脳内炎症伝播の司令塔ペリサイトから「熱性けいれんのてんかん原性」に挑む

• Project/Area Number: 20K17909
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Tokyo Medical University
• Principal Investigator: 森地 振一郎 東京医科大学, 医学部, 講師 (00532269)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 熱性けいれん / ペリサイト / フローサイトメトリー / サイトカイン / 神経炎症 / 血管内皮障害 / てんかん / 血管新生因子 / 血液脳関門 / 小児

Outline of Research at the Start

こどもの10人にひとりはけいれんする。熱性けいれんは予後良好とされているが、近年てんかんや認知機能障害との関連が指摘される。一方、脳内炎症伝播における司令塔である「ペリサイト」は血液脳関門のタイトジャンクションを担うが、てんかん原性の発生と密接に関係するとされる。
本研究は、けいれん疾患と「ペリサイト」の関連性を解析する。ヒトにおいて末梢血液中の各種バイオマーカーとそれを産生する細胞について探索し、同定した細胞がペリサイトや血液脳関門に与える影響について追及する。基礎と臨床、中枢と末梢から多角的に熱性けいれんによるてんかん原性の解明に挑む。

Outline of Annual Research Achievements

本研究はペリサイトを中心に，熱性けいれん(FS)によるてんかん原性に対する免疫学的機序の関与を検討した．主な実験は(A)ペリサイトマーカー解析，(B)フローサイトメトリー(FACS)，(C)サイトカイン／ケモカインの網羅的解析を行った．
令和2-4年度に実施した(A)-(C)の結果をまとめる．(A) ペリサイト関連因子であるPDGFRβ/CD13/BMPを測定し，併せてDAMPsに関連したHMGB1/BDNF/VEGFと比較した．結果は中枢神経感染症，難治性てんかんのうち有熱性けいれん後に神経学的後遺症を有した群でPDGFRβ/HMGB1/BDNF/VEGFが有意に上昇していた．(B)FACSにて末梢血単核細胞のLPS刺激によるサイトカインの反応性の違いを解析した．(1)複雑型FSで発作前後の検体で評価したところ，発作後に速やかにIL-1βが低下した．(2)発達性てんかん性脳症(DEE)の代表である，乳児てんかん性スパズム症候群(IESS)を各病相で評価した．CD8陽性T細胞であるIL-1β/IL-1RA陽性単球およびIFN-γの割合が，非けいれん性疾患群よりも有意に上昇していた．(C)FS群/てんかん群/非けいれん性疾患群に対して，血清/血漿/髄液検体でサイトカイン解析を実施したところ，PDGF-BB/VEGF/IL-1β/IL-6がFS(特に複雑型)群とてんかん群で上昇していた．
令和5年度はFSとDEEの発症機序における，ペリサイト関与の差異を確認した．IESSを中心としたDEEを対象としてペリサイト解析/サイトカイン解析を進めた．DEE群は非けいれん性疾患群と比較してCD13が有意に上昇し，PDGFRβが低下していた．
以上から，ペリサイト関連因子は特定のサイトカイン群と相互的に動き，FSを含めたけいれん性疾患における血液脳関門の脆弱性や神経炎症に関与すると考えた．

Research Products

• [Journal Article] Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome (2023)
  • Author(s): Watanabe Yusuke、Yamanaka Gaku、Morichi Shinichiro、Hayashi Kanako、Suzuki Shinji、Takeshita Mika、Morishita Natsumi、Ishida Yu、Oana Shingo、Takata Fuyuko、Kawashima Hisashi
  • Journal Title: Brain and Development Volume: 45 Issue: 9 Pages: 479-486
  • DOI: 10.1016/j.braindev.2023.05.005
  • Peer Reviewed
• [Journal Article] Clinical features of a pediatric case of recurrent mild encephalopathy with reversible splenial lesion (MERS) triggered by different infections (2023)
  • Author(s): Shinichiro Morichi, Haruka Nakazawa, Yusuke Watanabe, Rie Ishimine, Tomoko Takamatsu, Yu Ishida, Shingo Oana, Yasuyo Kashiwagi, Gaku Yamanaka
  • Journal Title: NEUROINFECTION Volume: 28 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Clinical investigation of children with acute encephalopathy associated with COVID-19 infection (2023)
  • Author(s): Konomi Okada, Shinichiro Morichi, Yusuke Watanabe, Haruka Nakazawa, Rie Ishimine, Kanako Hayashi, Tomoko Takamatsu, Akiko Kasuga, Mika Takeshita, Soken Go, Yu Ishida, Shingo Oana, Yasuyo Kashiwagi, Gaku Yamanaka
  • Journal Title: NEUROINFECTION Volume: 28 Pages: 53-59
  • Peer Reviewed
• [Journal Article] A child with acute subdural abscess with no sequelae after neuroendoscopic lavage (2023)
  • Author(s): Suzuka Uchida, Shinichiro Morichi, Takeaki Sasamoto, Kanako Hayashi, Tomoko Takamatsu, Yu Ishida, Shingo Oana, Atsushi Kumada, Nobuyuki Nakajima, Gaku Yamanaka
  • Journal Title: NEUROINFECTION Volume: 28 Pages: 46-52
  • Peer Reviewed
• [Journal Article] Involvement of Peripheral Monocytes with IL-1β in the Pathogenesis of West Syndrome (2022)
  • Author(s): Takamatsu Tomoko、Yamanaka Gaku、Ohno Koko、Hayashi Kanako、Watanabe Yusuke、Takeshita Mika、Suzuki Shinji、Morichi Shinichiro、Go Soken、Ishida Yu、Oana Shingo、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 2 Pages: 447-447
  • DOI: 10.3390/jcm11020447
  • Peer Reviewed / Open Access
• [Journal Article] Chemokine/Interleukin Imbalance Aggravates the Pathology of Respiratory Syncytial Virus Infection (2022)
  • Author(s): Mori Kentaro、Sasamoto Takeaki、Nakayama Tetsuo、Morichi Shinichiro、Kashiwagi Yasuyo、Sawada Akihito、Kawashima Hisashi
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 20 Pages: 6042-6042
  • DOI: 10.3390/jcm11206042
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Late-Onset Group B Streptococcus Serotype Ⅰb Meningitis With Absence of Pleocytosis at the Initial Cerebrospinal Fluid Analysis (2022)
  • Author(s): Chida Rie、Morichi Shinichiro、Watanabe Yusuke、Yamanaka Gaku
  • Journal Title: Cureus Volume: 14(11)
  • DOI: 10.7759/cureus.31138
  • Peer Reviewed / Open Access
• [Journal Article] The Neuroinflammatory Role of Pericytes in Epilepsy (2021)
  • Author(s): Yamanaka Gaku、Takata Fuyuko、Kataoka Yasufumi、Kanou Kanako、Morichi Shinichiro、Dohgu Shinya、Kawashima Hisashi
  • Journal Title: Biomedicines Volume: 9 Issue: 7 Pages: 759-759
  • DOI: 10.3390/biomedicines9070759
  • Peer Reviewed / Open Access
• [Journal Article] Epileptic encephalopathy patients with <i>SCN2A</i> variant initiated by neonatal seizure (2021)
  • Author(s): Morichi Shinichiro、Ishida Yu、Yamanaka Gaku、Kato Mitsuhiro、Kawashima Hisashi
  • Journal Title: Pediatrics International Volume: 63 Issue: 8 Pages: 971-972
  • DOI: 10.1111/ped.14509
  • Peer Reviewed
• [Journal Article] Towards a Treatment for Neuroinflammation in Epilepsy: Interleukin-1 Receptor Antagonist, Anakinra, as a Potential Treatment in Intractable Epilepsy (2021)
  • Author(s): Yamanaka Gaku、Ishida Yu、Kanou Kanako、Suzuki Shinji、Watanabe Yusuke、Takamatsu Tomoko、Morichi Shinichiro、Go Soken、Oana Shingo、Yamazaki Takashi、Kawashima Hisashi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 12 Pages: 6282-6282
  • DOI: 10.3390/ijms22126282
  • Peer Reviewed / Open Access
• [Journal Article] Role of Neuroinflammation and Blood-Brain Barrier Permutability on Migraine (2021)
  • Author(s): Yamanaka Gaku、Suzuki Shinji、Morishita Natsumi、Takeshita Mika、Kanou Kanako、Takamatsu Tomoko、Suzuki Shunsuke、Morichi Shinichiro、Watanabe Yusuke、Ishida Yu、Go Soken、Oana Shingo、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 16 Pages: 8929-8929
  • DOI: 10.3390/ijms22168929
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between Cerebrospinal Fluid IL-12 Levels and Severity of Encephalopathy in Children (2021)
  • Author(s): Kawashima Hisashi、Morichi Shinichiro、Yamanaka Gaku、Terashi Hiroo、Kashiwagi Yasuyo
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 17 Pages: 3873-3873
  • DOI: 10.3390/jcm10173873
  • Peer Reviewed / Open Access
• [Journal Article] Complementary and Integrative Medicines as Prophylactic Agents for Pediatric Migraine: A Narrative Literature Review (2021)
  • Author(s): Yamanaka Gaku、Kanou Kanako、Takamatsu Tomoko、Takeshita Mika、Morichi Shinichiro、Suzuki Shinji、Ishida Yu、Watanabe Yusuke、Go Soken、Oana Shingo、Kawashima Hisashi
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 1 Pages: 138-138
  • DOI: 10.3390/jcm10010138
  • Peer Reviewed / Open Access
• [Journal Article] Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines (2021)
  • Author(s): Yamanaka Gaku、Suzuki Shinji、Morishita Natsumi、Takeshita Mika、Kanou Kanako、Takamatsu Tomoko、Morichi Shinichiro、Ishida Yu、Watanabe Yusuke、Go Soken、Oana Shingo、Kawashima Hisashi
  • Journal Title: Nutrients Volume: 13 Issue: 8 Pages: 2612-2612
  • DOI: 10.3390/nu13082612
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac Complications Caused by Respiratory Syncytial Virus Infection: Questionnaire Survey and a Literature Review (2021)
  • Author(s): Kawashima Hisashi、Inagaki Natsuko、Nakayama Toshihiro、Morichi Shinichiro、Nishimata Shigeo、Yamanaka Gaku、Kashiwagi Yasuyo
  • Journal Title: Global Pediatric Health Volume: 8
  • DOI: 10.1177/2333794x211044114
  • Peer Reviewed / Open Access
• [Journal Article] Sudden infant death suspected to be due to human bocavirus infection: a case report and literature review (2021)
  • Author(s): Yamada Mai、Morichi Shinichiro、Nishimata Shigeo、Yamanaka Gaku、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: J. Tokyo Med. Univ. Volume: 79 Pages: 157-162
  • NAID: 120007052827
  • Peer Reviewed
• [Journal Article] Primary Stabbing Headache in Children and Adolescents (2021)
  • Author(s): Takeshita Mika、Ishida Yu、Kano Kanako、Go Soken、Morichi Shinichiro、Morishita Natsumi、Suzuki Shinji、Takamatsu Tomoko、Watanabe Yusuke、Oana Shingo、Kawashima Hisashi、Yamanaka Gaku
  • Journal Title: Indian Journal of Pediatrics Volume: 88 Issue: 11 Pages: 1160-1160
  • DOI: 10.1007/s12098-021-03889-0
  • Peer Reviewed
• [Journal Article] High mobility group box 1 and angiogenetic growth factor levels in children with central nerve system infections (2021)
  • Author(s): Morichi Shinichiro、Yamanaka Gaku、Watanabe Yusuke、Takamatsu Tomoko、Kasuga Akiko、Takeshita Mika、Go Soken、Ishida Yu、Oana Shingo、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: Journal of Infection and Chemotherapy Volume: 27 Issue: 6 Pages: 840-844
  • DOI: 10.1016/j.jiac.2021.01.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased Platelet-Derived Growth Factor and Cytokine Levels in the Cerebrospinal Fluid of Patients of Sudden Unexpected Death with or without Viral Infection (2021)
  • Author(s): Morichi Shinichiro、Suzuki Shinji、Nishimata Shigeo、Yamanaka Gaku、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: The Indian Journal of Pediatrics Volume: Online ahead of print. Issue: 9 Pages: 879-884
  • DOI: 10.1007/s12098-020-03588-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Interleukin-1β in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy. (2021)
  • Author(s): Yamanaka G, Takamatsu T, Morichi S, Yamazaki T, Mizoguchi I, Ohno K, Watanabe Y, Ishida Y, Oana S, Suzuki S, Kashiwagi Y, Takata F, Sakuma H, Yoshimoto T, Kato M, Kawashima H
  • Journal Title: J Neuroimmunol. Volume: 352 Pages: 577475-577475
  • DOI: 10.1016/j.jneuroim.2021.577475
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Links between Immune Cells from the Periphery and the Brain in the Pathogenesis of Epilepsy: A Narrative Review (2021)
  • Author(s): Yamanaka Gaku、Morichi Shinichiro、Takamatsu Tomoko、Watanabe Yusuke、Suzuki Shinji、Ishida Yu、Oana Shingo、Yamazaki Takashi、Takata Fuyuko、Kawashima Hisashi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 9 Pages: 4395-4395
  • DOI: 10.3390/ijms22094395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Improvement in recurrent anti-myelin oligodendrocyte glycoprotein antibody - positive cerebral cortical encephalitis not requiring anti - inflammatory therapy following the decrease in cytokine/chemokine levels (2020)
  • Author(s): Takamatsu Tomoko、Yamanaka Gaku、Uryu Hideko、Takeshita Mika、Morishita Natsumi、Morichi Shinichiro、Ishida Yu、Oana Shingo、Terashi Hiroo、Shichino Hiroyuki、Sakuma Hiroshi、Kawashima Hisashi
  • Journal Title: Multiple Sclerosis and Related Disorders Volume: 43 Pages: 102168-102168
  • DOI: 10.1016/j.msard.2020.102168
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Beta‐propeller protein-associated neurodegeneration presenting Rett‐like features: A case report and literature review (2020)
  • Author(s): Kano Kanako、Yamanaka Gaku、Muramatsu Kazuhiro、Morichi Shinichiro、Ishida Yu、Takamatsu Tomoko、Suzuki Shinji、Miyajima Tasuku、Nakagawa Eiji、Nishino Ichizo、Kawashima Hisashi
  • Journal Title: American Journal of Medical Genetics Part A Volume: 185 Issue: 2 Pages: 579-583
  • DOI: 10.1002/ajmg.a.61993
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Granzyme A Participates in the Pathogenesis of Infection-Associated Acute Encephalopathy (2019)
  • Author(s): Yamanaka Gaku、Morichi Shinichiro、Takamatsu Tomoko、Takahashi Ryou、Watanabe Yusuke、Ishida Yu、Takeshita Mika、Morishita Natsumi、Kasuga Akiko、Kanou Kanako、Oana Singo、Suzuki Shunsuke、Go Soken、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: Journal of Child Neurology Volume: 35 Issue: 3 Pages: 208-214
  • DOI: 10.1177/0883073819886217
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A New Pathogenic Variant of CAKUTHED Diagnosed Based on Intellectual Disability (2019)
  • Author(s): Morichi Shinichiro、Suzuki Shinji、Kasuga Akiko、Ishida Yu、Yamanaka Gaku、Kashiwagi Yasuyo、Kawashima Hisashi
  • Journal Title: The Indian Journal of Pediatrics Volume: 87 Issue: 6 Pages: 480-481
  • DOI: 10.1007/s12098-019-03091-3
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 難治性てんかんにおける血中ペリサイトマーカーの検討 (2023)
  • Author(s): 高橋諒、森地振一郎、渡邊由祐、林佳奈子、高松朋子、鈴木慎二、石田悠、小穴信吾、高田芙友子、山中岳
  • Organizer: 第56回日本てんかん学会学術集会
• [Presentation] FilmArray&#174;髄膜炎・脳炎パネルにより早期診断し、良好な予後を辿ったインフルエンザ菌b型髄膜炎の一例 (2023)
  • Author(s): 南 早織、堤 範音、渡邉 駿、山田 ひかり、斎藤 直子、森地 振一郎、西亦 繁雄、山崎 崇志、柏木 保代、山中
  • Organizer: 第55回日本小児感染症学会総会・学術集会
• [Presentation] FilmArray髄膜炎・脳炎パネルを用いることで早期診断・治療が可能となった単純ヘルペス1型脳炎の乳児例 (2023)
  • Author(s): 石嶺里枝、森地振一郎、渡邊由祐、村上美佐子、三瓶みずほ、中澤はる香、高橋英城、石田悠、山中岳
  • Organizer: 第27回日本神経感染症学会学術大会
• [Presentation] Involvement of Peripheral Monocytes with IL-1β in the Pathogenesis of West Syndrome. (2022)
  • Author(s): Tomoko Takamatsu, Kanako Hayashi, Yusuke Watanabe, Koko Oono, Mika Takeshita, Natsumi Morishita, Shinichiro Morichi, Yu Ishida, Shingo Oana, Hisashi Kawashima, Gaku Yamanaka
  • Organizer: neuro2022
  • Int'l Joint Research
• [Presentation] Immunological pathogenesis of West syndrome - approach from pericyte marker - (2022)
  • Author(s): Yusuke Watanabe, Gaku Yamanaka, Kanako Kanou, Tomoko Takamatsu, Shinji Suzuki, Mika Takeshita, Natsumi Morishita, Shinichiro Morichi, Soken Go, Yu Ishida, Shingo Oana, Fuyuko Takata, Yasuyo Kashiwagi, Hisashi Kawashima
  • Organizer: neuro2022
  • Int'l Joint Research
• [Presentation] 視神経炎を呈した抗MOG抗体関連疾患の一例 (2022)
  • Author(s): 中野英太郎, 森地振一郎, 岡田このみ, 中澤はる香, 林佳奈子, 竹下美佳, 呉宗憲, 小穴信吾, 山中岳
  • Organizer: 第686回日本小児科学会東京都地方会
• [Presentation] COVID-19罹患中に急性脳症を発症した２小児例 (2022)
  • Author(s): 岡田このみ, 森地振一郎, 中野英太郎, 中澤はる香, 林佳奈子, 竹下美佳, 呉宗憲, 長尾竜兵, 小穴信吾, 山中岳
  • Organizer: 第26回日本神経感染学会総会・学術大会
• [Presentation] ペリサイトマーカーによるWest症候群の免疫学的検討 (2022)
  • Author(s): 渡邊 由祐, 山中 岳, 林 佳奈子, 高松 朋子, 鈴木 慎二, 竹下 美佳, 森下 那月美, 森地 振一郎, 呉 宗憲, 石田 悠, 小穴 信吾, 高田 芙友子, 柏木 保代, 沼部 博直, 河島 尚志
  • Organizer: 第64回日本小児神経学会学術集会
• [Presentation] 頭囲拡大、発達遅滞を契機にBannayan-Riley-Ruvalcaba症候群の診断に至った1例 (2021)
  • Author(s): 森地振一郎，沼部博直，石田悠，渡邊由祐，加納佳奈子，高松朋子，竹下美佳，森島靖行，小穴信吾，山中岳，河島尚志
  • Organizer: 第63回日本小児神経学会学術集会
• [Presentation] フローサイトメトリーを用いたWest症候群の末梢血由来因子の免疫学的検討 (2021)
  • Author(s): 高松朋子，山中岳, 大野幸子, 森健太郎, 直宮理絵 ,加納佳奈子, 渡邊由祐, 竹下美佳, 鈴木慎二, 森地振一郎, 石田悠, 小穴信吾, 河島尚志
  • Organizer: 第63回日本小児神経学会学術集会
• [Presentation] 髄液中アミノ酸及び類似物質からみたロタウイルス関連痙攣の病態解析 (2021)
  • Author(s): 伊上敦哉，森地振一郎, 西亦繁雄, 山中岳, 柏木保代, 河島尚志
  • Organizer: 第17回日本小児消化感染症研究会
• [Presentation] RSウイルス感染症の重症化病態におけるケモカイン/サイトカインimbalanceの関与の検討 (2021)
  • Author(s): 森健太郎，中山俊宏，木村将裕，森地振一郎，柏木保代，河島尚志，澤田成史
  • Organizer: 第95回日本感染症学会学術講演会/第69回日本化学療法学会総会合同学会
• [Presentation] RSウイルス感染症におけるケモカインと重症化の検討 (2021)
  • Author(s): 森健太郎，中山俊宏, 森地振一郎，柏木保代，河島尚志，澤田成史
  • Organizer: 第10回小児呼吸器ウイルス感染症研究会
• [Presentation] フローサイトメトリーを用いた West症候群の末梢血由来因子の免疫学的検討 (2021)
  • Author(s): 高松朋子、山中岳、大野幸子、森健太郎、直宮理絵、加納佳奈子、渡邊由祐、竹下美佳、鈴木慎二、森地振一郎、石田悠、小穴信吾、河島尚志
  • Organizer: 第74回日本小児神経学会関東地方会
• [Presentation] Expression of intracellular cytokines in twins with intractable epilepsy associated with lissencephaly (2020)
  • Author(s): Yamanaka Gaku、Mizoguchi Izuru、Yamazaki Takashi、Matsuoka Takayuki、Takata Fuyuko、Sakuma Hiroshi、Takamatsu Tomoko、Morichi Shinichiro、Yoshimoto Takayuki、Kato Mitsuhiro、Kawashima Hisashi
  • Organizer: The 21th Annual Meeting of Infantile Seizure Society
  • Int'l Joint Research
• [Presentation] Examination of CAKUTHED diagnosed based on intellectual disability in which a new pathogenic variant was identified (2020)
  • Author(s): Morichi Shinichiro、Suzuki Shinji、Yamanaka Gaku、Take Yoshiki、Takamatsu Tomoko、Kasuga Akiko、Ishida Yu、Kashiwagi Yasuyo、Kawashima Hisashi
  • Organizer: The 21th Annual Meeting of Infantile Seizure Society
  • Int'l Joint Research
• [Presentation] Different phenotypes in three patients with SCN2A epileptic encephalopathy (2020)
  • Author(s): Watanabe Yusuke、Morichi Shinichiro、Kano Kanako、Takamatsu Tomoko、Takeshita Mika、Morishita Natsumi、Ishida Yu、Oana Shingo、Yamanaka Gaku、Kato Mitsuhiro、Kawashima Hisashi
  • Organizer: 第186回東京医科大学医学会総会