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scRNA-seq analysis using PCA and TD based unsupervised feature extraction

Research Project

Project/Area Number 20K12067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionChuo University

Principal Investigator

Taguchi Y-h.  中央大学, 理工学部, 教授 (30206932)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsテンソル分解 / 教師なし学習 / 変数選択 / 一細胞計測 / マルチオミックスデータ / 主成分分析 / 一細胞RNA-seq
Outline of Research at the Start

本研究計画は提案者が従来から提唱している「テンソル分解を用いた教師なし学習による変数選択法」を一細胞RNA-seqという新しい計測法で得られたデータに応用して従来では得られなかった新しい結果を出すことを目的とするものである。提案手法は特に多数の変数があるのにサンプル数は少ない場合に適しており、ゲノムサイエンスには最適であることが経験上知られている。この方法を一細胞RNA-seqと組み合わせることで従来は得られなかったような画期的な知見を得ることを目指す。

Outline of Final Research Achievements

The effectiveness of the tensor decomposition method for the analysis of single cell multimics was confirmed and published in scientific papers and as research reports in international conferences. In particular, the method was found to be effective for integrated analysis of gene expression profiles, methylation and ATAC-seq.This is expected to facilitate the use of tensor decomposition for single-cell analysis in the future. This is a very valuable research result, as such research has not been done before.

Academic Significance and Societal Importance of the Research Achievements

この方法の開発により一細胞解析を教師なし学習で行う道が開けた。教師なし学習は人間の偏見から自由に結果を出すことができるので非常に貴重な成果であると言える。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (77 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (3 results) Journal Article (43 results) (of which Int'l Joint Research: 21 results,  Peer Reviewed: 35 results,  Open Access: 26 results) Presentation (25 results) (of which Int'l Joint Research: 12 results,  Invited: 5 results) Book (4 results) Remarks (2 results)

  • [Int'l Joint Research] Asia University(その他の国・地域)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] King Abdulaziz University(サウジアラビア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] IIT Madras/Vellore Institute of Technology(インド)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Integrative Meta-Analysis of Huntington’s Disease Transcriptome Landscape2023

    • Author(s)
      Sneha Nela Pragathi、Dharshini S. Akila Parvathy、Taguchi Y.-H.、Gromiha M. Michael
    • Journal Title

      Genes

      Volume: 13 Issue: 12 Pages: 2385-2385

    • DOI

      10.3390/genes13122385

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bioinformatic tools for epitranscriptomics2023

    • Author(s)
      Taguchi Y.-H.
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 324 Issue: 2 Pages: C447-C457

    • DOI

      10.1152/ajpcell.00437.2022

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Features extracted using tensor decomposition reflect the biological features of the temporal patterns of human blood multimodal metabolome2023

    • Author(s)
      Fujita Suguru、Karasawa Yasuaki、Hironaka Ken-ichi、Taguchi Y.-h.、Kuroda Shinya
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 2 Pages: e0281594-e0281594

    • DOI

      10.1371/journal.pone.0281594

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new machine learning based computational framework identifies therapeutic targets and unveils influential genes in pancreatic islet cells2023

    • Author(s)
      Turki Turki、Taguchi Y-h.
    • Journal Title

      Gene

      Volume: 853 Pages: 147038-147038

    • DOI

      10.1016/j.gene.2022.147038

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Principal component analysis- and tensor decomposition-based unsupervised feature extraction to select more suitable differentially methylated cytosines: Optimization of standard deviation versus state-of-the-art methods2023

    • Author(s)
      Taguchi Y.-H.、Turki Turki
    • Journal Title

      Genomics

      Volume: 115 Issue: 2 Pages: 110577-110577

    • DOI

      10.1016/j.ygeno.2023.110577

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tensor decomposition discriminates tissues using scATAC-seq2023

    • Author(s)
      Taguchi Y.-H.、Turki Turki
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1867 Issue: 6 Pages: 130360-130360

    • DOI

      10.1016/j.bbagen.2023.130360

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrated analysis of human DNA methylation, gene expression, and genomic variation in iMETHYL database using kernel tensor decomposition-based unsupervised feature extraction2023

    • Author(s)
      Taguchi Y-h.、Komaki Shohei、Sutoh Yoichi、Ohmomo Hideki、Otsuka-Yamasaki Yayoi、Shimizu Atsushi
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 8 Pages: e0289029-e0289029

    • DOI

      10.1371/journal.pone.0289029

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optimized Tensor Decomposition and Principal Component Analysis Outperforming State-of-the-Art Methods When Analyzing Histone Modification Chromatin Immunoprecipitation Profiles2023

    • Author(s)
      Turki Turki、Roy Sanjiban Sekhar、Taguchi Y.-H.
    • Journal Title

      Algorithms

      Volume: 16 Issue: 9 Pages: 401-401

    • DOI

      10.3390/a16090401

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated Analysis of Gene Expression and Protein?Protein Interaction with Tensor Decomposition2023

    • Author(s)
      Taguchi Y-H.、Turki Turki
    • Journal Title

      Mathematics

      Volume: 11 Issue: 17 Pages: 3655-3655

    • DOI

      10.3390/math11173655

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GENEvaRX: A novel AI-driven method and web tool can identify critical genes and effective drugs for Lichen Planus2023

    • Author(s)
      Turki Turki、Taguchi Y-h.
    • Journal Title

      Engineering Applications of Artificial Intelligence

      Volume: 124 Pages: 106607-106607

    • DOI

      10.1016/j.engappai.2023.106607

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application note: TDbasedUFE and TDbasedUFEadv: bioconductor packages to perform tensor decomposition based unsupervised feature extraction2023

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      Frontiers in Artificial Intelligence

      Volume: 6 Pages: 1-1

    • DOI

      10.3389/frai.2023.1237542

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigating Neuron Degeneration in Huntington’s Disease Using RNA-Seq Based Transcriptome Study2023

    • Author(s)
      Sneha Nela Pragathi、Dharshini S. Akila Parvathy、Taguchi Y.-h.、Gromiha M. Michael
    • Journal Title

      Genes

      Volume: 14 Issue: 9 Pages: 1801-1801

    • DOI

      10.3390/genes14091801

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Advanced Tensor Decomposition-Based Integrated Analysis of Protein-Protein Interaction with Cancer Gene Expression Can Improve Coincidence with Clinical Labels2023

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      11th International Conference on Bioinformatics and Computational Biology (ICBCB)

      Volume: 1 Pages: 1-2

    • DOI

      10.1109/icbcb57893.2023.10246633

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of circulating <scp>miRNAs</scp> in the treatment of primary liver tumors2023

    • Author(s)
      Umezu Tomohiro、Tanaka Shogo、Kubo Shoji、Enomoto Masaru、Tamori Akihiro、Ochiya Takahiro、Taguchi Y.‐H.、Kuroda Masahiko、Murakami Yoshiki
    • Journal Title

      Cancer Reports

      Volume: 7 Issue: 2 Pages: 1-9

    • DOI

      10.1002/cnr2.1964

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated Analysis of Tissue-Specific Gene Expression in Diabetes by Tensor Decomposition Can Identify Possible Associated Diseases2022

    • Author(s)
      Taguchi Y-H.、Turki Turki
    • Journal Title

      Genes

      Volume: 13 Issue: 6 Pages: 1097-1097

    • DOI

      10.3390/genes13061097

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Handbook of Machine Learning Applications for Genomics2022

    • Author(s)
      Taguchi Y.-H.
    • Journal Title

      Handbook of Machine Learning Applications for Genomics

      Volume: 1 Pages: 155-176

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sincle Cell RNA-seq Analysis Using Tensor Decomposition and Principal Component Analysis Based Unsupervised Feature Extraction2022

    • Author(s)
      Taguchi Y.-H.
    • Journal Title

      Handbook of Machine Learning Applications for Genomics

      Volume: 1 Pages: 155-176

    • DOI

      10.1007/978-981-16-9158-4_11

    • ISBN
      9789811691577, 9789811691584
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Silico Drug Discovery Using Tensor Decomposition Based Unsupervised Feature Extraction2022

    • Author(s)
      Taguchi Y.-H.
    • Journal Title

      Handbook of Machine Learning Applications for Genomics

      Volume: 1 Pages: 101-120

    • DOI

      10.1007/978-981-16-9158-4_7

    • ISBN
      9789811691577, 9789811691584
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiomics Data Analysis of Cancers Using Tensor Decomposition and Principal Component Analysis Based Unsupervised Feature Extraction2022

    • Author(s)
      Taguchi Y.-H.
    • Journal Title

      Handbook of Machine Learning Applications for Genomics

      Volume: 1 Pages: 1-17

    • DOI

      10.1007/978-981-16-9158-4_1

    • ISBN
      9789811691577, 9789811691584
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] RNA m6A modification and microRNAs2022

    • Author(s)
      Taguchi Y.-H.
    • Journal Title

      Handbook of Machine Learning Applications for Genomics

      Volume: 1 Pages: 169-180

    • DOI

      10.1016/b978-0-323-89774-7.00020-0

    • ISBN
      9780323897747
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of intrahepatic cholangiocarcinoma cell growth by <scp>SKI</scp> via upregulation of the <scp>CDK</scp> inhibitor p212022

    • Author(s)
      Kawamura E、Matsubara T、Daikoku A、et al.
    • Journal Title

      FEBS Open Bio

      Volume: 12 Issue: 12 Pages: 2122-2135

    • DOI

      10.1002/2211-5463.13489

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimation of Metabolic Effects upon Cadmium Exposure during Pregnancy Using Tensor Decomposition2022

    • Author(s)
      Amakura Yuki、Taguchi Y-h.
    • Journal Title

      Genes

      Volume: 13 Issue: 10 Pages: 1698-1698

    • DOI

      10.3390/genes13101698

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection tools2022

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 9 Pages: e0275472-e0275472

    • DOI

      10.1371/journal.pone.0275472

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adapted tensor decomposition and PCA based unsupervised feature extraction select more biologically reasonable differentially expressed genes than conventional methods2022

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17438-17438

    • DOI

      10.1038/s41598-022-21474-z

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] microRNA Bioinformatics2022

    • Author(s)
      Taguchi Y-h.
    • Journal Title

      Cells

      Volume: 11 Issue: 22 Pages: 3677-3677

    • DOI

      10.3390/cells11223677

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A tensor decomposition-based integrated analysis applicable to multiple gene expression profiles without sample matching2022

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 21242-21242

    • DOI

      10.1038/s41598-022-25524-4

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel feature selection method via kernel tensor decomposition for improved multi-omics data analysis2022

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      BMC Medical Genomics

      Volume: 15 Issue: 1 Pages: 37-37

    • DOI

      10.1186/s12920-022-01181-4

    • Related Report
      2021 Research-status Report
  • [Journal Article] Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus Can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 Infection2021

    • Author(s)
      Taguchi Y-H.、Turki Turki
    • Journal Title

      IEEE Journal of Selected Topics in Signal Processing

      Volume: 15 Issue: 3 Pages: 746-758

    • DOI

      10.1109/jstsp.2021.3061251

    • Related Report
      2021 Research-status Report
  • [Journal Article] Mathematical formulation and application of kernel tensor decomposition based unsupervised feature extraction2021

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      Knowledge-Based Systems

      Volume: 217 Pages: 106834-106834

    • DOI

      10.1016/j.knosys.2021.106834

    • Related Report
      2021 Research-status Report
  • [Journal Article] Identification of genes associated with altered gene expression and m6A profiles during hypoxia using tensor decomposition based unsupervised feature extraction2021

    • Author(s)
      Roy Sanjiban Sekhar、Taguchi Y.-H.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 8909-8909

    • DOI

      10.1038/s41598-021-87779-7

    • Related Report
      2021 Research-status Report
  • [Journal Article] Unsupervised tensor decomposition-based method to extract candidate transcription factors as histone modification bookmarks in post-mitotic transcriptional reactivation2021

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 5 Pages: e0251032-e0251032

    • DOI

      10.1371/journal.pone.0251032

    • Related Report
      2021 Research-status Report
  • [Journal Article] PCA-based unsupervised feature extraction for gene expression analysis of COVID-19 patients2021

    • Author(s)
      Fujisawa Kota、Shimo Mamoru、Taguchi Y.-H.、Ikematsu Shinya、Miyata Ryota
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 17351-17351

    • DOI

      10.1038/s41598-021-95698-w

    • Related Report
      2021 Research-status Report
  • [Journal Article] Identification of Enhancers and Promoters in the Genome by Multidimensional Scaling2021

    • Author(s)
      Ishibashi Ryo、Taguchi Y-h.
    • Journal Title

      Genes

      Volume: 12 Issue: 11 Pages: 1671-1671

    • DOI

      10.3390/genes12111671

    • Related Report
      2021 Research-status Report
  • [Journal Article] Effects of Collagen?Glycosaminoglycan Mesh on Gene Expression as Determined by Using Principal Component Analysis-Based Unsupervised Feature Extraction2021

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      Polymers

      Volume: 13 Issue: 23 Pages: 4117-4117

    • DOI

      10.3390/polym13234117

    • Related Report
      2021 Research-status Report
  • [Journal Article] Identifying suitable tools for variant detection and differential gene expression using RNA-seq data2020

    • Author(s)
      Dharshini S. Akila Parvathy、Taguchi Y.-H.、Gromiha M. Michael
    • Journal Title

      Genomics

      Volume: 112 Issue: 3 Pages: 2166-2172

    • DOI

      10.1016/j.ygeno.2019.12.011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incremental Dilations Using CNN for Brain Tumor Classification2020

    • Author(s)
      Roy Sanjiban Sekhar、Rodrigues Nishant、Taguchi Y-h.
    • Journal Title

      Applied Sciences

      Volume: 10 Issue: 14 Pages: 4915-4915

    • DOI

      10.3390/app10144915

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Universal Nature of Drug Treatment Responses in Drug-Tissue-Wide Model-Animal Experiments Using Tensor Decomposition-Based Unsupervised Feature Extraction2020

    • Author(s)
      Taguchi Yh.、Turki Turki
    • Journal Title

      Frontiers in Genetics

      Volume: 11 Pages: 695-695

    • DOI

      10.3389/fgene.2020.00695

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction2020

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 9 Pages: 0238907-0238907

    • DOI

      10.1371/journal.pone.0238907

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of miRNA signatures for kidney renal clear cell carcinoma using the tensor-decomposition method2020

    • Author(s)
      Ng Ka-Lok、Taguchi Y.-H.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 15149-15149

    • DOI

      10.1038/s41598-020-71997-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tensor-Decomposition-Based Unsupervised Feature Extraction Applied to Prostate Cancer Multiomics Data2020

    • Author(s)
      Taguchi Y-h.、Turki Turki
    • Journal Title

      Genes

      Volume: 11 Issue: 12 Pages: 1493-1493

    • DOI

      10.3390/genes11121493

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developing a diagnostic method for latent tuberculosis infection using circulating miRNA2020

    • Author(s)
      Hashimoto Shoji、Zhao Hong、Hayakawa Michiyo、Nakajima Koichi、Taguchi Y-h、Murakami Yoshiki
    • Journal Title

      Translational Medicine Communications

      Volume: 5 Issue: 1 Pages: 25-25

    • DOI

      10.1186/s41231-020-00078-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of liver and blood miRNA in precancerous conditions2020

    • Author(s)
      Umezu Tomohiro、Tsuneyama Koichi、Kanekura Kohsuke、Hayakawa Michiyo、Tanahashi Toshihito、Kawano Mitsuoki、Taguchi Y-h、Toyoda Hidenori、Tamori Akihiro、Kuroda Masahiko、Murakami Yoshiki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21766-21766

    • DOI

      10.1038/s41598-020-78500-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Transcription Factors, Biological Pathways, and Diseases as Mediated by N6-methyladenosine Using Tensor Decomposition-Based Unsupervised Feature Extraction2020

    • Author(s)
      Taguchi Y-h.、Dharshini S. Akila Parvathy、Gromiha M. Michael
    • Journal Title

      Applied Sciences

      Volume: 11 Issue: 1 Pages: 213-213

    • DOI

      10.3390/app11010213

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] TDbasedUFE and TDbasedUFEadv: bioconductor packages to perform tensor decomposition based unsupervised feature extraction2023

    • Author(s)
      Y-h. Taguchi
    • Organizer
      BiocAsia2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advanced Tensor Decomposition-Based Integrated Analysis of Protein-Protein Interaction with Cancer Gene Expression Can Improve Coincidence with Clinical labels2023

    • Author(s)
      YH Taguchi , Turki Turki
    • Organizer
      2023 11th International Conference on Bioinformatics and Computational Biology (ICBCB)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tensor decomposition and principal component analysis based unsupervised feature extraction with optimized standard deviation applied to gene expression, DNA methylation and histone modification2022

    • Author(s)
      Y-H. Taguchi , Ryo Ishibashi
    • Organizer
      ISMB2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of DNA loops in the Genome by Multi-Dimensional Scaling2022

    • Author(s)
      Ryo Ishibashi , Y-H. Taguchi
    • Organizer
      ISMB2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tensor-Decomposition-Based Unsupervised Feature Extraction Applied to Prostate Cancer Multiomics Data2021

    • Author(s)
      Y-h. Taguchi
    • Organizer
      8th ANNUAL CONGRESS of the European society for translational medicine
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Application of PCA-based unsupervised feature extraction for gene selection associated with COVID-19 severity2021

    • Author(s)
      Mamoru Shimo , Kota Fujisawa , Y-H. Taguchi , Sinya Ikematu , Ryota Miyata
    • Organizer
      第10回生命医薬情報学連合大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Mathematical formulation and application of kernel tensor decomposition based unsupervised feature extraction2021

    • Author(s)
      Y-h. Taguchi , Turki Turki
    • Organizer
      第10回生命医薬情報学連合大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection tools2021

    • Author(s)
      Y-h. Taguchi , Turki Turki
    • Organizer
      The 20th International Conference on Bioinformatics
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The 20th International Conference on Bioinformatics2021

    • Author(s)
      Y-h. Taguchi
    • Organizer
      The 3rd International Symposium on Engineering and Technology (ISET 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] テンソル分解に基づく教師なし学習による変数選択のRNAi 処理を行ったプラナリアのRNA-seq解析への適用2020

    • Author(s)
      田口善弘 , 鹿島誠
    • Organizer
      情報処理学会バイオ情報学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Conjecturing human genes that are easy to be double strand breaks by tensor decomposition2020

    • Author(s)
      Nobuo Hosaka , Y-h. Taguchi
    • Organizer
      情報処理学会バイオ情報学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] テンソル分解を用いた教師無し学習による変数選択法によるmiRNA/mRNA/プロテオームの統合解析2020

    • Author(s)
      田口善弘
    • Organizer
      情報処理学会バイオ情報学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] カーネルテンソル分解を用いた教師なし学習による変数選択法 ~ バイオインフォマティクスへの応用 ~2020

    • Author(s)
      田口善弘
    • Organizer
      情報論的学習理論と機械学習 (IBISML) 研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] カーネルテンソル分解を用いた教師なし学習による変数選択法 ~ バイオインフォマティクスへの応用 ~2020

    • Author(s)
      田口善弘
    • Organizer
      情報処理学会バイオ情報学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Application of Tensor Decomposition based Unsupervised Feature Extraction to Single Cell RNA-seq Data Analysis2020

    • Author(s)
      Y-h. Taguchi
    • Organizer
      ICBCB2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Tensor decomposition based unsupervised Feature Extraction applied to in silico COVID-19 drug siscovery based upon analysis of gene expression profiles altered by SARS-CoV-2 infection2020

    • Author(s)
      Y-h. Taguchi
    • Organizer
      第九回生命医薬情報学連合大会(IIBMP2020)
    • Related Report
      2020 Research-status Report
  • [Presentation] テンソル分解により二本鎖切断になりやすいヒト遺伝子の推定2020

    • Author(s)
      保坂伸生 , 田口善弘
    • Organizer
      第九回生命医薬情報学連合大会(IIBMP2020)
    • Related Report
      2020 Research-status Report
  • [Presentation] In silico drug discovery for COVID-19 using gene expression profiles of mouse infected by MHV and those of human cell lines infected by SARS-CoV-22020

    • Author(s)
      Y-h. Taguchi
    • Organizer
      7th Annual Congress of the European Society for Translational Medicine on Covid-19
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Selecting the genes related to COVID-19 with PCA-based unsupervised feature extraction2020

    • Author(s)
      Kota Fujisawa , Mamoru Shimo , Yoshihiro Taguchi , Shinya Ikematu , Ryota Miyata
    • Organizer
      CBI学会2020年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Identification of Transcription Factors, Biological Pathways, and Diseases as Mediated by N6-methyladenosine using Tensor Decomposition-Based Unsupervised Feature Extraction.2020

    • Author(s)
      Y-h. Taguchi , S Akila Parvathy Dharshini , M. Michael , Gromiha
    • Organizer
      The 2nd International Symposium on Engineering and Technology (ISET 2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] テンソル分解を用いた教師無し学習による変数選択法を用いたCOVID-19治療薬の探索2020

    • Author(s)
      田口善弘
    • Organizer
      IBIS2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Unsupervised tensor decomposition-based method to extract candidate transcription factors as histone modification bookmarks in post-mitotic transcriptional reactivation2020

    • Author(s)
      Y-h. Taguchi
    • Organizer
      The 19th International Conference on Bioinformatics (InCoB 2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] テンソル分解を用いた教師無し学習による変数選択法を用いたCOVID-19治療薬のリポジショニング2020

    • Author(s)
      田口善弘
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] テンソル分解を用いた教師なし学習による変数選択法を用いたゲノムデータ解析2020

    • Author(s)
      田口善弘
    • Organizer
      イノベーションジャパン
    • Related Report
      2020 Research-status Report
  • [Presentation] Principal Component Analysis, Tensor Decomposition, and Kernel Tensor Decomposition Based Unsupervised Feature Extraction Applied to Bioinformatics2020

    • Author(s)
      Y-h. Taguchi
    • Organizer
      2020 International Symposium on Automation, Information and Computing
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] はじめての機械学習 中学数学でわかるAIのエッセンス2024

    • Author(s)
      田口 善弘
    • Total Pages
      272
    • Publisher
      講談社
    • ISBN
      9784065239605
    • Related Report
      2023 Annual Research Report
  • [Book] 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用2022

    • Author(s)
      執筆者:81名、技術情報協会
    • Total Pages
      530
    • Publisher
      技術情報協会
    • ISBN
      9784861048777
    • Related Report
      2021 Research-status Report
  • [Book] はじめての機械学習 中学数学でわかるAIのエッセンス2021

    • Author(s)
      田口 善弘
    • Total Pages
      224
    • Publisher
      講談社
    • ISBN
      9784065239605
    • Related Report
      2021 Research-status Report
  • [Book] 生命はデジタルでできている 情報から見た新しい生命像2020

    • Author(s)
      田口 善弘
    • Total Pages
      224
    • Publisher
      講談社
    • ISBN
      9784065195970
    • Related Report
      2020 Research-status Report
  • [Remarks] TDbasedUFE

    • URL

      https://doi.org/doi:10.18129/B9.bioc.TDbasedUFE

    • Related Report
      2022 Research-status Report
  • [Remarks] TDbasedUFEadv

    • URL

      https://doi.org/doi:10.18129/B9.bioc.TDbasedUFEadv

    • Related Report
      2022 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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