Elucidation of the pathogenesis of idiopathic aldosteronism by focusing on gender and fat distribution
| Project/Area Number |
20K17514
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 特発性アルドステロン症 / 性差 / 肥満 / レプチン / ステロイドプロファイル / アルドステロン |
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| Outline of Research at the Start |
特発性アルドステロン症(idiopathic hyperaldosteronism; IHA)は、アルドステロン過剰分泌の程度、臓器障害合併の程度も様々でありながら、その成因解明は進んでおらず、その全てに一様の診断、治療がなされている。病態解明によるその診断の精緻化、真に治療介入を必要とする高リスク患者の抽出は急務である。本研究はレプチン測定、メタボロミクス解析、性別・肥満の有無による臨床像の比較、単球機能評価を通して、「肥満を伴うIHA」の成因、臨床像、病原性を明らかにし、肥満合併高血圧の病態解明、IHAの診断・治療の精緻化への端緒となることを目指すものである。
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| Outline of Final Research Achievements |
First, we constructed an adrenal disease registry including idiopathic aldosteronism (IHA), then, as a method to efficiently diagnose and extract IHA from hypertensive patients, we identified the aldosterone secretion profile characteristic of IHA. Furthermore, using machine learning, we developed a model to predict IHA from blood test items performed in a routine outpatient clinic.
In the study of IHA cases, we found that serum leptin concentration, which reflects the amount of subcutaneous adipose tissue, correlates with the amount of aldosterone secretion in women. This suggests the existence of "obesity-induced aldosteronism," a leptin-dependent hypersecretion of aldosterone in obese women.
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| Academic Significance and Societal Importance of the Research Achievements |
女性において肥満がハイリスク高血圧である原発性アルドステロン症に類似する病態を誘導することが明らかになった。これにより、肥満者に合併する高血圧の病態の一部、その性差が明らかとなり、高血圧診療および原発性アルドステロン症診療の精緻化、個別化につながるものと考えられる。
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Report
(3 results)
Research Products
(17 results)
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[Presentation] Machine Learning-Based Models for Prediction of Subtype Diagnosis of Primary Aldosteronism Using Blood Test2021
Author(s)
Hiroki Kaneko, Hironobu Umakoshi, Masatoshi Ogata, Norio Wada, Norifusa Iwahashi, Tazuru Fukumoto, Maki Yokomoto-Umakoshi, Yui Nakano, Yayoi Matsuda, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa.
Organizer
米国内分泌学会（ENDO2021）
Related Report
Int'l Joint Research
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[Presentation] Significance of Discordant Results between Confirmatory Tests in Diagnosis of Primary Aldosteronism2021
Author(s)
Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa.
Organizer
米国内分泌学会（ENDO2021）
Related Report
Int'l Joint Research
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