• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Association of cerebral oxygenation and cognitive function with nutritional status in chronic kidney disease patients without dialysis therapy

Research Project

Project/Area Number 20K11534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionJichi Medical University

Principal Investigator

Ookawara Susumu  自治医科大学, 医学部, 教授 (50724522)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords栄養指導 / 慢性腎臓病 / 認知機能 / Body mass index / 脳内局所酸素飽和度 / 栄養学的指標 / 血液透析 / 透析低血圧 / 肝臓内局所酸素飽和度 / 脳内酸素動態 / Body Mass Index / 肝臓内酸素動態 / 血清アルブミン濃度 / BMI / 腎性貧血 / 食事療法 / 24時間蓄尿
Outline of Research at the Start

慢性腎臓病(CKD)診療で食事療法は重要な柱の一つであり、24時間蓄尿検査と食事調査から食塩摂取量、たんぱく質摂取量、エネルギー摂取量の把握が可能となる。これまでに腎機能の低下は脳内酸素動態の悪化を招き、その悪化が認知機能の低下に関連することが報告されている。しかしながら現在まで、保存期CKD症例の食事療法と脳内酸素代謝・認知機能評価の関連に関する検討はない。
本研究を通じて、CKD診療における食事療法が腎機能保持のみならず脳内酸素代謝および認知機能維持にも重要な役割を果たすことを明らかにしたい。

Outline of Final Research Achievements

To summarize the study on "The relationship between cerebral oxygen dynamics, cognitive function, and nutritional parameters in patients with chronic kidney disease," it was revealed that in patients with chronic kidney disease not undergoing dialysis therapy, changes in the Mini-Mental State Examination score, an assessment scale for cognitive function, showed a significant positive correlation with changes in BMI and changes in regional cerebral oxygen saturation, respectively. Therefore, these results would be considered that maintaining cerebral oxygen dynamics and physical condition through nutritional intervention leads to the maintenance and improvement of cognitive function in patients with chronic kidney disease not undergoing dialysis therapy.

Academic Significance and Societal Importance of the Research Achievements

本邦における慢性腎臓病症例は増加の一途をたどり、腎機能障害自体が認知機能障害の危険因子となるため、日常臨床では慢性腎臓病に認知機能障害を合併する症例の増加が問題となっている。本研究により、慢性腎臓病治療の柱の一つである適切な栄養管理を通したBMIに代表される体格の維持が、脳内酸素動態の維持とともに認知機能の維持・改善に働くことが明らかとなった。慢性腎臓病症例では、食塩およびたんぱく質の制限とともに適切なエネルギー摂取による体格の維持が認知機能障害の予防につながり、栄養指導の新たな重要性が示唆された。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (28 results)

All 2023 2022 2021 2020

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (14 results) (of which Invited: 8 results)

  • [Journal Article] Factors affecting intradialytic hepatic oxygenation: Associations between ultrafiltration rate and changes in systemic blood pressure.2023

    • Author(s)
      Ookawara S, Ito K, Ueda Y, Minato S, Kaneko S, Hirata M, Kitano T, Miyazawa H, Hirai K, Morishita Y.
    • Journal Title

      Int J Artif Organs.

      Volume: 3913988231168656 Issue: 5 Pages: 256-263

    • DOI

      10.1177/03913988231168656

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences between Hepatic and Cerebral Regional Tissue Oxygen Saturation at the Onset of Intradialytic Hypotension.2023

    • Author(s)
      Kaneko S, Ookawara S, Ito K, Minato S, Mutsuyoshi Y, Ueda Y, Hirai K, Morishita Y.
    • Journal Title

      J Clin Med.

      Volume: 12 Issue: 15 Pages: 4904-4904

    • DOI

      10.3390/jcm12154904

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Body fluid volume calculated using the uric acid kinetic model relates to the vascular event.2023

    • Author(s)
      Nakai S, Ito T, Shibata K, Ozawa K, Matsuoka T, Maeda K, Ohashi Y, Hamano T, Hanafusa N, Shinzato T, Ookawara S, Masakane I
    • Journal Title

      J Artif Organs

      Volume: ー Issue: 3 Pages: 253-260

    • DOI

      10.1007/s10047-023-01421-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 体液量評価とその適正化の臨床的意義2023

    • Author(s)
      大河原 晋
    • Journal Title

      日本透析医会雑誌

      Volume: 38巻1号 Pages: 29-36

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of percutaneous transluminal angioplasty and associated factors in access hand oxygenation in patients undergoing hemodialysis.2023

    • Author(s)
      Sugiyama T, Ito K, Ookawara S, Shimoyama H, Shindo M, Hirata M, Shimoyama H, Nakazato Y, Morishita Y.
    • Journal Title

      Sci Rep

      Volume: 13(1) Issue: 1 Pages: 2576-2576

    • DOI

      10.1038/s41598-023-29879-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in cerebral oxygenation during hemodialysis before and after carotid artery stenting2022

    • Author(s)
      Sato Hisashi、Ookawara Susumu、Ito Kiyonori、Ueda Yuichiro、Hirai Keiji、Yoshino Yoshikazu、Morishita Yoshiyuki
    • Journal Title

      Radiology Case Reports

      Volume: 17 Issue: 8 Pages: 2589-2593

    • DOI

      10.1016/j.radcr.2022.04.054

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebral oxygenation and body mass index association with cognitive function in chronic kidney disease patients without dialysis: a longitudinal study.2022

    • Author(s)
      Ookawara S, Ito K, Sasabuchi Y, Miyahara M, Miyashita T, Takemi N, Nagamine C, Nakahara S, Horiuchi Y, Inose N, Shiina M, Murakoshi M, Sanayama H, Hirai K, Morishita Y.
    • Journal Title

      Sci Rep

      Volume: 12(1) Issue: 1 Pages: 10809-10809

    • DOI

      10.1038/s41598-022-15129-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebral oxygenation changes in response to post-hemodialysis standing2022

    • Author(s)
      Imai S, Ookawara S, Ito K, Hattori T, Fueki M, Iguchi M, Kiryu S, Sanayama H, Kakei M, Tabei K, Morishita Y.
    • Journal Title

      J Artif Organs.

      Volume: - Issue: 2 Pages: 127-133

    • DOI

      10.1007/s10047-022-01343-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Does food ingestion during hemodialysis lead to change in hepatic oxygenation?2022

    • Author(s)
      Imai S, Ito K, Ookawara S, Kiryu S, Iguchi M, Sanayama H, Kakei M, Tabei K, Morishita Y
    • Journal Title

      Nefrologia

      Volume: 16 Issue: 4 Pages: 506-508

    • DOI

      10.1016/j.nefroe.2022.11.009

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis2021

    • Author(s)
      Ueda Y, Ookawara S, Ito K, Sasabuchi Y, Hayasaka H, Kofuji M, Uchida T, Imai S, Kiryu S, Minato S, Miyazawa H, Sanayama H, Hirai K, Tabei K, Morishita Y
    • Journal Title

      PoS One

      Volume: 16 Issue: 10 Pages: e0259064-e0259064

    • DOI

      10.1371/journal.pone.0259064

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical factors affecting cerebral oxygenation in patients undergoing peritoneal dialysis2021

    • Author(s)
      Kitano T, Ito K, Ookawara S, Hoshin T, Hayasaka H, Kofuji M, Uchida T, Morino J, Minato S, Kaneko S, Yanai K, Mutsuyoshi Y, Ishii H, Matsuyama-Hirata M, Shindo M, Miyazawa H, Ueda Y, Hirai K, Morishita Y.
    • Journal Title

      Int J Artif Organs

      Volume: 44 Issue: 11 Pages: 822-828

    • DOI

      10.1177/03913988211020017

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Cerebral Oxygenation, as Evaluated with Near-Infrared Spectroscopy, and Cognitive Function in Patients Undergoing Hemodialysis2021

    • Author(s)
      Ookawara Susumu、Ito Kiyonori、Sasabuchi Yusuke、Ueda Yuichiro、Hayasaka Hideyuki、Kofuji Masaya、Uchida Takayuki、Horigome Keita、Aikawa Toshiko、Imada Satoru、Minato Saori、Miyazawa Haruhisa、Shimoyama Hirofumi、Hirai Keiji、Watanabe Akihisa、Shimoyama Hiromi、Morishita Yoshiyuki
    • Journal Title

      Nephron

      Volume: 145 Issue: 2 Pages: 1-8

    • DOI

      10.1159/000513327

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difference in Cerebral and Hepatic Oxygenation in Response to Ultrafiltration in a Hemodialysis Patient With Congestive Heart Failure2021

    • Author(s)
      Mutsuyoshi Yuko、Ito Kiyonori、Ookawara Susumu、Uchida Takayuki、Morishita Yoshiyuki
    • Journal Title

      Cureus

      Volume: 13

    • DOI

      10.7759/cureus.13023

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of cerebral oxygenation with hemoglobin levels evaluated by near-infrared spectroscopy in hemodialysis patients2020

    • Author(s)
      Ookawara Susumu、Ito Kiyonori、Sasabuchi Yusuke、et al.
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 8 Pages: e0236720-e0236720

    • DOI

      10.1371/journal.pone.0236720

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] HD時肝臓内局所酸素飽和度変化に関連する臨床的因子の検討2023

    • Author(s)
      大河原 晋, 湊 さおり, 宮澤 晴久, 植田 裕一郎, 伊藤 聖学, 森下 義幸
    • Organizer
      日本透析医学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 肝臓内局所酸素飽和度測定から見たIHDFの有用性について2023

    • Author(s)
      大河原 晋、伊藤聖学、森下義幸
    • Organizer
      IHDF研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 血液透析中の循環動態の経時的変化-その安定化と臓器内酸素動態の関連-2023

    • Author(s)
      大河原晋
    • Organizer
      日本腎臓リハビリテーション学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 体液量評価とその適正化の臨床的意義2022

    • Author(s)
      大河原晋
    • Organizer
      日本透析医会 2022年度秋期研修セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 血液透析治療における最適な除水コントロールとその多様性2022

    • Author(s)
      大河原晋
    • Organizer
      I-HDF研究会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 体液量評価とUltrafiltration control2022

    • Author(s)
      大河原晋
    • Organizer
      第67回日本透析医学会学術集会・総会 教育講演28
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 血液透析患者の肝臓内酸素飽和度と臨床的因子の関連2022

    • Author(s)
      大河原晋、平田桃子、北野泰佑、植田裕一郎、伊藤聖学、森下義幸
    • Organizer
      第67回日本透析医学会学術集会・総会
    • Related Report
      2022 Research-status Report
  • [Presentation] BV計を使用した体液量調整と臓器内酸素動態安定化の連関について2022

    • Author(s)
      大河原晋
    • Organizer
      第48回東北腎不全研究会ランチョンセミナー5
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 透析患者の脳の酸素化に関する研究2021

    • Author(s)
      伊藤聖学、大河原晋 、森下義幸
    • Organizer
      日本透析医学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 血液透析患者の脳内酸素動態から見た目標ヘモグロビン濃度に関する検討2021

    • Author(s)
      大河原晋、北野泰佑、宮沢晴久、伊藤聖学、森下義幸
    • Organizer
      日本腎臓学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 透析低血圧症に伴う臓器内酸素動態変化を観察し得た1症例2020

    • Author(s)
      内田隆行、大河原晋 、伊藤聖学、早坂秀幸、小藤誠也、北野泰佑、百瀬直樹、森下義幸
    • Organizer
      日本透析医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 血液透析患者における急性心不全治療前後での脳内局所酸素飽和度の変化2020

    • Author(s)
      湊さおり、大河原晋、北野泰佑、宮沢晴久、伊藤聖学、森下義幸
    • Organizer
      日本透析医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 透析患者の脳血流・脳局所酸素飽和度2020

    • Author(s)
      伊藤聖学、大河原晋、森下義幸
    • Organizer
      日本透析医学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 保存期CKD症例における脳内酸素動態と食事療法の関連2020

    • Author(s)
      大河原晋、北野泰佑、村越美穂、森下義幸
    • Organizer
      日本腎臓学会総会
    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi