| Project/Area Number |
20K09671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Shimane University |
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Principal Investigator |
Kanasaki Haruhiko 島根大学, 学術研究院医学・看護学系, 准教授 (10325053)
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| Co-Investigator(Kenkyū-buntansha) |
折出 亜希 島根大学, 学術研究院医学・看護学系, 講師 (00423278)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 視床下部 / キスペプチン / GnRH / インヒビン / アクチビン / フォリスタチン / kisspeptin / Hypothalamus / HPG axis / ゴナドトロピン |
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| Outline of Research at the Start |
本研究の目的はキスペプチンニューロンを制御しうる因子を同定し、それらの因子と女性ホルモンとの関係を解明することである。エストロゲンによるフィードバック機構を含め、キスペプチンニューロンを取り巻く神経的、内分泌的因子に関する体系的な理解を目指したい。
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| Outline of Final Research Achievements |
1）Activin, inhibin, and follistatin expressed in the brain participate in the E2-induced feedback control of the hypothalamic-pituitary-gonadal axis.2）Hyperandrogenemia affects KNDy neurons and changes their neuronal characteristics by increasing kisspeptin and NKB levels and decreasing DynA levels. These changes might cause dysfunction of the hypothalamic-pituitary-gonadal axis.3）AMH participates in hypothalamic-pituitary-gonadal axis control by stimulating GnRH expression. In addition, AMH might be a potent repressor of Kiss-1 gene expression induced by KP10.4）Kisspeptin and GnRH affected Kiss-1- and GnRH-expressing hypothalamic cells and modulated Kiss-1 and/or GnRH gene expression with a concomitant increase in c-Fos protein expression. A mutual- or self-regulatory system might be present in Kiss-1 and/or GnRH neurons in the hypothalamus.
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| Academic Significance and Societal Importance of the Research Achievements |
キスペプチンニューロンの制御機構の一端を解明できた。
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