Elucidation of fibrosis in hypersensitivity pneumonitis: Antigen-presenting cells and gdT cells
| Project/Area Number |
20K08515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Miyazaki Yasunari 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30396999)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 過敏性肺炎 / 樹状細胞 / γδT細胞 / 線維化 / 抗原提示細胞 |
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| Outline of Research at the Start |
慢性過敏性肺炎は潜在性に肺が線維化する。慢性・線維化するタイプは国内推定２万人の患者が存在し、5年生存率は30～40%と極めて予後不良である。申請者は慢性過敏性肺炎患者ではTH1/TH2バランスの変化あること見いだした。しかしその肺線維症発症のメカニズムは未だ不明である。本研究では本症の免疫反応の変化が肺線維化を誘導することを明らかにし、予後不良因子である線維化抑制治療に応用可能な研究を目指して① 抗原の種類による樹状細胞の役割② 急性・慢性期におけるgdT 細胞の役割③ 肺線維症関連の樹状細胞・gdT細胞群の同定 の３つの研究を行う。
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| Outline of Final Research Achievements |
Hypersensitivity pneumonitis develops due to an allergic reaction caused by a chain of antigen-presenting cells and immune cells. In this study, we elucidated the roles of dendritic cells and γδT cells in fibrosis, which have not been elucidated in the chain process of allergic reactions. IL-17A-producing γδ T cells were found to increase in bird-associated hypersensitivity pneumonitis, but not in the farmer's lung model. ConventionalDC2 was predominantly increased in the anti-bird-associated hypersensitivity pneumonitis model, suggesting that it is related to immune linkage to Th17.
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| Academic Significance and Societal Importance of the Research Achievements |
過敏性肺炎は特定の抗原に対する免疫・アレルギー反応で発症する間質性肺炎である。このうち慢性過敏性肺炎は潜在性に肺が線維化する。慢性・線維化するタイプはの5年生存率は30〜40%と極めて予後不良である。本研究成果により特発性肺線維症にも共通する肺線維化のメカニズムが明らかになり、線維化をきたす間質性肺炎の治療の一助になると考える。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP®2021
Author(s)
Shirai T, Tanino Y, Nikaido T, Takaku Y, Hashimoto S, Taguchi Y, Baba T, Ogura T, Kataoka K, Nakayama M, Yamada Y, Matsushima S, Nakayama S, Miyazaki Y
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Journal Title
Allergology International
Volume: 70
Issue: 2
Pages: 208-214
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hypersensitivity pneumonitis.2020
Author(s)
Ulrich Costabel, Yasunari Miyazaki, Annie Pardo, Dirk Koschel, Francesco Bonella, Paolo Spagnolo, Josune Guzman, Christopher J Ryerson, Moises Selman
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Journal Title
Nature reviews. Disease primers
Volume: 6
Issue: 1
Pages: 65-65
DOI
Related Report
Peer Reviewed
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