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Research on the practical use of electrolyzed acidic functional water as a mouthwash for super-elderly people

Research Project

Project/Area Number 20K10057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionNihon University

Principal Investigator

ASANO Masatake  日本大学, 歯学部, 教授 (10231896)

Co-Investigator(Kenkyū-buntansha) 西尾 健介  日本大学, 歯学部, 助教 (50780558)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords電解酸性機能水 / 含嗽剤 / 殺菌効果 / interleukin-1 alpha / propiece IL-1 alpha / IL-1 receptor / alarmin / 酸性電解機能水 / IL-1 alpha / AIF-1 / interleukin-1α / 高齢者
Outline of Research at the Start

これまでの研究で、高齢者で入れ歯などを使っている患者さんに、電解酸性機能水という食塩水を電気分解することにより得られる水によってうがいをしてもらいアンケートを行った。その結果、「口の中が爽快になった」など、臨床的に有用と思われる効果があることが推測された。そこで免疫力向上に貢献するsecretory IgAという物質の唾液中の濃度を測定したところ、その濃度が上昇していることが解った。こうしたことから本研究では、どうしてsIgAの濃度が上がるのか、その作用メカニズムの解明を目指して研究することにした。

Outline of Final Research Achievements

Electrolyzed acid functional water (FW) is obtained by electrolyzing salt water, and has an extremely high bactericidal effect. Aiming for practical use as a mouthwash for super-elderly people who have difficulty physically cleaning their mouths, we compared the bactericidal effect with a commercially available mouthwash. As a result, it was demonstrated that FW exhibited comparable bactericidal effects compared to other mouthwashes, and was also superior in safety. In addition, experiments using oral cancer-derived cultured cells have revealed that FW promotes the extracellular release of interleukin-1 alpha (IL-1a), a type of inflammatory cytokine. Since the regulation of IL-1a secretion is extremely important in the control of inflammatory diseases, we also investigated its molecular mechanism.

Academic Significance and Societal Importance of the Research Achievements

生理機能の低下などにより、歯ブラシなどの物理的口腔清掃が困難な超高齢者は、誤嚥性肺炎などを発症するリスクが高い。本研究で用いた電解酸性機能水(FW)は、極めて高い殺菌効果を有することが明らかとなった。FWは、食塩水の電気分解で得られる水で、安価なうえに安全性にも優れている。FWを超高齢者の口腔清掃に応用できれば、健康寿命の延伸にも寄与するものと考えられる。こうした取り組みは、超高齢社会の到来とともに危惧される社会保障費の抑制にもつながる可能性があり、社会的に極めて意義深いものと考える。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2022 2021

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Establishment of interleukin-1 receptor type 1 knockout HeLa strain by CRISP/Cas9 system.2022

    • Author(s)
      Hanayama M, Ishiyama Y, Sadamura M, Moriyama A, Imaoka S, Tsunoda M, Asano M
    • Journal Title

      Journal of Biomedical Science and Research

      Volume: 4 Pages: 1-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear localization of propiece IL-1α in HeLa cells2022

    • Author(s)
      Kudo Y, Tamagawa T, Nishio K, Kaneko T,Yonehara Y, Tsunoda M
    • Journal Title

      Journal of Oral Science

      Volume: 64 Issue: 2 Pages: 151-155

    • DOI

      10.2334/josnusd.21-0540

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of acid-electrolyzed functional water for mouth wash: an in vitro study2022

    • Author(s)
      Oikawa D, Nishio K, Tamura M, Fukasawa M, Yoshida T, Okada S, Ito T, Tsunoda M, Asano M, Iinuma T
    • Journal Title

      In vivo

      Volume: 36 Issue: 5 Pages: 2211-2217

    • DOI

      10.21873/invivo.12947

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acid-electrolyzed functional water-induces interleukin-1α release from intracellular storage sites in oral squamous cell carcinoma.2021

    • Author(s)
      Takemoto T, Kaetsu R, Hanayama M, Ishiyama Y, Sadamura M, Nishio K, Tsunoda M, Asano M, Motoyoshi M.
    • Journal Title

      International Journal of Medical Sciences

      Volume: 18 Issue: 8 Pages: 1746-1752

    • DOI

      10.7150/ijms.53999

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] IL-1aの核内輸送における分子制御機構の解明2022

    • Author(s)
      和気清尊、山本亜希子、角田麻里子、浅野正岳
    • Organizer
      第111回 日本病理学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] IL-1αの細胞外放出におけるHAX-1の関与2022

    • Author(s)
      今岡沙耶、浅野正岳
    • Organizer
      第15回 日本口腔検査学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] IL-1R1の核局在とその役割について2022

    • Author(s)
      森山鮎子、浅野正岳
    • Organizer
      第15回 日本口腔検査学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] IL-1α N末断片の機能解明2021

    • Author(s)
      角田麻里子、工藤 圭紘、浅野正岳
    • Organizer
      第110回 日本病理学会
    • Related Report
      2020 Research-status Report
  • [Presentation] IL-1α の processing と機能2021

    • Author(s)
      角田麻里子、浅野正岳
    • Organizer
      第32回 日本臨床口腔病理学会
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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