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Understanding the distribution of resistant bacteria in the oral cavity and the impact of oral hygiene management by dentists on healthcare-associated pneumonia

Research Project

Project/Area Number 20K10248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionHiroshima University

Principal Investigator

Yoshikawa Mineka  広島大学, 医系科学研究科(歯), 准教授 (00444688)

Co-Investigator(Kenkyū-buntansha) 菅井 基行  国立感染症研究所, 薬剤耐性研究センター, センター長 (10201568)
太田 耕司  広島大学, 医系科学研究科(歯), 教授 (20335681)
梶原 俊毅  国立感染症研究所, 薬剤耐性研究センター, 主任研究官 (40816948)
吉田 光由  藤田医科大学, 医学部, 教授 (50284211)
鹿山 鎭男  国立感染症研究所, 薬剤耐性研究センター, 室長 (50432761)
津賀 一弘  広島大学, 医系科学研究科(歯), 教授 (60217289)
大毛 宏喜  広島大学, 病院(医), 教授 (70379874)
小松澤 均  広島大学, 医系科学研究科(歯), 教授 (90253088)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords薬剤耐性菌 / 要介護高齢者 / 口腔衛生 / 口腔 / 非経口摂取 / 専門的口腔衛生管理 / 誤嚥性肺炎 / 医療・介護関連肺炎 / 要介護 / 口腔ケア / 介護医療院 / 口腔内耐性菌 / 口腔衛生管理
Outline of Research at the Start

2020年度は広島県内某介護保険施設2ヵ所へ入所する要介護高齢者100名の口腔内細菌を採取し,口腔内に薬剤耐性菌がどのくらいの割合で存在するかを確認する.
2021-2022年度は,2020年度における調査で口腔内に薬剤耐性菌の保有していることが判明した要介護高齢者に対し,歯科医師と歯科衛生士が週1回8週間に渡って専門的な口腔清掃(口腔衛生管理)を実施し,実施直後,半年後,1年後において,2020年度と同様に口腔内細菌を採取し口腔内細菌叢の変化等について検討する.加えて診療録から全研究協力者の医療・介護関連肺炎発症の有無やその重症度を評価する.

Outline of Final Research Achievements

The purpose of this study was to clarify the oral and rectal carriage of antimicrobial-resistant bacteria (ARB) in elderly people with severe dependency of long-term care, and to clarify the effect of professional oral hygiene intervention by dental health care workers on oral ARB carriage in those with oral ARB.
Among 57 participants in the cross-sectional study, ARB were isolated from the oral cavity of 29 participants (50.9%) and from the rectum of 44 participants (77.2%). In the intervention study, 23 participants cooperated, and professional oral hygiene was performed once a week in addition to daily oral hygiene, but ARB did not disappear. ARB carriage is observed at a high rate in elderly people with severe long-term care, and it is important for medical and care workers to have correct knowledge of ARB infection control measures and practice standard precautions.

Academic Significance and Societal Importance of the Research Achievements

今後、薬剤耐性菌(ARB)の大幅な増加が懸念され、日本でもARB対策の行動計画が策定されている。 そして医療機関だけでなく、高齢者介護施設などでもARBの感染対策に力を入れている現状がある。高齢者介護施設などではARB感染対策に関する対応が急性期と比べて十分ではない状況がある。今回の研究結果から、多くの医療・介護サポートの必要な重度要介護高齢者において口腔内や便内からARBが保菌されていることが明らかとなった。高齢者の医療・介護に携わるスタッフにおいても、ARBの感染対策の徹底や正しい知識のアップデートが必要である。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (13 results)

All 2023 2022 2021

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Oral hypofunction and its relation to frailty and sarcopenia in community-dwelling older people.2022

    • Author(s)
      Yoshida M, Hiraoka A, Takeda C, Mori T, Maruyama M, Yoshikawa M, Tsuga K.
    • Journal Title

      Gerodontology.

      Volume: 39 Issue: 1 Pages: 26-32

    • DOI

      10.1111/ger.12603

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between Food Crushing and Oral Function in Older Adults Requiring Nursing Home Care: A Pilot Study.2022

    • Author(s)
      Yamawaki K, Mori T, Itaki S, Haruta A, Takeda C, Hiraoka A, Maruyama M, Yoshikawa M, Yoshida M, Tsuga K.
    • Journal Title

      Int J Environ Res Public Health

      Volume: 19 Issue: 6 Pages: 3419-3419

    • DOI

      10.3390/ijerph19063419

    • Related Report
      2021 Research-status Report
  • [Journal Article] Improper sitting posture while eating adversely affects maximum tongue pressure.2021

    • Author(s)
      Yoshikawa M, Nagakawa K, Tanaka R, Yamawaki K, Mori T, Hiraoka A, Higa C, Nishikawa Y, Yoshida M, Tsuga K.
    • Journal Title

      J Dent Sci

      Volume: 16 Issue: 1 Pages: 467-473

    • DOI

      10.1016/j.jds.2020.08.012

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between stroke lesions and videofluoroscopic findings in acute stroke patients.2021

    • Author(s)
      Nakamori M, Hosomi N, Imamura E, Matsushima H, Maetani Y, Yoshida M, Yoshikawa M, Takeda C, Nagasaki T, Masuda S, Kayashita J, Tsuga K, Tanimoto K, Wakabayashi S, Maruyama H.
    • Journal Title

      J Neurol.

      Volume: 268 Issue: 3 Pages: 1025-1035

    • DOI

      10.1007/s00415-020-10244-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the Iowa Oral Performance Instrument and JMS tongue pressure measurement device2021

    • Author(s)
      Yoshikawa Mineka、Fukuoka Tatsuyuki、Mori Takahiro、Hiraoka Aya、Higa Chiaki、Kuroki Azusa、Takeda Chiho、Maruyama Mariko、Yoshida Mitsuyoshi、Tsuga Kazuhiro
    • Journal Title

      Journal of Dental Sciences

      Volume: 16 Issue: 1 Pages: 214-219

    • DOI

      10.1016/j.jds.2020.06.005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Oral And rectal colonization by antimicrobial-resistant Gram-Negative bacteria in older adults requiring severe intensive nursing care admitted to a long-term care facility2023

    • Author(s)
      Yoshikawa M, Haruta A, Kajihara T, Takeuchi M, Kawada-Matsuo M, Nguyen-Tra Le M, Tsuga K, Komatsuzawa H, Ohge H, Sugai M
    • Organizer
      IAGG Asia/Oceania Regional Congress2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral and rectal colonization by Antimicrobial-resistant gram negative bacteria in older adults requiring severe intensive nursing care admitted to a long-term care facility2023

    • Author(s)
      Yoshikawa M, Haruta A, Kajihara T, Takeuchi M, Kawada-Matsuo M, Le MN, Tsuga K, Komatsuzawa H, Ohge H, Sugai M
    • Organizer
      IAGG Asia/Oceania regional congress 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 一介護医療院における口腔内薬剤耐性菌の保菌調査2022

    • Author(s)
      竹内真帆,春田梓,吉川峰加,平岡綾,森隆浩,丸山真理子,竹田智帆,髙橋優太朗,上田裕次,吉田光由,津賀一弘
    • Organizer
      (一社)日本老年歯科医学会第33回学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 一介護医療院における口腔内薬剤耐性菌の保菌調査2022

    • Author(s)
      竹内真帆,春田梓,吉川峰加,吉田光由,津賀一弘
    • Organizer
      日本老年歯科医学会第33回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 電子聴診システムによる嚥下強度定量化の試み(中間報告)2021

    • Author(s)
      向井明里,清水慶隆,髙橋珠世,吉川峰加,大下慎一郎,佐伯昇,貞森琢拓磨,志馬伸朗,津賀一弘
    • Organizer
      日本顎口腔機能学会第66回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 要介護高齢者における口腔内薬剤耐性菌の保菌状況と経口摂取2021

    • Author(s)
      吉川峰加
    • Organizer
      第16回・第17回共催日本神経摂食嚥下・栄養学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 要介護高齢者における口腔内薬剤耐性菌の保菌状況と経口摂取2021

    • Author(s)
      吉川峰加
    • Organizer
      第91回日本感染症学会西日本地方会学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Isolation/characterization of oral antibiotic-resistant Gram-negative bacteria in nursing homes2021

    • Author(s)
      Haruta A, Matsuo M, Yoshikawa M, Takeuchi M, Le Tra Nguyen M, Yahara K, Ouge H, Tsuga K, Sugai M, Komatsuzawa H
    • Organizer
      The 94th Annual Meeting of Japanese Society for bacteriology
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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