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Fabrication of an artificial cornea as a potential alternative to corneal transplantation for veterinary clinical application

Research Project

Project/Area Number 20K15666
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionKitasato University

Principal Investigator

Tajima Kazuki  北里大学, 獣医学部, 助教 (50770393)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords角膜移植 / 脱細胞化 / 獣医療 / 小動物 / 人工角膜 / 犬 / 豚 / 再生医療 / 角膜 / 獣医
Outline of Research at the Start

本研究では、獣医小動物臨床応用が可能な人工角膜の創出を目指す。人医領域においては人工角膜について現在まで様々な物質が検討されているが、種々の問題により完全に普及せず、やはりドナー角膜を用いた移植術がなされている。獣医療領域においてはドナー角膜が得られないため、角膜移植が選択肢とならず、最悪の場合は眼球摘出となってしまう。こうした症例をレスキューすべく、長期保存可能な人工角膜の作成にトライする。本研究が遂行されれば、犬、猫を中心とした小動物の角膜疾患に対し新たな治療法を提案することができる。

Outline of Final Research Achievements

Kitasato University Veterinary Hospital has a large number of animal ophthalmology cases, and corneal diseases are very common. Although corneal diseases can be treated by corneal transplantation in humans, in the worst case scenario, a removal of eye ball may be required in dogs and cats because a corneal transplant cannot be performed in veterinary medicine. It is difficult to secure corneal donors in animals, and it is also difficult to establish infrastructure such as eye banks. In this study, we will attempt to create an artificial cornea by applying the technique of decellularization, a regenerative medicine technology. The transparency of the artificial cornea is currently a major issue, and the purpose of this research is to create an artificial cornea for animals that maintains transparency by establishing the causes and an evaluation system for the transparency.

Academic Significance and Societal Importance of the Research Achievements

本研究によって角膜脱細胞化の手法が確立され、動物にこの人工角膜を応用する第一歩を踏み出すことができた。これにより今まで眼球摘出となっていた難治性角膜疾患の犬や猫に対し、眼球を摘出せずにこの人工角膜を使用可能となる未来が一歩現実のものとなった。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (5 results)

All 2022 2021 2020

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Primary cell culture of canine corneal endothelial cells2021

    • Author(s)
      Tajima Kazuki、Okada Misaki、Kudo Rina、Otaka Yuya、Kita Mizuki、Yamashita Yohei、Kanai Kazutaka
    • Journal Title

      Veterinary Ophthalmology

      Volume: 24 Issue: 5 Pages: 447-454

    • DOI

      10.1111/vop.12924

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Decellularization of canine kidney for three-dimensional organ regeneration2020

    • Author(s)
      Tajima Kazuki、Kuroda Kohei、Otaka Yuya、Kinoshita Rie、Kita Mizuki、Oyamada Toshifumi、Kanai Kazutaka
    • Journal Title

      Veterinary World

      Volume: 13 Issue: 3 Pages: 452-457

    • DOI

      10.14202/vetworld.2020.452-457

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] イヌ角膜内皮再生に向けた脱細胞化角膜の再細胞化2022

    • Author(s)
      田島一樹、工藤莉奈、岡田岬、喜多瑞樹、大高裕也、岡田大輝、山下洋平、金井一享
    • Organizer
      第21回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ex vivoにおけるブタ脱細胞化角膜(DC)の再細胞化モデルの開発2021

    • Author(s)
      小田愛, 田島一樹, 工藤莉奈, 岡田大輝, 大高裕也, 喜多瑞樹, 山下洋平, 金井一享
    • Organizer
      東北地区獣医師大会
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 不死化された伴侶動物由来角膜細胞株及びその使用2021

    • Inventor(s)
      田島一樹、松村海波
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-166873
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2023-01-30  

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