• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of novel skeletal muscle cell-secreted protein aiming for the establishment of novel therapeutic strategies for sarcopenia

Research Project

Project/Area Number 20K07810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Takemoto Minoru  国際医療福祉大学, 医学部, 主任教授 (60447307)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsサルコペニア / マイオカイン / 自己抗体 / 筋衛星細胞 / 骨格筋 / 高齢者
Outline of Research at the Start

本研究の目的はR3hdmlを将来、サルコペニアの新たな治療に結び付けるべく ① 老化モデルマウスや筋萎縮モデルマウスに対するR3hdmlによる治療介入効果とそのメカニズム解析、 ② R3hdmlを実臨床に結びつけるべく、血液中R3hdml濃度を測定しその臨床的意義を明らかにすることである。超高齢社会を迎えている今、健康長寿延伸のためにもサルコペニアのメカニズムの解明と治療法の確立は喫緊の課題である。R3hdml研究を通じて、サルコペニアや筋萎縮で悩む患者の福音としたい。

Outline of Final Research Achievements

Age-related sarcopenia is a risk factor that hinders healthy longevity. Sarcopenia is associated with age-related declining in skeletal muscle regenerative capacity that substantially impairs daily lifestyle activities in the elderly. The proliferation and differentiation of muscle satellite cells are critical for skeletal muscle regeneration. We discovered a new protein called R3h domain containing-like (R3hdml), which is secreted by satellite cells and promotes the proliferation and differentiation of muscle satellite cells. In this study, autoantibodies that inhibit R3hdml action were found to be more prevalent in patients with diabetes, dyslipidemia, fatty liver, obesity, and chronic kidney disease. Inhibiting R3hdml's physiological action may promote sarcopenia through lifestyle-related diseases or by inhibiting the proliferation and differentiation of muscle satellite cells.

Academic Significance and Societal Importance of the Research Achievements

昨年度はR3hdmlに対する自己抗体が慢性腎臓病患者で増加していることを明らかにした。R3hdmlはTGFβ-p38MAPK経路を抑制し、ポドサイトのアポトーシスを抑制する(J Mol Med (Berl). 2021)。今年度の成果によりR3hdml抗体は糖尿病をはじめとした様々な生活習慣病で上昇していることを明らかにした。この上昇したR3hdml抗体は生活習慣病を通じて、もしくは直接、筋衛星細胞の増殖・分化阻害することでサルコペニアを助長する可能性がある。今後、R3hdml抗体に対する介入をすることで、将来のサルコペニア予防のための新たな治療法開発につながる可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (22 results)

All 2023 2022 2021 2020

All Journal Article (22 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 22 results,  Open Access: 19 results)

  • [Journal Article] Association of high proprotein convertase subtilisin/kexin type 9 antibody level with poor prognosis in patients with diabetes: a prospective study2023

    • Author(s)
      Yamagata Hiroki、Hayashi Aiko、Yoshida Yoich、Koshizaka Masaya、Onishi Shunichiro、Yoshida Tomohiko、Hiwasa Takaki、Takemoto Minoru
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 5391-5391

    • DOI

      10.1038/s41598-023-32644-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of atherosclerosis-associated serum antibodies against colony-stimulating factor 2 in predicting the onset of acute ischemic stroke and prognosis of colorectal cancer2023

    • Author(s)
      Li SY, Yoshida Y, Kubota M, 他10名, Ohno M, Nishi E, Kitamura K, Kamitsukasa I, Takizawa H, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Iwase K, Shimada H, Iwadate Y, Hiwasa T.
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 10 Pages: 1-19

    • DOI

      10.3389/fcvm.2023.1042272

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Case of Werner syndrome with significant improvement of refractory skin ulcer despite fibroblast cellular senescence2023

    • Author(s)
      Kinoshita Daisuke、Kato Hisaya、Kaneko Hiyori、Ishikawa Takahiro、Teramoto Naoya、Tsukagoshi Ayano、Maeda Yukari、Minamizuka Takuya、Hayashi Aiko、Shoji Mayumi、Sawada Daisuke、Funayama Shinichiro、Koshizaka Masaya、Ogata Hideyuki、Kubota Yoshitaka、Mitsukawa Nobuyuki、Takemoto Minoru、Yokote Koutaro、Maezawa Yoshiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 23 Issue: 3 Pages: 239-241

    • DOI

      10.1111/ggi.14546

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rothmund‐Thomson syndrome investigated by two nationwide surveys in Japan2022

    • Author(s)
      Kaneko Hideo、Takemoto Minoru、Murakami Hiroaki、Ihara Kenji、Kosaki Rika、Motegi Sei‐ichiro、Taniguchi Akira、Matsuo Muneaki、Yamazaki Naoya、Nishigori Chikako、Takita Junko、Koshizaka Masaya、Maezawa Yoshiro、Yokote Koutaro
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15120

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases2022

    • Author(s)
      Miller Danny E.、Lee Lin、Galey Miranda、Kandhaya-Pillai Renuka、Tischkowitz Marc、Amalnath Deepak、Vithlani Avadh、Yokote Koutaro、Kato Hisaya、Maezawa Yoshiro、Takada-Watanabe Aki、Takemoto Minoru、Martin George M.、Eichler Evan E.、Hisama Fuki M.、Oshima Junko
    • Journal Title

      Journal of Medical Genetics

      Volume: 59 Issue: 11 Pages: 1087-1094

    • DOI

      10.1136/jmedgenet-2022-108485

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency2022

    • Author(s)
      Kato Hisaya、Ogawa Seishi, et al.
    • Journal Title

      Experimental Hematology

      Volume: 109 Pages: 11-17

    • DOI

      10.1016/j.exphem.2022.02.005

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane2021

    • Author(s)
      Ishikawa Takahiro、Takemoto Minoru、Akimoto Yoshihiro、Takada-Watanabe Aki、Yan Kunimasa、Sakamoto Kenichi、Maezawa Yoshiro、Suguro Miyuki、He Liqun、Tryggvason Karl、Betsholtz Christer、Yokote Koutaro
    • Journal Title

      Journal of Molecular Medicine

      Volume: 6 Issue: 6 Pages: 859-876

    • DOI

      10.1007/s00109-021-02050-w

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan2020

    • Author(s)
      Koshizaka M, Maezawa Y, Maeda Y, Shoji M, Kato H, Kaneko H, Ishikawa T, Kinoshita D, Kobayashi K, Kawashima J, Sekiguchi A, Motegi SI, Nakagami H, Yamada Y, Tsukamoto S, Taniguchi A, Sugimoto K, Shoda Y, Hashimoto K, Yoshimura T, Suzuki D, Kuzuya M, Takemoto M, Yokote K.
    • Journal Title

      Aging

      Volume: 12 Issue: 24 Pages: 24940-24956

    • DOI

      10.18632/aging.202441

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020 8. Calcification in tendons associated with Werner syndrome2020

    • Author(s)
      Taniguchi Akira、Tanaka Yasuhito、Takemoto Minoru、Kubota Yoshitaka、Taniguchi Toshibumi、Motegi Sei‐ichiro、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Tsukamoto Kazuhisa、Mori Seijiro、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 163

    • DOI

      10.1111/ggi.14084

    • URL

      https://pure.teikyo.jp/en/publications/5501fea4-c12a-4b8f-8396-bd739cd7d2e4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020 1. Dyslipidemia and fatty liver associated with Werner syndrome2020

    • Author(s)
      Tsukamoto Kazuhisa、Takemoto Minoru、Kubota Yoshitaka、Taniguchi Toshibumi、Motegi Sei‐ichiro、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Mori Seijiro、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 133

    • DOI

      10.1111/ggi.14095

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020. 6. Skin ulcers associated with Werner syndrome: Prevention and non-surgical and surgical treatment2020

    • Author(s)
      Kubota Yoshitaka、Takemoto Minoru、Taniguchi Toshibumi、Motegi Sei‐ichiro、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Mori Seijiro、Tsukamoto Kazuhisa、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 153

    • DOI

      10.1111/ggi.14096

    • URL

      https://pure.teikyo.jp/en/publications/11c31ff1-2b8f-4df3-837a-a43c2d68c1c4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome2020

    • Author(s)
      Takemoto Minoru、Kubota Yoshitaka、Taniguchi Toshibumi、Motegi Sei‐ichiro、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Tsukamoto Kazuhisa、Mori Seijiro、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 142

    • DOI

      10.1111/ggi.14083

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome2020

    • Author(s)
      Kuzuya Masafumi、Takemoto Minoru、Kubota Yoshitaka、Taniguchi Toshibumi、Motegi Sei‐Ichiro、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Mori Seijiro、Tsukamoto Kazuhisa、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 139

    • DOI

      10.1111/ggi.14076

    • URL

      https://pure.teikyo.jp/en/publications/f221c4cb-c9d3-45c0-a8e6-c55385a4662f

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020. 4. Osteoporosis associated with Werner syndrome2020

    • Author(s)
      Mori Seijiro、Takemoto Minoru、Kubota Yoshitaka、Taniguchi Toshibumi、Motegi Sei‐ichiro、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Tsukamoto Kazuhisa、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 146

    • DOI

      10.1111/ggi.14078

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020. 7. Skin ulcer associated with Werner syndrome: Dermatological treatment2020

    • Author(s)
      Motegi Sei‐ichiro、Takemoto Minoru、Taniguchi Toshibumi、Kubota Yoshitaka、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Mori Seijiro、Tsukamoto Kazuhisa、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 160

    • DOI

      10.1111/ggi.14077

    • URL

      https://pure.teikyo.jp/en/publications/3fca93ca-341a-46ac-93d7-bacd617fdcab

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management guideline for Werner syndrome 2020. 5. Infection associated with Werner syndrome2020

    • Author(s)
      Taniguchi Toshibumi、Takemoto Minoru、Kubota Yoshitaka、Motegi Sei‐ichiro、Taniguchi Akira、Nakagami Hironori、Maezawa Yoshiro、Koshizaka Masaya、Kato Hisaya、Mori Seijiro、Tsukamoto Kazuhisa、Kuzuya Masafumi、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 150

    • DOI

      10.1111/ggi.14073

    • URL

      https://pure.teikyo.jp/en/publications/39f8fcd1-ef0b-465b-b8db-f6103de329b0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preface to Management guideline for Werner syndrome 20202020

    • Author(s)
      Takemoto Minoru、Yokote Koutaro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 131-132

    • DOI

      10.1111/ggi.14074

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Visceral Fat Reduction by Ipragliflozin and Metformin in Elderly Type 2 Diabetes Patients: Sub-Analysis of a Randomized-Controlled Study2020

    • Author(s)
      Koshizaka Masaya、Ishikawa Ko、Ishibashi Ryoichi、Takahashi Sho、Sakamoto Kenichi、Yokoh Hidetaka、Baba Yusuke、Ide Shintaro、Ide Kana、Ishikawa Takahiro、Onishi Shunichiro、Kobayashi Kazuki、Takemoto Minoru、Horikoshi Takuro、Shimofusa Ryota、Maezawa Yoshiro、Yokote Koutaro
    • Journal Title

      Diabetes Therapy

      Volume: 12 Issue: 1 Pages: 183-196

    • DOI

      10.1007/s13300-020-00949-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between serum anti-ASXL2 antibody levels and acute aschemic stroke, acute myocardial infarction, diabetes mellitus, chronic kidney disease and digestive organ cancer, and their possible association with atherosclerosis and hypertension.2020

    • Author(s)
      Li SY, Yoshida Y, Kobayashi E, Adachi A, Iwadate Y, et al.
    • Journal Title

      Int J Mol Med

      Volume: 46 Pages: 1274-1288

    • DOI

      10.3892/ijmm.2020.4690

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum anti-LRPAP 1 is a common biomarker for digestive organ cancers and atherosclerotic diseases2020

    • Author(s)
      Sumazaki M, Shimada H, Ito M, Shiratori F, Iwadate Y, et al.
    • Journal Title

      Cancer Sci

      Volume: 111 Issue: 12 Pages: 4453-4464

    • DOI

      10.1111/cas.14652

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elevated levels of autoantibodies against DNAJC2 in sera of patients with atherosclerotic diseases2020

    • Author(s)
      Yoshida Y, Zhang XM, Wang H, Machida T, Iwadate Y, et al.
    • Journal Title

      Heliyon

      Volume: 6 Issue: 8 Pages: e04661-e04661

    • DOI

      10.1016/j.heliyon.2020.e04661

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type?2 diabetes mellitus: Subanalysis of a prospective, randomized, controlled study (PRIME‐V study)2020

    • Author(s)
      Koshizaka M, Ishikawa K, Ishibashi R, Maezawa Y, Sakamoto K, Uchida D et al.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 12 Issue: 2 Pages: 200-206

    • DOI

      10.1111/jdi.13340

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi