• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Endothelial glycocalyx damage in pathophysiology of sepsis: analysis from complex acute on chronic damage and ultrastructural alterations

Research Project

Project/Area Number 20K09281
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionTohoku University

Principal Investigator

Kushimoto Shigeki  東北大学, 医学系研究科, 教授 (50195434)

Co-Investigator(Kenkyū-buntansha) 岡田 英志  岐阜大学, 医学部附属病院, 准教授 (30402176)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords敗血症 / 糖尿病 / グリコカリックス / 血管内皮細胞傷害 / 超微形態解析 / 血管内皮障害
Outline of Research at the Start

敗血症は血管内皮障害が合併症に関連する糖尿病により、発生頻度増加と重症化が生じる。血管内皮細胞障害の本態であることが明らかにされつつあるグリコカリックスであるが、糖尿病による慢性障害に感染により惹起される急性障害が加わり、”acute on chronic” complex glycocalyx damageによる複合障害によって重症化し、敗血症病態形成に関与する可能性がある。グリコカリックス構造の超微形態評価を用い、構造変化を灌流環境の異なる臓器ごとに解析する。そして、糖尿病性慢性障害+敗血症性急性障害による複合障害として捉えることにより、敗血症の病態を明らかにするものである。

Outline of Final Research Achievements

This research provided the ultrastructure of endothelial glycocalyx injury under diabetic conditions. In diabetic mice, endothelial glycocalyx is already injured before infection, and the migration of inflammatory cells is both delayed and expanded. This extended inflammation may be involved in endothelial glycocalyx damage due to the attenuation of endothelial glycocalyx synthesis, leading to unfavorable outcomes. Appropriate glycemic control or administration of heparan sulfates may improve the endothelial glycocalyx injury under diabetic conditions.
Endothelial glycocalyx is composed of variable glycoproteins and polysaccharides, and identifying the component with efficacy on outcome will be a novel research issue.

Academic Significance and Societal Importance of the Research Achievements

感染症や生活習慣病の病態として、微小循環障害が注目されている。微小循環を維持する血管は内皮細胞により支持され、その内腔側表面をグリコカリックスと呼ばれる糖タンパク複合体によって覆われている。血管内皮グリコカリックスは微小循環の恒常性を保つが、その構造は脆弱で容易に傷害され、様々な疾患や病態に影響を与える可能性がある。
糖尿病患者が感染症で重篤化しやすいこと、糖尿病・敗血症ともに微小循環障害を有することに着目し、病態と血管内皮グリコカリックス傷害との関係、治療法を検討した。血管内皮グリコカリックスの保護による重症化予防の可能性は、これからの医療に大きなインパクをと与える可能性があるものと考える。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (56 results)

All 2023 2022 2021 2020 2019

All Journal Article (38 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 38 results,  Open Access: 37 results) Presentation (18 results) (of which Invited: 3 results)

  • [Journal Article] Serum syndecan-1 concentration in hemolysis, elevated liver enzymes, and low platelets syndrome: A case report2023

    • Author(s)
      Nishio Ayane ...... Ogura Shinji
    • Journal Title

      Frontiers in Medicine

      Volume: 10 Pages: 1111139-1111139

    • DOI

      10.3389/fmed.2023.1111139

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective study examining the probability of cerebral fat embolism based on magnetic resonance imaging2023

    • Author(s)
      Kanda Norihide et al.
    • Journal Title

      Heliyon

      Volume: 9 Issue: 3 Pages: e14073-e14073

    • DOI

      10.1016/j.heliyon.2023.e14073

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo2023

    • Author(s)
      Niwa Ayumi、Taniguchi Toshiaki、Tomita Hiroyuki、Okada Hideshi、Kinoshita Takamasa、Mizutani Chika、Matsuo Mikiko、Imaizumi Yuko、Kuroda Takahito、Ichihashi Koki、Sugiyama Takaaki、Kanayama Tomohiro、Yamaguchi Yu、Sugie Shigeyuki、Matsuhashi Nobuhisa、Hara Akira
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 2 Pages: e0281820-e0281820

    • DOI

      10.1371/journal.pone.0281820

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spinal injury with spinal ankylosing disorders as a primary cause of death: report of two cases2023

    • Author(s)
      Miyake Takahito........Ogura Shinji
    • Journal Title

      International Journal of Emergency Medicine

      Volume: 16 Issue: 1 Pages: 7-7

    • DOI

      10.1186/s12245-023-00488-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective cohort study to determine the effect of preinjury antiplatelet or anticoagulant therapy on mortality in patients with major trauma2023

    • Author(s)
      Yamaji Fuminori......Ogura Shinji
    • Journal Title

      Frontiers in Medicine

      Volume: 9 Pages: 1089219-1089219

    • DOI

      10.3389/fmed.2022.1089219

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics of patients with snow sports trauma transported to a trauma care center: A retrospective observational study2023

    • Author(s)
      Yoshimura Genki.........Ogura Shinji
    • Journal Title

      Injury

      Volume: 54 Issue: 5 Pages: 1379-1385

    • DOI

      10.1016/j.injury.2022.12.028

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study2023

    • Author(s)
      Wada Takeshi、Yamakawa Kazuma、Kabata Daijiro、Abe Toshikazu、Fujishima Seitaro、Kushimoto Shigeki、et al
    • Journal Title

      Journal of Intensive Care

      Volume: 11 Issue: 1

    • DOI

      10.1186/s40560-023-00656-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recombinant thrombomodulin may protect cardiac capillary endothelial glycocalyx through promoting Glypican-1 expression under experimental endotoxemia2022

    • Author(s)
      Kakino Yoshinori、Doi Tomoaki、Okada Hideshi、Suzuki Kodai et al.
    • Journal Title

      Heliyon

      Volume: 8 Issue: 11 Pages: e11262-e11262

    • DOI

      10.1016/j.heliyon.2022.e11262

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pediatric case of axial rotary fixation associated with severe head trauma requiring emergency craniotomy for hematoma removal2022

    • Author(s)
      Minamiyama Toru........Ogura Shinji
    • Journal Title

      Trauma Case Reports

      Volume: 42 Pages: 100724-100724

    • DOI

      10.1016/j.tcr.2022.100724

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Syndecan-1 as a severity biomarker for patients with trauma2022

    • Author(s)
      Suzuki Keiko、Okada Hideshi、......Kanda Norihide et al.
    • Journal Title

      Frontiers in Medicine

      Volume: 9 Pages: 985955-985955

    • DOI

      10.3389/fmed.2022.985955

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypergranulation over a meshed split-thickness skin graft, a complication of negative-pressure wound therapy: a case report2022

    • Author(s)
      Shiba Masato......Ogura Shinji
    • Journal Title

      Journal of Medical Case Reports

      Volume: 16 Issue: 1 Pages: 335-335

    • DOI

      10.1186/s13256-022-03521-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Vascular Endothelial Glycocalyx in Cardiovascular Disease2022

    • Author(s)
      Tomita Hiroyuki、Suzuki Kodai、Komatsu Masanobu、Okada Hideshi
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 9 Pages: 952022-952022

    • DOI

      10.3389/fcvm.2022.952022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Form follows function: The endothelial glycocalyx2022

    • Author(s)
      Suzuki Akio、TOMITA HIROYUKI、OKADA HIDESHI
    • Journal Title

      Translational Research

      Volume: in press Pages: 158-167

    • DOI

      10.1016/j.trsl.2022.03.014

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of mRNA COVID-19 Vaccines in Japan during the Nationwide Pandemic of the Delta Variant2022

    • Author(s)
      Akaishi Tetsuya、Kushimoto Shigeki、Katori Yukio、Sugawara Noriko、Igarashi Kaoru、Fujita Motoo、Kure Shigeo、Takayama Shin、Abe Michiaki、Kikuchi Akiko、Ishizawa Kota、Abe Yoshiko、Imai Hiroyuki、Inaba Yohei、Iwamatsu-Kobayashi Yoko、Nishioka Takashi、Onodera Ko、Ishii Tadashi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 257 Issue: 1 Pages: 1-6

    • DOI

      10.1620/tjem.2022.J012

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan2022

    • Author(s)
      Akaishi T, Kushimoto S, Katori Y, Sugawara N, Egusa H, Igarashi K, Fujita M, Kure S, Takayama S, Abe M, Kikuchi A, Ohsawa M, Ishizawa K, Abe Y, Imai H, Inaba Y, Iwamatsu-Kobayashi Y, Nishioka T, Onodera K, Ishii T
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 13589-13589

    • DOI

      10.1038/s41598-022-17990-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan2022

    • Author(s)
      Akaishi T, Kushimoto S, Katori Y, Sugawara N, Egusa H, Igarashi K, Fujita M, Kure S, Takayama S, Abe M, Kikuchi A, Ohsawa M, Ishizawa K, Abe Y, Imai H, Inaba Y, Iwamatsu-Kobayashi Y, Nishioka T, Onodera K, Ishii T
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 258 Issue: 2 Pages: 103-110

    • DOI

      10.1620/tjem.2022.J067

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of trauma severity with antibody seroconversion in heparin-induced thrombocytopenia: A multicenter, prospective, observational study2022

    • Author(s)
      Fujita Motoo、Maeda Takuma、Miyata Shigeki、Mizugaki Asumi、Hayakawa Mineji、Miyagawa Noriko、Ushio Noritaka、Shiraishi Atsushi、Ogura Takayuki、Irino Shiho、Sekine Kazuhiko、Fujinami Yoshihisa、Kiridume Kazutaka、Hifumi Toru、Kushimoto Shigeki
    • Journal Title

      Journal of Trauma and Acute Care Surgery

      Volume: 93 Issue: 3 Pages: 402-408

    • DOI

      10.1097/ta.0000000000003603

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of tranexamic acid on coagulofibrinolytic markers during the early stage of severe trauma: A propensity score-matched analysis2022

    • Author(s)
      Gando Satoshi、Shiraishi Atsushi、Wada Takeshi、for the JAAM FORECAST TRAUMA Study Group
    • Journal Title

      Medicine

      Volume: 101 Issue: 32 Pages: e29711-e29711

    • DOI

      10.1097/md.0000000000029711

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Web-based application for predicting the potential target phenotype for recombinant human thrombomodulin therapy in patients with sepsis: analysis of three multicentre registries2022

    • Author(s)
      Goto Tadahiro、Kudo Daisuke、Uchimido Ryo、Hayakawa Mineji、Yamakawa Kazuma、Abe Toshikazu、Shiraishi Atsushi、Kushimoto Shigeki
    • Journal Title

      Critical Care

      Volume: 26 Issue: 1 Pages: 145-145

    • DOI

      10.1186/s13054-022-04020-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between low body temperature on admission and in-hospital mortality according to body mass index categories of patients with sepsis2022

    • Author(s)
      Ito Yuta、Kudo Daisuke、Kushimoto Shigeki
    • Journal Title

      Medicine

      Volume: 101 Issue: 44 Pages: e31657-e31657

    • DOI

      10.1097/md.0000000000031657

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antiplatelet pretreatment and mortality in patients with severe sepsis: A secondary analysis from a multicenter, prospective survey of severe sepsis in Japan2022

    • Author(s)
      Kobayashi Masakazu、Kudo Daisuke、Ohbe Hiroyuki、Kushimoto Shigeki
    • Journal Title

      Journal of Critical Care

      Volume: 69 Pages: 154015-154015

    • DOI

      10.1016/j.jcrc.2022.154015

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison between midazolam and propofol in acute phase for ventilated patients with sepsis: a post‐hoc analysis of the DESIRE trial2022

    • Author(s)
      Miyagawa Noriko、Kawazoe Yu、Sato Tetsuya、Kushimoto Shigeki、Miyamoto Kyohei、Ohta Yoshinori、Morimoto Takeshi、Yamamura Hitoshi、DESIRE Trial Investigators
    • Journal Title

      Acute Medicine & Surgery

      Volume: 9 Issue: 1

    • DOI

      10.1002/ams2.746

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trends in survival during the pandemic in patients with critical COVID-19 receiving mechanical ventilation with or without ECMO: analysis of the Japanese national registry data.2022

    • Author(s)
      Ohshimo S, Liu K, Ogura T, Iwashita Y, Kushimoto S, Shime N, Hashimoto S, Fujino Y, Takeda S
    • Journal Title

      Crit Care

      Volume: 26 Issue: 1 Pages: 354-354

    • DOI

      10.1186/s13054-022-04187-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient return of spontaneous circulation related to favourable outcomes in out-of-hospital cardiac arrest patients resuscitated with extracorporeal cardiopulmonary resuscitation: A secondary analysis of the SAVE-J II study2022

    • Author(s)
      Takayuki Otani, Toru Hifumi, Akihiko Inoue, Toshikazu Abe, Tetsuya Sakamoto, Yasuhiro Kuroda, Hirotaka Sawano, Yuko Egawa, Kazuhiro Sugiyama, Maki Tanabe, Naofumi Bunya, Takehiko Kasai, Shinichi Ijuin, Shinichi Nakayama, Jun Kanda, Seiya Kanou, Toru Takiguchi, Shoji Yokobori, et al.
    • Journal Title

      Resuscitation Plus

      Volume: 12 Pages: 100300-100300

    • DOI

      10.1016/j.resplu.2022.100300

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Nutrition Protocol with Clostridium butyricum MIYAIRI 588 and Reduced Incidence of Clostridioides difficile Infection in Critically Ill Patients: A Single-Center, Before-and-After Study2022

    • Author(s)
      Sato Takeaki、Kudo Daisuke、Kushimoto Shigeki
    • Journal Title

      Surgical Infections

      Volume: 23 Issue: 5 Pages: 483-488

    • DOI

      10.1089/sur.2022.030

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis2022

    • Author(s)
      Wada Takeshi、Yamakawa Kazuma、Kabata Daijiro、Abe Toshikazu、Gando Satoshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 9304-9304

    • DOI

      10.1038/s41598-022-13346-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes2022

    • Author(s)
      Wada Takeshi、Shiraishi Atsushi、Gando Satoshi、Kabata Daijiro、Yamakawa Kazuma、Fujishima Seitaro、Saitoh Daizoh、Kushimoto Shigeki、Ogura Hiroshi、Abe Toshikazu、Mayumi Toshihiko、Otomo Yasuhiro
    • Journal Title

      Frontiers in Immunology

      Volume: 13 Pages: 1-12

    • DOI

      10.3389/fimmu.2022.1026163

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Virus-Driven Carcinogenesis2021

    • Author(s)
      Hatano Yuichiro、Ideta Takayasu、Hirata Akihiro、Hatano Kayoko、Tomita Hiroyuki、Okada Hideshi、Shimizu Masahito、Tanaka Takuji、Hara Akira
    • Journal Title

      Cancers

      Volume: 13 Issue: 11 Pages: 2625-2625

    • DOI

      10.3390/cancers13112625

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum syndecan-1 reflects organ dysfunction in critically ill patients2021

    • Author(s)
      Suzuki Keiko、Okada Hideshi......Doi Tomoaki et al.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 8864-8864

    • DOI

      10.1038/s41598-021-88303-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia2021

    • Author(s)
      Okamoto Haruka、Muraki Isamu、Okada Hideshi........Doi Tomoaki et al.
    • Journal Title

      The American Journal of Pathology

      Volume: 191 Issue: 9 Pages: 1526-1536

    • DOI

      10.1016/j.ajpath.2021.05.015

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice2021

    • Author(s)
      Kinoshita Takamasa、Tomita Hiroyuki、Okada Hideshi et al.
    • Journal Title

      Discover Oncology

      Volume: 12 Issue: 1 Pages: 50-50

    • DOI

      10.1007/s12672-021-00444-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival2021

    • Author(s)
      Kitagawa Yuichiro、Kawamura Itta、Suzuki Keiko、Okada Hideshi........Doi Tomoaki et al.
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 12 Pages: e0260350-e0260350

    • DOI

      10.1371/journal.pone.0260350

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study2021

    • Author(s)
      Kamidani Ryo、Miyake Takahito、Okada Hideshi.......Doi Tomoaki et al.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 18458-18458

    • DOI

      10.1038/s41598-021-97954-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx Injury During Hemodialysis2021

    • Author(s)
      Kusuzawa Keigo、Suzuki Keiko、Okada Hideshi........Doi Tomoaki et al.
    • Journal Title

      Frontiers in Medicine

      Volume: 8 Pages: 791309-791309

    • DOI

      10.3389/fmed.2021.791309

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validity and risk factor analysis for helicopter emergency medical services in Japan: a pilot study2021

    • Author(s)
      Yamada Noriaki、Kitagawa Yuichiro、Yoshida Takahiro、Nachi Sho、Okada Hideshi、Ogura Shinji
    • Journal Title

      BMC Emergency Medicine

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12873-021-00471-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial Glycocalyx Disorders May Be Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model2021

    • Author(s)
      Sampei So、Okada Hideshi、.......Doi Tomoaki et al.
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 623582-623582

    • DOI

      10.3389/fcell.2021.623582

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ultrastructural alteration of pulmonary tissue under conditions of high oxygen concentration2020

    • Author(s)
      Yano H, Kuroda A, Okada H, Tomita H, Suzuki K, Takada C, Fukuda H, Kawasaki Y, Muraki I, Wakayama Y, Kano S, Tamaoki Y, Nishio A, Inagawa R, Sampei S, Kamidani R, Kakino Y, Yasuda R, Kitagawa Y, Fukuta T, Miyake T, Kanda N, Miyazaki N, Doi T, Yoshida T, Suzuki A, Yoshida S, Ogura S
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 13 Pages: 3004-3012

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx2019

    • Author(s)
      Fukuta T, Okada H, Takemura G, Suzuki K, Takada C, Tomita H, Suzuki A, Oda K, Uchida A, Matsuo S, Fukuda H, Yano H, Muraki I, Zaikokuji R, Kuroda A, Nishio A, Sampei S, Miyazaki N, Hotta Y, Yamada N, Watanabe T, Morishita K, Doi T, Yoshida T, Ushikoshi H, Yoshida S, Maekawa Y, Ogura S
    • Journal Title

      Shock

      Volume: 2019 Nov 19. Issue: 3 Pages: 1-1

    • DOI

      10.1097/shk.0000000000001482

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 超微形態でみるトロンボモジュリンの多彩な血管内皮保護作用2022

    • Author(s)
      岡田 英志
    • Organizer
      第49回日本集中治療医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] シンデカン-1を用いてHELLP症候群の微小血管内皮障害を評価した1例2022

    • Author(s)
      西尾 紋音, 上谷 遼, 岡田 英志, 鈴木 景子, 三宅 喬人, 土井 智章, 鈴木 昭夫, 吉田 省造, 小倉 真治
    • Organizer
      第49回日本集中治療医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] グリコカリクス 糖尿病の感染症には血管内皮グリコカリックス傷害が関与する2022

    • Author(s)
      三瓶 想, 岡田 英志, 久志本 成樹, 小倉 真治
    • Organizer
      第49回日本集中治療医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] グリコカリクス 血管内皮障害で敗血症の重症化を紐解く グリコカリックスでつなぐ病態生理と臨床2022

    • Author(s)
      岡田 英志
    • Organizer
      第49回日本集中治療医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 横紋筋融解症によるマウス急性腎障害モデルにおける遺伝子組換えトロンボモジュリンの血管内皮保護作用の検討2022

    • Author(s)
      奥田 知輝, 岡田 英志, 福田 陽平, 鈴木 浩大, 川崎 雄輝, 西尾 紋音, 福田 洋丞, 上谷 遼, 三宅 喬人, 吉田 省造, 小倉 真治
    • Organizer
      第50回日本救急医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] "体温異常"を知らずに敗血症診療ができるのか?2022

    • Author(s)
      久志本成樹
    • Organizer
      第49回日本集中治療医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Serum Syndecan-1 Concentration in Hospitalized Patients with Heart Failure may Predict Readmission-free Survival2022

    • Author(s)
      岡田英志、川村一太、北川雄一郎、渡邉崇量、松尾仁司、小倉真治
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血管内皮におけるヘパラン硫酸の減少は組織の炎症増悪に関与する2022

    • Author(s)
      川崎雄輝、岡田英志、富田弘之、柿野圭紀、鈴木浩大、北川雄一郎、三宅喬人、土井智章、吉田省造、小倉真治
    • Organizer
      第49回日本集中治療医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血管内皮障害で敗血症の重症化を紐解く~グリコカリックスでつなぐ病態生理と臨床~2022

    • Author(s)
      岡田英志
    • Organizer
      第49回日本集中治療医学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 糖尿病の感染症には血管内皮グリコカリックス傷害が関与する2022

    • Author(s)
      三瓶想 岡田英志 久志本成樹 小倉真治
    • Organizer
      第49回日本集中治療医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血液浄化療法により生じる血管内皮グリコカリックス障害の定量2021

    • Author(s)
      岡田英志、楠澤佳吾、鈴木景子、北川雄一郎、長屋聡一郎、土井智章、鈴木昭夫、吉田省造、小倉真治
    • Organizer
      第66回日本透析医学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 心不全による血管内皮グリコカリックス障害は炎症細胞の遊走を増加させる2021

    • Author(s)
      福田洋丞、岡田英志、鈴木浩大、玉置祐斗、南山徹、吉村絃希、大岩秀明、福田哲也、土井智章、小倉真治
    • Organizer
      第49回日本救急医学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 膵炎における好中球組織動態と役割についての考察2021

    • Author(s)
      福田陽平、岡田英志、塚田真菜、上谷遼、三浦智孝、柿野圭紀、水野洋佑、安田立、北川雄一郎、三宅喬人、小倉真治
    • Organizer
      第49回日本救急医学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 横紋筋融解症に伴う急性腎障害に対するアンチトロンビン治療の考察2021

    • Author(s)
      奥田知輝、岡田英志、川崎雄輝、中島優介、島田卓人、吉田知生、柴將人、神田倫秀、名知祥、吉田隆浩、小倉真治
    • Organizer
      第49回日本救急医学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血管内皮グリコカリックス障害は微小血栓生成を促進する2021

    • Author(s)
      浅野博敬、岡田英志、加島朔、宮田遥香、高田ちひろ、三瓶想、加納壮一郎、若山佑豪、吉田省造、小倉真治
    • Organizer
      第49回日本救急医学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血液浄化療法により生じる血管内皮グリコカリックス障害の定量とその要因解析2021

    • Author(s)
      西尾紋音、岡田英志、楠澤佳吾、鈴木景子、石原拓磨、岡本遥、長屋聡一郎、安田立、鈴木昭夫、吉田省造、小倉真治
    • Organizer
      第49回日本救急医学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血液浄化療法により生じる血管内皮グリコカリックス障害の定量2021

    • Author(s)
      岡田英志、楠澤佳悟、北川雄一郎、長屋聡一郎、土井智章、吉田省造、小倉真治、鈴木景子、鈴木昭夫
    • Organizer
      第66回日本透析医学会学術集会・総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 糖尿病モデルマウスのグリコカリックス障害と敗血症血管炎下における炎症細胞の遊走遅延2020

    • Author(s)
      三瓶 想、岡田英志、久志本成樹
    • Organizer
      第48回 日本救急医学会総会・学術集会
    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi