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Association between diabetes mellitus and regional brain atrophy in a general older Japanese population: the Hisayama Study

Research Project

Project/Area Number 20K16524
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionKyushu University

Principal Investigator

Hirabayashi Naoki  九州大学, 伊都診療所, 講師 (20784474)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords糖尿病 / 糖負荷後2時間血糖値 / 脳部位別灰白質容積 / voxel based morphometry / 地域高齢住民 / 糖負荷後2時間血糖 / 頭部MRI / 灰白質容積 / 地域高齢者 / 縦断研究
Outline of Research at the Start

近年、疫学研究にて糖尿病と認知症発症の関連が報告されている。脳構造変化についての報告も散見されるが、全脳、海馬容積の報告が多く、地域住民を対象とした糖尿病と脳の部位別容積との関連を詳細に検討した研究は少ない。近年、脳容積の差異を評価できる統計画像解析手法であるvoxel based morphometry(VBM)が用いられるようになった。糖尿病に関連した認知症の病態生理を明らかにするためにはVBMが有用であると考えられる。そこで2012年および2017年に福岡県久山町の高齢者を対象に実施した頭部MRI画像データをVBMの手法を用いて解析し、糖尿病による脳の部位別萎縮の経時的変化を検討する。

Outline of Final Research Achievements

We investigated the associations of diabetes and related parameters with regional gray matter volumes and gray matter atrophy patterns using voxel-based morphometry (VBM) among 1,189 community-dwelling Japanese aged 65 years or over. Participants with diabetes had significantly lower gray matter volumes in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than participants without diabetes after adjusting for potential confounders. In the VBM analysis, the increased 2-h postload glucose levels correlated with atrophy of the bilateral superior, middle, inferior gyri, bilateral temporal poles, bilateral insulae, left parietal operculum, right opercular part of the inferior frontal gyrus, and right thalamus. In contrast, there were no significantly decreased gray matter areas that were correlated with higher fasting plasma glucose levels.

Academic Significance and Societal Importance of the Research Achievements

糖尿病と脳構造変化の関係を検討した疫学研究の成績が散見されるが、全脳容積、海馬容積についての報告が多く、地域住民を対象とした糖尿病と脳の部位別の容積との関連を詳細に検討した研究は少ない。久山町の頭部MRI検査を含む疫学調査の成績を用いて、糖尿病は前頭葉、側頭葉、島、深部灰白質、小脳の灰白質萎縮の危険因子であることが示唆され、とくに食後高血糖の指標である糖負荷後2時間血糖値が灰白質萎縮と強く関連することが明らかとなった。本研究結果は認知症の病態解明やその予防対策の一助になると考えられる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (24 results)

All 2024 2023 2022 2021 2020

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (13 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study2024

    • Author(s)
      Hirabayashi Naoki、Hata Jun、Furuta Yoshihiko、Nakazawa Taro、Ohara Tomoyuki、Shibata Mao、Yamashita Fumio、Kitazono Takanari、Sudo Nobuyuki、Ninomiya Toshiharu
    • Journal Title

      The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

      Volume: 79 Issue: 5

    • DOI

      10.1093/gerona/glae075

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between frequency of social contact and brain atrophy in community-dwelling older people without dementia: the JPSC-AD Study.2023

    • Author(s)
      Hirabayashi N, Honda T, Hata J, Furuta Y, Shibata M, Ohara T, Tatewaki Y, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; as the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study
    • Journal Title

      Neurology

      Volume: 101 Issue: 11 Pages: 1-1

    • DOI

      10.1212/wnl.0000000000207602

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inadequate care and excessive overprotection during childhood are associated with the presence of diabetes mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study2023

    • Author(s)
      Shibata Mao、Hosoi Masako、Anno Kozo、Hirabayashi Naoki、Hirakawa Yoichiro、Kawata Hiroshi、Iwaki Rie、Sawamoto Ryoko、Sudo Nobuyuki、Ninomiya Toshiharu
    • Journal Title

      BMC Endocrine Disorders

      Volume: 23 Issue: 1 Pages: 222-222

    • DOI

      10.1186/s12902-023-01474-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study2023

    • Author(s)
      Nakazawa Taro、Ohara Tomoyuki、Hirabayashi Naoki、Furuta Yoshihiko、Hata Jun、Shibata Mao、Honda Takanori、Kitazono Takanari、Nakao Tomohiro、Ninomiya Toshiharu
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: Online ahead of print Issue: 6 Pages: 330-337

    • DOI

      10.1111/pcn.13533

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study2023

    • Author(s)
      Tajimi Takahiro、Furuta Yoshihiko、Hirabayashi Naoki、Honda Takanori、Hata Jun、Ohara Tomoyuki、Shibata Mao、Nakao Tomohiro、Kitazono Takanari、Nakashima Yasuharu、Ninomiya Toshiharu
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 106 Pages: 104883-104883

    • DOI

      10.1016/j.archger.2022.104883

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study2022

    • Author(s)
      Hirabayashi Naoki、Hata Jun、Furuta Yoshihiko、Ohara Tomoyuki、Shibata Mao、Hirakawa Yoichiro、Yamashita Fumio、Yoshihara Kazufumi、Kitazono Takanari、Sudo Nobuyuki、Ninomiya Toshiharu
    • Journal Title

      Diabetes Care

      Volume: 45 Issue: 6 Pages: 1364-1371

    • DOI

      10.2337/dc21-1911

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population2022

    • Author(s)
      Ueda Emi、Hirabayashi Naoki、Ohara Tomoyuki、Hata Jun、Honda Takanori、Fujiwara Kohta、Furuta Yoshihiko、Shibata Mao、Hashimoto Sawako、Nakamura Shun、Nakazawa Taro、Nakao Tomohiro、Kitazono Takanari、Ninomiya Toshiharu、Sonoda Koh-Hei
    • Journal Title

      Ophthalmology Science

      Volume: 2 Issue: 2 Pages: 100157-100157

    • DOI

      10.1016/j.xops.2022.100157

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study2022

    • Author(s)
      Asada Masako、Shibata Mao、Hirabayashi Naoki、Ohara Tomoyuki、Furuta Yoshihiko、Nakazawa Taro、Honda Takanori、Hata Jun、Hosoi Masako、Sudo Nobuyuki、Yamaura Ken、Ninomiya Toshiharu
    • Journal Title

      Pain

      Volume: Publish Ahead of Print Issue: 11 Pages: 2185-2193

    • DOI

      10.1097/j.pain.0000000000002612

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study2021

    • Author(s)
      Nakazawa Taro、Ohara Tomoyuki、Hirabayashi Naoki、Furuta Yoshihiko、Hata Jun、Shibata Mao、Honda Takanori、Kitazono Takanari、Nakao Tomohiro、Ninomiya Toshiharu
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 93 Issue: 3 Pages: 263-271

    • DOI

      10.1136/jnnp-2021-326611

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese ― The Hisayama Study ―2020

    • Author(s)
      Yamasaki Keisuke、Hata Jun、Furuta Yoshihiko、Hirabayashi Naoki、Ohara Tomoyuki、Yoshida Daigo、Hirakawa Yoichiro、Nakano Toshiaki、Kitazono Takanari、Ninomiya Toshiharu
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 6 Pages: 935-942

    • DOI

      10.1253/circj.CJ-19-1069

    • NAID

      130007846238

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2020-05-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study2020

    • Author(s)
      Shibata M, Ohara T, Hosoi M, Jun H, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T
    • Journal Title

      The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

      Volume: - Issue: 9 Pages: 1756-1766

    • DOI

      10.1093/geronb/gbaa196

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] ASSOCIATION OF IMPAIRED OLFACTORY IDENTIFICATION WITH PREVALENT MILD COGNITIVE IMPAIRMENT AND REGIONAL BRAIN ATROPHY: THE HISAYAMA STUDY2023

    • Author(s)
      Toshifumi Minohara, Tomoyuki Ohara, Taro Nakazawa, Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Akane Mihara, Mao Shibata, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya
    • Organizer
      23rd WPA (World Psychiatric Association) World Congress of Psychiatry
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域高齢住民におけるサルコペニアと脳萎縮との関連:久山町研究2023

    • Author(s)
      多治見昂洋, 平林直樹, 古田芳彦, 本田貴紀, 秦淳, 小原知之, 柴田舞欧, 北園孝成, 中島康晴, 二宮利治
    • Organizer
      第96回日本整形外科学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Association between sarcopenia and regional brain atrophy in a general older population: the Hisayama Study2023

    • Author(s)
      Tajimi Takahiro, Naoki Hirabayashi, Yoshihiko Furuta, Takanori Honda, Jun Hata, Tomoyuki Ohara, Mao Shibata, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya
    • Organizer
      Orthopaedic Research Society (ORS) 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Association between frequency of social contact and brain atrophy in community-dwelling older people: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study2022

    • Author(s)
      Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Nobuyuki Sudo, Toshiharu Ninomiya, on the behalf of JPSC-AD study group
    • Organizer
      International College of Psychosomatic Medicine (ICPM) 26th World Congress
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 地域高齢者における慢性腰痛と領域別脳容積の関連:久山町研究2022

    • Author(s)
      柴田 舞欧、浅田 雅子、平林 直樹、小原 知之、古田 芳彦、中澤 太郎、本田 貴紀、秦 淳、二宮 利治
    • Organizer
      日本臨床疫学会 第5回年次学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 地域高齢住民における領域別脳容積と慢性腰痛の関連:久山町研究2022

    • Author(s)
      柴田舞欧、浅田雅子、平林直樹、小原知之、古田芳彦、中澤太郎、本田貴紀、秦淳、細井昌子、二宮利治、須藤信行
    • Organizer
      第26回 日本心療内科学会総会・学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 嗅覚低下と軽度認知障害および部位別脳萎縮の関連:久山町研究2022

    • Author(s)
      三野原 敏文、小原 知之、中澤 太郎、平林 直樹、秦 淳、古田 芳彦、三原 茜、柴田 舞欧、中尾 智博、二宮 利治
    • Organizer
      第41回日本認知症学会学術集会/第37回日本老年精神医学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 地域高齢者における慢性疼痛と脳領域別萎縮の関連2021

    • Author(s)
      浅田雅子, 柴田舞欧, 平林直樹, 小原知之, 山浦健, 二宮利治
    • Organizer
      日本麻酔科学会第68回学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢住民における脳部位別の灰白質萎縮が認知症発症に及ぼす影響:久山町研究2021

    • Author(s)
      中澤太郎, 小原知之, 平林直樹, 古田芳彦, 秦 淳, 柴田舞欧, 本田貴紀, 北園孝成, 中尾智博, 二宮利治
    • Organizer
      第43回日本生物学的精神医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢住民における脳部位別灰白質容積低下と認知症発症の関連:久山町研究2021

    • Author(s)
      中澤太郎, 小原知之, 平林直樹, 古田芳彦, 秦 淳, 柴田舞欧, 本田貴紀, 北園孝成, 中尾智博, 二宮利治
    • Organizer
      第117回日本精神神経学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢住民における大脳白質病変と認知症発症の関係:久山町研究2021

    • Author(s)
      中澤太郎, 小原知之, 平林直樹, 古田芳彦, 秦 淳, 柴田舞欧, 本田貴紀, 北園孝成, 中尾智博, 二宮利治
    • Organizer
      第36回日本老年精神医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢住民における歩行速度と認知症発症および脳容積との関連:久山町研究2021

    • Author(s)
      多治見昂洋, 古田芳彦, 平林直樹, 本田貴紀, 秦 淳, 小原知之, 柴田舞欧, 中尾智博, 北園孝成, 中島康晴, 二宮利治
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 地域高齢者における血清NT-proBNPと脳灰白質萎縮パターンとの関連:久山町研究2021

    • Author(s)
      平林直樹, 秦 淳, 小原知之, 古田芳彦, 柴田舞欧, 山下典生, 北園孝成, 須藤信行, 二宮利治
    • Organizer
      日本臨床疫学会 第4回年次学術大会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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