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MicroRNA-181c as a potential biomarker for efficacy of cardiac rehabilitation in geriatric heart failure

Research Project

Project/Area Number 20K11291
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionShowa University

Principal Investigator

Iso Yoshitaka  昭和大学, 医学部, 准教授 (60384244)

Co-Investigator(Kenkyū-buntansha) 木庭 新治  昭和大学, 医学部, 教授 (20276546)
鈴木 洋  昭和大学, 医学部, 教授 (90266106)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords心臓リハビリテーション / 心不全 / マイクロRNA / 運動耐容能 / microRNA / 高齢者 / 高齢者心不全
Outline of Research at the Start

高齢者心不全では、心肺運動負荷試験実施困難例が多く、病態評価や心臓リハビリテーション効果・予後判定が不十分であるのが現状である。
末梢循環中マイクロRNAは、疾患や治療効果判定のバイオマーカーとしての可能性が注目されている。申請者は、予備試験よりマイクロRNAの一種miR-181cの末梢循環中発現レベルが心筋梗塞例の運動耐容能と相関することを同定した。高齢者心不全にも応用可能であると考え、本研究において、心臓リハビリテーションの効果予測への有用性を検証する。マイクロRNAと言う新たな診断技術の可能性を探索し、心臓リハビリテーション学において学術的展開を起こすための基盤研究となることを目指す。

Outline of Final Research Achievements

In this study, we investigated the potential utility of circulating microRNAs (miRs) as discerning biomarkers for exercise capacity in patients with cardiovascular diseases. We focused on miR-181c and miR-484 known as miRs related to mitochondria in cardiomyocytes. Among patients recovering from acute myocardial infarction, both miRs demonstrated a substantial correlation with the pinnacle of oxygen consumption. Furthermore, in patients with heart failure, the levels of miR-181c exhibited a significant correlation with the levels of miR-484. Both miRs tended to be higher in the elderly population compared to their younger counterparts. The levels of miR-484 exhibited an association with an exercise tolerance index, specifically, the efficiency slope of oxygen consumption. Our findings imply that miR-181c and miR-484 could potentially serve as predictive indicators of exercise capacity in cardiovascular disease patients.

Academic Significance and Societal Importance of the Research Achievements

「臨床応用に向けた心疾患患者における正確な運動耐容能バイオマーカーとしてのmiRの探索」の観点から実施された研究はこれまでになく、本研究は、世界に先駆けmiR-181cとmiR-484を有力な候補として同定した。この成果は、基礎も含めたmiR研究に新たな視点をもたらすともに、運動生理学におけるバイオマーカー研究を進歩させ得る。評価系の確立においても新知見をもたらした。miR測定における新規のデジタルPCRの有用性や心肺運動負荷試験における酸素摂取効率勾配(OUES)の妥当性を示した。本研究成果は、心臓リハビリテーション学の発展に寄与すると考える。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (29 results)

All 2023 2022 2021 2020

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (18 results) (of which Invited: 6 results) Book (2 results)

  • [Journal Article] Effects of beta-hydroxy beta-methyl butyrate calcium combined with exercise therapy in patients with cardiac disease: a study protocol for clinical trial2023

    • Author(s)
      Ikeda Takashi、Miyazawa Ryo、Inoue Eisuke、Iso Yoshitaka、Nakamura Daisuke、Abe Satoko、Hachisu Mitsugu、Tashiro Naonori、Iguchi Akihiro、Aimoto Kenji、Nakamura Shoko、Ichikawa Hiroo
    • Journal Title

      BMJ Open

      Volume: 13 Issue: 2 Pages: e066633-e066633

    • DOI

      10.1136/bmjopen-2022-066633

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac Structure and Cardiorespiratory Fitness in Young Male Japanese Rugby Athletes2023

    • Author(s)
      Iso Yoshitaka、Kitai Hitomi、Ichimori Keiko、Kubota Megumi、Tsujiuchi Miki、Nagumo Sakura、Toshida Tsutomu、Yonechi Toru、Ebato Mio、Suzuki Hiroshi
    • Journal Title

      Journal of Cardiovascular Development and Disease

      Volume: 10 Issue: 1 Pages: 12-12

    • DOI

      10.3390/jcdd10010012

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease2022

    • Author(s)
      Makita Shigeru、Yasu Takanori、Akashi Yoshihiro J、Adachi Hitoshi、Izawa Hideo、Ishihara Shunichi、Iso Yoshitaka、Ohuchi Hideo、Omiya Kazuto、Ohya Yusuke、Okita Koichi、Kimura Yutaka、Koike Akira、Kohzuki Masahiro、Koba Shinji、Sata Masataka、Shimada Kazunori、et al.
    • Journal Title

      Circulation Journal

      Volume: 87 Issue: 1 Pages: 155-235

    • DOI

      10.1253/circj.CJ-22-0234

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2022-12-23
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Prognostic Value of Left Atrial Reservoir Functional Indices Measured by Three-Dimensional Speckle-Tracking Echocardiography for Major Cardiovascular Events2021

    • Author(s)
      Tsujiuchi Miki、Ebato Mio、Maezawa Hideyuki、Ikeda Naoko、Mizukami Takuya、Nagumo Sakura、Iso Yoshitaka、Yamauchi Takenori、Suzuki Hiroshi
    • Journal Title

      Circulation Journal

      Volume: 85 Issue: 5 Pages: 631-639

    • DOI

      10.1253/circj.CJ-20-0617

    • NAID

      130008028956

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-04-23
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors related to independent of walking at discharge in patient on mechanical ventilation for more than 48 hours2021

    • Author(s)
      Miyazawa Ryo、Iso Yoshitaka、Tashiro Naonori、Suzuki Hiroshi、Hayashi Munetaka、Miyagawa Tetsuo
    • Journal Title

      Journal of the Japanese Society of Intensive Care Medicine

      Volume: 28 Issue: 2 Pages: 93-98

    • DOI

      10.3918/jsicm.28_93

    • NAID

      130007993168

    • ISSN
      1340-7988, 1882-966X
    • Year and Date
      2021-03-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Exercise-Based Cardiac Rehabilitation on the Mid-Term Outcomes of Patients After Acute Myocardial Infarction Treated With Current Acute-Phase Management and Optimal Medical Therapy2021

    • Author(s)
      Kyuno Etsushi、Iso Yoshitaka、Tsujiuchi Miki、Maeda Atsuo、Miyazawa Ryo、Kowaita Hitoshi、Kitai Hitomi、Sato Tokutada、Ebato Mio、Sambe Takeyuki、Suzuki Hiroshi
    • Journal Title

      Heart, Lung and Circulation

      Volume: 30 Issue: 9 Pages: 1320-1328

    • DOI

      10.1016/j.hlc.2021.03.268

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] スポーツと心電図2021

    • Author(s)
      礒良崇, 市森恵子,北井仁美
    • Journal Title

      臨床検査

      Volume: 65 Pages: 920-926

    • Related Report
      2021 Research-status Report
  • [Journal Article] Are sleep disorders a cause of sudden death during sports activities?2021

    • Author(s)
      Iso Yoshitaka
    • Journal Title

      European Society of Cardiology E-Journal of Cardiology Practice

      Volume: 19

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential Association of Circulating MicroRNA-181c and MicroRNA-484 Levels with Cardiorespiratory Fitness after Myocardial Infarction: A Pilot Study2021

    • Author(s)
      Miyazawa Ryo、Iso Yoshitaka、Tsujiuchi Miki、Shoji Makoto、Takahashi Tetsuya、Koba Shinji、Ebato Mio、Miyagawa Tetsuo、Geshi Eiichi、Suzuki Hiroshi
    • Journal Title

      Progress in Rehabilitation Medicine

      Volume: 6 Issue: 0 Pages: n/a

    • DOI

      10.2490/prm.20210017

    • NAID

      130008000168

    • ISSN
      2432-1354
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] HFpEF患者における心血管イベント発症予測因子としての尿酸値の検討2023

    • Author(s)
      辻内美希、礒 良崇、近江真歩、沼尻祐貴、久保田芽生、大村 歩、南雲さくら、土至田勉 、江波戸美緒、鈴木 洋
    • Organizer
      第267回日本循環器学会関東甲信越地方会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Athletic Cardiac Remodeling and Cardiorespiratory Fitness in Young Japanese Male Athletes2023

    • Author(s)
      Megumi Kubota, Yoshitaka Iso, Miki Tsujiuchi, Sakura Nagumo, Tsutomu Toshida, Mio Ebato, Hiroshi Suzuki
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Guidance for return to play in athletes following SARS-CoV-2 infection in Japan2022

    • Author(s)
      礒 良崇
    • Organizer
      第28回日本心臓リハビリテーション学会総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 横浜市心臓リハビリテーション推進事業における 維持期継続に向けた地域スポーツ施設との連携2022

    • Author(s)
      宮澤僚、野末剛、片桐浩二、水越慶、笠原酉介、古賀美弥子、礒良崇
    • Organizer
      第28回日本心臓リハビリテーション学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 腫瘍循環器における身体活動能力評価と心臓リハビリテーションの意義2022

    • Author(s)
      礒 良崇,宮澤 僚,土至田 勉,江波戸 美緒,鈴木 洋
    • Organizer
      第70回日本心臓病学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] An Introduction to Sports Cardiology2022

    • Author(s)
      Yoshiaka Iso
    • Organizer
      第86 回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 回復期心臓リハビリテーションの非参加要因の探索2021

    • Author(s)
      宮澤僚,礒良崇,田代尚範,中島真奈美,辻内美希,相本賢二,鈴木駿平,北井仁美,小和板仁,江波戸美緒,正司真,角田史敬,市川博雄,鈴木洋
    • Organizer
      第27回日本心臓リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ICUせん妄患者における回復期リハビリテーションの有用性2021

    • Author(s)
      田代尚範,宮澤僚,中島真奈美,正司真,辻内美希,礒良崇,鈴木洋,諸富伸夫,市川博雄
    • Organizer
      第27回日本心臓リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] PAD治療としての運動療法2021

    • Author(s)
      礒良崇
    • Organizer
      第27回日本心臓リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] アスリート心臓 心電図・心エコーの判定tips2021

    • Author(s)
      北井仁美,高萩恵子,江波戸美緒,鈴木 洋,礒良崇
    • Organizer
      第27回日本心臓リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] An Introduction to Sports Cardiology2021

    • Author(s)
      礒良崇,高萩恵子,北井仁美
    • Organizer
      第27回日本心臓リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] HIIT概論2021

    • Author(s)
      礒良崇
    • Organizer
      第7回日本心臓リハビリテーション学会近畿地方会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] ガイドラインから考える包括的PADリハビリテーション2021

    • Author(s)
      礒良崇
    • Organizer
      第6回日本心臓リハビリテーション学会関東甲信越支部地方会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 慢性腎不全合併心不全において心臓リハビリテーションは腎機能を悪化させずに予後を改善する2021

    • Author(s)
      宮澤僚、礒良崇、ほか
    • Organizer
      第11回日本腎臓リハビリテーション学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Clinical features and impact of cardiac rehabilitation on prognosis in geriatric patients with cachexia after acute decompensated heart failure2021

    • Author(s)
      宮澤僚、礒良崇、ほか
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Mid-term outcome of Cardiovascular Rehabilitation Participants with Peripheral Arterial Disease2021

    • Author(s)
      正司真、礒良崇、ほか
    • Organizer
      第85回日本循環器学会学術集会シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] 心臓リハビリテーションは慢性腎不全合併心不全の腎機能を悪化させずに予後を改善する2020

    • Author(s)
      宮澤僚、礒良崇、ほか
    • Organizer
      第24回日本心不全学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 心腎連関におけるphase-II心臓リハビリテーションの可能性2020

    • Author(s)
      礒 良崇
    • Organizer
      第26回日本心臓リハビリテーション学会学術集会シンポジウム
    • Related Report
      2020 Research-status Report
  • [Book] すべての診療科で役立つ 身体運動学と運動療法2022

    • Author(s)
      礒 良崇(分担執筆)
    • Total Pages
      187
    • Publisher
      羊土社
    • ISBN
      9784758123884
    • Related Report
      2022 Annual Research Report
  • [Book] 3.心臓リハビリテーショングリーンノート2021

    • Author(s)
      礒 良崇(分担執筆)
    • Total Pages
      291
    • Publisher
      中外医学社㈱
    • ISBN
      9784498067349
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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