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The role of YAP/TAZ signaling in Keloid and hypertrophic scars

Research Project

Project/Area Number 20K18419
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research InstitutionKeio University

Principal Investigator

IKURA Naohiko  慶應義塾大学, 医学部(信濃町), 助教 (10867758)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsYAP / TAZ / ケロイド / 肥厚性瘢痕 / YAP/TAZ
Outline of Research at the Start

YAP/TAZの検討を行い、ケロイドの病態形成にYAP/TAZが関与する機械的シグナルが関与している可能性を検討し、そのシグナルを阻害することで将来的な治療への応用を目指す。

Outline of Final Research Achievements

In human keloid tissue, the nuclear translocation rate of YAP / TAZ was significantly increased in lesion fibroblasts compared to normal skin at the margin, whereas the nuclear translocation rate was no significant difference in vascular endothelial cells and in epidermal cells. These data suggested that fibroblasts may be involved in the keloid tissue hardness signal. Furthermore, in the mouse back scar model, the nuclear translocation rate of YAP / TAZ in fibroblasts was higher than that of the control group, similar to the result of human tissue. In the future, we plan to investigate the possibility of application to treatment with YAP / TAZ nuclear translocation inhibitors.

Academic Significance and Societal Importance of the Research Achievements

ケロイド組織やマウス瘢痕モデルでも線維芽細胞におけるYAP/TAZの核内移行が認められたことから、持続する炎症や病変拡大に線維芽細胞のYAP/TAZシグナルが関与している可能性が示唆され、また核内移行阻害薬を用いることでケロイド治療に発展する可能性が考えられた。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2023-01-30  

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