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Influence on the effectiveness of periodontal tissue regeneration therapy using tcp in diabetes

Research Project

Project/Area Number 20K18525
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Takeda Kohei  東京医科歯科大学, 東京医科歯科大学病院, 非常勤講師 (10868110)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords歯周病 / 創傷治癒 / 糖尿病 / 歯周組織再生療法 / 歯周組織再生治療
Outline of Research at the Start

歯周病により失われた組織を再生する歯周組織再生療法はエナメルマトリックスタンパク質、骨移植術が臨床的に広く用いられており、歯の保存に効果的であると多く報告されている。しかし糖尿病状態と歯周組織再生療法の効果の関連性についての報告はほとんどない。歯周組織再生療法の効果に期待が高まっているが、糖尿病患者への歯周組織再生療法の一定のコンセンサスは得られていない。本研究により、糖尿病患者における歯周組織再生治療の新たなエビデンスの構築への寄与を目指す。

Outline of Final Research Achievements

This in vivo study suggested that hyperglycemia and blood glucose control in diabetic model are associated with the improvement of gingival wound healing and healing in periodontal regeneration therapy. This study also suggested the effect of oxidative stress in the early healing stage of periodontal regeneration therapy. These results of research may contribute to the establishment of more predictable periodontal regeneration therapy for diabetic patients with severe periodontitis.

Academic Significance and Societal Importance of the Research Achievements

糖尿病患者は歯周炎が進行しやすいことから、重度歯周炎により歯が失われるリスクが大きい。しかしながら糖尿病患者への歯周組織再生療法は学術的に確立していない部分もあり、本研究の成果により治療法が確立されることは学術的に意義があると考える。また歯科臨床において糖尿病患者に対する歯周炎の治療として歯周組織再生療法の有効性を示すことは社会的に意義が大きいと考える。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (25 results)

All 2024 2023 2022 2021 2020

All Journal Article (21 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 21 results,  Open Access: 13 results) Presentation (4 results)

  • [Journal Article] Genetic analysis of impaired healing responses after periodontal therapy in type 2 diabetes: Clinical and in?vivo studies2024

    • Author(s)
      Nakagawa Keita、Watanabe Kazuki、Mizutani Koji、Takeda Kohei、Takemura Shu、Sakaniwa Eri、Mikami Risako、Kido Daisuke、Saito Natsumi、Kominato Hiromi、Hattori Atsuhiko、Iwata Takanori
    • Journal Title

      Journal of Periodontal Research

      Volume: - Issue: 4 Pages: 1-16

    • DOI

      10.1111/jre.13249

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of periodontal parameters following intensive diabetes care and supragingival dental prophylaxis in patients with type 2 diabetes: A prospective cohort study2024

    • Author(s)
      Mizutani Koji、Minami Isao、Mikami Risako、Kido Daisuke、Takeda Kohei、Nakagawa Keita、Takemura Shu、Saito Natsumi、Kominato Hiromi、Sakaniwa Eri、Konuma Kuniha、Izumi Yuichi、Ogawa Yoshihiro、Iwata Takanori
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 51 Issue: 6 Pages: 733-741

    • DOI

      10.1111/jcpe.13958

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Malnutrition- inflammation- atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: a cross-sectional study2023

    • Author(s)
      Mikami Risako、Mizutani Koji、Gohda Tomohito、Matsuyama Yusuke、Gotoh Hiromichi、Nakagawa Keita、Takemura Shu、Aoyama Norio、Matsuura Takanori、Kido Daisuke、Takeda Kohei、Saito Natsumi、Izumi Yuichi、Iwata Takanori
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 11805-11805

    • DOI

      10.1038/s41598-023-38959-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low‐level erbium‐doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies2023

    • Author(s)
      Takemura Shu、Mizutani Koji、Mikami Risako、Nakagawa Keita、Hakariya Masahiro、Sakaniwa Eri、Saito Natsumi、Kominato Hiromi、Kido Daisuke、Takeda Kohei、Aoki Akira、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: - Issue: 9 Pages: 1-14

    • DOI

      10.1002/jper.23-0458

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessment of bone defect morphology for the adjunctive use of bone grafting combined with enamel matrix derivative: A 3‐year cohort study2023

    • Author(s)
      Matsuura Takanori、Mikami Risako、Mizutani Koji、Shioyama Hidehiro、Aoyama Norio、Suda Tomonari、Kusunoki Yukako、Takeda Kohei、Izumi Yuichi、Aida Jun、Aoki Akira、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: - Issue: 9 Pages: 1-12

    • DOI

      10.1002/jper.23-0538

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study2022

    • Author(s)
      Mikami Risako、Sudo Takeaki、Fukuba Shunsuke、Takeda Kohei、Matsuura Takanori、Kariya Tomoaki、Takeuchi Shunsuke、Ochiai Akane、Kawamoto Sakurako、Toyoshima Keita、Mizutani Koji、Arakawa Shinichi、Aoki Akira、Iwata Takanori
    • Journal Title

      Regenerative Therapy

      Volume: 21 Pages: 271-276

    • DOI

      10.1016/j.reth.2022.07.006

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of type 2 diabetes with periodontitis and tooth loss in patients undergoing hemodialysis2022

    • Author(s)
      Mikami Risako、Mizutani Koji、Matsuyama Yusuke、Gohda Tomohito、Gotoh Hiromichi、Aoyama Norio、Matsuura Takanori、Kido Daisuke、Takeda Kohei、Saito Natsumi、Fujiwara Takeo、Izumi Yuichi、Iwata Takanori
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 5 Pages: e0267494-e0267494

    • DOI

      10.1371/journal.pone.0267494

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Income-related inequalities in the association of smoking with periodontitis: a cross-sectional analysis in Tokyo Metropolitan Districts2022

    • Author(s)
      Mikami Risako、Mizutani Koji、Aoyama Norio、Matsuura Takanori、Suda Tomonari、Takeda Kohei、Saito Natsumi、Arakawa Shinichi、Izumi Yuichi、Iwata Takanori、Aida Jun
    • Journal Title

      Clinical Oral Investigations

      Volume: 27 Issue: 2 Pages: 519-528

    • DOI

      10.1007/s00784-022-04747-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological analysis of the impact of diabetes on gingival capillaries with non-invasive blood flow scope ? A preliminary study2022

    • Author(s)
      Takeda Kohei、Mizutani Koji、Mikami Risako、Fujino Aiko、Ito Yuri、Takeuchi Shunsuke、Saito Natsumi、Iwata Takanori
    • Journal Title

      Journal of Dental Sciences

      Volume: 10 Issue: 3 Pages: 024-024

    • DOI

      10.1016/j.jds.2022.10.024

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antioxidant effect of enamel matrix derivative for early phase of periodontal tissue regeneration in diabetes2022

    • Author(s)
      Takeda Kohei、Mizutani Koji、Matsuura Takanori、Kido Daisuke、Mikami Risako、Buranasin Prima、Saito Natsumi、Kominato Hiromi、Takemura Shu、Nakagawa Keita、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: - Issue: 8 Pages: 1206-1217

    • DOI

      10.1002/jper.21-0413

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice2022

    • Author(s)
      54.Hiromi Kominato, Kohei Takeda, Koji Mizutani, Risako Mikami, Daisuke Kido, Prima Buranasin, Natsumi Saito , Shu Takemura , Keita Nakagawa , Toshiyuki Nagasawa , Takanori Iwata
    • Journal Title

      J Periodontol

      Volume: 93 Issue: 2 Pages: 256-158

    • DOI

      10.1002/jper.21-0362

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired dental implant osseointegration in rat with streptozotocin‐induced diabetes2022

    • Author(s)
      Saito Natsumi、Mikami Risako、Mizutani Koji、Takeda Kohei、Kominato Hiromi、Kido Daisuke、Ikeda Yuichi、Buranasin Prima、Nakagawa Keita、Takemura Shu、Ueno Takeshi、Hosaka Keiichi、Hanawa Takao、Shinomura Tamayuki、Iwata Takanori
    • Journal Title

      Journal of Periodontal Research

      Volume: 57 Issue: 2 Pages: 412-424

    • DOI

      10.1111/jre.12972

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical Comparison of a Newly Developed Ionic Toothbrush with Soft Rubber Filaments and a Manual Toothbrush in Plaque Reduction: A Crossover Clinical Trial2021

    • Author(s)
      岡田 宗大、岩田 隆紀、和泉 雄一、井川 貴博、水谷 幸嗣、三神 亮、武田 浩平、須藤 毅顕、落合 茜、木内 佑実音、池田 裕一
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 64 Issue: 5 Pages: 339-347

    • DOI

      10.11471/shikahozon.64.339

    • NAID

      130008109352

    • ISSN
      0387-2343, 2188-0808
    • Year and Date
      2021-10-31
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2021

    • Author(s)
      Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata.
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 8 Pages: 1304-1304

    • DOI

      10.3390/antiox10081304

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study2021

    • Author(s)
      Takeda Kohei、Mizutani Koji、Minami Isao、Kido Daisuke、Mikami Risako、Konuma Kuniha、Saito Natsumi、Kominato Hiromi、Takemura Shu、Nakagawa Keita、Izumi Yuichi、Ogawa Yoshihiro、Iwata Takanori
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 9 Issue: 1 Pages: e002139-e002139

    • DOI

      10.1136/bmjdrc-2021-002139

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of aging on periodontal regenerative therapy using enamel matrix derivative: A 3‐year prospective cohort study2021

    • Author(s)
      Mikami Risako、Mizutani Koji、Shioyama Hidehiro、Matsuura Takanori、Aoyama Norio、Suda Tomonari、Kusunoki Yukako、Takeda Kohei、Izumi Yuichi、Aida Jun、Aoki Akira、Iwata Takanori
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 49 Issue: 2 Pages: 123-133

    • DOI

      10.1111/jcpe.13552

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between periodontal inflammation and serum lipid profile in a healthy population: A cross‐sectional study2021

    • Author(s)
      Mikami Risako、Mizutani Koji、Matsuyama Yusuke、Matsuura Takanori、Kido Daisuke、Takeda Kohei、Takemura Shu、Nakagawa Keita、Mukaiyama Yuto、Suda Tomonari、Yasuda Takako、Ohta Syujiro、Takaya Norihide、Fujiwara Takeo、Izumi Yuichi、Iwata Takanori
    • Journal Title

      Journal of Periodontal Research

      Volume: 56 Issue: 6 Pages: 1037-1045

    • DOI

      10.1111/jre.12917

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3‐year observation: A prospective cohort study2021

    • Author(s)
      Mizutani Koji、Shioyama Hidehiro、Matsuura Takanori、Mikami Risako、Takeda Kohei、Izumi Yuichi、Aoki Akira、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: online ahead Issue: 9 Pages: 1262-1273

    • DOI

      10.1002/jper.20-0590

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study2021

    • Author(s)
      Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 25 Issue: 1 Pages: 58-65

    • DOI

      10.1007/s10157-020-01952-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study.2020

    • Author(s)
      Mizutani K, Mikami R, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Sasaki Y, Iwata T
    • Journal Title

      Scientific reports

      Volume: 10 Issue: 1 Pages: 21872-21872

    • DOI

      10.1038/s41598-020-78724-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Screening for Periodontitis during Medical Checkup: A Single Center Cross-sectional Study2020

    • Author(s)
      水谷 幸嗣、須田 智也、和泉 雄一、岩田 隆紀、三上 理沙子、佐々木 好幸、髙谷 典秀、太田 秀二郎、松浦 孝典、城戸 大輔、武田 浩平、向山 雄人
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 63 Issue: 3 Pages: 245-253

    • DOI

      10.11471/shikahozon.63.245

    • NAID

      130007871266

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 糖尿病による歯科用インプラントのオッセオインテグレーションの低下2021

    • Author(s)
      齋藤 夏実, 三上 理沙子, 水谷 幸嗣, 武田 浩平, 小湊 広美, 城戸 大輔, 池田 裕一, 中川 佳太, 竹村 修, 上野 剛史, 保坂 啓一, 塙 隆夫, 篠村 多摩之, 岩田 隆紀
    • Organizer
      第64回春季日本歯周病学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高脂肪食誘発型糖尿病マウスにおける歯肉創傷治癒に対するメトホルミン投与の効果2021

    • Author(s)
      小湊 広美, 水谷 幸嗣, 武田 浩平, 城戸 大輔, 三上 理沙子, 齋藤 夏実, 竹村 修, 中川 佳太, 岩田 隆紀
    • Organizer
      第154回 日本歯科保存学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 2型糖尿病が歯肉毛細血管に及ぼす影響2020

    • Author(s)
      藤野愛子,武田浩平,水谷幸嗣,三上理沙子,石角 篤,木平成子,竹内俊介,伊藤裕理,岩田隆紀
    • Organizer
      第63回秋季日本歯周病学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 日本歯周病学会学術大会におけるハンズオンセミナー"歯周組織再生療法に必要なTips"の開催と受講者の満足度調査2020

    • Author(s)
      石川 聡, 土岡弘明, 臼井通彦, 鬼塚 理, 工藤 求, 酒井和人, 澤辺正規, 竹内祥吾, 武田浩平, 山脇史寛, 杵渕恵那, 中島啓介
    • Organizer
      第63回春季日本歯周病学会学術大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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