Endothelial glycocalyx damage in pathophysiology of sepsis: analysis from complex acute on chronic damage and ultrastructural alterations

• Project/Area Number: 20K09281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Tohoku University
• Principal Investigator: Kushimoto Shigeki 東北大学, 医学系研究科, 教授 (50195434)
• Co-Investigator(Kenkyū-buntansha): 岡田 英志 岐阜大学, 医学部附属病院, 准教授 (30402176)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 敗血症 / 糖尿病 / グリコカリックス / 血管内皮細胞傷害 / 超微形態解析 / 血管内皮障害

Outline of Research at the Start

敗血症は血管内皮障害が合併症に関連する糖尿病により、発生頻度増加と重症化が生じる。血管内皮細胞障害の本態であることが明らかにされつつあるグリコカリックスであるが、糖尿病による慢性障害に感染により惹起される急性障害が加わり、”acute on chronic” complex glycocalyx damageによる複合障害によって重症化し、敗血症病態形成に関与する可能性がある。グリコカリックス構造の超微形態評価を用い、構造変化を灌流環境の異なる臓器ごとに解析する。そして、糖尿病性慢性障害＋敗血症性急性障害による複合障害として捉えることにより、敗血症の病態を明らかにするものである。

Outline of Final Research Achievements

This research provided the ultrastructure of endothelial glycocalyx injury under diabetic conditions. In diabetic mice, endothelial glycocalyx is already injured before infection, and the migration of inflammatory cells is both delayed and expanded. This extended inflammation may be involved in endothelial glycocalyx damage due to the attenuation of endothelial glycocalyx synthesis, leading to unfavorable outcomes. Appropriate glycemic control or administration of heparan sulfates may improve the endothelial glycocalyx injury under diabetic conditions.
Endothelial glycocalyx is composed of variable glycoproteins and polysaccharides, and identifying the component with efficacy on outcome will be a novel research issue.

Academic Significance and Societal Importance of the Research Achievements

感染症や生活習慣病の病態として、微小循環障害が注目されている。微小循環を維持する血管は内皮細胞により支持され、その内腔側表面をグリコカリックスと呼ばれる糖タンパク複合体によって覆われている。血管内皮グリコカリックスは微小循環の恒常性を保つが、その構造は脆弱で容易に傷害され、様々な疾患や病態に影響を与える可能性がある。
糖尿病患者が感染症で重篤化しやすいこと、糖尿病・敗血症ともに微小循環障害を有することに着目し、病態と血管内皮グリコカリックス傷害との関係、治療法を検討した。血管内皮グリコカリックスの保護による重症化予防の可能性は、これからの医療に大きなインパクをと与える可能性があるものと考える。

Research Products

• [Journal Article] Serum syndecan-1 concentration in hemolysis, elevated liver enzymes, and low platelets syndrome: A case report (2023)
  • Author(s): Nishio Ayane ...... Ogura Shinji
  • Journal Title: Frontiers in Medicine Volume: 10 Pages: 1111139-1111139
  • DOI: 10.3389/fmed.2023.1111139
  • Peer Reviewed / Open Access
• [Journal Article] Prospective study examining the probability of cerebral fat embolism based on magnetic resonance imaging (2023)
  • Author(s): Kanda Norihide et al.
  • Journal Title: Heliyon Volume: 9 Issue: 3 Pages: e14073-e14073
  • DOI: 10.1016/j.heliyon.2023.e14073
  • Peer Reviewed / Open Access
• [Journal Article] Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo (2023)
  • Author(s): Niwa Ayumi、Taniguchi Toshiaki、Tomita Hiroyuki、Okada Hideshi、Kinoshita Takamasa、Mizutani Chika、Matsuo Mikiko、Imaizumi Yuko、Kuroda Takahito、Ichihashi Koki、Sugiyama Takaaki、Kanayama Tomohiro、Yamaguchi Yu、Sugie Shigeyuki、Matsuhashi Nobuhisa、Hara Akira
  • Journal Title: PLOS ONE Volume: 18 Issue: 2 Pages: e0281820-e0281820
  • DOI: 10.1371/journal.pone.0281820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spinal injury with spinal ankylosing disorders as a primary cause of death: report of two cases (2023)
  • Author(s): Miyake Takahito........Ogura Shinji
  • Journal Title: International Journal of Emergency Medicine Volume: 16 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s12245-023-00488-y
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective cohort study to determine the effect of preinjury antiplatelet or anticoagulant therapy on mortality in patients with major trauma (2023)
  • Author(s): Yamaji Fuminori......Ogura Shinji
  • Journal Title: Frontiers in Medicine Volume: 9 Pages: 1089219-1089219
  • DOI: 10.3389/fmed.2022.1089219
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of patients with snow sports trauma transported to a trauma care center: A retrospective observational study (2023)
  • Author(s): Yoshimura Genki.........Ogura Shinji
  • Journal Title: Injury Volume: 54 Issue: 5 Pages: 1379-1385
  • DOI: 10.1016/j.injury.2022.12.028
  • Peer Reviewed / Open Access
• [Journal Article] Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study (2023)
  • Author(s): Wada Takeshi、Yamakawa Kazuma、Kabata Daijiro、Abe Toshikazu、Fujishima Seitaro、Kushimoto Shigeki、et al
  • Journal Title: Journal of Intensive Care Volume: 11 Issue: 1
  • DOI: 10.1186/s40560-023-00656-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recombinant thrombomodulin may protect cardiac capillary endothelial glycocalyx through promoting Glypican-1 expression under experimental endotoxemia (2022)
  • Author(s): Kakino Yoshinori、Doi Tomoaki、Okada Hideshi、Suzuki Kodai et al.
  • Journal Title: Heliyon Volume: 8 Issue: 11 Pages: e11262-e11262
  • DOI: 10.1016/j.heliyon.2022.e11262
  • Peer Reviewed / Open Access
• [Journal Article] A pediatric case of axial rotary fixation associated with severe head trauma requiring emergency craniotomy for hematoma removal (2022)
  • Author(s): Minamiyama Toru........Ogura Shinji
  • Journal Title: Trauma Case Reports Volume: 42 Pages: 100724-100724
  • DOI: 10.1016/j.tcr.2022.100724
  • Peer Reviewed / Open Access
• [Journal Article] Syndecan-1 as a severity biomarker for patients with trauma (2022)
  • Author(s): Suzuki Keiko、Okada Hideshi、......Kanda Norihide et al.
  • Journal Title: Frontiers in Medicine Volume: 9 Pages: 985955-985955
  • DOI: 10.3389/fmed.2022.985955
  • Peer Reviewed / Open Access
• [Journal Article] Hypergranulation over a meshed split-thickness skin graft, a complication of negative-pressure wound therapy: a case report (2022)
  • Author(s): Shiba Masato......Ogura Shinji
  • Journal Title: Journal of Medical Case Reports Volume: 16 Issue: 1 Pages: 335-335
  • DOI: 10.1186/s13256-022-03521-5
  • Peer Reviewed / Open Access
• [Journal Article] Editorial: Vascular Endothelial Glycocalyx in Cardiovascular Disease (2022)
  • Author(s): Tomita Hiroyuki、Suzuki Kodai、Komatsu Masanobu、Okada Hideshi
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 9 Pages: 952022-952022
  • DOI: 10.3389/fcvm.2022.952022
  • Peer Reviewed / Open Access
• [Journal Article] Form follows function: The endothelial glycocalyx (2022)
  • Author(s): Suzuki Akio、TOMITA HIROYUKI、OKADA HIDESHI
  • Journal Title: Translational Research Volume: in press Pages: 158-167
  • DOI: 10.1016/j.trsl.2022.03.014
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of mRNA COVID-19 Vaccines in Japan during the Nationwide Pandemic of the Delta Variant (2022)
  • Author(s): Akaishi Tetsuya、Kushimoto Shigeki、Katori Yukio、Sugawara Noriko、Igarashi Kaoru、Fujita Motoo、Kure Shigeo、Takayama Shin、Abe Michiaki、Kikuchi Akiko、Ishizawa Kota、Abe Yoshiko、Imai Hiroyuki、Inaba Yohei、Iwamatsu-Kobayashi Yoko、Nishioka Takashi、Onodera Ko、Ishii Tadashi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 257 Issue: 1 Pages: 1-6
  • DOI: 10.1620/tjem.2022.J012
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan (2022)
  • Author(s): Akaishi T, Kushimoto S, Katori Y, Sugawara N, Egusa H, Igarashi K, Fujita M, Kure S, Takayama S, Abe M, Kikuchi A, Ohsawa M, Ishizawa K, Abe Y, Imai H, Inaba Y, Iwamatsu-Kobayashi Y, Nishioka T, Onodera K, Ishii T
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 13589-13589
  • DOI: 10.1038/s41598-022-17990-7
  • Peer Reviewed / Open Access
• [Journal Article] COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan (2022)
  • Author(s): Akaishi T, Kushimoto S, Katori Y, Sugawara N, Egusa H, Igarashi K, Fujita M, Kure S, Takayama S, Abe M, Kikuchi A, Ohsawa M, Ishizawa K, Abe Y, Imai H, Inaba Y, Iwamatsu-Kobayashi Y, Nishioka T, Onodera K, Ishii T
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 258 Issue: 2 Pages: 103-110
  • DOI: 10.1620/tjem.2022.J067
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Association of trauma severity with antibody seroconversion in heparin-induced thrombocytopenia: A multicenter, prospective, observational study (2022)
  • Author(s): Fujita Motoo、Maeda Takuma、Miyata Shigeki、Mizugaki Asumi、Hayakawa Mineji、Miyagawa Noriko、Ushio Noritaka、Shiraishi Atsushi、Ogura Takayuki、Irino Shiho、Sekine Kazuhiko、Fujinami Yoshihisa、Kiridume Kazutaka、Hifumi Toru、Kushimoto Shigeki
  • Journal Title: Journal of Trauma and Acute Care Surgery Volume: 93 Issue: 3 Pages: 402-408
  • DOI: 10.1097/ta.0000000000003603
  • Peer Reviewed
• [Journal Article] Effects of tranexamic acid on coagulofibrinolytic markers during the early stage of severe trauma: A propensity score-matched analysis (2022)
  • Author(s): Gando Satoshi、Shiraishi Atsushi、Wada Takeshi、for the JAAM FORECAST TRAUMA Study Group
  • Journal Title: Medicine Volume: 101 Issue: 32 Pages: e29711-e29711
  • DOI: 10.1097/md.0000000000029711
  • Peer Reviewed / Open Access
• [Journal Article] Web-based application for predicting the potential target phenotype for recombinant human thrombomodulin therapy in patients with sepsis: analysis of three multicentre registries (2022)
  • Author(s): Goto Tadahiro、Kudo Daisuke、Uchimido Ryo、Hayakawa Mineji、Yamakawa Kazuma、Abe Toshikazu、Shiraishi Atsushi、Kushimoto Shigeki
  • Journal Title: Critical Care Volume: 26 Issue: 1 Pages: 145-145
  • DOI: 10.1186/s13054-022-04020-1
  • Peer Reviewed / Open Access
• [Journal Article] Association between low body temperature on admission and in-hospital mortality according to body mass index categories of patients with sepsis (2022)
  • Author(s): Ito Yuta、Kudo Daisuke、Kushimoto Shigeki
  • Journal Title: Medicine Volume: 101 Issue: 44 Pages: e31657-e31657
  • DOI: 10.1097/md.0000000000031657
  • Peer Reviewed / Open Access
• [Journal Article] Antiplatelet pretreatment and mortality in patients with severe sepsis: A secondary analysis from a multicenter, prospective survey of severe sepsis in Japan (2022)
  • Author(s): Kobayashi Masakazu、Kudo Daisuke、Ohbe Hiroyuki、Kushimoto Shigeki
  • Journal Title: Journal of Critical Care Volume: 69 Pages: 154015-154015
  • DOI: 10.1016/j.jcrc.2022.154015
  • Peer Reviewed / Open Access
• [Journal Article] Comparison between midazolam and propofol in acute phase for ventilated patients with sepsis: a post‐hoc analysis of the DESIRE trial (2022)
  • Author(s): Miyagawa Noriko、Kawazoe Yu、Sato Tetsuya、Kushimoto Shigeki、Miyamoto Kyohei、Ohta Yoshinori、Morimoto Takeshi、Yamamura Hitoshi、DESIRE Trial Investigators
  • Journal Title: Acute Medicine & Surgery Volume: 9 Issue: 1
  • DOI: 10.1002/ams2.746
  • Peer Reviewed / Open Access
• [Journal Article] Trends in survival during the pandemic in patients with critical COVID-19 receiving mechanical ventilation with or without ECMO: analysis of the Japanese national registry data. (2022)
  • Author(s): Ohshimo S, Liu K, Ogura T, Iwashita Y, Kushimoto S, Shime N, Hashimoto S, Fujino Y, Takeda S
  • Journal Title: Crit Care Volume: 26 Issue: 1 Pages: 354-354
  • DOI: 10.1186/s13054-022-04187-7
  • Peer Reviewed / Open Access
• [Journal Article] Transient return of spontaneous circulation related to favourable outcomes in out-of-hospital cardiac arrest patients resuscitated with extracorporeal cardiopulmonary resuscitation: A secondary analysis of the SAVE-J II study (2022)
  • Author(s): Takayuki Otani, Toru Hifumi, Akihiko Inoue, Toshikazu Abe, Tetsuya Sakamoto, Yasuhiro Kuroda, Hirotaka Sawano, Yuko Egawa, Kazuhiro Sugiyama, Maki Tanabe, Naofumi Bunya, Takehiko Kasai, Shinichi Ijuin, Shinichi Nakayama, Jun Kanda, Seiya Kanou, Toru Takiguchi, Shoji Yokobori, et al.
  • Journal Title: Resuscitation Plus Volume: 12 Pages: 100300-100300
  • DOI: 10.1016/j.resplu.2022.100300
  • Peer Reviewed / Open Access
• [Journal Article] Association between Nutrition Protocol with Clostridium butyricum MIYAIRI 588 and Reduced Incidence of Clostridioides difficile Infection in Critically Ill Patients: A Single-Center, Before-and-After Study (2022)
  • Author(s): Sato Takeaki、Kudo Daisuke、Kushimoto Shigeki
  • Journal Title: Surgical Infections Volume: 23 Issue: 5 Pages: 483-488
  • DOI: 10.1089/sur.2022.030
  • Peer Reviewed / Open Access
• [Journal Article] Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis (2022)
  • Author(s): Wada Takeshi、Yamakawa Kazuma、Kabata Daijiro、Abe Toshikazu、Gando Satoshi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 9304-9304
  • DOI: 10.1038/s41598-022-13346-3
  • Peer Reviewed / Open Access
• [Journal Article] Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes (2022)
  • Author(s): Wada Takeshi、Shiraishi Atsushi、Gando Satoshi、Kabata Daijiro、Yamakawa Kazuma、Fujishima Seitaro、Saitoh Daizoh、Kushimoto Shigeki、Ogura Hiroshi、Abe Toshikazu、Mayumi Toshihiko、Otomo Yasuhiro
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 1-12
  • DOI: 10.3389/fimmu.2022.1026163
  • Peer Reviewed / Open Access
• [Journal Article] Virus-Driven Carcinogenesis (2021)
  • Author(s): Hatano Yuichiro、Ideta Takayasu、Hirata Akihiro、Hatano Kayoko、Tomita Hiroyuki、Okada Hideshi、Shimizu Masahito、Tanaka Takuji、Hara Akira
  • Journal Title: Cancers Volume: 13 Issue: 11 Pages: 2625-2625
  • DOI: 10.3390/cancers13112625
  • Peer Reviewed / Open Access
• [Journal Article] Serum syndecan-1 reflects organ dysfunction in critically ill patients (2021)
  • Author(s): Suzuki Keiko、Okada Hideshi......Doi Tomoaki et al.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 8864-8864
  • DOI: 10.1038/s41598-021-88303-7
  • Peer Reviewed / Open Access
• [Journal Article] Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia (2021)
  • Author(s): Okamoto Haruka、Muraki Isamu、Okada Hideshi........Doi Tomoaki et al.
  • Journal Title: The American Journal of Pathology Volume: 191 Issue: 9 Pages: 1526-1536
  • DOI: 10.1016/j.ajpath.2021.05.015
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice (2021)
  • Author(s): Kinoshita Takamasa、Tomita Hiroyuki、Okada Hideshi et al.
  • Journal Title: Discover Oncology Volume: 12 Issue: 1 Pages: 50-50
  • DOI: 10.1007/s12672-021-00444-3
  • Peer Reviewed / Open Access
• [Journal Article] Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival (2021)
  • Author(s): Kitagawa Yuichiro、Kawamura Itta、Suzuki Keiko、Okada Hideshi........Doi Tomoaki et al.
  • Journal Title: PLOS ONE Volume: 16 Issue: 12 Pages: e0260350-e0260350
  • DOI: 10.1371/journal.pone.0260350
  • Peer Reviewed / Open Access
• [Journal Article] Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study (2021)
  • Author(s): Kamidani Ryo、Miyake Takahito、Okada Hideshi.......Doi Tomoaki et al.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 18458-18458
  • DOI: 10.1038/s41598-021-97954-5
  • Peer Reviewed / Open Access
• [Journal Article] Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx Injury During Hemodialysis (2021)
  • Author(s): Kusuzawa Keigo、Suzuki Keiko、Okada Hideshi........Doi Tomoaki et al.
  • Journal Title: Frontiers in Medicine Volume: 8 Pages: 791309-791309
  • DOI: 10.3389/fmed.2021.791309
  • Peer Reviewed / Open Access
• [Journal Article] Validity and risk factor analysis for helicopter emergency medical services in Japan: a pilot study (2021)
  • Author(s): Yamada Noriaki、Kitagawa Yuichiro、Yoshida Takahiro、Nachi Sho、Okada Hideshi、Ogura Shinji
  • Journal Title: BMC Emergency Medicine Volume: 21 Issue: 1
  • DOI: 10.1186/s12873-021-00471-x
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial Glycocalyx Disorders May Be Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model (2021)
  • Author(s): Sampei So、Okada Hideshi、.......Doi Tomoaki et al.
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 9 Pages: 623582-623582
  • DOI: 10.3389/fcell.2021.623582
  • Peer Reviewed / Open Access
• [Journal Article] Ultrastructural alteration of pulmonary tissue under conditions of high oxygen concentration (2020)
  • Author(s): Yano H, Kuroda A, Okada H, Tomita H, Suzuki K, Takada C, Fukuda H, Kawasaki Y, Muraki I, Wakayama Y, Kano S, Tamaoki Y, Nishio A, Inagawa R, Sampei S, Kamidani R, Kakino Y, Yasuda R, Kitagawa Y, Fukuta T, Miyake T, Kanda N, Miyazaki N, Doi T, Yoshida T, Suzuki A, Yoshida S, Ogura S
  • Journal Title: Int J Clin Exp Pathol Volume: 13 Pages: 3004-3012
  • Peer Reviewed / Open Access
• [Journal Article] Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx (2019)
  • Author(s): Fukuta T, Okada H, Takemura G, Suzuki K, Takada C, Tomita H, Suzuki A, Oda K, Uchida A, Matsuo S, Fukuda H, Yano H, Muraki I, Zaikokuji R, Kuroda A, Nishio A, Sampei S, Miyazaki N, Hotta Y, Yamada N, Watanabe T, Morishita K, Doi T, Yoshida T, Ushikoshi H, Yoshida S, Maekawa Y, Ogura S
  • Journal Title: Shock Volume: 2019 Nov 19. Issue: 3 Pages: 1-1
  • DOI: 10.1097/shk.0000000000001482
  • Peer Reviewed / Open Access
• [Presentation] 超微形態でみるトロンボモジュリンの多彩な血管内皮保護作用 (2022)
  • Author(s): 岡田 英志
  • Organizer: 第49回日本集中治療医学会
  • Invited
• [Presentation] シンデカン-1を用いてHELLP症候群の微小血管内皮障害を評価した1例 (2022)
  • Author(s): 西尾 紋音, 上谷 遼, 岡田 英志, 鈴木 景子, 三宅 喬人, 土井 智章, 鈴木 昭夫, 吉田 省造, 小倉 真治
  • Organizer: 第49回日本集中治療医学会
• [Presentation] グリコカリクス 糖尿病の感染症には血管内皮グリコカリックス傷害が関与する (2022)
  • Author(s): 三瓶 想, 岡田 英志, 久志本 成樹, 小倉 真治
  • Organizer: 第49回日本集中治療医学会
• [Presentation] グリコカリクス 血管内皮障害で敗血症の重症化を紐解く グリコカリックスでつなぐ病態生理と臨床 (2022)
  • Author(s): 岡田 英志
  • Organizer: 第49回日本集中治療医学会
  • Invited
• [Presentation] 横紋筋融解症によるマウス急性腎障害モデルにおける遺伝子組換えトロンボモジュリンの血管内皮保護作用の検討 (2022)
  • Author(s): 奥田 知輝, 岡田 英志, 福田 陽平, 鈴木 浩大, 川崎 雄輝, 西尾 紋音, 福田 洋丞, 上谷 遼, 三宅 喬人, 吉田 省造, 小倉 真治
  • Organizer: 第50回日本救急医学会
• [Presentation] "体温異常"を知らずに敗血症診療ができるのか? (2022)
  • Author(s): 久志本成樹
  • Organizer: 第49回日本集中治療医学会
• [Presentation] Serum Syndecan-1 Concentration in Hospitalized Patients with Heart Failure may Predict Readmission-free Survival (2022)
  • Author(s): 岡田英志、川村一太、北川雄一郎、渡邉崇量、松尾仁司、小倉真治
  • Organizer: 第86回日本循環器学会学術集会
• [Presentation] 血管内皮におけるヘパラン硫酸の減少は組織の炎症増悪に関与する (2022)
  • Author(s): 川崎雄輝、岡田英志、富田弘之、柿野圭紀、鈴木浩大、北川雄一郎、三宅喬人、土井智章、吉田省造、小倉真治
  • Organizer: 第49回日本集中治療医学会学術集会
• [Presentation] 血管内皮障害で敗血症の重症化を紐解く～グリコカリックスでつなぐ病態生理と臨床～ (2022)
  • Author(s): 岡田英志
  • Organizer: 第49回日本集中治療医学会学術集会
  • Invited
• [Presentation] 糖尿病の感染症には血管内皮グリコカリックス傷害が関与する (2022)
  • Author(s): 三瓶想 岡田英志 久志本成樹 小倉真治
  • Organizer: 第49回日本集中治療医学会学術集会
• [Presentation] 血液浄化療法により生じる血管内皮グリコカリックス障害の定量 (2021)
  • Author(s): 岡田英志、楠澤佳吾、鈴木景子、北川雄一郎、長屋聡一郎、土井智章、鈴木昭夫、吉田省造、小倉真治
  • Organizer: 第66回日本透析医学会総会・学術集会
• [Presentation] 心不全による血管内皮グリコカリックス障害は炎症細胞の遊走を増加させる (2021)
  • Author(s): 福田洋丞、岡田英志、鈴木浩大、玉置祐斗、南山徹、吉村絃希、大岩秀明、福田哲也、土井智章、小倉真治
  • Organizer: 第49回日本救急医学会総会・学術集会
• [Presentation] 膵炎における好中球組織動態と役割についての考察 (2021)
  • Author(s): 福田陽平、岡田英志、塚田真菜、上谷遼、三浦智孝、柿野圭紀、水野洋佑、安田立、北川雄一郎、三宅喬人、小倉真治
  • Organizer: 第49回日本救急医学会総会・学術集会
• [Presentation] 横紋筋融解症に伴う急性腎障害に対するアンチトロンビン治療の考察 (2021)
  • Author(s): 奥田知輝、岡田英志、川崎雄輝、中島優介、島田卓人、吉田知生、柴將人、神田倫秀、名知祥、吉田隆浩、小倉真治
  • Organizer: 第49回日本救急医学会総会・学術集会
• [Presentation] 血管内皮グリコカリックス障害は微小血栓生成を促進する (2021)
  • Author(s): 浅野博敬、岡田英志、加島朔、宮田遥香、高田ちひろ、三瓶想、加納壮一郎、若山佑豪、吉田省造、小倉真治
  • Organizer: 第49回日本救急医学会総会・学術集会
• [Presentation] 血液浄化療法により生じる血管内皮グリコカリックス障害の定量とその要因解析 (2021)
  • Author(s): 西尾紋音、岡田英志、楠澤佳吾、鈴木景子、石原拓磨、岡本遥、長屋聡一郎、安田立、鈴木昭夫、吉田省造、小倉真治
  • Organizer: 第49回日本救急医学会総会・学術集会
• [Presentation] 血液浄化療法により生じる血管内皮グリコカリックス障害の定量 (2021)
  • Author(s): 岡田英志、楠澤佳悟、北川雄一郎、長屋聡一郎、土井智章、吉田省造、小倉真治、鈴木景子、鈴木昭夫
  • Organizer: 第66回日本透析医学会学術集会・総会
• [Presentation] 糖尿病モデルマウスのグリコカリックス障害と敗血症血管炎下における炎症細胞の遊走遅延 (2020)
  • Author(s): 三瓶 想、岡田英志、久志本成樹
  • Organizer: 第48回 日本救急医学会総会・学術集会