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IgA response in relation to the salivary microbiota of diabetic patients with periodontal disease.

Research Project

Project/Area Number 20K18521
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionOsaka Medical and Pharmaceutical University

Principal Investigator

Omori Michi  大阪医科薬科大学, 医学部, 助教 (60803137)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔細菌叢 / IgA抗体 / 糖尿病 / 口腔内細菌叢 / IgA / 歯周病 / メタゲノム解析
Outline of Research at the Start

糖尿病は歯周病と相互に関連することから,糖尿病患者の歯周病治療,口腔管理が重要である。糖尿病患者の口腔細菌環境およびそれに対する応答性は健常者とは異なることが示唆されているがその詳細は明らかでない。近年の細菌叢研究の進展により,唾液細菌叢が歯周病および2型糖尿病と関連することが明らかになってきた。本研究は,2型糖尿病の歯周疾患患者の口腔細菌環境の特徴を,唾液中の細菌叢,歯周病関連細菌の相対量,さらに免疫グロブリンA (IgA) 抗体応答性から評価,把握することを目的とした。2型糖尿病患者の口腔管理において,唾液を利用した口腔細菌環境の診断,リスク評価のための基礎的データになると考える。

Outline of Final Research Achievements

The aim of this study was to characterize the oral bacterial environment of diabetic patients with a focus on the salivary microbiota and immunoglobulin A (IgA) antibody response. We found that the salivary microbiota of diabetic and prediabetic subjects was different from that of healthy subjects. In addition, salivary IgA antibody responses differed among bacterial species and were associated with salivary microbiota, and may be related to glycemic status.

Academic Significance and Societal Importance of the Research Achievements

口腔細菌叢は,全身状態と関連することが近年明らかになってきている。口腔細菌叢を規定する要因の一つとして宿主の免疫応答性,なかでも口腔の IgA 抗体応答性が関連する可能性を明らかにしたことは,学術的意義がある。また,本研究結果は,糖尿病および前糖尿病の段階を唾液の細菌叢によってスクリーニングできる可能性を示唆している。世界的な高齢化の進行により,今後糖尿病患者の増加が予測されていること,早期の発見が糖尿病予後と関連することから,臨床的意義がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (16 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] National Dental Centre Singapore(シンガポール)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Salivary Microbiota Associated with Peripheral Microvascular Endothelial Dysfunction2023

    • Author(s)
      Kato-Kogoe Nahoko、Kamiya Kuniyasu、Sakaguchi Shoichi、Omori Michi、Komori Eri、Kudo Asako、Nakamura Shota、Nakano Takashi、Ueno Takaaki、Tamaki Junko、Hoshiga Masaoki
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 7 Pages: 820-833

    • DOI

      10.5551/jat.63681

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-07-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Oral Microbiota Following Chemotherapy in Patients With Hematopoietic Malignancies2023

    • Author(s)
      Omori Michi、Kato-Kogoe Nahoko、Sakaguchi Shoichi、Komori Eri、Inoue Kazuya、Yamamoto Kayoko、Hamada Wataru、Hayase Tomoyoshi、Tano Tomoyuki、Nakamura Shota、Nakano Takashi、Une Hidenori、Ueno Takaaki
    • Journal Title

      Integrative Cancer Therapies

      Volume: 22 Pages: 1-11

    • DOI

      10.1177/15347354231159309

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Salivary Microbiota in Patients with Atherosclerotic Cardiovascular Disease: A Case-Control Study2022

    • Author(s)
      Nahoko Kato-Kogoe, Shoichi Sakaguchi, Kuniyasu Kamiya, Michi Omori, Yan-Hong Gu, Yuri Ito, Shota Nakamura, Takashi Nakano, Junko Tamaki, Takaaki Ueno, Masaaki Hoshiga.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 3 Pages: 403-421

    • DOI

      10.5551/jat.60608

    • NAID

      130008165675

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-03-01
    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of the gastric microbiome in Billroth I and Roux-en-Y reconstructions after distal gastrectomy2022

    • Author(s)
      Imai Yoshiro、Lee Sang-Woong、Sakaguchi Shoichi、Kato-Kogoe Nahoko、Taniguchi Kohei、Omori Michi、Tanaka Ryo、Honda Kotaro、Osumi Wataru、Nakano Takashi、Ueno Takaaki、Uchiyama Kazuhisa
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 10594-10594

    • DOI

      10.1038/s41598-022-14886-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of salivary microbiota in elderly patients with type 2 diabetes mellitus: a matched case-control study.2022

    • Author(s)
      Michi Omori, Nahoko Kato-Kogoe, Shoichi Sakaguchi, Kuniyasu Kamiya, Nozomu Fukui, Yan-Hong Gu, Shota Nakamura, Takashi Nakano, Masaaki Hoshiga, Akihisa Imagawa, Chee Hoe Kit, Junko Tamaki, Takaaki Ueno.
    • Journal Title

      Clin Oral Investig.

      Volume: 26 Issue: 1 Pages: 493-504

    • DOI

      10.1007/s00784-021-04027-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship between Oral Function and Occlusal Bite Force in the Elderly2020

    • Author(s)
      Imagawa Naoko、Kato-Kogoe Nahoko、Suzuki Kei、Omori Michi、Suwa Yoshifumi、Inoue Kazuya、Nakano Hiroyuki、Yamamoto Kayoko、Kamiya Kuniyasu、Ikehara Satoyo、Hoshiga Masaaki、Tamaki Junko、Kawata Ryo、Ueno Takaaki
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 29 Issue: 3 Pages: 165-168

    • DOI

      10.2485/jhtb.29.165

    • NAID

      130007877471

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Preliminary Study of the Relationship between Oral and Vascular Function in the Elderly Population2020

    • Author(s)
      Suzuki Kei、Nakano Hiroyuki、Kato-Kogoe Nahoko、Inoue Kazuya、Omori Michi、Imagawa Naoko、Suwa Yoshifumi、Yamamoto Kayoko、Kamiya Kuniyasu、Ikehara Satoyo、Tamaki Junko、Hoshiga Masaaki、Ueno Takaaki
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 29 Issue: 3 Pages: 161-164

    • DOI

      10.2485/jhtb.29.161

    • NAID

      130007877474

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative evaluation of microbial profiles of oral samples obtained at different collection time points and using different methods2020

    • Author(s)
      Omori Michi、Kato-Kogoe Nahoko、Sakaguchi Shoichi、Fukui Nozomu、Yamamoto Kayoko、Nakajima Yoichiro、Inoue Kazuya、Nakano Hiroyuki、Motooka Daisuke、Nakano Takashi、Nakamura Shota、Ueno Takaaki
    • Journal Title

      Clinical Oral Investigations

      Volume: 25 Issue: 5 Pages: 2779-2789

    • DOI

      10.1007/s00784-020-03592-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Characterization of the salivary microbiota in Japanese and Singaporean populations with type 2 diabetes mellitus2022

    • Author(s)
      Michi Omori
    • Organizer
      The IDF World Diabetes Congress 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次世代シーケンサーを用いた消化器系悪性腫瘍患者の口腔細菌叢のメタゲノム解析2022

    • Author(s)
      大森実知
    • Organizer
      第67回口腔外科学会総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高齢2型糖尿病患者のOral Microbiomeの特徴2021

    • Author(s)
      大森実知 小越菜保子 井上和也 中島世市郎 中野旬之 植野高章
    • Organizer
      日本口腔科学会関東地方部会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高齢2型糖尿病患者の唾液細菌叢のメタゲノム解析2021

    • Author(s)
      大森実知 小越菜保子 井上和也 中島世市郎 中野旬之 植野高章
    • Organizer
      第33回日本口腔科学会近畿地方部会
    • Related Report
      2021 Research-status Report
  • [Presentation] 産官学連携事業「健康寿命をのばす~たかつきモデル」の取り組み2021

    • Author(s)
      1.今川尚子,小越菜保子,矢島美香,成瀬麻衣子,大田知果,砂川葵,西川美幸,鈴木慶,松本佳輔,越智文子,山本佳代子,大森実知,井上和也,山本直典,中島世市郎,中野旬之,植野高章
    • Organizer
      第18回日本口腔ケア学会総会・学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Exploratory research on the relationship between oral microbiome and systemic conditions.2021

    • Author(s)
      Michi Oomori.
    • Organizer
      Meenakshi Academy of Higher Educational and Research.
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 造血器腫瘍患者の化学療法によるOral Microbiotaの変化に関するメタゲノム解析2020

    • Author(s)
      大森実知,小越菜保子,福居希,越智文子,山本佳代子,寺井陽彦,早瀬友克,田野智之,宇根秀則,植野高章.
    • Organizer
      第65回日本口腔外科学会総会・学術大会.
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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