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3D ultrasonography for intestinal fibrosis in Crohn's disease

Research Project

Project/Area Number 20K16707
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKitasato University

Principal Investigator

Sagami Shintaro  北里大学, 北里研究所病院, 副センター長 (10837371)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords炎症性腸疾患 / クローン病 / 造影超音波 / MRエンテログラフィー / 腸管エコー / 線維化 / エラストグラフィー / 3次元超音波 / Crohn
Outline of Research at the Start

クローン病は腸管特異的に炎症が生じ狭窄や穿通/穿孔をきたす原因不明の疾患である。狭窄には浮腫による炎症性狭窄と線維性狭窄があるが、両者は治療法が異なるため鑑別可能な画像検査の確立が望まれる。本研究ではCDの狭窄における3次元(3D)超音波検査所見による壁肥厚、血流増加、組織弾性のパラメーターと病理組織学的な線維化・炎症による浮腫や血管新生・炎症細胞浸潤、免疫学的なサイトカイン、成長因子といった病態を示唆する所見との相関関係の有無を立証する。これにより低侵襲にクローン病の病態を把握し、腸管狭窄に対する適切な治療を行うことが可能となる。

Outline of Final Research Achievements

Crohn's disease (CD) is an idiopathic condition characterized by intestinal-specific inflammation that leads to strictures. There are two main types of strictures: inflammatory strictures caused by edema and fibrotic strictures. As treatments differ for these types, establishing imaging tests that can distinguish between them is essential. This study aims to demonstrate the correlation between 3D ultrasound parameters in CD strictures. By March 2024, we gathered data from 38 cases and analyzed. Some data has already confirmed that the stiffness of inflamed intestinal areas (measured by elastography) predicts poor response to induction therapy with biological agents. This finding underscores the importance of 3D ultrasound in both diagnostic and therapeutic strategies for CD.

Academic Significance and Societal Importance of the Research Achievements

本研究の主要な目標は、3D超音波のパラメーターを用いて炎症性狭窄と線維性狭窄の鑑別方法の有用性を証明することであった。最終的に治療予後不良因子として、寛解導入治療開始時の最重症部のエラストグラフィーの値が高い(硬い)ことが相関することを報告した。治療予後に線維化が関与する可能性を示した。
社会的意義として本研究の成果は、線維化抑制薬の臨床適用や効果判定に役立つ可能性がある。現在、線維化抑制薬は臨床試験中であり、今後の使用が期待されている。本研究の結果は、重症度評価や寛解導入治療のモニタリングにも転用可能であり、臨床現場での実用化が期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (31 results)

All 2024 2023 2022 2021

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (15 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results)

  • [Journal Article] Letter: Modifying the Mayo endoscopic subscore for improved prognostic insights2024

    • Author(s)
      Asonuma Kunio、Sagami Shintaro、Kobayashi Taku
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 59 Issue: 8 Pages: 1005-1006

    • DOI

      10.1111/apt.17912

    • Related Report
      2023 Annual Research Report
  • [Journal Article] A case of cytomegalovirus esophagitis difficult to distinguish from Crohn’s disease exacerbation2024

    • Author(s)
      Misaki Mika、Sagami Shintaro、Yamana Yoko、Maeda Masa、Hojo Aya、Miyatani Yusuke、Maeda Ichiro、Nakano Masaru、Hibi Toshifumi、Kobayashi Taku
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: - Issue: 4 Pages: 593-597

    • DOI

      10.1007/s12328-024-01978-z

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria2024

    • Author(s)
      Naganuma M, Nakamura N, Kunisaki R, Matsuoka K, Yamamoto S, Kawamoto A, Saito D, Kobayashi T, Nanki K, Narimatsu K, Shiga H, Esaki M, Yoshioka S, Kato S, Saruta M, Tanaka S, Yasutomi E, Yokoyama K, Moriya K, Tsuzuki Y, Ooi M, Fujiya M, Nakazawa A, Takagi T, Omori T, Tahara T, Hisamatsu T; Japanese UC Study Group.
    • Journal Title

      J Gastroentrol

      Volume: 59 Issue: 4 Pages: 302-314

    • DOI

      10.1007/s00535-024-02079-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Editorial: Extending upadacitinib induction dosing in ulcerative colitis‐A delicate balance of efficacy and safety2024

    • Author(s)
      Sagami Shintaro、Kobayashi Taku
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 59 Issue: 4 Pages: 579-580

    • DOI

      10.1111/apt.17829

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Milan Ultrasound Criteria Predict Relapse of Ulcerative Colitis in Remission2023

    • Author(s)
      Maeda Masa、Sagami Shintaro、Tashima Moyu、Yamana Yoko、Karashima Ryo、Miyatani Yusuke、Hojo Aya、Nakano Masaru、Hibi Toshifumi、Kobayashi Taku
    • Journal Title

      Inflammatory Intestinal Diseases

      Volume: 8 Issue: 3 Pages: 95-104

    • DOI

      10.1159/000532052

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Real-world efficacy and safety of first- and second-advanced therapy in hospitalized patients with ulcerative colitis.2023

    • Author(s)
      Naganuma M, Kobayashi T, Kinisaki R, Yamamoto S, Matsuoka K, Kawamoto A, Saito D, Nanki K, Narimatsu K,Shiga H, T,Esaki M, Yoshioka S, Kato S, Saruta M, Tanaka S, Yasutomi E, Yokoyama K,Moriya K, Tsuzuki Y, Ooi M, Fujiya M,Nakazawa A, Abe T,Hisamatsu T.
    • Journal Title

      J Gastroentrol

      Volume: 58 Issue: 12 Pages: 1198-1210

    • DOI

      10.1007/s00535-023-02048-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Letter: Transperineal ultrasonography for ulcerative proctitis?Applicability in the pregnant population? Authors' reply2023

    • Author(s)
      Sagami Shintaro、Hojo Aya、Asonuma Kunio、Kobayashi Taku
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 58 Issue: 8 Pages: 836-837

    • DOI

      10.1111/apt.17705

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn’s disease in Japan (SPREAD-J study)2023

    • Author(s)
      Sakurai T, the SPREAD-J group, et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 58 Issue: 10 Pages: 1003-1014

    • DOI

      10.1007/s00535-023-02017-3

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Optimal Use of Serum Leucine-Rich Alpha-2 Glycoprotein as a Biomarker for Small Bowel Lesions of Crohn’s Disease2023

    • Author(s)
      Asonuma Kunio、Kobayashi Taku、Kikkawa Nao、Nakano Masaru、Sagami Shintaro、Morikubo Hiromu、Miyatani Yusuke、Hojo Aya、Fukuda Tomohiro、Hibi Toshifumi
    • Journal Title

      Inflammatory Intestinal Diseases

      Volume: 8 Issue: 1 Pages: 13-22

    • DOI

      10.1159/000530825

    • Related Report
      2023 Annual Research Report
  • [Journal Article] An open competition involving thousands of competitors failed to construct useful abstract classifiers for new diagnostic test accuracy systematic reviews2023

    • Author(s)
      Kataoka Y, Sagami S, et al.
    • Journal Title

      Research Synthesis Methods

      Volume: 14 Issue: 5 Pages: 707-717

    • DOI

      10.1002/jrsm.1649

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Early improvement in bowel wall thickness on transperineal ultrasonography predicts treatment success in active ulcerative colitis2022

    • Author(s)
      Sagami Shintaro、Kobayashi Taku、Aihara Kanako、Umeda Misaki、Odajima Kazuhiro、Morikubo Hiromu、Asonuma Kunio、Miyatani Yusuke、Fukuda Tomohiro、Matsubayashi Mao、Kiyohara Hiroki、Nakano Masaru、Hibi Toshifumi
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 55 Issue: 10 Pages: 1320-1329

    • DOI

      10.1111/apt.16817

    • Related Report
      2022 Research-status Report 2021 Research-status Report
  • [Journal Article] Editorial: the importance of utilising gastrointestinal ultrasound via transperineal approach in ulcerative colitis?an accurate early predictor of response to treatment. Authors' reply2022

    • Author(s)
      Sagami Shintaro、Kobayashi Taku
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 55 Issue: 9 Pages: 1204-1205

    • DOI

      10.1111/apt.16895

    • Related Report
      2022 Research-status Report 2021 Research-status Report
  • [Journal Article] Usefulness of colestimide for diarrhea in postoperative Crohn's disease2022

    • Author(s)
      Hojo Aya、Kobayashi Taku、Matsubayashi Mao、Morikubo Hiromu、Miyatani Yusuke、Fukuda Tomohiro、Asonuma Kunio、Sagami Shintaro、Nakano Masaru、Matsuda Takahisa、Hibi Toshifumi
    • Journal Title

      JGH Open

      Volume: 6 Issue: 8 Pages: 547-553

    • DOI

      10.1002/jgh3.12786

    • Related Report
      2022 Research-status Report
  • [Journal Article] Transperineal ultrasound predicts endoscopic and histological healing in ulcerative colitis2021

    • Author(s)
      Sagami Shintaro、Kobayashi Taku、Aihara Kanako、Umeda Misaki、Morikubo Hiromu、Matsubayashi Mao、Kiyohara Hiroki、Nakano Masaru、Ohbu Makoto、Hibi Toshifumi
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 51 Issue: 12 Pages: 1373-1383

    • DOI

      10.1111/apt.15767

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial: transperineal ultrasound in addition to a transabdominal ultrasound in ulcerative colitis-one more arrow in the quiver of non-invasive diagnostics. Authors’ reply2021

    • Author(s)
      Sagami Shintaro、Kobayashi Taku、Hibi Toshifumi
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 52 Issue: 2 Pages: 403-403

    • DOI

      10.1111/apt.15871

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Journal Article] Accuracy of Ultrasound for Evaluation of Colorectal Segments in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis2021

    • Author(s)
      Sagami Shintaro、Kobayashi Taku、Miyatani Yusuke、Okabayashi Shinji、Yamazaki Hajime、Takada Toshihiko、Kinoshita Kenji、Allocca Mariangela、Kunisaki Reiko、Ramaswamy Pradeep Kakkadasam、Shiraki Manabu、Hibi Toshifumi、Kataoka Yuki
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: 19 Issue: 5 Pages: 908-921.e6

    • DOI

      10.1016/j.cgh.2020.07.067

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Presentation] Diagnostic accuracy of contrast-enhanced ultrasound for fibrotic strictures of Crohn’s disease: a systematic review and meta-analysis of individual participant data2024

    • Author(s)
      S. Sagami, Y. Miyatani, K. Nylund, R. Wilkens, E. Quaia, Y. Kataoka, T. Hibi, T. Kobayashi.
    • Organizer
      ECCO
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utilizing IUS to Assess Treatment Response in Ulcerative colitis2024

    • Author(s)
      S. Sagami
    • Organizer
      IMKASID
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] EARLY TRANSPERINEAL ULTRASONOGRAPHY AS A PREDICTOR OF HISTOLOGICAL REMISSION IN ULCERATIVE COLITIS FOLLOWING ADVANCED THERAPY2024

    • Author(s)
      S. Sagami
    • Organizer
      DDW
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IUS in Special situations: Pregnancy, TPUS, AI2024

    • Author(s)
      S. Sagami
    • Organizer
      DDW
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Shear Wave Elastography Predicts Short-Term Response To Induction Therapy in Patients with Crohn’s Disease.2023

    • Author(s)
      Sagami S, Kobayashi T, Fujiyoshi K, Torisu M, Odajima K, Otsuka A, Hibi T.
    • Organizer
      DDW
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炎症性腸疾患診療における超音波の役割:CT,MRI, 内視鏡との比較2023

    • Author(s)
      佐上晋太郎
    • Organizer
      日本超音波医学会第96回学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 炎症性腸疾患の炎症モニタリングにおける腸管エコー2023

    • Author(s)
      佐上晋太郎
    • Organizer
      日本超音波医学会第96回学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 経会陰腸管エコーの直腸壁肥厚早期改善は、潰瘍性大腸炎の内視鏡的・組織学的治癒を予測する2023

    • Author(s)
      佐上晋太郎、中野 雅、前田一郎、日比紀文、小林 拓
    • Organizer
      JSIBD
    • Related Report
      2023 Annual Research Report
  • [Presentation] Shear wave elastography predicts short-term response to induction therapy in patients with Crohn’s disease2023

    • Author(s)
      S. Sagami, H. Morikubo, Y. Miyatani, T. Fukuda, K. Asonuma, M. Maeda, Y. Yoko, R. Karashima, A. Hojo, M. Nakano, T. Hibi, T. Kobayashi
    • Organizer
      ECCO2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Basic Techniques and Methods for Practicing IUS2023

    • Author(s)
      Shintaro Sagami
    • Organizer
      AOCC2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cutting Edge Issues in Intestinal Ultrasonography for IBD Management2023

    • Author(s)
      Shintaro Sagami
    • Organizer
      AOCC2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ARLY REDUCTION OF BOWEL WALL THICKNESS BY TRANSPERINEAL ULTRASONOGRAPHY PREDICTS BIOLOGICS-INDUCED DEEP REMISSION IN ULCERATIVE COLITIS2022

    • Author(s)
      Shintaro Sagami, Taku Kobayashi, Ryo Karashima, Aya Hojo, Hiromu Morikubo, Yusuke Miyatani, Tomohiro Fukuda, Kunio Asonoma, Masaru Nakano, Toshifumi Hibi
    • Organizer
      UEGW2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Shear wave elastography predicts short-term response to remission induction therapy in patients with Crohn’s disease2022

    • Author(s)
      Shintaro Sagami,Taku Kobayashi, Toshifumi Hibi
    • Organizer
      ENDO2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Early improvement in bowel wall thickness on transperineal ultrasonography predicts treatment success in active ulcerative colitis2021

    • Author(s)
      Shintaro Sagami, Kobayashi, Kanako Aihara, Misaki Umeda, Kazuhiro Odajima3, Hiromu Morikubo1,2Kunio Asonuma, Yusuke Miyatani, Tomohiro Fukuda, Mao Matsubayashi, Hiroki Kiyohara, Masaru Nakano,Toshifumi Hibi
    • Organizer
      17th congress of ECCO
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 潰瘍性大腸炎における寛解導入1週後腸管エコーの短期予後予測能2021

    • Author(s)
      佐上晋太郎, 小林拓, 日比紀文
    • Organizer
      JDDW 2021
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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