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The association between indoor cold exposure and cardiovascular risk: a prospective cohort study

Research Project

Project/Area Number 20K10476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionNara Medical University

Principal Investigator

Saeki Keigo  奈良県立医科大学, 医学部, 教授 (60364056)

Co-Investigator(Kenkyū-buntansha) 大林 賢史  奈良県立医科大学, 医学部, 特任准教授 (30596656)
山上 優紀  奈良県立医科大学, 医学部, 助教 (90823956)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords室温 / 心血管疾患 / 外気温 / 前向きコホート研究 / 寒冷曝露 / 室内寒冷曝露 / 肥満 / 動脈硬化
Outline of Research at the Start

外気温低下に関連する死亡数は、高血圧や喫煙に関連する死亡数に匹敵する。冬の室温が保たれている北欧諸国では寒冷曝露関連死亡が少ないことや、室温介入試験から室温調整の重要性が示唆されるが、実生活下の室温と動脈硬化の進行、心血管疾患の罹患の関連は明らかではない。申請者らは高齢者を対象とする前向きコホート研究から、肥満・糖尿病の罹患、動脈硬化の進行、心血管疾患罹患との縦断的関連を検討する。

Outline of Final Research Achievements

We conducted a mail survey using a questionnaire asking incidence of cardiovascular disease during five years among participants of a cohort study investigating the indoor environment at baseline. We received 2665 responses (94.5%), and the mean age of respondents was 73.5 (standard deviation: 8.16) years. The incidence proportion of cardiovascular disease was 4.5 %. Based on the indoor and outdoor temperatures at the baseline survey, we divided the respondents into the cold house group (n = 1300) and the control group (n= 1338). The incidence proportion of cardiovascular disease among the cold house group (5.15%) was higher than that of the control group (3.89%), but the difference between them was not significant (p = 0.133).

Academic Significance and Societal Importance of the Research Achievements

本研究は住環境の温度と心血管疾患罹患の関連を調査した初めての大規模前向きコホート研究である。温かい住宅に住む対象者と寒い住宅にする対象者の間で、過去5年間の心血管疾患の発生状況に統計学的有意な差は認めなかったが、さらに長期の観察によって重要な知見を見出す可能性が示された。研究成果は、冬に上昇する心血管疾患死亡を予防し、健康寿命の延伸のためには、住環境の温度をどのように調整すべきであるかを検討するための科学的エビデンスとなるものである。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (17 results)

All 2023 2022 2021 2020 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (9 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Association Between Before-bedtime Passive Body Heating and Nocturia During the Cold Season Among Older Adults2023

    • Author(s)
      Tai Yoshiaki、Obayashi Kenji、Okumura Kazuki、Yamagami Yuki、Negoro Hiromitsu、Kurumatani Norio、Saeki Keigo
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 8 Pages: 398-404

    • DOI

      10.2188/jea.JE20210471

    • NAID

      130008161541

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-08-05
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of Depression on the Association between Colder Indoor Temperature and Higher Blood Pressure2022

    • Author(s)
      Okumura K, Obayashi K, Tai Y, Yamagami Y, Kurumatani N, Saeki K.
    • Journal Title

      Journal of Hypertensions

      Volume: 40(10) Issue: 10 Pages: 2013-2021

    • DOI

      10.1097/hjh.0000000000003221

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverse Association of Skin Temperature With Ambulatory Blood Pressure and the Mediation of Skin Temperature in Blood Pressure Responses to Ambient Temperature2022

    • Author(s)
      Tai Y, Obayashi K, Yamagami Y, Saeki K
    • Journal Title

      Hypertension

      Volume: - Issue: 8 Pages: 1845-1855

    • DOI

      10.1161/hypertensionaha.122.19190

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Between Passive Body Heating by Hot Water Bathing Before Bedtime and Depressive Symptoms Among Community-Dwelling Older Adults2022

    • Author(s)
      Tai Yoshiaki、Obayashi Kenji、Yamagami Yuki、Kurumatani Norio、Saeki Keigo
    • Journal Title

      The American Journal of Geriatric Psychiatry

      Volume: 30 Issue: 2 Pages: 161-170

    • DOI

      10.1016/j.jagp.2021.06.010

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hot water bathing before bedtime and shorter sleep onset latency is accompanied by a higher distal-proximal skin temperature gradient in older adults2021

    • Author(s)
      Tai Y, Obayashi K, Yamagami Y, Yoshimoto K, Kurumatani N, Nishio K, Saeki K.
    • Journal Title

      J Clin Sleep Med

      Volume: Epub ahead of print Issue: 6 Pages: 1257-1266

    • DOI

      10.5664/jcsm.9180

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between NT-proBNP and nocturia among community-dwelling elderly males and females: A cross-sectional analysis of the HEIJO-KYO study。2021

    • Author(s)
      Okumura K, Obayashi K, Tai Y, Yamagami Y, Negoro H, Kataoka H, Kurumatani N, Saeki K.
    • Journal Title

      Neurourol Urodyn

      Volume: 40 Issue: 1 Pages: 112-119

    • DOI

      10.1002/nau.24550

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development and validation of nutrient estimates based on a food-photographic record in Japan2020

    • Author(s)
      Keigo Saeki, Naoto Otaki, Maiko Kitagawa,Nobuhiro Tone, Ribeka Takachi,Rika Ishizuka, Norio Kurumatani and Kenji Obayashi
    • Journal Title

      Nutrition Journal

      Volume: 19 Issue: 1 Pages: 1-13

    • DOI

      10.1186/s12937-020-00615-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 生活環境における温度曝露とその影響の測定2023

    • Author(s)
      佐伯圭吾
    • Organizer
      日本疫学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 実生活環境下の入浴と夜間頻尿の短期縦断的関連:平城京スタディ2023

    • Author(s)
      田井義彬, 大林賢史, 山上優紀, 佐伯圭吾
    • Organizer
      日本疫学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 総死亡の相対危険が最低となる室温の推計:既存データとコホートデータを用いた分析2022

    • Author(s)
      佐伯圭吾, 田井義彬, 山上優紀, 大林賢史
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 実生活環境下における寒冷曝露時の血圧上昇における皮膚温の媒介効果:平城京スタディ2022

    • Author(s)
      田井義彬, 大林賢史, 山上優紀, 佐伯圭吾
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 冬の室内寒冷曝露と筋力・歩行速度低値の横断関連: 平城京スタディ2022

    • Author(s)
      諏訪内宏益, 大林賢史, 田井義彬, 山上優紀, 佐伯圭吾
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 実生活の入浴中の血圧変動と皮膚温の関連:1527人の大規模疫学研究(平城京スタディ)2021

    • Author(s)
      田井義彬, 大林賢史, 山上優紀, 佐伯圭吾
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Association between Circadian Characteristics of the Distal Skin Temperature Rhythm and Actigraphic Sleep in Community-Dwelling Older Adults.2021

    • Author(s)
      Tai Y, Obayashi K, Yamagami Y, Saeki K
    • Organizer
      日本時間生物学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高齢者における夜間頻尿と入浴との関連:平城京スタディ2021

    • Author(s)
      田井義彬, 大林賢史, 山上優紀, 車谷典男, 佐伯圭吾
    • Organizer
      日本睡眠学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 住環境因子と健康との関連-平城京スタディからわかったこと-2020

    • Author(s)
      佐伯圭吾
    • Organizer
      第79回 日本公衆衛生学会総会
    • Related Report
      2020 Research-status Report
  • [Remarks] 奈良県立医科大学 疫学・予防医学講座

    • URL

      https://www.naramed-u.ac.jp/~epi/posts/research_archive.html

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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