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Imbalance of oral microbiome influences on severity of the oral ulcerative mucositis

Research Project

Project/Area Number 20K09894
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57010:Oral biological science-related
Research InstitutionNihon University

Principal Investigator

HITOMI Suzuro  日本大学, 歯学部, 講師 (70548924)

Co-Investigator(Kenkyū-buntansha) 小野 堅太郎  九州歯科大学, 歯学部, 教授 (40316154)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口内炎 / 口腔細菌叢 / 潰瘍性口内炎 / 口腔乾燥
Outline of Research at the Start

がん治療中の患者に発症する口内炎は、激痛を生じるため会話や食事などが困難になる。さらに、唾液腺萎縮による口腔乾燥も併発するため、臨床上大きな問題となっている。以前の研究から、このような口内炎の増悪には口腔細菌数の増加が関与すると考えられるが、ドライマウスや歯周病患者に認められる口腔細菌叢バランス失調も影響する可能性がある。本研究では、口腔乾燥により口腔細菌叢がどう変化するのか、その変化は口内炎の治癒過程や疼痛にどの程度影響するのかを明らかにする。口腔乾燥による口内炎増悪機構が解明されれば、適切な治療法や予防法を見出すことにつながり、口内炎で苦しむ患者のQOL 向上に貢献できると考える。

Outline of Final Research Achievements

Recently, alterations in the oral microbiota composition have been reported to be induced by various systemic diseases including Sjogren's syndrome. The object of the present study was to investigate the oral microbiota in hyposalivation model rats and examine the involvement of oral bacteria in healing process of oral ulcerative mucositis. In the hyposalivation model, composition of oral microbiota was changed. The severity of oral ulcerative mucositis and bacterial loading level in the ulcer region were exacerbated in the model. The exacerbations were recovered by antibiotic application. Increase in bacterial loading and alteration of oral microbiota composition are likely to be involved in the exacerbation of oral ulcerative mucositis in the hyposalivation model.

Academic Significance and Societal Importance of the Research Achievements

本研究は、頭頸部がん治療中など口腔乾燥に苦しむ患者の口腔内環境変化と口腔粘膜疾患の治癒過程に着目して行われた。本研究結果は、そのような患者における口腔粘膜疾患の病態の理解につながる。また、今後より詳細な口腔細菌叢の解析を行うことで、どの細菌種がどのように疾患の治癒や疼痛に関与しているかが明らかになれば、口腔粘膜疾患の予防や、治療薬の選択に役立つ可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (5 results)

All 2023 2021

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Hepcidin expression in the trigeminal ganglion and the oral mucosa in an oral ulcerative mucositis rat model2023

    • Author(s)
      Suzuro Hitomi, Tomotaka Nodai, Shoichiro Kokabu, Takemi Shikayama, Misa Sago-Ito, Chihiro Nakatomi, Kiyoshi Terawaki, Yuji Omiya, Masamichi Shinoda and Kentaro Ono
    • Journal Title

      Plos One

      Volume: NA

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neonatal Injury Modulates Incisional Pain Sensitivity in Adulthood: An Animal Study2023

    • Author(s)
      Soma Kumi、Hitomi Suzuro、Hayashi Yoshinori、Soma Chihiro、Otsuji Jo、Shibuta Ikuko、Furukawa Akihiko、Urata Kentaro、Kurisu Ryoko、Yonemoto Mamiko、Hojo Yasushi、Shirakawa Tetsuo、Iwata Koichi、Shinoda Masamichi
    • Journal Title

      Neuroscience

      Volume: 519 Pages: 60-72

    • DOI

      10.1016/j.neuroscience.2023.03.018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontal acidification contributes to tooth pain hypersensitivity during orthodontic tooth movement2021

    • Author(s)
      Osada Ayaka、Hitomi Suzuro、Nakajima Akira、Hayashi Yoshinori、Shibuta Ikuko、Tsuboi Yoshiyuki、Motoyoshi Mitsuru、Iwata Koichi、Shinoda Masamichi
    • Journal Title

      Neuroscience Research

      Volume: 177 Pages: 103-110

    • DOI

      10.1016/j.neures.2021.11.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 口内炎モデルラットの三叉神経節におけるhepcidinの発現とその役割2021

    • Author(s)
      人見涼露,篠田雅路,小野堅太郎
    • Organizer
      第63回歯科基礎医学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 歯移動時に生じる歯痛に対する酸感受性疼痛関連チャネルASIC3の役割2021

    • Author(s)
      長田彩佳、人見涼露、中嶋昭、篠田雅路
    • Organizer
      第26回日本口腔顔面痛学会学術大会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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