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Development of a step-by-step analyzable artificial vision experimental system using small animals

Research Project

Project/Area Number 20K12633
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionNara Institute of Science and Technology (2022)
Advanced Telecommunications Research Institute International (2021)
Doshisha University (2020)

Principal Investigator

Masuda Akira  奈良先端科学技術大学院大学, 先端科学技術研究科, 客員助教 (30612121)

Co-Investigator(Kenkyū-buntansha) 春田 牧人  奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (40733663)
高橋 晋  同志社大学, 脳科学研究科, 教授 (20510960)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords人工視覚 / 光遺伝学 / 視覚野 / 小動物 / 神経細胞 / 行動 / 神経活動イメージング / 行動評価
Outline of Research at the Start

ラットにおいて「人工視覚を段階的に検証可能な実験系」を確立するため、本研究では、主に3つのことに取り組み、それぞれを統合する。
①高照度かつ高密度LEDアレイを搭載した小型光学顕微鏡の製作を行い、高度な光刺激-観察システムを構築する。
②製作したシステムを用いて、視覚応答と対応づけた様々な人工視覚刺激に対する脳活動を観察し、解析する。
③人工視覚刺激をベースとする行動実験による評価系を確立する。

Outline of Final Research Achievements

Artificial vision stimulates the visual system to reproduce experiences and holds promise for restoring visual impairments. To achieve advanced restoration, understanding the relationship between brain activity and artificial vision perception is crucial. Our objective is to establish a platform that clarifies the stimulus-neural response-behavior relationship. We pursue three tasks: (1) developing a multi-point light stimulation system with a red LED array and focusing lens, (2) integrating electrophysiological measurement into a compact neural activity imaging device, and (3) constructing an artificial vision segregation task with light stimulation and a dual-licking system in the primary visual cortex, validating performance for each. Combining these efforts will comprehensively elucidate the stimulus-neural response-behavior relationship in the future.

Academic Significance and Societal Importance of the Research Achievements

人工視覚の研究は、視覚障害者の回復に期待される技術であり、視覚障害者だけでなく、その周囲の支援を行う方も含め、社会的に重要な意義を持つ。この研究では、人工視覚の刺激、神経応答、行動の関係を明確にするための要素技術としてプラットフォームを確立し、これらを組み合わせることで、刺激、神経応答、行動の関係をより明確にし、さらにはより自然に近い人工視覚の実現へ応用されることが期待さされる。その先には、視覚障害者の生活の質を向上させ、彼らの社会参加を促進する可能性があると思われる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 2020

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Miniaturized Cell Fluorescence Imaging Device Equipped with Multielectrode Array2022

    • Author(s)
      Sais Barbara Teixeira、Haruta Makito、Tso Kuang-Chih、Hagita Mizuki、Hagiwara Takanori、Sugie Kenji、Kimura Ayaka、Takehara Hironari、Tashiro Hiroyuki、Sasagawa Kiyotaka、Ohta Jun
    • Journal Title

      Sensors and Materials

      Volume: 34 Issue: 4 Pages: 1587

    • DOI

      10.18494/SAM3758

    • ISSN
      0914-4935, 2435-0869
    • Year and Date
      2022-04-26
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Cell-type Specific Optogenetic Cortical Stimulation Targeting Distinct Neural Populations for the Restoration of Vision2021

    • Author(s)
      Masuda Akira、Takahashi Susumu
    • Journal Title

      2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)

      Volume: - Pages: 954-957

    • DOI

      10.1109/ner49283.2021.9441189

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early identification of Alzheimer's disease in mouse models: Application of deep neural network algorithm to cognitive behavioral parameters2021

    • Author(s)
      Stephanie Sutoko, Akira Masuda, Akihiko Kandori, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Tsukasa Funane
    • Journal Title

      iScience

      Volume: 24 Issue: 3 Pages: 1-13

    • DOI

      10.1016/j.isci.2021.102198

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Compact device for simultaneous cell electrophysiological signal and fluorescence imaging acquisition2022

    • Author(s)
      Barbara Teixeira Sais, Makito Haruta, Kuang-Chih Tso, Mizuki Hagita, Takanori Hagiwara, Kenji Sugie, Ayaka Kimura, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta
    • Organizer
      NEURO2022, 沖縄コンベンションセンター,2022年6月30日
    • Related Report
      2022 Annual Research Report
  • [Presentation] Activity Patterns of the Visual Cortical Neurons for Optogenetic Visual Prosthesis2021

    • Author(s)
      Akira Masuda, Susumu Takahashi
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Cell-type-selective cortical stimulation with optogenetic tools for visual restoration2020

    • Author(s)
      Akira Masuda, Susumu Takahashi
    • Organizer
      The 43rd Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2020 Research-status Report
  • [Presentation] A physiological comparison between two distinct types of optogenetic cortical stimulations for visual restoration2020

    • Author(s)
      Akira Masuda, Susumu Takahashi
    • Organizer
      12th FENS (Forum of Neuroscience)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2024-01-30  

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