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Development of novel therapies for endocrine cell originated colorectal cancer

Research Project

Project/Area Number 20K17687
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKobe University

Principal Investigator

Mukohyama Jyunko  神戸大学, 医学研究科, 医学研究員 (70734987)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords大腸癌 / 最適化治療 / 内分泌細胞 / 細胞系譜
Outline of Research at the Start

大腸癌による死亡数は増加の一途にある。死因の大半は転移や再発によるものであり、これらの制御機構の解明は、予後改善のための重要課題である。近年、大腸癌の予後が不良なサブタイプとして内分泌系細胞を起源とする大腸癌が注目されている。本研究では同大腸癌の細胞系譜と悪性化の分子機構の解明を目指し、最適化治療の確立を行う。本研究の成果は同大腸癌の最適化治療の早期の臨床応用や治療成績の向上に貢献できる。

Outline of Final Research Achievements

CDX2Low colorectal cancer (CRC) is a subtype of colorectal cancer with a poor prognosis with frequent postoperative recurrence. By establishing live single-cell RNA-Seq. analysis of CDX2Low CRC, the applicant has shown that this colorectal cancer has a unique cell lineage, including an APC gene-independent oncogenic mechanism and endocrine cells. Omics analysis of animal models and clinical specimens also revealed a possible involvement of chronic inflammation in the carcinogenesis of CDX2LowCRC. Disease classification and treatment selection based on cellular origin has been established in hematological malignancies, and the results of this study may lead to the establishment of optimized treatment based on cell lineage for the first time in solid tumor.

Academic Significance and Societal Importance of the Research Achievements

本邦における大腸癌による死亡数はこの20年間で2.5倍と増加の一途にあり、現在では年間5万人を超えている。死因の大半は転移や再発によるものであり、これらの制御機構の解明は、大腸癌の予後改善のための重要課題である。
本研究では根治切除後の転移再発が多い大腸癌のサブタイプであるCDX2低発現大腸癌の細胞起源に着目した解析をおこなった。血液腫瘍では細胞由来による疾患分類や治療選択が標準化されており、本研究の成果も大腸癌の予後改善に貢献できる可能性を持つ。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (14 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (4 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Int'l Joint Research] Columbia University(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Columbia University(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Columbia University/Stanford University(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Columbia University(米国)

    • Related Report
      2020 Research-status Report
  • [Journal Article] CDX2 Is a Prognostic Biomarker for Unresectable Metastatic Colorectal Cancer2023

    • Author(s)
      MUKOHYAMA JUNKO、AGAWA KYOSUKE、YAMASHITA KIMIHIRO、MATSUDA TAKERU、SHINODA MASAHIRO、ITANO OSAMU、KAKEJI YOSHIHIRO
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 8 Pages: 3763-3767

    • DOI

      10.21873/anticanres.16561

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022

    • Author(s)
      Hisamori Shigeo、Mukohyama Junko、Koul Sanjay、Hayashi Takanori、Rothenberg Michael Evan、Maeda Masao、Isobe Taichi、Valencia Salazar Luis Enrique、Qian Xin、Johnston Darius Michael、Qian Dalong、Lao Kaiqin、Asai Naoya、Kakeji Yoshihiro、Gennarino Vincenzo Alessandro、Sahoo Debashis、Dalerba Piero、Shimono Yohei
    • Journal Title

      Journal of Gastroenterology

      Volume: Online ahead of print Issue: 6 Pages: 407-422

    • DOI

      10.1007/s00535-022-01865-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells.2022

    • Author(s)
      Shigeo Hisamori, *, Junko Mukohyama*, 6yt5Koul Sanjay, Takanori Hayashi, Michael E. Rothenberg, Masao Maeda, Taichi Isobe, Luis E. Valencia Salazar, Xin Qian, Darius M. Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai,, Yoshihiro Kakeji, Vincenzo A. Gennarino, Debashis Sahoo Piero Dalerba, Yohei Shimono
    • Journal Title

      Journal of Gastroenterology

      Volume: in print

    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Structural basis of cytokine-mediated activation of ALK family receptors2021

    • Author(s)
      De Munck Steven、Provost Mathias、Kurikawa Michiko、Omori Ikuko、Mukohyama Junko、Felix Jan、Bloch Yehudi、Abdel-Wahab Omar、Bazan J. Fernando、Yoshimi Akihide、Savvides Savvas N.
    • Journal Title

      Nature

      Volume: 600 Issue: 7887 Pages: 143-147

    • DOI

      10.1038/s41586-021-03959-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma2021

    • Author(s)
      AGAWA KYOSUKE、YAMASHITA KIMIHIRO、NAKAGAWA AKIO、YAMADA KOUTA、WATANABE AKIHIRO、MUKOHYAMA JUNKO、SAITO MASAFUMI、FUJITA MITSUGU、TAKIGUCHI GOSUKE、URAKAWA NAOKI、HASEGAWA HIROSHI、KANAJI SHINGO、MATSUDA TAKERU、OSHIKIRI TARO、NAKAMURA TETSU、SUZUKI SATOSHI、KAKEJI YOSHIHIRO
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 8 Pages: 4117-4126

    • DOI

      10.21873/anticanres.15214

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 三刀流ママ外科医、Surgeon-scientistとして「外科的治療だけでは治癒が難しい癌」を研究する2024

    • Author(s)
      向山順子、篠田昌宏、掛地吉弘、板野理
    • Organizer
      日本外科学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] CDX2低発現大腸癌の腫瘍生物学的特徴の検討2022

    • Author(s)
      CDX2低発現大腸癌の腫瘍生物学的特徴の検討
    • Organizer
      第77回日本消化器外科学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] DX2低発現大腸癌に対する最適化治療の確立に向けた研究2021

    • Author(s)
      向山順子, Piero Dalerba
    • Organizer
      第121回日本外科学会定期学術集会, 外科学再興シンポジウム13
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] miR-221 targets QKI5 and enhances functional behaviors of cancer stem cells in human colon cancers.2021

    • Author(s)
      Junko Mukohyama, Osamu Itano, Yoshihiro Kakej, Yohei Shimono.
    • Organizer
      International Colorectal Research Summit (ICRS)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] CDX2 as a prognostic and predictive biomarker in colon cancer.2020

    • Author(s)
      Junko Mukohyama, Piero Dalerba
    • Organizer
      第79回日本癌学会総会
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2025-01-30  

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