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Development of novel risk stratification index in hypertensive patients: endothelial function and microRNA

Research Project

Project/Area Number 20K08431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Hirooka Yoshitaka  国際医療福祉大学, 福岡保健医療学部, 教授 (90284497)

Co-Investigator(Kenkyū-buntansha) 梅村 創  国際医療福祉大学, 臨床医学研究センター, 教授 (90136432)
安田 聖子  国際医療福祉大学, 福岡保健医療学部, 講師 (70747097)
篠原 啓介  九州大学, 大学病院, 医員 (30784491)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords高血圧 / 血管内皮機能 / 心不全 / マイクロRNA / 神経体液性因子
Outline of Research at the Start

近年、高血圧におけるマイクロRNA(miRNAs)の役割が注目され、内皮細胞への影響や炎症による血管内皮機能障害との関連が示唆されている。しかし、高血圧患者で内皮機能異常とmiRNAs変化を評価した研究はない。本研究では高血圧患者においてFMD検査による血管内皮機能低下レベルと血中miRNAs項目・変動を調べることにより、血圧管理・治療状況、病態の特徴や臓器障害との関係を明らかにする。FMD値による区分と探索したmiRNAsの種類を組み合わせ、新たなリスク層別化の指標を提案することができれば、より精度の高い個別治療につながると考えられる。

Outline of Final Research Achievements

In the present study, we investigated vascular endothelial function and circulating microRNA (miRNA) in untreated patients with hypertension as novel risk stratification.
Flow-mediated vasodilation (FMD) examination was performed in visited patients with untreated hypertension. Atherosclerotic and heart failure index were also examined in these patients. In patients with hypertension, endothelial function was attenuated corelated with aging, male, blood pressure levels, and cardiac diastolic function. In addition, we measured miRNA21, miRNA126, and miRNA155 and found that there was partially correlation with endothelial function and some other index. These results suggest that endothelial function and miRNAs changes contribute to pathophysiology such as cardiac diastolic function and glucose metabolism in hypertensive patients.

Academic Significance and Societal Importance of the Research Achievements

高血圧患者における血圧管理・治療は多くの有効な薬剤が開発されているにも関わらず未だ不十分であり、超高齢化社会を迎え患者数・脳心血管病による死亡数は増加している。多くの高血圧患者は無症状であるがゆえに患者側、医師側の血圧管理の重要性に対する認識を高める指標が必要である。
そこで既に血管不全の検査として臨床検査として可能である内皮機能検査としてのFMDと新規血中バイオマーカーとして注目されているmiRNAの測定により病態との関連を示す候補を探索し得た。これらを組み合わせた新たなリスク層別化を行い医師・患者相互が認識し精度の高い個別化治療へ結びつけることが期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (23 results)

All 2023 2022 2021 2020 2019

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] A Retrospective Analysis of Risk Factors for Mortality during Hemodialysis at a General Hospital That Treats Comprehensive Diseases2023

    • Author(s)
      Kitajima Akira、Kishi Takuya、Yamanouchi Kohei、Hirooka Yoshitaka、Toda Shuji、Takamori Ayako、Fujimoto Kazuma、Kishi Chie、Tomiyoshi Yoshiyuki
    • Journal Title

      Internal Medicine

      Volume: 62 Issue: 8 Pages: 1117-1121

    • DOI

      10.2169/internalmedicine.0040-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-04-15
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of Awareness and Careful Follow-Up of Suspected IgG4-Related Periaortitis2023

    • Author(s)
      Nakashima Fumiaki、Watanabe Tsukasa、Tomiyoshi Yoshiyuki、Ejima Kazuhisa、Ootsuka Takateru、Nojiri Junichi、Fujimoto Kazuma、Hirooka Yoshitaka
    • Journal Title

      International Heart Journal

      Volume: 64 Issue: 1 Pages: 109-113

    • DOI

      10.1536/ihj.22-470

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2023-03-31
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age distribution and disease severity of COVID-19 patients continued to change in a time-dependent manner from May 2021 to April 2022 in the regional core hospital in Japan2023

    • Author(s)
      Kawaura Futoshi、Kishi Takuya、Yamamoto Tadashi、Nakayama Shiki、Goto Taku、Tsurusawa Reimi、Katagiri Toshio、Yamanouchi Kohei、Matsuo Ayako、Kobayashi-Watanabe Naomi、Imamura Tomohiro、Hirooka Yoshitaka、Takagi Kuniyasu、Umemura Tsukuru、Fujimoto Kazuma、Hayashi Shinichiro、Takamori Ayako
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 17 Issue: 1 Pages: 60-65

    • DOI

      10.5582/ddt.2022.01111

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2023-02-28
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient receptor potential vanilloid 1-expressing cardiac afferent nerves may contribute to cardiac hypertrophy in accompany with an increased expression of brain-derived neurotrophic factor within nucleus tractus solitarius in a pressure overload model2022

    • Author(s)
      Shibata Risa、Shinohara Keisuke、Ikeda Shota、Iyonaga Takeshi、Matsuura Taku、Kashihara Soichiro、Ito Koji、Kishi Takuya、Hirooka Yoshitaka、Tsutsui Hiroyuki
    • Journal Title

      Clinical and Experimental Hypertension

      Volume: 44 Issue: 3 Pages: 249-257

    • DOI

      10.1080/10641963.2022.2029470

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Effects of Physical Activity Intensity, Blood Pressure, and Body Fat Percentage on Vascular Endothelial Function in Male University Students2022

    • Author(s)
      濵地 望、岡 真一郎、森田 正治、廣岡 良隆
    • Journal Title

      Physical Therapy Japan

      Volume: 49 Issue: 2 Pages: 124-130

    • DOI

      10.15063/rigaku.12199

    • NAID

      130008161862

    • ISSN
      0289-3770, 2189-602X
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum High-Sensitivity C-Reactive Protein Levels and the Development of Atrial Fibrillation in a General Japanese Population ― The Hisayama Study ―2021

    • Author(s)
      Yoshikawa Tomoko、Hata Jun、Sakata Satoko、Nagata Takuya、Hirakawa Yoichiro、Hirooka Yoshitaka、Tsutsui Hiroyuki、Kitazono Takanari、Ninomiya Toshiharu
    • Journal Title

      Circulation Journal

      Volume: 85 Issue: 8 Pages: 1365-1372

    • DOI

      10.1253/circj.CJ-20-0751

    • NAID

      130008066717

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-07-21
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carpal tunnel syndrome as an early red-flag sign of ATTRwt amyloidosis2021

    • Author(s)
      Maeda-Ogata S, Tahara N, Bekki M, Tahara A, Sugiyama Y, Honda A, Igata S, Abe T, Ueda M, Ando Y, Hirooka Y, Fukumoto Y.
    • Journal Title

      J Nucl Cardiol

      Volume: ー Issue: 6 Pages: 3562-3563

    • DOI

      10.1007/s12350-021-02584-z

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationships between Vascular Endothelial Function and Physical Activity/Diastolic Blood Pressure in Male University Students2021

    • Author(s)
      HAMACHI Nozomi、OKA Shinichiro、MORITA Masaharu、HIROOKA Yoshitaka
    • Journal Title

      Rigakuryoho Kagaku

      Volume: 36 Issue: 2 Pages: 227-232

    • DOI

      10.1589/rika.36.227

    • NAID

      130008027770

    • ISSN
      1341-1667, 2434-2807
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sympathetic Activation in Hypertension: Importance of the Central Nervous System2020

    • Author(s)
      Hirooka Yoshitaka
    • Journal Title

      American Journal of Hypertension

      Volume: 33 Issue: 10 Pages: 914-926

    • DOI

      10.1093/ajh/hpaa074

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高血圧の成因2020

    • Author(s)
      廣岡 良隆
    • Journal Title

      日本臨牀

      Volume: 78 Pages: 197-203

    • Related Report
      2020 Research-status Report
  • [Journal Article] Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation2019

    • Author(s)
      Iyonaga Takeshi、Shinohara Keisuke、Mastuura Taku、Hirooka Yoshitaka、Tsutsui Hiroyuki
    • Journal Title

      Hypertension Research

      Volume: 43 Issue: 2 Pages: 99-110

    • DOI

      10.1038/s41440-019-0333-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of the sympathetic nervous system in hypertension: focused on the central nervous system.2022

    • Author(s)
      Yoshitaka Hirooka
    • Organizer
      International Society of Hypertension 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of the sympathetic nervous system in hypertension: focused on the central nervous system.2022

    • Author(s)
      Yoshitaka Hirooka
    • Organizer
      The 20th International SHR Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高血圧患者におけるmicroRNAと心不全関連指標との関連.2022

    • Author(s)
      西之園栞、安田 聖子、廣岡良隆
    • Organizer
      第44回日本高血圧学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高血圧患者におけるmiRNA-21と心不全指標との関連.2022

    • Author(s)
      西之園栞、安田 聖子、廣岡良隆
    • Organizer
      第26回 日本心不全学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 将来的な心不全バロメーターである血管内皮機能検査を実施した若年男性の特徴.2022

    • Author(s)
      濱地望,廣岡良隆
    • Organizer
      第26回 日本心不全学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 地域未治療高血圧患者における血管内皮機能からみた心不全予防の可能性.地域未治療高血圧患者における血管内皮機能からみた心不全予防の可能性.2021

    • Author(s)
      西之園 栞、安田 聖子、廣岡 良隆.
    • Organizer
      第25回 日本心不全学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 心不全バロメーターとしての血管内皮機能に対する身体活動要因の影響:若年健常男性での検討.2021

    • Author(s)
      濱地 望,岡 真一郎,森田 正治,廣岡 良隆.
    • Organizer
      第25回 日本心不全学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高血圧患者における血管内皮機能への影響因子:年齢・性別で区別した評価.2021

    • Author(s)
      西之園栞、安田聖子、廣岡 良隆.
    • Organizer
      第43回日本高血圧学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域未治療高血圧患者における内皮機能異常と心不全指標との関係に関する観察研究.2020

    • Author(s)
      西之園栞,廣岡 良隆
    • Organizer
      第24回 日本心不全学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 高血圧患者における新規リスク層別化開発:内皮機能・マイクロRNA探索.2020

    • Author(s)
      廣岡 良隆、安田聖子、梅村創
    • Organizer
      第10回 国際医療福祉大学学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 循環細胞外小胞のアレイ解析の疾患バイオマーカーへの応用.2020

    • Author(s)
      梅村創、高田勇吉、渋田樹、廣岡良隆
    • Organizer
      第10回 国際医療福祉大学学会学術大会
    • Related Report
      2020 Research-status Report
  • [Book] 腎疾患治療薬 update2021

    • Author(s)
      廣岡 良隆
    • Total Pages
      817
    • Publisher
      東京医学社
    • Related Report
      2021 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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