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Effects of Modulation of Cortical Activity on Two-point Discrimination Sensation in Accordance with Individual Characteristics of Brain Rhythm

Research Project

Project/Area Number 20K19429
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

Yokota Hirotake  新潟医療福祉大学, リハビリテーション学部, 助教 (20827472)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords二点識別覚 / α律動 / 経頭蓋交流電流刺激 / 左後頭頂皮質 / 一次体性感覚野 / 後頭頂皮質
Outline of Research at the Start

近年,慢性疼痛患者において二点識別覚(TPD)の改善と疼痛軽減の関連が報告されており,TPDを効果的に改善させる手法が新規治療として望まれている.そこで本研究では,TPDを向上させる効果的な脳刺激法を明らかにすることを目的とした.具体的には,TPD処理に重要とされる一次体性感覚野(S1)または後頭頂皮質(PPC)に対するα帯域の経頭蓋交流電流刺激(tACS)がTPD閾値に及ぼす影響を解明し,次に,個人の安静時脳律動に合わせた周波数でtACSを行い,より効果的なTPD向上を試みる.一連の検証をもとに,将来的に慢性疼痛患者の痛覚知覚との関連を明らかにし,慢性疼痛の新たな治療法開発を目指す.

Outline of Final Research Achievements

Brain rhythms in the alpha band (8-13 Hz) are known to influence perception, but the effects of changes in alpha band activity in the left posterior parietal cortex (PPC) and primary somatosensory cortex (S1), which have been suggested to play different roles for a higher-order perceptual measure, two-point discrimination (TPD), on TPD threshold are unknown .
We stimulated the left PPC and S1 using 10 Hz transcranial alternating current stimulation (tACS), which can noninvasively modulate brain rhythms, in 17 healthy students and measured TPD threshold in the right index finger. The results demonstrated that tACS lowered TPD threshold when applied over the left PPC but did not change it when applied over left S1, demonstrating a region-specific effect on TPD threshold determination.

Academic Significance and Societal Importance of the Research Achievements

本研究によりtACSを用いて感覚皮質の可塑的変化を誘導することで二点識別覚(TPD)の向上が得られることが明らかとなった.将来的に慢性疼痛患者の痛覚知覚との関連を明らかにできれば,これまで効果が限定的であった慢性疼痛における新たな治療法開発につながることが期待できる.さらに,対象部位を変えれば,脳律動の関与が指摘される認知機能や運動機能の低下などに対しても汎用の可能性があり,様々な領域の障害回復に応用できる可能性がある.

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (3 results)

All 2021 2020

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Region-Specific Effects of 10-Hz Transcranial Alternate Current Stimulation Over the Left Posterior Parietal Cortex and Primary Somatosensory Area on Tactile Two-Point Discrimination Threshold2021

    • Author(s)
      Yokota Hirotake、Otsuru Naofumi、Saito Kei、Kojima Sho、Miyaguchi Shota、Inukai Yasuto、Nagasaka Kazuaki、Onishi Hideaki
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 1-11

    • DOI

      10.3389/fnins.2021.576526

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 左後頭頂皮質および一次体性感覚野に対する10Hz経頭蓋交流電流刺激が       二点識別覚閾値に及ぼす領域特異的効果2021

    • Author(s)
      横田裕丈,大鶴直史,齊藤 慧,小島 翔, 宮口翔太,犬飼康人,長坂和明,江玉睦明,大西秀明
    • Organizer
      第25回日本基礎理学療法学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 左後頭頂皮質および一次体性感覚野に対する10Hz経頭蓋交流電流刺激が二点識別覚閾値に及ぼす領域特異的効果2020

    • Author(s)
      横田裕丈
    • Organizer
      第25回日本基礎理学療法学会学術大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2023-01-30  

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