • DOI: 10.1016/j.mex.2020.101095
  • NAID: 120006955829
  • Peer Reviewed
• [Book] 大腸癌第2版 腫瘍病理鑑別診断アトラス (2021)
  • Author(s): 吉野 正
  • Total Pages: 300
  • Publisher: 文光堂
  • ISBN: 9784830622588
• [Book] 上部消化管のリンパ腫 消化器病学第3版 (2021)
  • Author(s): 岡田裕之、吉野 正
  • Total Pages: 450
  • Publisher: 医学書院
  • ISBN: 9784260045797
• [Book] 腸癌第2版 腫瘍病理鑑別診断アトラス (2021)
  • Author(s): 吉野 正
  • Total Pages: 293
  • Publisher: 文光堂
  • ISBN: 9784830622588
• [Book] 病理組織の見方と鑑別診断 第7版 (2020)
  • Author(s): 吉野 正
  • Total Pages: 740
  • Publisher: 医歯薬出版
  • ISBN: 9784263731970
• [Book] 外科病理学第5版 (2020)
  • Author(s): 吉野 正
  • Total Pages: 1754
  • Publisher: 文光堂
  • ISBN: 9784830604812