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The method for evaluation of COPD using morphological/functional image fusion imaging in the same spatiotemporal quantitative image.

Research Project

Project/Area Number 20K08025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionYamaguchi University

Principal Investigator

Asami Maki  山口大学, 医学部附属病院, 講師 (60808187)

Co-Investigator(Kenkyū-buntansha) 松永 和人  山口大学, 大学院医学系研究科, 教授 (20347602)
平野 綱彦  山口大学, 医学部附属病院, 准教授 (00382333)
椎木 健裕  山口大学, 医学部附属病院, 講師 (30610456)
平野 靖  山口大学, 医学部附属病院, 准教授 (90324459)
間普 真吾  山口大学, 大学院創成科学研究科, 教授 (70434321)
原田 美沙  山口大学, 医学部附属病院, 診療助教(4日/週) (70894799)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsCOPD / 気道炎症 / FDGーPET / PRM / 機能的微小気道病変 / PRM-CT / FDG-PET / 気流制限 / フェノタイプ / ACO / 末梢気道炎症 / PRM-CT法 / PET
Outline of Research at the Start

COPD(慢性閉塞性肺疾患)は、たばこ煙などの有害粒子が肺の炎症を誘発し、その結果正常な肺組織構造が破壊され、呼吸困難などの症状をきたすとされてきた。しかし近年では幼少期に気道や肺の重篤な障害を受けることで成人期の肺の発育不全をもたらしCOPDに至ることが知られており、その発症や進展には炎症性だけでなく、非炎症性機転も存在するという概念が提唱されている。
本システムでCOPDにおける気道・肺の炎症/非炎症と構造変化の関係を明らかにすることで、病因に基づくフェノタイプ分類が可能となり、新たな診断基準の提案が可能となることが期待される。

Outline of Final Research Achievements

The PRM-CT and (FDG)-PET were used as a method to evaluate the relationship between peripheral airway structure, degree of airway inflammation, and clinical symptoms, and their images were fused and analyzed in the same time and space. 21 cases were analyzed, all of which were lung cancer cases, and the cancerous areas were removed by trimming. Based on the voxel-by-voxel CT values, specific gravity was measured for each pixel, and the SUV of PET was corrected (normalized). The mean value of normal lung in each case was set as 1, and fSAD and emphysema were viewed as their respective ratios. fSAD mean/normal lung mean showed no correlation with parameters such as PS, CAT score, number of smokers, BMI, %FVC, FEV1%, %FEV1, %DLco and FeNO.

Academic Significance and Societal Importance of the Research Achievements

たばこ煙などの有害粒子により、気道の炎症が起こり、その結果正常な肺組織構造が破壊され、気腫性病変や末梢気道の線維化によって、肺の静的(安静時)、動的(労作時)過膨張や進行性の気流制限に至り、患者は労作時呼吸困難などの症状を来すとされている。本研究ではPET-CTを撮影した症例において吸気呼気CTで作成したPRM画像で正常肺、気腫肺、機能的微小気道病変の領域に分けた部位についてそれぞれFDG集積を評価したが、FDG集積の平均値ではそれぞれ差は見られなかった。症例ごとに正常肺、気腫、fSAD領域でFDG集積をヒストグラムで示し、各種臨床パラメーターと関連があるか解析予定である。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (38 results)

All 2021 2020

All Journal Article (16 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 16 results,  Open Access: 13 results) Presentation (20 results) (of which Int'l Joint Research: 3 results) Book (2 results)

  • [Journal Article] What are key symptoms to be captured for preventing a physician's underestimation of asthma control?2021

    • Author(s)
      Chikumoto A, Matsunaga K, Oishi K, Hamada K, Yamaji Y, Hirano T
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 9 Pages: 564-566

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese Respiratory Society Assembly on Pulmonary Physiology: An official JRS statement: The principles of fractional exhaled nitric oxide (FeNO) measurement and interpretation of the results in clinical practice.2021

    • Author(s)
      Matsunaga K, Kuwahira I, Hanaoka M, Saito J, Tsuburai T, Fukunaga K, Matsumoto H, Sugiura H, Ichinose M
    • Journal Title

      Respiratory Investigation

      Volume: 59 Pages: 34-52

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abundant TNF-LIGHT expression in the airways of patients with asthma with persistent airflow limitation: Association with nitrative and inflammatory profiles.2021

    • Author(s)
      Hirano T, Matsunaga K, Oishi K, Doi K, Harada M, Suizu J, Murakawa K, Chikumoto A, Ohteru Y, Matsuda K, Uehara S, Hamada K, Ohata S, Murata Y, Yamaji Y, Asami-Noyama M, Edakuni N
    • Journal Title

      Respiratory Investigation

      Volume: 59 Pages: 651-660

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease2021

    • Author(s)
      Takahashi S, Hirano T, Yasuda K, Donishi T, Suga K, Doi K, Oishi K, Ohata S, Murata Y, Yamaji Y, Asami-Noyama M, Edakuni N and Matsunaga K
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 9 Pages: 1103-1103

    • DOI

      10.3390/biomedicines9091103

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of Discontinuing Biologics in Severe Asthma: An Algorithmic Approach.2021

    • Author(s)
      Hamada K, Oishi K, Murata Y, Hirano T, Matsunaga K
    • Journal Title

      Journal of Asthma and Allergy.

      Volume: 7 Pages: 1463-1471

    • DOI

      10.2147/jaa.s340684

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An official JRS statement: The principles of fractional exhaled nitric oxide (FeNO) measurement and interpretation of the results in clinical practice2021

    • Author(s)
      Matsunaga Kazuto、Kuwahira Ichiro、Hanaoka Masayuki、Saito Junpei、Tsuburai Takahiro、Fukunaga Koichi、Matsumoto Hisako、Sugiura Hisatoshi、Ichinose Masakazu
    • Journal Title

      Respiratory Investigation

      Volume: 59 Issue: 1 Pages: 34-52

    • DOI

      10.1016/j.resinv.2020.05.006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence, disease burden, and treatment reality of patients with severe, uncontrolled asthma in Japan2020

    • Author(s)
      Nagase Hiroyuki、Adachi Mitsuru、Matsunaga Kazuto、Yoshida Atsushi、Okoba Tomoko、Hayashi Nobuya、Emoto Kahaku、Tohda Yuji
    • Journal Title

      Allergology International

      Volume: 69 Issue: 1 Pages: 53-60

    • DOI

      10.1016/j.alit.2019.06.003

    • NAID

      130007788687

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of sinus surgery on type 2 airway and systemic inflammation in asthma2020

    • Author(s)
      Hamada Kazuki、Oishi Keiji、Chikumoto Ayumi、Murakawa Keita、Ohteru Yuichi、Matsuda Kazuki、Uehara Sho、Suetake Ryo、Ohata Shuichiro、Murata Yoriyuki、Yamaji Yoshikazu、Asami-Noyama Maki、Ito Kosuke、Edakuni Nobutaka、Hirano Tsunahiko、Matsunaga Kazuto
    • Journal Title

      Journal of Asthma

      Volume: Epub ahead of print Issue: 6 Pages: 1-9

    • DOI

      10.1080/02770903.2020.1729380

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of type2 biomarkers for response in COPD2020

    • Author(s)
      Yamaji Yoshikazu、Oishi Keiji、Hamada Kazuki、Ohteru Yuichi、Chikumoto Ayumi、Murakawa Keita、Matsuda Kazuki、Suetake Ryo、Murata Yoriyuki、Ito Kosuke、Asami-Noyama Maki、Edakuni Nobutaka、Hirano Tsunahiko、Matsunaga Kazuto
    • Journal Title

      Journal of Breath Research

      Volume: 14 Issue: 2 Pages: 026007-026007

    • DOI

      10.1088/1752-7163/ab71a4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A voxel image‐based pulmonary airflow simulation method with an automatic detection algorithm for airway outlets2020

    • Author(s)
      Jiang Fei、Hirano Tsunahiko、Ohgi Junji、Chen Xian
    • Journal Title

      International Journal for Numerical Methods in Biomedical Engineering

      Volume: 36 Issue: 3 Pages: 1-16

    • DOI

      10.1002/cnm.3305

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dupilumab: Basic aspects and applications to allergic diseases2020

    • Author(s)
      Matsunaga Kazuto、Katoh Norito、Fujieda Shigeharu、Izuhara Kenji、Oishi Keiji
    • Journal Title

      Allergology International

      Volume: 69 Issue: 2 Pages: 187-196

    • DOI

      10.1016/j.alit.2020.01.002

    • NAID

      130007832970

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of low-dosage systemic corticosteroid use with disease burden in asthma2020

    • Author(s)
      Matsunaga Kazuto、Adachi Mitsuru、Nagase Hiroyuki、Okoba Tomoko、Hayashi Nobuya、Tohda Yuji
    • Journal Title

      npj Primary Care Respiratory Medicine

      Volume: 30 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41533-020-00192-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD2020

    • Author(s)
      Tsunahiko Hirano, Keiko Doi, Kazuto Matsunaga, Tomoyuki Kakugawa et al.
    • Journal Title

      Journal of Clinical Medecine

      Volume: 9(9) Issue: 9 Pages: 2737-2737

    • DOI

      10.3390/jcm9092737

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Type2 Inflammatory Biomarkers in Chronic Obstructive Pulmonary Disease2020

    • Author(s)
      Oishi Keiji、Matsunaga Kazuto、Shirai Toshihiro、Hirai Keita、Gon Yasuhiro
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 8 Pages: 2670-2670

    • DOI

      10.3390/jcm9082670

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comorbid Conditions in Chronic Obstructive Pulmonary Disease: Potential Therapeutic Targets for Unmet Needs2020

    • Author(s)
      Matsunaga Kazuto、Harada Misa、Suizu Junki、Oishi Keiji、Asami-Noyama Maki、Hirano Tsunahiko
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 10 Pages: 3078-3078

    • DOI

      10.3390/jcm9103078

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A New Dyspnea Evaluation System Focusing on Patients’ Perceptions of Dyspnea and Their Living Disabilities: The Linkage between COPD and Frailty2020

    • Author(s)
      Oishi Keiji、Matsunaga Kazuto、Harada Misa、Suizu Junki、Murakawa Keita、Chikumoto Ayumi、Ohteru Yuichi、Matsuda Kazuki、Uehara Sho、Hamada Kazuki、Ohata Shuichiro、Murata Yoriyuki、Yamaji Yoshikazu、Asami-Noyama Maki、Edakuni Nobutaka、Kakugawa Tomoyuki、Hirano Tsunahiko
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 11 Pages: 3580-3580

    • DOI

      10.3390/jcm9113580

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Treatment of severe asthma with consideration of airflow limitation, symptoms, and exacerbations2021

    • Author(s)
      Matsunaga K
    • Organizer
      The 25th Congress of the Asian Pacific Society of Respirology (ASPR2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Airway obstruction in asthma2021

    • Author(s)
      Matsunaga K
    • Organizer
      The 25th Congress of the Asian Pacific Society of Respirology (ASPR2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiscale modeling for pulmonary airflow simulation2021

    • Author(s)
      Jiang F, Chen X, Hirano T, Matsunaga K, Ohgi J
    • Organizer
      International Conference on Computational Methods2021 (ICCM2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prediction of progression of airflow limitation in asthma using machine learning approach.2021

    • Author(s)
      5.濱田和希, 安部武士, 早野崇英, 中津井雅彦, 村田順之, 大石景士, 平野綱彦, 浅井義之, 松永和人
    • Organizer
      第30回国際喘息学会日本・北アジア部会.
    • Related Report
      2021 Research-status Report
  • [Presentation] Significance of brain network on physical activity among obstructive lung disease.2020

    • Author(s)
      Hirano T, Donishi T, Takahashi S, Suga K, Doi K, Tsukamoto T, Murakawa K, Chikumoto A, Ohteru Y, Matsuda K, Hamada K, Suetake R, Murata Y, Oishi K, Yamaji Y, Asami-Noyama M, Edakuni N, Kakugawa T, Matsunaga K
    • Organizer
      European Respiratory Society international congress 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Exploring factors related to physical inactivity in asthma and COPD overlap (ACO).2020

    • Author(s)
      Hirano T, Doi K, Murakawa K, Chikumoto A, Ohteru Y, Matsuda K, Hamada K, Suetake R, Murata Y, Oishi K, Yamaji Y, Asami-Noyama M, Edakuni N, Kakugawa T, Matsunaga K
    • Organizer
      European Respiratory Society international congress 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Association between lung dysfunction and extra-pulmonary factors in young people.2020

    • Author(s)
      Doi K, Hirano T, Murakawa K, Chikumoto A, Ohteru Y, Matsuda K, Hamada K, Suetake R, Murata Y, Oishi K, Yamaji Y, Asami-Noyama M, Edakuni N, Kakugawa T, Matsunaga K
    • Organizer
      European Respiratory Society international congress 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Symptom assessment for preventing physician’s underestimation of asthma control.2020

    • Author(s)
      Chikumoto A, Matsunaga K, Hamada K, Oishi K, Yano M, Yamaji Y, Hirano T
    • Organizer
      European Respiratory Society international congress 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Significance of Growth Differentiation Factor 15 (GDF15) in Relationship Between Physical Inactivity and Cognitive Impairment in COPD.2020

    • Author(s)
      Hirano T, Takahashi S, Donishi T, Yasuda K, Suga K, Mimura Y, Doi K, Murakawa K, Chikumoto A, Ohteru Y, Matsuda K, Murata Y, Hamada K, Suetake R, Oishi K, Yamaji Y, Asami M, Edakuni N, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] The Role of Inflammatory Mediator Profiles on Development of Airway Remodeling in Stable Asthma.2020

    • Author(s)
      Hirano T, Doi K, Chikumoto A, Murakawa K, Ohteru Y, Matsuda K, Hamada K, Suetake R, Murata Y, Oishi Y, Yamaji Y, Asami M, Edakuni N, Kakukawa T, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Factors Associated with Frequent Asthma Exacerbations in Clinical Setting.2020

    • Author(s)
      Asami M, Hirano T, Oishi K, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Biomarker-Based Detection of Type-2 Inflammation in COPD Patients.2020

    • Author(s)
      Oishi K, Hirano T, Chikumoto A, Ohteru Y, Murakawa K, Matsuda K, Hamada K, Suetake R, Yamaji Y, Murata Y, Asami-Noyama M, Edakuni N, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Airway TNF-LIGHT expression and associated molecular inflammatory profiles in asthma patients with persistent airflow limitation.2020

    • Author(s)
      Hirano T
    • Organizer
      APSR Assembly Virtual Meeting, virtual
    • Related Report
      2020 Research-status Report
  • [Presentation] COPDの身体活非活動と認知機能障害の連関における脳白質微細構造障害の意義.2020

    • Author(s)
      平野綱彦, 高橋隼, 堂西倫弘, 安田香澄, 菅一能, 土居恵子, 筑本愛祐美, 大輝祐一, 村川慶多, 松田和樹, 濱田和希, 末竹諒, 村田順之, 大石景士, 山路義和, 浅見麻紀, 枝國信貴, 角川智之, 松永和人
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 肺イメージングバイオマーカーを用いたCOPDにおける末梢気道病変と肺血流の関連についての検討2020

    • Author(s)
      濱田和希, 大石景士, 岡田宗正, 椎木健裕, 平野綱彦, 原田佳明, 大輝祐一, 筑本愛祐美, 村川慶多, 松田和樹, 末竹諒, 村田順之, 山路義和, 浅見麻紀, 枝國信貴, 國弘佳枝, 松永和人
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 日常臨床における喘息増悪関連因子の検討-SEACON surveyより-2020

    • Author(s)
      浅見麻紀, 平野綱彦, 大輝祐一, 筑本愛祐美, 村川慶多, 松田和樹, 濱田和希, 末竹諒, 山路義和, 村田順之, 大石景士, 枝國信貴, 松永和人
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 医師-患者間の症状評価不一致に関連する喘息患者の症状の検討2020

    • Author(s)
      筑本愛祐美, 濱田和希, 大石景士, 山路義和, 平野綱彦, 大輝祐一, 村川慶多, 松田和樹, 末竹諒, 村田順之, 浅見麻紀, 枝國信貴, 角川智之, 松永和人
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] COPDにおけるT2バイオマーカー発言とステロイド反応性2020

    • Author(s)
      山路義和, 大石景士, 濱田和希, 大輝祐一, 筑本愛祐美, 村川慶多, 松田和樹, 末竹諒, 村田順之, 浅見麻紀, 枝國信貴, 平野綱彦, 角川智之, 松永和人
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 気管支喘息におけるParametric Response Mappingの検討2020

    • Author(s)
      大石景士, 平野綱彦, 濱田和希, 椎木健裕, 松田和樹, 末竹諒, 村田順之, 山路義和, 浅見麻紀, 枝国信貴, 松永和人
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] コントロール不良因子とbiological signatureを組み合わせて弁別した重症喘息の臨床特性2020

    • Author(s)
      大石景士, 平野綱彦, 水津純輝, 原田美沙, 村川慶多, 大輝祐一, 松田和樹, 上原翔, 濱田和希, 大畑秀一郎, 山路義和, 村田順之, 浅見麻紀, 枝国信貴, 角川智之, 松永和人
    • Organizer
      第1回日本喘息学会学術大会
    • Related Report
      2020 Research-status Report
  • [Book] 在宅ケアのためのエッセンス2020

    • Author(s)
      大草 知子、松永 和人、吉田 俊子、亀井 智子、濱田 和希、酒木 保、若林 律子、猪飼 やす子、岡本 香津美、上田 博臣、中西 美貴、名尾 朋子、柿並 洋子、李 民純、東雲 紀子、菅原 亜希
    • Total Pages
      160
    • Publisher
      エム・イー・タイムス
    • ISBN
      9784943920229
    • Related Report
      2020 Research-status Report
  • [Book] 新 呼吸器専門医テキスト(改訂第2版)2020

    • Author(s)
      平野 綱彦
    • Total Pages
      726
    • Publisher
      南江堂
    • ISBN
      9784524226894
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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