• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Detection of harmonic signals of magnetic particles by diamond quantum sensor

Research Project

Project/Area Number 20K14392
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 13020:Semiconductors, optical properties of condensed matter and atomic physics-related
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Masuyama Yuta  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 量子機能創製研究センター, 主任研究員 (00814790)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords量子センサー / NVセンター / 磁性ナノ粒子 / ダイヤモンド / 量子センシング
Outline of Research at the Start

近年、患者の負担が少ない、微量の磁性粒子を用いた医療応用技術が開発され始めている。特に、がん転移の位置特定の場合、体内に注入した磁性粒子の微小な磁場信号を計測し、その位置や量を評価する。従来、微小な磁場信号を計測するには、高価で大型な冷凍機や磁気シールドルームを用いた高感度なセンサーを要することが、この技術の普及の課題であった。本研究では、冷凍機や磁気シールドルームを用いないダイヤモンド量子センサーにより、生体内に注入した微量の磁性粒子を検出する手法を開発する。

Outline of Final Research Achievements

This study aims to develop a method for detecting small amounts of magnetic particles at a distance by means of a diamond quantum sensor with higher sensitivity by quantum control and a system for generating harmonic components of the response magnetic field of magnetic particles. To this end, this study set up a system for generating harmonic components of the response magnetic field of magnetic particles, developed a method for evaluating and improving the performance of the diamond quantum sensor, and constructed a quantum control sequence for detecting harmonic components of the response magnetic field of magnetic particles with the diamond quantum sensor.

Academic Significance and Societal Importance of the Research Achievements

近年、直径1 μm未満の微小な磁性粒子の医療応用が実用化され始めている。さらに、ガンの検出、ハイパーサーミア、などさまざまな医療応用が期待されており、体内に注入した磁性粒子が、期待した位置へ集積する量などを検出する必要が生じている。その磁性粒子の位置特定のためには、高感度な磁気センサが必要である。しかし、従来の冷凍機を用いた超伝導磁気センサ(SQUID)などは大型で高価なため、技術普及・発展の妨げとなっている。本研究の成果は、体内に注入した微量な磁性粒子を検出可能な、室温・磁気シールドレスで動作する高感度量子センサーシステムの重要な技術要素である。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (35 results)

All 2024 2023 2022 2021 2020

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (29 results) (of which Int'l Joint Research: 15 results,  Invited: 7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Nitrogen concentration control during diamond growth for NV- centre formation2023

    • Author(s)
      Teraji T.、Shinei C.、Masuyama Y.、Miyakawa M.、Taniguchi T.
    • Journal Title

      Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

      Volume: 382 Issue: 2265 Pages: 20220322-20220322

    • DOI

      10.1098/rsta.2022.0322

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NV-センタどうしの磁気双極子双極子相互作用強度の決定2023

    • Author(s)
      眞榮力,増山 雄太,宮川仁,阿部浩之,石井秀弥,佐伯誠一,小野田忍,谷口尚,大島武,寺地徳之
    • Journal Title

      New diamond

      Volume: 39 Pages: 12-18

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Nitrogen related paramagnetic defects: Decoherence source of ensemble of NV- center2022

    • Author(s)
      Shinei Chikara、Masuyama Yuta、Miyakawa Masashi、Abe Hiroshi、Ishii Shuya、Saiki Seiichi、Onoda Shinobu、Taniguchi Takashi、Ohshima Takeshi、Teraji Tokuyuki
    • Journal Title

      Journal of Applied Physics

      Volume: 132 Issue: 21 Pages: 214402-214402

    • DOI

      10.1063/5.0103332

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ensemble Negatively-Charged Nitrogen-Vacancy Centers in Type-Ib Diamond Created by High Fluence Electron Beam Irradiation2021

    • Author(s)
      Ishii Shuya、Saiki Seiichi、Onoda Shinobu、Masuyama Yuta、Abe Hiroshi、Ohshima Takeshi
    • Journal Title

      Quantum Beam Science

      Volume: 6 Issue: 1 Pages: 2-2

    • DOI

      10.3390/qubs6010002

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gradiometer Using Separated Diamond Quantum Magnetometers2021

    • Author(s)
      Masuyama Yuta、Suzuki Katsumi、Hekizono Akira、Iwanami Mitsuyasu、Hatano Mutsuko、Iwasaki Takayuki、Ohshima Takeshi
    • Journal Title

      Sensors

      Volume: 21 Issue: 3 Pages: 977-977

    • DOI

      10.3390/s21030977

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Hydrogen incorporation in nitrogen-doped CVD diamond2024

    • Author(s)
      Tokuyuki Teraji, Chikara Shinei, Yuta Masuyama
    • Organizer
      Hasselt Diamond Workshop 2024 - SBDD XXVIII
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In-plane strain distribution in HPHT diamond detected by ODMR of NV- centers2024

    • Author(s)
      Chikara Shinei, Yuta Masuyama, Hiroshi Abe, Masashi Miyakawa, Takashi Taniguchi, Takeshi Ohshima, Tokuyuki Teraji
    • Organizer
      Hasselt Diamond Workshop 2024 - SBDD XXVIII
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 固体量子センサーの基礎と応用2024

    • Author(s)
      増山雄太
    • Organizer
      第31回原子衝突セミナー
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fast evaluation method for the spatial distribution of the quantum properties of color centers across a mm-sized diamond2023

    • Author(s)
      Yuta Masuyama, Chikara Shinei, Shuya Ishii, Hiroshi Abe, Takashi Taniguchi, Tokuyuki Teraji, Takeshi Ohshima
    • Organizer
      33rd International Conference on Diamond and Carbon Materials
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nitrogen concentration control in diamond crystal growth for quantum sensing applications2023

    • Author(s)
      T. Teraji, C. Shinei, Y. Masuyama, M. Miyakawa, T. Taniguchi
    • Organizer
      33rd International Conference on Diamond and Carbon Materials
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dipole-dipole interaction between ensemble of NV- centers in diamond2023

    • Author(s)
      Chikara Shinei, Yuta Masuyama, Masashi Miyakawa, Hiroshi Abe, Shuya Ishii, Seiichi Saiki, Shinobu Onoda, Takashi Taniguchi, Takeshi Ohshima, Tokuyuki Teraji
    • Organizer
      33rd International Conference on Diamond and Carbon Materials
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dipole-dipole interaction between NV- center and nitrogen related defects2023

    • Author(s)
      Chikara Shinei, Yuta Masuyama, Masashi Miyakawa, Hiroshi Abe, Shuya Ishii, Seiichi Saiki, Shinobu Onoda, Takashi Taniguchi, Takeshi Ohshima, Teraji Tokuyuki
    • Organizer
      6th IFQMS/Quantum Innovation 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Creation of NV- center in type-Ib diamonds by high temperature post-annealing2023

    • Author(s)
      Ishii Shuya, Saiki Seiichi, Onoda Shinobu, Masuyama Yuta, Abe Hiroshi, Ohshima Takeshi
    • Organizer
      6th IFQMS/Quantum Innovation 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高温熱処理によるIbタイプダイヤモンド中でのNVセンター形成2023

    • Author(s)
      石井秀弥、佐伯誠一、小野田忍、増山雄太、阿部浩之、大島武
    • Organizer
      QST高崎サイエンスフェスタ2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 量子技術とOpen Quantum System2023

    • Author(s)
      増山雄太
    • Organizer
      第4回若手放談会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] NVH-センターの弱い磁気双極子相互作用2023

    • Author(s)
      真栄力、増山雄太、宮川仁、阿部浩之、石井秀弥、佐伯誠一、小野田忍、谷口尚、大島武、寺地 徳之
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] バルクアンサンブルNVセンタを用いたDC磁気センサ高感度化のためのHPHTダイヤモンドの特性評価2023

    • Author(s)
      関口武治、上坪優希、辻赳行、増山雄太、谷口尚、宮川仁、真栄力、小野田忍、阿部浩之、佐伯誠一、石井秀弥、寺地徳之、大島武、岩崎孝之、波多野睦子
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 電子線照射によるIbタイプダイヤモンド中のNVセンター形成2022

    • Author(s)
      石井秀弥、佐伯誠一、小野田忍、増山雄太、大島武
    • Organizer
      第4回量子生命科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] Equilibrium charge state and decoherence of ensembles of NV- center2022

    • Author(s)
      Chikara Shinei,Yuta Masuyama, Masashi Miyakawa, Shuya Ishii, Seiichi Saiki, Shinobu Onoda, Takashi Taniguchi, Takeshi Ohshima and Tokuyuki Teraji
    • Organizer
      New Diamond and Nano Carbons 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impurity control for diamond and boron nitride single crystals growth under high pressure2022

    • Author(s)
      Takashi Taniguchi, Masashi Miyakawa, Chikara Shinei, Tokuyuki Teraji, Kenji Watanabe, Kazunobu Kojima, Masuyama Yuta, Abe Hiroshi, Ohshima Takeshi
    • Organizer
      New Diamond and Nano Carbons 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Ensemble NV- center in diamond for quantum sensing created by high fluence electron beam irradiation2022

    • Author(s)
      Shuya Ishii, Seiichi Saiki, Shinobu Onoda, Yuta Masuyama, Hiroshi Abe, Takeshi Ohshima
    • Organizer
      RadTech Asia 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] アンサンブル NV-センターのデコヒーレンス源の探索2022

    • Author(s)
      真栄 力, 増山 雄太, 宮川 仁, 阿部 浩之, 石井 秀弥, 佐伯 誠一, 小野田 忍, 谷口 尚, 大島 武, 寺地 徳之
    • Organizer
      第83回応用物理学会秋季学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 固体中の量子欠陥のセンサ応用2022

    • Author(s)
      増山雄太
    • Organizer
      第1回次世代センサ基盤技術分科会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] T. Sekiguchi, Y. Kamitsubo, T. Tsuji, Y. Aoki, Y. Masuyama, T. Taniguchi, M. Miyakawa, C. Shinei, S. Onoda, H. Abe, S. Saiki, S. Ishii, T. Teraji, T. Ohshima, T. Iwasaki, M. Hatano2022

    • Author(s)
      Characterization of HPHT Diamonds with NV Centers for High-Sensitivity Bulk-Ensemble Magnetometer
    • Organizer
      14th International Symposium on Atomic Level Characterizations for New Materials and Devices '22
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 電子線照射によるIbタイプダイヤモンド中でのNVセンター形成2022

    • Author(s)
      石井 秀弥、佐伯 誠一、 小野田 忍、 増山 雄太、 阿部 浩之、 大島 武
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] Effect of P1 concentration on NV centers created by electron beam irradiation2021

    • Author(s)
      Shuya Ishii, Shinobu Onoda, Seiichi Saiki, Yuta Masuyama, Masashi Miyakawa, Takashi Taniguchi, Kenji Watanabe, Tokuyuki Teraji, Yuki Kamitsubo, Takeharu Sekiguchi, Mutsuko Hatano, Junichi Isoya, Takeshi Ohshima
    • Organizer
      New Diamond and Nano Carbons 2020/2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diamond quantum sensor towards robust biosensing2021

    • Author(s)
      Yuta Masuyama
    • Organizer
      第45回日本磁気学会学術講演会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 高温電子線照射によるダイヤモンドNVセンターの形成2021

    • Author(s)
      石井 秀弥、佐伯 誠一、小野田 忍、阿部 浩之、増山 雄太、大島 武
    • Organizer
      量子生命科学会第3回大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Diamond crystal growth aiming at quantum magnetic sensor application2021

    • Author(s)
      Tokuyuki Teraji, Chikara Shinei, Taisuke Kageura, Masashi Miyakawa, Takahide Yamaguchi, Yuta Masuyama, Takeshi Ohshima, Takashi Taniguchi
    • Organizer
      NIMS WEEK
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 環境ノイズに強い高感度固体量子センサー2021

    • Author(s)
      増山雄太
    • Organizer
      QST高崎サイエンスフェスタ2021
    • Related Report
      2021 Research-status Report
  • [Presentation] Highly sensitive diamond quantum magnetometer with robustness against environmental noise2021

    • Author(s)
      Yuta Masuyama
    • Organizer
      The 4th International Symposium for The Core Research Cluster for Spintronics
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Highly sensitive diamond quantum magnetometer with large sensor volume2020

    • Author(s)
      Yuta Masuyama
    • Organizer
      第44回日本磁気学会学術講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 固体量子センサーとマイクロ波2020

    • Author(s)
      増山雄太
    • Organizer
      IEEE MTT-S Kansai Chapter「量子技術とマイクロ波」ワークショップ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Digital signal processing for portable highly sensitive diamond quantum magnetometer2020

    • Author(s)
      Yuta Masuyama, Takeshi Ohshima
    • Organizer
      4th QST International Symposium “Quantum Life Science”
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] カラーセンター特性の測定方法および測定装置2022

    • Inventor(s)
      増山雄太、大島武
    • Industrial Property Rights Holder
      量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-163487
    • Filing Date
      2022
    • Related Report
      2022 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi