Fundamental research to elucidate the role of gammadelta T cells in pulmonary fibrosis and therapeutic application

• Project/Area Number: 20K08543
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Nagasaki University
• Principal Investigator: Sakamoto Noriho 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30448493)
• Co-Investigator(Kenkyū-buntansha): 迎 寛 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80253821) ; 田中 義正 長崎大学, 先端創薬イノベーションセンター, 教授 (90280700)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: γδ型T細胞 / 肺線維症 / 気管支肺胞洗浄 / 肺線維芽細胞 / コラーゲン / γδT細胞

Outline of Research at the Start

特発性肺線維症は、原因不明の肺線維化を特徴とする難治性疾患である。その病態は不明な点が多く、完治させうる治療法も存在しないため、病態解明、新規治療の開発が急務となっている。γδ型T細胞は、自然免疫系のT細胞であり、感染防御や腫瘍細胞排除に働いていることが報告されているが、肺線維症との関連は不明な点が多い。本研究では、肺線維症とヒトγδ型T細胞との臨床的関連性を明らかにするとともに、ヒトγδ型T細胞が肺線維症に及ぼす影響や治療応用の可能性について細胞モデル、動物モデルを用いて明らかにすることを目的とする。

Outline of Final Research Achievements

The inhibitory effect of human γδ T cells, which are T cells with γδ-type T cell receptors and mainly involved in innate immunity, on lung fibrosis was examined in vitro. Expanded γδT cells suppressed type I collagen expression in lung fibroblasts by co-culture, but the suppressive effect was abolished by a non-contact cell-to-cell model. On the other hand, stimulation of γδ T cells with (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) suppressed collagen production in the non-contact model, and the suppressive effect was attenuated by anti-IFNγ antibody. Human γδ T cells inhibit collagen production by lung fibroblasts, suggesting that human γδ T cells may be a potential cell therapy for pulmonary fibrosis.

Academic Significance and Societal Importance of the Research Achievements

学術的意義としては、ヒトγδ型T細胞の肺線維化における役割を、研究分担者が独自開発したPTAを用いた培養系によって高純度かつ大量に培養されたヒトγδ型T細胞を用いて明らかにすることであり、ヒトγδ型T細胞の肺線維芽細胞に対するコラーゲン抑制作用は直接接触が主であるが、液性因子の関与も示唆され、ヒトγδ型T細胞が抗線維化効果をもつ可能性が示唆された。また本研究で達成した結果を基盤として、大量に培養されたヒトγδ型T細胞を肺線維症患者に投与する細胞治療の開発が視野に入り、難治で知られる肺線維症に対するヒトγδ型T細胞を用いた細胞療法という画期的な治療法の開発に繋がる社会的意義がある。

Research Products

• [Journal Article] Two Distinct Mechanisms Underlying γδ T Cell-Mediated Regulation of Collagen Type I in Lung Fibroblasts (2022)
  • Author(s): Okuno Daisuke、Sakamoto Noriho、Akiyama Yoshiko、Tokito Takatomo、Hara Atsuko、Kido Takashi、Ishimoto Hiroshi、Ishimatsu Yuji、Tagod Mohammed S. O.、Okamura Haruki、Tanaka Yoshimasa、Mukae Hiroshi
  • Journal Title: Cells Volume: 11 Issue: 18 Pages: 2816-2816
  • DOI: 10.3390/cells11182816
  • Peer Reviewed / Open Access
• [Journal Article] A comparative study of the sarcopenia screening in older patients with interstitial lung disease. (2022)
  • Author(s): Hanada M, Sakamoto N, Ishimoto H, Kido T, Miyamura T, Oikawa M, Nagura H, Takeuchi R, Kawazoe Y, Sato S, Hassan SA, Ishimatsu Y, Takahata H, Mukae H, Kozu R.
  • Journal Title: BMC Pulm Med. Volume: 25 Issue: 1 Pages: 45-45
  • DOI: 10.1186/s12890-022-01840-3
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of idiopathic interstitial pneumonias with anti-Ro52/tripartite motif-containing 21 antibodies (2022)
  • Author(s): Tahara Masahiro、Sakamoto Noriho、Satoh Minoru、Ishimoto Hiroshi、Yura Hirokazu、Yamasaki Kei、Kido Takashi、Fujino Yoshihisa、Hasegawa Tomoko、Tanaka Shin、Yatera Kazuhiro、Mukae Hiroshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 11122-11122
  • DOI: 10.1038/s41598-022-15321-4
  • Peer Reviewed / Open Access
• [Journal Article] Screening of Inhibitors Targeting Heat Shock Protein 47 Involved in the Development of Idiopathic Pulmonary Fibrosis (2021)
  • Author(s): Okuno Daisuke、Sakamoto Noriho、Tagod Mohammed S. O.、Akiyama Yoshiko、Moriyama Sakiko、Miyamura Takuto、Hara Atsuko、Kido Takashi、Ishimoto Hiroshi、Ishimatsu Yuji、Tanaka Takashi、Ishihara Jun、Takeda Kohsuke、Tanaka Yoshimasa、Mukae Hiroshi
  • Journal Title: ChemMedChem Volume: 16 Issue: 16 Pages: 2515-2523
  • DOI: 10.1002/cmdc.202100064
  • Peer Reviewed
• [Journal Article] Evaluation of QFT-Plus performance using blood samples stored at room temperature (2021)
  • Author(s): Fukushima K.、Akagi K.、Kondoh A.、Kubo T.、Ito Y.、Oda Y.、Nagihara Y.、Sakamoto N.、Mukae H.
  • Journal Title: The International Journal of Tuberculosis and Lung Disease Volume: 25 Issue: 11 Pages: 948-949
  • DOI: 10.5588/ijtld.21.0319
  • Peer Reviewed
• [Journal Article] Clinical evaluation of QuantiFERON-TB Gold Plus directly compared with QuantiFERON-TB Gold In-Tube and T-Spot.TB for active pulmonary tuberculosis in the elderly (2021)
  • Author(s): Fukushima Kiyoyasu、Kubo Toru、Akagi Kazumasa、Miyashita Ritsuko、Kondo Akira、Ehara Naomi、Takazono Takahiro、Sakamoto Noriho、Mukae Hiroshi
  • Journal Title: Journal of Infection and Chemotherapy Volume: 27 Issue: 12 Pages: 1716-1722
  • DOI: 10.1016/j.jiac.2021.08.016
  • Peer Reviewed
• [Journal Article] Infectious Pneumonia and Lower Airway Microorganisms in Patients with Rheumatoid Arthritis (2021)
  • Author(s): Ideguchi Shuhei、Yamamoto Kazuko、Tahara Masahiro、Koga Tomohiro、Ide Shotaro、Hirayama Tatsuro、Takazono Takahiro、Imamura Yoshifumi、Miyazaki Taiga、Sakamoto Noriho、Morimoto Shimpei、Izumikawa Koichi、Yanagihara Katsunori、Ashizawa Kazuto、Aoki Takatoshi、Kawakami Atsushi、Yatera Kazuhiro、Mukae Hiroshi
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 16 Pages: 3552-3552
  • DOI: 10.3390/jcm10163552
  • NAID: 120007172259
  • Peer Reviewed / Open Access
• [Journal Article] Combined detection of lymphocyte clonality and MALT1 translocations in bronchoalveolar lavage fluid for diagnosing pulmonary lymphomas (2021)
  • Author(s): Kido Takashi、Ishimoto Hiroshi、Ishii Hiroshi、Hara Kanako、Ozasa Mutsumi、Kawabata Hiroki、Kawanami Toshinori、Suzuki Yu、Yoshikawa Hiroki、Hara Atsuko、Sakamoto Noriho、Matsumoto Nobuhiro、Yoshii Chiharu、Fukuoka Junya、Fujita Masaki、Nakazato Masamitsu、Kadota Junichi、Mukae Hiroshi、Yatera Kazuhiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 23430-23430
  • DOI: 10.1038/s41598-021-02861-4
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Corticosteroid Administration within 7 Days of the Hospitalization for Influenza Pneumonia with Respiratory Failure: A Propensity Score Analysis Using a Nationwide Administrative Database (2021)
  • Author(s): Okuno Daisuke、Kido Takashi、Muramatsu Keiji、Tokutsu Kei、Moriyama Sakiko、Miyamura Takuto、Hara Atsuko、Ishimoto Hiroshi、Yamaguchi Hiroyuki、Miyazaki Taiga、Sakamoto Noriho、Obase Yasushi、Ishimatsu Yuji、Fujino Yoshihisa、Yatera Kazuhiro、Matsuda Shinya、Mukae Hiroshi
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 3 Pages: 494-494
  • DOI: 10.3390/jcm10030494
  • Peer Reviewed / Open Access
• [Journal Article] Recognition of Connective Tissue Disease-Related Interstitial Pneumonia Based on Histological Score-A Validation Study of an Online Diagnostic Decision Support Tool (2021)
  • Author(s): Ozasa Mutsumi、Zaizen Yoshiaki、Tabata Kazuhiro、Kataoka Kensuke、Sato Shuntaro、Bychkov Andrey、Sakamoto Noriho、Mukae Hiroshi、Kondoh Yasuhiro、Fukuoka Junya
  • Journal Title: Diagnostics Volume: 11 Issue: 8 Pages: 1359-1359
  • DOI: 10.3390/diagnostics11081359
  • NAID: 120007172267
  • Peer Reviewed
• [Journal Article] Efficacy and safety of nintedanib in Japanese patients with early-stage idiopathic pulmonary fibrosis: a study protocol for an observational study (2021)
  • Author(s): Sakamoto Noriho、Hamada Naoki、Okamoto Masaki、Tobino Kazunori、Ichiyasu Hidenori、Ishii Hiroshi、Ichikado Kazuya、Morimoto Shimpei、Hosogaya Naoki、Mukae Hiroshi
  • Journal Title: BMJ Open Volume: 11 Issue: 6 Pages: e047249-e047249
  • DOI: 10.1136/bmjopen-2020-047249
  • NAID: 120007172283
  • Peer Reviewed / Open Access
• [Journal Article] HLA-B54 is an independent risk factor for pneumonia in Japanese patients with interstitial lung disease: A multicenter retrospective cohort study (2021)
  • Author(s): Sakamoto Noriho、Ishimoto Hiroshi、Tahara Masahiro、Kido Takashi、Hara Atsuko、Miyamura Takuto、Okuno Daisuke、Tokito Takatomo、Yoshioka Sumako、Morimoto Shimpei、Takazono Takahiro、Yamamoto Kazuko、Yamaguchi Hiroyuki、Obase Yasushi、Ishimatsu Yuji、Yatera Kazuhiro、Mukae Hiroshi
  • Journal Title: Respiratory Medicine Volume: 188 Pages: 106612-106612
  • DOI: 10.1016/j.rmed.2021.106612
  • Peer Reviewed
• [Journal Article] Exposure to PM2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case?control study (2021)
  • Author(s): Tahara Masahiro、Fujino Yoshihisa、Yamasaki Kei、Oda Keishi、Kido Takashi、Sakamoto Noriho、Kawanami Toshinori、Kataoka Kensuke、Egashira Ryoko、Hashisako Mikiko、Suzuki Yuzo、Fujisawa Tomoyuki、Mukae Hiroshi、Suda Takafumi、Yatera Kazuhiro
  • Journal Title: Respiratory Research Volume: 22 Issue: 1 Pages: 80-80
  • DOI: 10.1186/s12931-021-01671-6
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of clarithromycin in patients with mild COVID-19 pneumonia not receiving oxygen administration: protocol for an exploratory, multicentre, open-label, randomised controlled trial (CAME COVID-19 study) (2021)
  • Author(s): Yamamoto Kazuko、Hosogaya Naoki、Sakamoto Noriho、Yoshida Haruo、Ishii Hiroshi、Yatera Kazuhiro、Izumikawa Koichi、Yanagihara Katsunori、Mukae Hiroshi
  • Journal Title: BMJ Open Volume: 11 Issue: 9 Pages: e053325-e053325
  • DOI: 10.1136/bmjopen-2021-053325
  • NAID: 120007175559
  • Peer Reviewed / Open Access
• [Journal Article] IL‐15 is a biomarker involved in the development of rapidly progressive interstitial lung disease complicated with polymyositis/dermatomyositis (2020)
  • Author(s): Shimizu T.、Koga T.、Furukawa K.、Horai Y.、Fujikawa K.、Okada A.、Okamoto M.、Endo Y.、Tsuji S.、Takatani A.、Umeda M.、Fukui S.、Sumiyoshi R.、Kawashiri S.‐y.、Iwamoto N.、Igawa T.、Ichinose K.、Tamai M.、Sakamoto N.、Nakamura H.、Origuchi T.、Mukae H.、Kuwana M.、Kawakami A.
  • Journal Title: Journal of Internal Medicine Volume: 289 Issue: 2 Pages: 206-220
  • DOI: 10.1111/joim.13154
  • Peer Reviewed
• [Journal Article] Human immunodeficiency virus-associated vacuolar encephalomyelopathy with granulomatous-lymphocytic interstitial lung disease improved after antiretroviral therapy: a case report (2020)
  • Author(s): Akagi Kazumasa、Yamamoto Kazuko、Umemura Asuka、Ide Shotaro、Hirayama Tatsuro、Takazono Takahiro、Imamura Yoshifumi、Miyazaki Taiga、Sakamoto Noriho、Shiraishi Hirokazu、Takahata Hideaki、Zaizen Yoshiaki、Fukuoka Junya、Morikawa Minoru、Ashizawa Kazuto、Teruya Katsuji、Izumikawa Koichi、Mukae Hiroshi
  • Journal Title: AIDS Research and Therapy Volume: 17 Issue: 1 Pages: 38-38
  • DOI: 10.1186/s12981-020-00295-y
  • NAID: 120006988123
  • Peer Reviewed
• [Journal Article] Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis. (2020)
  • Author(s): Shoichi Fukui, Shimpei Morimoto, Kunihiro Ichinose, Shota Nakashima, Hiroshi Ishimoto, Atsuko Hara, Tomoyuki Kakugawa, et al.
  • Journal Title: Sci Rep Volume: 10(1) Issue: 1 Pages: 9466-9466
  • DOI: 10.1038/s41598-020-66178-4
  • NAID: 120006988158
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of Anti-Cancer Drug-Induced Pneumonia in Lung Cancer Patients: Novel High-Resolution Computed Tomography Fibrosis Scoring. (2020)
  • Author(s): Hiroshi Gyotoku, Hiroyuki Yamaguchi, Hiroshi Ishimoto, Shuntaro Sato, Hirokazu Taniguchi, Hiroaki Senju, Tomoyuki Kakugawa, Katsumi Nakatomi, Noriho Sakamoto, Minoru Fukuda, Yasushi Obase, Hiroshi Soda, Kazuto Ashizawa, Hiroshi Mukae
  • Journal Title: J Clin Med Volume: 9(4) Issue: 4 Pages: 1045-1045
  • DOI: 10.3390/jcm9041045
  • Peer Reviewed / Open Access
• [Journal Article] Corticosteroids are associated with reduced skeletal muscle function in interstitial lung disease patients with mild dyspnea (2020)
  • Author(s): Masatoshi Hanada, Yuji Ishimatsu, Noriho Sakamoto, Hiroki Nagura, Masato Oikawa, Yosuke Morimoto, Shuntaro Sato, Hiroshi Mukae, Ryo Kozu
  • Journal Title: Respiratory Medicine Volume: 174 Pages: 106184-106184
  • DOI: 10.1016/j.rmed.2020.106184
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review (2020)
  • Author(s): Hayashi Fumiko、Kido Takashi、Sakamoto Noriho、Zaizen Yoshiaki、Ozasa Mutsumi、Yokoyama Mitsuru、Yura Hirokazu、Hara Atsuko、Ishimoto Hiroshi、Yamaguchi Hiroyuki、Miyazaki Taiga、Obase Yasushi、Ishimatsu Yuji、Eishi Yoshinobu、Fukuoka Junya、Mukae Hiroshi
  • Journal Title: Medicina Volume: 56 Issue: 11 Pages: 630-630
  • DOI: 10.3390/medicina56110630
  • Peer Reviewed
• [Journal Article] Thrombomodulin Alfa for Acute Exacerbation of Idiopathic Pulmonary Fibrosis. A Randomized, Double-Blind Placebo-controlled Trial (2020)
  • Author(s): Kondoh Y, Suda T, et al
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 201 Issue: 9 Pages: 1110-1119
  • DOI: 10.1164/rccm.201909-1818oc
  • Peer Reviewed
• [Journal Article] Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer (2020)
  • Author(s): Takuto Miyamura, Noriho Sakamoto, Kaori Ishida, Tomoyuki Kakugawa, Hirokazu Taniguchi , Yoshiko Akiyama, Daisuke Okuno, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Takeshi Nagayasu, Hiroshi Mukae
  • Journal Title: Respiratory Research Volume: 21(1) Issue: 1 Pages: 234-234
  • DOI: 10.1186/s12931-020-01490-1
  • Peer Reviewed / Open Access
• [Journal Article] Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro. (2020)
  • Author(s): Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Hirokazu Taniguchi, Yoshiko Akiyama, Daisuke Okuno, Sakiko Moriyama, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Yoshimasa Tanaka, Hiroshi Mukae
  • Journal Title: Biochem Biophys Res Commun Volume: 530(3) Issue: 3 Pages: 561-565
  • DOI: 10.1016/j.bbrc.2020.07.085
  • Peer Reviewed
• [Journal Article] Coinfection With Multiple Nontuberculous Mycobacteria as a Possible Exacerbating Factor in Pulmonary Nontuberculous Mycobacteriosis (2020)
  • Author(s): Naito Keisuke、Noguchi Shingo、Yatera Kazuhiro、Kawanami Toshinori、Yamasaki Kei、Fukuda Kazumasa、Ikegami Hiroaki、Akata Kentaro、Kido Takashi、Sakamoto Noriho、Saito Mitsumasa、Mukae Hiroshi
  • Journal Title: Chest Volume: 158 Issue: 6 Pages: 2304-2313
  • DOI: 10.1016/j.chest.2020.06.027
  • Peer Reviewed
• [Journal Article] Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells (2020)
  • Author(s): Okuno Daisuke、Sugiura Yuki、Sakamoto Noriho、Tagod Mohammed S. O.、Iwasaki Masashi、Noda Shuto、Tamura Akihiro、Senju Hiroaki、Umeyama Yasuhiro、Yamaguchi Hiroyuki、Suematsu Makoto、Morita Craig T.、Tanaka Yoshimasa、Mukae Hiroshi
  • Journal Title: Frontiers in Immunology Volume: 11 Pages: 1405-1405
  • DOI: 10.3389/fimmu.2020.01405
  • NAID: 120006988092
  • Peer Reviewed
• [Journal Article] Novel and potent antimicrobial effects of caspofungin on drug-resistant Candida and bacteria (2020)
  • Author(s): Sumiyoshi Makoto、Miyazaki Taiga、Makau Juliann Nzembi、Mizuta Satoshi、Tanaka Yoshimasa、Ishikawa Takeshi、Makimura Koichi、et al.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 17745-17745
  • DOI: 10.1038/s41598-020-74749-8
  • NAID: 120006988489
  • Peer Reviewed / Open Access
• [Presentation] ヒトγδT細胞を用いた肺線維症治療薬の開発 (2023)
  • Author(s): 奥野大輔
  • Organizer: 第1回 九州呼吸器カンファレンス
• [Presentation] ヒトγδT細胞を用いた肺線維症治療薬の開発 (2022)
  • Author(s): 奥野大輔, 坂本憲穂, 時任高諄, 由良博一, 城戸貴志, 石本裕士, 田中義正, 迎 寛
  • Organizer: 第2回日本びまん性肺疾患研究会
• [Presentation] Risk factors for pneumonia during biological treatments in patients with rheumatoid arthritis (2021)
  • Author(s): Kazuko Yamamoto，Yukitaka Ueki, Tomohiro Koga， Kunihiro Ichinose，Atsushi Kawakami，Hiroshi Mukae
  • Organizer: 第65回日本リウマチ学会総会・学術講演会
• [Presentation] 生物学的製剤治療中の関節リウマチ患者における肺炎の検討 (2021)
  • Author(s): 山本和子、坂本憲穂、井手口周平、芦澤信之、平山達朗、高園貴弘、今村圭文、宮崎泰可、田代将人、田中健之、泉川公一、栁原克紀、川上 純、迎 寛
  • Organizer: 第95回 日本感染症学会学術講演会 第69回日本化学療法学会総会 合同学会
• [Presentation] 関節リウマチ患者の喫煙に関連する肺免疫細胞分布についての検討 (2021)
  • Author(s): 山本和子，坂本憲穂，井手口周平，芦澤信之，平山達朗，高園貴弘，今村圭文、宮崎泰可，迎 寛
  • Organizer: 第44回日本呼吸器内視鏡学会学術集会
• [Presentation] 当院における経気管支鏡下クライオ肺生検症例の検討 (2021)
  • Author(s): 宮村拓人、石本裕士、小笹 睦、森山咲子、奥野大輔、原 敦子、城戸貴志、坂本憲穂、石松祐二、福岡順也、迎 寛
  • Organizer: 第44回日本呼吸器内視鏡学会学術集会
• [Presentation] 過敏性肺炎の診断と治療：新ガイドラインをめぐって (2021)
  • Author(s): 坂本憲穂
  • Organizer: 第87回日本呼吸器学会・日本結核 非結核性抗酸菌症学会 日本サルコイドーシス/肉芽腫性疾患学会 九州支部 秋季学術講演会
• [Presentation] 間質性肺疾患における肺炎発症リスク因子としてのHLAタイピングの検討 (2021)
  • Author(s): 坂本憲穂、石本裕士、城戸貴志、原 敦子、宮村拓人、奥野大輔、時任高諄、吉岡寿麻子、髙園貴弘、山本和子、石松祐二、矢寺和博、迎 寛
  • Organizer: 第91回日本感染症学会西日本地方会学術集会・第64回日本感染症学会中日本地方会学術集会・第69回日本化学療法学会西日本支部総会
• [Presentation] Identification of inhibitors targeting heat shock protein 47 for the development of anti-fibrotic therapeutics (2021)
  • Author(s): Daisuke Okuno, Noriho Sakamoto, Takatomo Tokito, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Yoshimasa Tanaka, Hiroshi Mukae
  • Organizer: Asian Pacific Society of Respirology 2021
• [Presentation] The Role of Epstein-Barr Virus-Encoded microRNAs in Pulmonary Fibrosis (2020)
  • Author(s): N. Sakamoto, H. Yura, D. Okuno, T. Miyamura, A. Hara, T. Kido, H. Ishimoto, Y. Ishimatsu, H. Mukae
  • Organizer: ATS 2020－American Thoracic Society International Conference. Virtual
  • Int'l Joint Research
• [Presentation] Immune Complexome Analysis Detects Apolipoprotein E as a Disease-Specific Immune Complex Antigen in Bronchoalveolar Fluids from Patients with Summer-Type Hypersensitivity Pneumonitis (2020)
  • Author(s): Y. Ishimatsu, A. Hara, N. Aibara, K. Ohyama, Y. Akiyama, D. Okuno, T. Miyamura, T. Kido, H. Ishimoto, N. Sakamoto, H. Mukae
  • Organizer: ATS 2020－American Thoracic Society International Conference. Virtual
  • Int'l Joint Research
• [Presentation] he Utility Of Combinate Detection Of Igh And Tcr Gene Rearrangement, And Malt1 Gene Translocation In Balf For The Diagnosis Of Pulmonary Lymphoma (2020)
  • Author(s): T. Kido, H. Ishimoto, H. Ishii, K. Hara, H. Kawabata, T. Kawanami, Y. Suzuki, H. Yoshikawa, A. Hara, N. Sakamoto, N. Matsumoto, C. Yoshii, M. Fujita, M. Nakazato, J. Kadota, H. Mukae, K. Yatera
  • Organizer: ATS 2020－American Thoracic Society International Conference. Virtual
  • Int'l Joint Research
• [Presentation] ffect of Zoledronic Acid and a Bisphosphonate Prodrug on γδ T Cell-Mediated Cytotoxicity Against Lung Cancer Cells (2020)
  • Author(s): D. Okuno, N. Sakamoto, T. Miyamura, A. Hara, T. Kido, H. Ishimoto, H. Yamaguchi, Y. Ishimatsu, Y. Tanaka, H. Mukae
  • Organizer: ATS 2020－American Thoracic Society International Conference. Virtual
  • Int'l Joint Research
• [Presentation] Heat Shock Protein 47 (HSP47) Positive Fibroblasts in Cancer Stroma Are Associated with Increased Risk of Postoperative Recurrence in Patients with Lung Cancer (2020)
  • Author(s): T. Miyamura, N. Sakamoto, T. Kakugawa, K. Ishida, H. Taniguchi, D. Okuno, A. Hara, T. Kido, H. Ishimoto, T. Miyazaki, K. Matsumoto, T. Tsuchiya, H. Yamaguchi, Y. Obase, Y. Ishimatsu, T. Nagayasu, H. Mukae
  • Organizer: ATS 2020－American Thoracic Society International Conference. Virtual
  • Int'l Joint Research
• [Presentation] 膵癌化学療法中に生じた薬剤性肺障害の検討 (2020)
  • Author(s): 宮下 律、石本裕士、奥野大輔、宮村 拓人、由良 博一、高園 貴弘、 原 敦子、 坂本 憲穂、石松 祐二、 尾長谷 靖 、 迎 寛
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 肺癌手術検体における，Heat shock protein 47発現の検討 (2020)
  • Author(s): 宮村 拓人、坂本 憲穂、角川 智之、石田 佳央理、奥野 大輔、 原 敦子、 宮崎 拓郎、 城戸 貴志、石本 裕士、 松本 桂太郎、土屋 智史、石松 祐二、永安 武、迎 寛
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Patent(Industrial Property Rights)] 特許権 肺線維症の治療薬及び肺線維症の治療方法 (2023)
  • Inventor(s): 坂本憲穂、奥野大輔、迎 寛、田中義正
  • Industrial Property Rights Holder: 坂本憲穂、奥野大輔、迎 寛、田中義正
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
  • Overseas
• [Patent(Industrial Property Rights)] 特許権 肺線維症の治療薬及び肺線維症の治療方法 (2022)
  • Inventor(s): 坂本憲穂、奥野大輔、田中義正、迎 寛
  • Industrial Property Rights Holder: 坂本憲穂、奥野大輔、田中義正、迎 寛
  • Industrial Property Rights Type: 特許
  • Filing Date: 2022